| Dynamic Spectrum Sharing with Limited Network State Information |
NOV 2010 |
16 pages |
| Authors:
Michael Honig; Randall Berry; NORTHWESTERN UNIV CHICAGO IL
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 | This project is concerned with the costs and benefits of learning and exchanging Network State Information (NSI) among cooperative nodes in a wireless network. NSI includes Channel State Information (CSI), along with information about quality of service requests. This report summarizes our main results on interference management and wireless resource allocation with limited information exchange. We introduce interference prices for optimizing powers and beams in an interference network with multiple ... |
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| US-Korea Nanotechnology, Biotechnology, and Information Technology (NBIT) Symbiosys Program - Phase 1 |
01 Oct 2010 |
227 pages |
| Authors:
Chad A Mirkin; Hongkun Park; Julie Kornfield; MOON KIM; Sungho Jin; Kang Shin; NORTHWESTERN UNIV CHICAGO IL
|
| Chapter 6: SiGe Alloy Nanowire Photonics; Chapter 7: Self-Assembled Liquid Crystalline Gels: From Nanostructure to Function; Chapter 8: Extremely Low Noise CNT for Peltier and Photodector Device Application; Chapter 9: High-Res, Large-Area, Nano Imprint Lithography. Chapter 10: Distributed Detection of Attacks/Intrusions and Prevention of Resource-Starvation Attacks in Mobile Ad Hoc Network. |
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| The Nanocrystalline State of Narrow Gap Semiconducting Chalcogenides |
23 Aug 2010 |
25 pages |
| Authors:
Mercouri G Kanatzidis; NORTHWESTERN UNIV CHICAGO IL
|
| The proposed program developed synthetic routes to nanocrystalline narrow band gap semiconductors relevant to efficient thermoelectric power generation and to a broader set of electronic applications. The investigated materials were selected from a well known class of narrow band gap semiconducting chalcogenides. We assessed the potential of the nanocrystal-derived materials for achieving high performance as thermoelectrics and found that the potential is low because of the inability to dope the ... |
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| Ebola Virus Uses Clathrin-Mediated Endocytosis as an Entry Pathway |
Jan 2010 |
12 pages |
| Authors:
Suchita Bhattacharyya; Kelly L Warfield; Gordon Ruthel; Sina Bavari; M J Aman; Thomas J Hope; NORTHWESTERN UNIV CHICAGO IL
|
| Ebola virus (EBOV) infects several cell types and while viral entry is known to be pH-dependent, the exact entry pathway(s) remains unknown. To gain insights into EBOV entry, the role of several inhibitors of clathrin-mediated endocytosis in blocking infection mediated by HIV pseudotyped with the EBOV envelope glycoprotein (EbGP) was examined. Wild type HIV and envelope-minus HIV pseudotyped with vesicular stomatitis virus glycoprotein (VSVg) were used as controls to assess ... |
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| Multidisciplinary Analysis of Cyclophilin a Function in Human Breast Cancer |
Mar-2009 |
48 pages |
| Authors:
Jiamao Zheng; NORTHWESTERN UNIV CHICAGO IL
|
| The major goal of the proposed project is to understand how cyclophilin A (CypA) modulates the prolactin (PRL) receptor (PRLr)-associated signaling and to determine the effects of altered CypA levels and activity on PRL signaling and breast cancer phenotype by combining biophysical structural investigations with studies in cell and animal models. The knowledge we obtained from this study will contribute to a greater understanding of the mechanism of PRL action. ... |
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| Molecular Mechanisms in Compromised Endothelial Barrier during Breast Cancer Metastasis |
Mar-2009 |
10 pages |
| Authors:
Teng-Leong Chew; NORTHWESTERN UNIV CHICAGO IL
|
| We have successfully devised a 3D tumor invasion assay that integrates 3D tissue engineering and FRET imaging to provide us with a means with which we could directly monitor, in real-time, the endothelial signaling event during tumor intravasation. Using this novel assay, we have demonstrated that breast cancer cells induce endothelial cell myosin light chain kinase (MLCK) activation at the site of tumor invasion, and that this transient MLCK activation ... |
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| Evaluation of Regional Travel-Time and Location Improvement Along the Tethyan Margin Using a New Three-Dimensional Velocity Model |
Sep 2008 |
11 pages |
| Authors:
Sung-Joon Chang; Megan P van der Flanagan; Suzan Lee; Eric M Matzel; Michael E Pasyanos; NORTHWESTERN UNIV CHICAGO IL
|
| For purposes of studying the lateral heterogeneity as well as predicting seismograms for this region, we construct a new 3-D S-velocity model by jointly inverting a variety of different seismic data. We jointly invert regional waveforms, surface wave group velocity measurements, teleseismic S and SKS arrival times, and crustal thickness estimates from receiver functions, refraction lines, and gravity surveys. These data types have complementary resolving power for crust and mantle ... |
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| Design and Development of Peptides from the Anti-Angiogenic Pigment Epithelial-Derived Factor for the Therapy of Prostate Cancer |
DEC 2007 |
13 pages |
| Authors:
Yelena Mirochnik; NORTHWESTERN UNIV CHICAGO IL
|
| To create PEDF based therapy for hormone-refractory CaP we have proposed to design short synthetic peptides corresponding to the 34- mer anti-angiogenic epitope of PEDF. The 3D structure of PEDF 34-mer peptide was analyzed using Protean software in terms of relative hydrophobicity, charge distribution, and antigenic index. Three synthetic peptides covering the 34-mer PEDF fragment were generated and tested for the ability to reproduce anti-angiogenic effect of PEDF. Although all ... |
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| Role of IKKs and Transcription Factor NF-kB in Prostate Tumorigenesis |
MAY 2006 |
71 pages |
| Authors:
Irina V. Budunova; NORTHWESTERN UNIV CHICAGO IL
|
| One of the central anti-apoptotic pathways in cells is mediated by NF-kB (nuclear factor kappa-B) transcription factors. There is mounting experimental evidence that NF- kB is activated during tumorigenesis in different tissues, and that NF-kB is critically important for cell protection against apoptosis induced by different treatments including chemotherapeutic drugs and gamma-irradiation. The key to NF-kB regulation is the inhibitory kB (IkB) proteins which retain NF-kB in an inactive form ... |
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| Expression of Transforming Growth Factor-Beta (TGF-Beta) in Prostate Cancer Progression |
SEP 2003 |
27 pages |
| Authors:
Chung Lee; NORTHWESTERN UNIV CHICAGO IL
|
| We have changed from using rats to mice. This change was approved by the DOD review committee. Our hypothesis is that if we render the host immune cells insensitive to TGF-beta, these immune cells would be able to eradicate tumor cells. There are three talks. Task 1 was to establish a dominant negative TGF-beta type II receptor bearing bone marrow cells, using GFP as a selectable marker. Task 2 was ... |
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| An Embryonic Growth Pathway is Reactivated in Human Prostate Cancer |
FEB 2003 |
69 pages |
| Authors:
Wade Bushman; NORTHWESTERN UNIV CHICAGO IL
|
| Epithelial-mesenchymal interactions in prostate cancer represent a promising target for drug therapies to arrest or slow tumor growth. For this potential to be realized, it is necessary to identify one specific epithelial- mesenchymal -interaction which is critical for tumor growth. We have shown that Sonic hedgehog (SHH) signaling pathway is absolutely required for normal prostate development. Our preliminary studies show this pathway is expressed at very low levels in the ... |
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| Expression of Transforming Growth Factor-Beta (TGF-Beta) in Prostate Cancer Cell Progression |
SEP 2002 |
35 pages |
| Authors:
Chung Lee; NORTHWESTERN UNIV CHICAGO IL
|
| The objective of the current Phase II proposal is to test a novel TGF-beta based gene therapy in prostate cancer. During the Phase I study, our findings demonstrate that TGF-beta over-production by the tumor cells was immunosuppressive. In the Phase II research we proposed to render host immune cells insensitive to TGF-beta by introducing a domina negative TGF-beta type II receptor (dnTBRII) to host immune cells. Three tasks were proposed. ... |
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| Oxidases as Breast Cancer Oncogens |
JUN 2002 |
25 pages |
| Authors:
Anjana V. Yeldandi; NORTHWESTERN UNIV CHICAGO IL
|
| This proposal examines the novel concept that H2O2 generating oxidase-mediated reactive oxygen species in breast epithelium contribute to the development of breast cancer. Constructs to express xanthine oxidase under the direction of mouse mammary tumor virus (MMTV) promoter were generated. Transfections performed to generate cell lines stable expressing the enzyme were unsuccessful hence urate oxidase was used as an alternative. The choice for urate oxidase is based on the fact ... |
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| Expression of Transforming Growth Factor-Beta (TGF-B) in Prostate Cancer Progression |
SEP 2001 |
21 pages |
| Authors:
Lee Chung; NORTHWESTERN UNIV CHICAGO IL
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| We have demonstrated that a non-immunogenic Dunning's rat prostate cancer cell line, MATLyLu, had become immunogenic by reducing the endogenous production of TGF-beta1. MATLyLu cells are immunogenic, when the endogenous production of TGF-beta1 is down regulated. The objective of the project was to evaluate the role of TGF-beta in prostate cancer progression. There are three specific aims. Specific aim 1 was to study the effect of TGF-beta expression on the ... |
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| Functional Angiogenic Mediators in Prostate Cancer |
AUG 2001 |
42 pages |
| Authors:
Jennifer A. Doll; NORTHWESTERN UNIV CHICAGO IL
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| The purpose of this study was to: (1) identify the key functional angiogenic mediators in the normal and diseased prostate, (2) determine the relationship between disease progression and angiogenic mediators in prostatic fluid; and, (3) determine the efficacy of the natural inhibitor thrombospondin-1 (TSP-1) in treating prostate cancer in model systems. Prostate cells secrete many molecules capable of regulating angiogenesis; however, which are functionally active in angiogenic regulation is unclear. ... |
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Reports by Corporate Author
