| A Tunable Magnetic Trap Platform for Single Particle Manipulation |
17 Aug 2009 |
5 pages |
| Authors:
R Sooryakumar; OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
|
 | In this Short Term Innovative Research (STIR) project, the physics of magnetic traps originating from domain walls in ferromagnetic zigzag wires was investigated. The design and architecture of the network of traps provided the framework for organizing well-defined planar assemblies of micro-particles and tethered biomolecules. A special feature of this platform is the ability to continuously tune the strength of the trapping potential through external magnetic fields that also render ... |
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| Ets2 Contributions of the Tumor Microenvironment in Breast Cancer Metastasis |
Mar-2009 |
31 pages |
| Authors:
Jillian L Werbeck; OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
|
| According to the American Cancer Society, the chance being diagnosed with invasive breast cancer is about 1 in 8 and the chance of dying from breast cancer is about 1 in 33. The recent trend toward a decrease in breast cancer mortality rate is largely due to increased diagnosis of early stage disease, while therapeutic options for advanced stage breast carcinomas are still fairly limited. Currently, metastasis is the most ... |
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| The Bone Marrow Stem Cell Origin of Human Breast Cancer Using Transgenic Mouse Models |
Oct-2008 |
13 pages |
| Authors:
Sanford H Barsky; OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
|
| There is emerging evidence that transformed stem cells may be the source of human cancers. We felt that transgenic mouse models were ideally suited to examine this question and proposed to conduct marrow transplant experiments to test whether marrow stem cells are the cells of breast cancer origin. Our most significant findings included: 1) the demonstration that stromal cells within the transgenic breast cancers contain significant percentages of tissue macrophages, ... |
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| Prestall Behavior of a Transonic Axial Compressor Stage via Time-Accurate Numerical Simulation |
Oct-2008 |
16 pages |
| Authors:
Jen-Ping Chen; Michael D Hathaway; Gregory P Herrick; OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
|
| CFD calculations using high-performance parallel computing were conducted to simulate the pre-stall flow of a transonic compressor stage, NASA compressor Stage 35. The simulations were run with a full-annulus grid that models the 3D, viscous, unsteady blade row interaction without the need for an artificial inlet distortion to induce stall. The simulation demonstrates the development of the rotating stall from the growth of instabilities. Pressure-rise performance and pressure traces are ... |
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| Molecular Modeling of High-Temperature Oxidation of Refractory Borides |
FEB 2008 |
9 pages |
| Authors:
Ju Li; OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
|
| Refractory diboride with silicon carbide additive has a unique oxide scale structure with two condensed oxide phases (solid + liquid), and demonstrates oxidation resistance superior to either monolithic diboride or silicon carbide. We rationalize that this is because the silica-rich liquid phase can retreat outward to remove the high SiO gas volatility region, while still holding onto the zirconia skeleton mechanically by capillary forces, to form a "solid pillars, liquid ... |
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| The Effect of COX-2 Inhibitors on the Aromatase Gene (CYP19) Expression in Human Breast Cancer |
DEC 2006 |
28 pages |
| Authors:
Charles L. Shapiro; OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
|
| Aromatase (CYP19) is responsible for estrogen biosynthesis, and CYP-19 and cyclooxygenase-2 (COX-2) are both overexpressed in human breast cancers. Prostaglandin activates the CYP19 promotor and increases gene expression therefore we hypothesized that celecoxib, a selective COX-2 inhibitor, will decrease PG and decrease the expression of CYP19. To test this hypothesis, celecoxib was administered to breast cancer patients after the initial core biopsy tumor tissue and then tumor tissue was collected ... |
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| A Computational Program for Multiple Scale Analysis of Failure in Non-Uniform Composite Materials |
31 MAR 2006 |
211 pages |
| Authors:
Somnath Ghosh; OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
|
| This work has developed an adaptive concurrent multi-level computational model for multi-scale analysis of composite structures undergoing damage initiation and growth due to microstructural damage induced by debonding at the fiber-matrix interface. The model combines macroscopic computations using a continuum damage model with explicit micromechanical computations of stresses and strain, including explicit debonding at the fiber-matrix interface. Three hierarchical levels of different resolution adaptively evolve in this to improve the ... |
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| Genetic Alterations in Epithelial and Stromal Compartments of Prostate Adenocarcinomas |
JAN 2006 |
36 pages |
| Authors:
Charis Eng; OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
|
| Genetic analyses on prostate cancer has been occurring for over a decade. However such studies were uniformly performed on the entire tumor without regard to its components despite the fact that a few groups were quite aware of both epithelial and stromal components of tumors and the cell biology of the tumor "microenvironment" has been described for the last 20 years. Thus until now when a genetic alterabon be it ... |
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| Dynamic Analysis of Sliding Friction in Rotorcraft Geared Systems |
17 SEP 2005 |
7 pages |
| Authors:
Rajendra Singh; OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
|
| This comprehensive study has examined the key effects of sliding friction in spur and helical gear dynamic models, vibro-acoustic sources and geared system responses. First, many dynamic phenomena that emerge due to the interactions between time-varying mesh stiffness, sliding friction and/or surface finish are successfully formulated. Second, new multi-degree-of-freedom models considering both torsional and translational dynamics of spur and helical gear pairs have been developed. These include time-varying mesh stiffness, ... |
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| Bio-Fluid Transport Models Through Nano and Micro-Fluidic Components |
AUG 2005 |
225 pages |
| Authors:
A. T. Conlisk; Derek Hansford; Minami Yoda; OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
|
| This project was a combined fabrication, experimental, and modeling effort to predict transport properties of micro and nanochannels. In this work, the governing equations for electrokinetic flow are solved for not only monovalent binary electrolytes, but also multi-component electrolytic systems containing multivalent ion species. For channel-reservoir systems, the wall concentrations of different ion species are obtained using electrochemical equilibrium consideration. For channel materials with known surface charge density, the results ... |
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| Development of a Novel Prognostic Marker to Link a Potential Tumor Suppressor Gene at Chromosome 6q to Aberrant Signal Transduction Pathway in Breast Cancer |
AUG 2005 |
85 pages |
| Authors:
Pan Zheng; OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
|
| This is the final report on the grant "Development of a novel diagnostic marker to link a potential tumor suppressor gene at chromosome 6q to aberrant signal transduction pathway in breast cancer." The purpose of the grant proposal is to examine the hypothesis that protein phosphatase laforin is a tumor suppressor in cancers through its function as the specific phosphatase of GSK-3BETA and the loss of function of laforin causes ... |
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| Syntheses of 1,2,3,4-Tetrazine Di-N-oxides, Pentazole Derivatives, Pentazine Poly-N-oxides, and Nitroacetylenes |
30 JUN 2005 |
51 pages |
| Authors:
H. Shechter; M. Venugopal; D. Srinivasulu; OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
|
| Study has been initiated of practical synthesis and the chemistry of 1) 1,2,3,4-tetrazines and their products, 2) 5,6-distubstituted- 1,2,3,4-tetrazine 1,3-di-N-oxides, 5,6-diketo- 1,2,3,4-tetrazine I ,3-di-N-oxide and its derivatives, isometric 1,2,3,4,5,6,7,8- octazanaphthalene tetroxides (DTTO and IsoDTTO), various substituted benzotetrazine 1,3-di -N-oxides and their transformations, isomeric furoxanotetrazine 1,3-di-N-oxides, furazanotetrazine 1,3-di-N-oxide, (FTDO), 5,6-(1 ,2,3-triazolo)-1 ,2,3,-tetrazine 1,3-di-N-oxides, and various 1- nitroacetylenes and dinitroacetylenes and their respective precursors and derivatives. The various synthetic routes studied have ... |
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| Rescuing High Avidity T Cells for Prostate Cancer Immunotherapy |
APR 2005 |
66 pages |
| Authors:
Pan Zheng; OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
|
| This is the second annual report on the grant "Rescuing high avidity T cells for prostate cancer immunotherapy". The purpose of the grant proposal is to rescuing high avidity tumor-antigen specific T cells that can respond effectively to prostate cancer cells and delay the delay the development of prostate cancer in the TRAMP mouse model. The innovative idea is based on the hypothesis that blockade of the T cell costimulatory ... |
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| The HEP Study: Head and Eye Pursuit Tracking under Natural Conditions |
21 FEB 2005 |
17 pages |
| Authors:
Nicklaus F. Fogt; OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
|
| The broad purpose of these experiments was to determine how the eye and head are normally coordinated, and to determine the optimal combination of eye and head movements for vision and reaching. The key findings were as follows: (A) head reticle disrupts eye position during head tracking, and is of little benefit for head tracking; (B) the head is moved to view targets only when such movements are unlikely to ... |
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| Genetic Alterations in Epithelial and Stromal Compartments of Prostate Adenocarcinomas |
JAN 2005 |
11 pages |
| Authors:
Charis E. Eng; OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
|
| Genetic analyses on prostate cancer has been occurring for over a decade. However, such studies were uniformly performed on the entire tumor without regard to its components despite the fact that a few groups were quite aware of both epithelial and stromal components of tumors, and the cell biology of the tumor "microenvironment" has been described for the last 20 years. Thus, until now, when a genetic alteration, be it ... |
|
| Sodium Iodide Symporter Gene Transfer for Imaging and Ablation of Prostate Cancer |
JAN 2005 |
31 pages |
| Authors:
Sissy M. Jhiang; OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
|
| The sodium iodide symporter (NIS) mediates iodide uptake in thyroid follicular cells and provides a mechanism for effective radioiodide treatment of residual, recurrent, and metastatic thyroid cancers. The objective of the proposed research is to test the hypothesis that expression of exogenous hNIS in prostatic tissue will enable radioiodide to localize and ablate residual prostate cancer following prostatectomy, such that recurrence and metastasis of the disease can be prevented. The ... |
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| The Combined Impact of Surgery and Immunomodulation With Low Dose Cytoxan and GM-CSF in the Early Treatment of Breast Cancer |
SEP 2004 |
20 pages |
| Authors:
Kari L. Kendra; OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
|
| The purpose of this study was to evaluate the combined impact of surgery and immunomodulation with low dose cytoxan and GM-CSF on the development of dendritic cells and the activation of T cells in vivo. MMTV Her2/neu mice, which spontaneously develop mammary tumors were treated with combinations of cytoxan, GM-CSF and surgery. Flow cytometry was used to evaluate blood (B), lymph nodal tissue (LN), and splenocytes (S) for evidence of ... |
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| The Effect of Cox-2 Inhibitors on the Aromatase Gene (CYP19) Expression in Human Breast Cancer |
JUN 2004 |
9 pages |
| Authors:
Charles L. Shapiro; William Burak; Robert Brueggemeier; OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
|
| Aromatase (CYP-l9) is responsible for estrogen biosynthesis within breast tumor tissue. Aromatase and cyclooxygenase-2 (COX-2) are both overexpressed in human breast cancer, and increased levels of prostaglandin (PG) activates the CYP19 promotor and increases gene expression. We hypothesize that celecoxib, a selective COX-2 inhibitor, will decrease PG, decrease the expression of CYPl9, and reduce estrogen biosynthesis within tumor tissue. To test this hypothesis, in DOD grant # DAMD17-C-01-0589, tumor tissue ... |
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| Antioxidant Therapy for Men With Asymptomatic Prostate Cancer |
MAY 2004 |
79 pages |
| Authors:
Shihua Wang; Steven Clinton; OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
|
| The Department of Defense (DOD) post-doctoral training grant was used to support the career development of 3 individuals, Dr. Thomas Boileau, Dr. Peter Carlton, and Dr. Shihua Wang. Dr. Boileau began his initial training at The Ohio State University under the direction of Dr. Tammy Bray (original mentor on this grant) in the Department of Human Nutrition. He initially completed several projects focusing on the relationships of dietary tomato products, ... |
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| Computational Auditory Scene Analysis Based Perceptual and Neural Principles |
MAR 2004 |
13 pages |
| Authors:
DeLiang Wang; OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
|
| A remarkable feat of the auditory system is its ability to disentangle the acoustic mixture and group the acoustic energy from the same event. This fundamental process of auditory perception is called auditory scene analysis. of particular importance in auditory scene analysis is the separation of speech from interfering sounds, or speech segregation. Consistent with specified objectives, this project made major advances along the following three directions. First, the problem ... |
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| Sodium Iodide Symporter Gene Transfer for Imaging and Ablation of Prostate Cancer |
JAN 2004 |
31 pages |
| Authors:
Sissy M. Jhiang; OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
|
| The sodium iodide symporter (NIS) mediates iodide uptake in thyroid follicular cells and provides a mechanism for effective radioiodide treatment of residual, recurrent, and metastatic thyroid cancers. The objective of the proposed research is to test the hypothesis that expression of exogenous hNIS in prostatic tissue will enable radioiodide to localize and ablate residual prostate cancer following prostatectomy, such that recurrence and metastasis of the disease can be prevented. The ... |
|
| C/EBP(delta): A Candidate Tumor Suppressor Gene in Breast Cancer |
SEP 2003 |
53 pages |
| Authors:
James W. DeWille; OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
|
| Inactivation of tumor suppressor genes, through a variety of mechanisms, is a key pathological step in breast cancer development and progression. The overall goal of this research is to investigate the regulation, expression and clinical relevance of CCAAT/Enhancer binding protein 5 (C/EBP5, CEBPD) as a candidate tumor suppressor gene in breast cancer. Our hypothesis is that C/EBP5 is a key regulator of mammary epithelial cell growth arrest and that loss ... |
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| A Novel Phosphatase Gene on 10q23, MINPP, in Hereditary and Sporadic Breast Cancer |
AUG 2003 |
49 pages |
| Authors:
Charis Eng; OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
|
| PTEN is a tumor suppressor gene on 10q23 and encodes a dual specificity phosphatase. One of the major substrates for PTEN is phosphotidylinositol (3,4,5) triphosphate in the P13 kinase pathway. When PTEN is dysfunctional or absent, P-Akt is high and hence, anti-apoptotic. PTEN is a major susceptibility gene for Cowden syndrome (CS), a hereditary disorder with a high risk of breast and thyroid cancer, and appears to be involved in ... |
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| Development of an erbB Antagonist |
JUL 2003 |
58 pages |
| Authors:
Amanda A. Simcox; OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
|
| Receptor tyrosine kinases of the erbB family play pivotal roles in growth and differentiation and aberrant activation of these receptors is associated with human cancers. Zn particular, ErbB-2 dysfunciton has been linked to about 30% of breast cancers with poor prognosis. Correspondingly, great efforts are being made to develop therapies that target ErbB pathways. ErbB-2 is activated by the neuregulins in heterodimers with the neuregulin receptors ErbB- 3 and ErbB-4. ... |
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| Development of KGF Antagonist as a Breast Cancer Therapeutic |
JUL 2003 |
34 pages |
| Authors:
Yasuro Sugimoto; OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
|
| This grant proposal was to synthesize potential KGF antagonists which will then be evaluated for efficacy in vitro assay systems. The results generated for the propose study would be useful for designing new therapeutic agent for breast cancer. We were able to show some potential intracellular KGFR target small molecules whereas extracellular target synthetic peptide antagonist was not able to do during this period We also added a new dimension ... |
|
| Sodium Iodide Symporter Gene Transfer for Imaging and Ablation of Prostate Cancer |
JAN 2003 |
51 pages |
| Authors:
Sissy M. Jhiang; OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
|
| The sodium iodide symporter (NIS) mediates iodide uptake in thyroid follicular cells and provides a mechanism for effective radioiodide treatment of residual, recurrent, and metastatic thyroid cancers. The objective of the proposed research is to test the hypothesis that expression of exogenous hNIS in prostatic tissue will enable radioiodide to localize and ablate residual prostate cancer following prostatectomy, such that recurrence and metastasis of the disease can be prevented. |
|
| Proto-Oncogene PML and Tumor Evasion in Prostate Cancer |
NOV 2002 |
79 pages |
| Authors:
Pan Zheng; OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
|
| This is the Final report on the grant "Proto-oncogene PML and tumor evasion in prostate cancer?" We proposed to identify the antigen presentation defects in human prostate cancer samples and to use mouse prostate cancer model (TRAMP mice) to study the immune regulation and immune tolerance in prostate cancer. In the past three years, we have completed the experiments proposed in the grant. We have shown that proto-oncogene PML and ... |
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| A Novel Phosphatase Gene on 10q23, MINNP, in Hereditary and Sporadic Breast Cancer |
AUG 2002 |
28 pages |
| Authors:
Charis Eng; OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
|
| PTEN is a tumor suppressor gene on 10q23 and encodes a dual specificity phosphatase. One of the major substrates for PTEN is phosphotidylinositol (3,4,5) triphosphate in the PI3 kinase pathway. When PTEN is dysfunctional or absent, P-Akt is high and hence, anti-apoptotic. PTEN is a major susceptibility gene for Cowden syndrome (CS), a hereditary disorder with a high risk of breast and thyroid cancer, and appears to be involved in ... |
|
| Development of an erbB Antagonist |
JUL 2002 |
11 pages |
| Authors:
Amanda A. Simcox; OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
|
| Receptor tyrosine kinases of the erbB family play pivotal roles in growth and differentiation and aberrant activation of these receptors is associated with human cancers. In particular, ErbB-2 dysfunction has been linked to about 30% of breast cancers with poor prognosis. Correspondingly, great efforts are being made to develop therapies that target ErbB pathways. ErbB-2 is activated by the neuregulins in heterodimers with the neuregulin receptors ErbB- 3 and ErbB-4. ... |
|
| The Effect of COX-2 Inhibitors on the Aromatase Gene (CYP19) Expression in Human Breast Cancer |
JUN 2002 |
4 pages |
| Authors:
Charles L. Shapiro; William Burak; Robert Brueggemeier; OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
|
| Aromatase (CYP-l9) is responsible for estrogen biosynthesis within breast tumor tissue Aromatase and cyclooxygenase-2 (COX-2) are both overexpressed in human breast cancer, and increased levels of prostaglandin (PG) activates the CYPl9 promotor and increases gene expression We hypothesize that celecoxib, a selective COX-2 inhibitor, will decrease PG, decrease the expression of CYPl9, and reduce estrogen biosynthesis within tumor tissue To test this hypothesis, in DOD grant # DAMDl7-0l-0589, tumor tissue ... |
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| Alteration of the Endothelial Barrier by Breast Cancer Cells as a Mechanism of Tumor Resistance |
MAY 2002 |
8 pages |
| Authors:
Carleton B. Jones; OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
|
| The endothelial cells lining blood vessels that perfuse breast tumors present a barrier that antineoplastic agents must cross to reach the tumor cells. The purpose of this award was to provide preliminary data to support the hypothesis that tumor cells can modulate this barrier by secreting soluble factors, by affecting extracellular matrix, or by a combination of these factors. The specific aims of this project were to 1) determine tumor ... |
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| Acquisition of a Nanometer-Scale Auger Electron Spectroscopy Analytical Microprobe |
25 MAR 2002 |
5 pages |
| Authors:
Leonard J. Brillson; OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
|
| We have acquired an Auger Electron Spectroscopy Microprobe Analysis System for elemental and bonding analysis of electronic materials, equipped with specimen stage, ion beam depth analyzer, and ultrahigh vacuum (UHV) preparation chamber interfaced to an existing UHV scanning electron microscope. The specific equipment purchased is: JEOL USA, Inc. Auger Electron Spectroscopy Depth Profiling Hardware and Software for the JAMP-7800 deg F. Its acquisition enhances a number of DoD-funded programs and ... |
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| Enhancement of Capabilities of Smart Electromagnetic Structures (SEMS) |
21 JAN 2002 |
7 pages |
| Authors:
Gregory Washington; OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
|
| New smart conformal antenna concepts where passive and electrically active materials are integrated to generate multifunction, adaptive and compact conformal arrays are being considered and developed. Besides, advanced electromagnetic field simulation tools for the design and analysis of conformal active integrated arrays are developed. In addition, novel phased array concepts are being examined. |
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| Thermal Stability of NI/NI3AL Nanolayered Materials |
10 DEC 2001 |
24 pages |
| Authors:
Peter M. Anderson; Hamish L. Fraser; OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
|
| The purpose of the research is to study the morphological stability of Ni/Ni3A1 layered materials, as a function of interfacial orientational relationships, columnar grain dimensions, bilayer thickness, applied stress, and temperature. This report describes our efforts over the past year to model critical features which control the strength of interfaces to dislocation transmission, and to study the morphological stability of Ni(Al)/Ni3Al that are heated to elevated temperature for prolonged periods. ... |
|
| Genetics of PTEN in Cowden Syndrome and Sporadic Breast Cancer |
OCT 2001 |
66 pages |
| Authors:
Charis Eng; OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
|
| Germline mutations in PTEN on 10q23.3 cause 80% of classic Cowden syndrome (CS) and SO of Bannayan-Riley-Ruvalcaba syndrome (CS) as well as up to 20% of Proteus syndrome and up to 50 of unclassified Proteus-like syndromes. The major thrust of this grant was to identify and characterize PTEN's involvement in families and individuals with one ore more CS component tumors, of which prominently is breast cancer. During the funding period, ... |
|
| Deformation Mechanisms in Multilayered Materials for High Temperature Application |
06 SEP 2001 |
6 pages |
| Authors:
Peter M. Anderson; Hamish L. Fraser; OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
|
| The aim of the proposed research is to understand how nanoscale laminates with optimal strength, ductility, and elevated temperature stability can be engineered through the selection of component chemistry, component layer thickness, and interfacial and grain boundary structure. The first effort is to develop computational tools to model the deformation and fracture processes in nanoscale laminates based on a well-known intermetallic system. The second effort is to apply the computational ... |
|
| Stress and Immunity Breast Cancer Project |
SEP 2001 |
41 pages |
| Authors:
Barbara L. Andersen; OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
|
| A biobehavioral model of cancer stress and disease course was proposed (see Andersen, Kiecolt Glaser, & Glaser, 1994) . We are testing the model with a clinical trial: 228 women with stage II or III breast cancer were randomized between assessment and intervention or assessment only (control) study arms. In addition to documenting the quality of life benefits of a psychological intervention, this study provides an experimental test of the ... |
|
| The Origin and Structure of Trailing Vortices in Aerodynamics |
06 JUL 2001 |
252 pages |
| Authors:
A. T. Conlisk; N. M. Komarath; OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
|
| The helicopter rotor wake is among the most complex flow-fields in aerodynamics. Despite the fact that a large amount of computational and experimental work on the rotor wake has been published, little of a quantitative nature is known about the origin of the main component of the rotor wake, the tip-vortex, as a function of the rotor speed, rotor blade geometry, and angle of attack. The primary objective of this ... |
|
| Development of KGF Antagonist as a Breast Cancer Therapeutic |
JUL 2001 |
9 pages |
| Authors:
Yasuro Sugimoto; OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
|
| This grant proposal is to synthesize potential KGF antagonists which will then be evaluated for efficacy in in vitro assay systems. The results generated for the proposed study will be useful for designing new therapeutic agent for breast cancer. KGF antagonist candidate peptides have been synthesized and evaluated its ability. There is, however lack of sensitivity issue underlies on the functional assay procedure. We then developed several KGF-receptor overexpressed cell ... |
|
| Deformation Mechanisms in Multilayered Materials for High Temperature Application |
MAR 2001 |
6 pages |
| Authors:
Peter M. Anderson; Hamish L. Fraser; OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
|
| The general aim of the proposed research is to understand how nanoscale laminates with optimal strength, ductility, and elevated temperature stability can be engineered through the selection of component chemistry, component layer thickness, and interfacial and grain boundary structure. The first effort is to develop computational tools to model the deformation and fracture processes in nanoscale laminates based on a well-known intermetallic system. The second effort is to apply the ... |
|
| X-Photon-to-Information Conversion Efficiency in Digital Telemammography |
DEC 2000 |
209 pages |
| Authors:
Bradley D. Clymer; Celeste B. Williams; OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
|
| Imaging techniques used for diagnosis and detection of breast cancer are all performed by deforming the breast. This deformation permits improved diagnostic imaging of the breast, however, the imaging techniques do not take into account the biomechanical nature of breast tissue. This is largely due to the fact that the biomechanical behavior of breast tissue is not fully understood. Since malignant masses tend to be stiffer than normal tissue, an ... |
|
| TAILSIM Users Guide. |
DEC 2000 |
|
| Authors:
D. W. Hiltner; OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
|
 | The TAILSIM program uses a 4th order Runge Kutta method to integrate the standard aircraft equations of motion (EOM). The EOM determine three translational and three rotational accelerations about the aircraft's body axis reference system. The forces and moments that drive the EOM are determined from aerodynamic coefficients, dynamic derivatives, and control inputs. Values for these terms are determined from linear interpolation of tables that are a function of parameters ... |
|
| Jet Noise and Mixing in High Speed Axisymmetric Jets |
13 OCT 2000 |
7 pages |
| Authors:
Mohammad Samimy; OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
|
| A coaxial jet facility and a modular, full anechoic chamber, which has extensive optical access windows, have been designed to investigate mixing and acoustic radiation, especially interrelation between mixing and noise, in high speed jets. The facility will enable us to simultaneously measure acoustic radiation via microphones and flow parameters using advanced optical techniques such as planar Doppler velocimetry (PDV). The primary and secondary jet ... |
|
| Feasibility of THz Remote Sensing for DoD Applications |
OCT 2000 |
20 pages |
| Authors:
Frank C. De Lucia; OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
|
| This project was designed to identify applications of THz technology of potential interest to the DoD and to provide a technical introduction for DARPA personnel to the underlying scientific and technical issues. The final report begins with a discussion of the physics which governs the interactions between radiation and matter in the THz, with emphasis on the differences between low pressure gases, atmospheric pressure gases, and solids. Atmospheric propagation is ... |
|
| Stress and Immunity Breast Cancer Project |
SEP 2000 |
30 pages |
| Authors:
Barbara L. Andersen; OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
|
| A biobehavioral model of cancer stress and disease course was proposed (see Andersen, Kiecolt- Glaser, & Glaser, 1994). We are testing the model with a clinical trial: 231 women with stage II or III breast cancer are randomized between assessment and intervention or assessment only (control) study arms. In addition to documenting the quality of life benefits of a psychological intervention, this study provides an experimental test of the psychological ... |
|
| Social Support and Endocrine Function: A Randomized Trial with Breast Cancer Patients |
AUG 2000 |
72 pages |
| Authors:
Deanna Golden-Kreutz; OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
|
| While there is clear evidence that psychological/behavioral interventions with cancer patients provide adjustment and coping benefits (Mark & Meyer, 1995) as well as positive immune and survival benefits (Fawzy et al., 1993; Speigel et al., 1989), the mechanisms for the benefits of such groups are not clearly understood. We propose that one of the mechanisms for the success of intervention groups may be through the provision of social support. Thus, ... |
|
| Potential Risk of Growth Promoter in Beef for Breast Cancer Growth |
JUL 2000 |
14 pages |
| Authors:
Lin Young; OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
|
| Anabolic agents increase weight gain in meat-producing farm animals by enhancing protein deposition and improving feed conversion, as well as increasing the muscle-to-fat ratio. By promoting growth, reducing feed costs and improving the quality of meat produced, the use of such agents has become an important practice in the meat-producing industry. These anabolic agents have biological activities in common with natural estrogenic, androgenic and progestogenic steroid hormones that have potential ... |
|
| Development of KGF Antagonist as a Breast Cancer Therapeutic |
JUL 2000 |
10 pages |
| Authors:
Yasuro Sugimoto; OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
|
| Our recent findings suggest that keratinocyte growth factor (KGF), the seventh member of the fibroblast growth factor family, is capable of acting as a mediator of the stimulatory effects of estrogen in human breast cancer cells. Interestingly, estrogen stimulates KGF expression. This role of estrogens in the regulation of KGF expression is intriguing because hormonal stimulation is an essential factor in the carcinogenesis of human breast cells, especially during early ... |
|
| Development of an erbB Antagonist |
JUL 2000 |
13 pages |
| Authors:
Amanda Simcox; OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
|
| Receptor tyrosine kinases of the erbB family play pivotal roles in growth and differentiation and aberrant activation of these receptors is associated with human cancers. In particular, ErbB-2 dysfunction has been linked to about 30% of breast cancers with poor prognosis. Correspondingly, great efforts are being made to develop therapies that target ErbB pathways. ErbB-2 is activated by the neuregulins in heterodimers with the neuregulin receptors ErbB- 3 and ErbB-4. ... |
|
| Parmagnetic Oligonucleotides for Breast Cancer Imaging |
JUL 2000 |
16 pages |
| Authors:
Jennifer Hines; OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
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| Our hypothesis is that novel paramagnetic oligonucleotide analogs will be useful MR contrast agents for breast cancer imaging. This novel approach of targeting MR contrast agents will ultimately aid in the early detection of metastatic breast cancer. The technical objectives are as follows along with progress to date. 1: Optimization of Paramagnetic Oligonucleotide Chelates: To prepare a series of paramagnetic chelate modified oligonucleotides to assess ... |
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