This Predoctoral Traineeship Award was specially intended to support Lingyan Jiang in Functional Studies of Tumor Suppressor RASSF1A in Breast Cancer. RASSF1A is a firmly established tumor suppressor, which is silenced in a variety of cancer. Our preliminary studies demonstrate RASSF1A directly interacts with a potential oncoprotein NAP1 (nucleosome assembly protein 1) through the MTinteracting region on RASSF1A. Based on these novel findings, we hypothesized that NAP1 could play an ...
The goal of this project is to characterize T cell tolerance to prostate tumor antigens and to identify the role of costimulatory receptors in overcoming this tolerance. Identification of these processes will assist in the development of novel therapeutic approaches for treating prostate cancer. We use the TRAMP model a transgenic mouse line that develops primary prostatic tumors due to expression of the SV40 T antigen (TAg) under the transcriptional ...
The goal of this project is to characterize T cell tolerance to prostate tumor antigens and identify the role of costimulatory receptors in overcoming this tolerance. Identification of these processes will assist in the development of novel therapeutic approaches for treating prostate cancer. We use the TRAMP model, a transgenic mouse line that develops primary prostatic tumors due to expression of the SV4O T antigen (TAg) under the transcriptional control ...
The goal of this project is to characterize T cell tolerance to prostate tumor antigens and identify the role of costimulatory receptors in overcoming this tolerance. Identification of these processes will assist in the development of novel therapeutic approaches for treating prostate cancer. We use the TRAMP model, a transgenic mouse line that develops primary prostatic tumors due to expression of the SV4O T antigen (Tag) under the transcriptional control ...
The goal of this project is to characterize T cell tolerance to prostate tumor antigens and identify the role of costimulatory receptors in overcoming this tolerance. Identification of these processes will assist in the development of novel therapeutic approaches for treating prostate cancer. -We currently use the TRAMP model which is a transgenic mouse line that develops primary prostatic tumors due to expression of the sv4O T antigen (TAg) under ...
Monkeys were given cholinergic drugs in doses considered to provide protection against organophosphate poisoning. Their eye movements were recorded while they carried out visual search and target tracking tasks. In general these agents had subtle effects. At the worst, monkeys remained capable of carrying out moderately good search and tracking performance. Pyridostigmine (7 mg/K) was the most benign, having no observable effect. Pralidoxime impaired behavior only at the highest dose ...
A number of cholinergic agents are deemed useful as prophylactics or antidotes to organophosphate poisoning yet have their own toxic effects. Dosages of these agents which are known to not grossly disrupt behavior may nonetheless degrade performance of sophisticated tasks required of the personnel of a modern mechanized army. The contract uses an animal model (primate) to assess the effects of cholinergic drugs on the performance of visual search and ...
A number of cholinergic agents are deemed useful as prophylactics or antidotes to organophosphate poisoning yet have their own toxic effects. Dosages of these agents which are known to not grossly disrupt behavior may nonetheless degrade performance of sophisticated tasks required of the personnel of a modern mechanized army. The contract uses on animal model (primate) to assess the effects of cholinergic drugs on the performance of visual search and ...
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