For some time microcalcifications associated with breast lesions were considered to represent an epiphomenon, useful only as a radiological indicator of breast carcinoma. However, the data presented here shows that HA crystals are capable of exerting significant biological effects on surrounding cells. In this study we report that HA increases mitogenesis in both normal and malignant mammary cell lines. Particles of latex beads, of similar size and concentration to HA ...
For some time microcalcifications associated with breast lesions were considered to represent an epiphomenon, useful only as a radiological indicator of breast carcinoma. However, the data presented here shows that HA crystals are capable of exerting significant biological effects on surrounding cells. In this study we report that HA increases mitogenesis in both normal and malignant mammary cell lines. Particles of latex beads, of similar size and concentration to HA ...
Radiographic mammary microcalcifications are one of the most pertinent diagnostic markers of breast cancer. Breast tissue calcification in the form of hydroxyapatite (HA) crystals is strongly associated with malignant disease. HA crystals play a well-described role in a number of disease processes unrelated to the breast, including severe cartilage destruction. The characteristics of HA believed to be essential to pathogenesis include their ability to induce I) cell replication and 2) ...
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