Integrin alpha 11 (Itga11) is the most recently identified integrin subunit and has been associated with fibrotic disease. To investigate the role of Itga11 in fibroblast behavior in wound healing and fibrosis we used Itga11 null mice. We have found that fibroblasts lacking Itga11 (KO) repair a scratch in a confluent monolayer faster than their normal (Het) counterparts, and show increased proliferation along the margins of the scratch. In an ...
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