| Characterizing the Dynamic Response of the Estrogen Receptor to Agonists and Antagonists by Multifrequency Electron Spin Resonance Spin-Labeling |
May-2008 |
14 pages |
| Authors:
David E Budil; NORTHEASTERN UNIV BOSTON MA
|
 | The overall objective of this project is to characterize the detailed structural and dynamic response of the estrogen receptor ligand binding domain (ER-LBD) to a variety of ligands ranging from strong estrogens to strong antiestrogens using electron spin labeling. The first two technical aims for this reporting period involved completing preparation of site-directed spin-labeled mutants of the ERLBD and completing synthesis new spin-labeled ligands for the proposed studies. These tasks ... |
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| Tunable Negative Refractive Index Metamaterials and Applications at X and Q-bands |
02-Mar-2008 |
|
| Authors:
Peng He; Carmine Vittoria; Jinsheng Gao; Pat V Parimi; Vincent G Harris; NORTHEASTERN UNIV BOSTON MA
|
 | The goal of the current DARPA-ARO funded project is to design, fabricate, and test a tunable negative index metamterial (TNIM) using ferrites as a constituents material in the frequency range of 36-44 GHz with a targeted center frequency of 50 GHz. During this one year program we successfully accomplished tasks and continued our effort in developing a Q band tunable phase shifter and X band TNIM technology for microwave integrated ... |
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| Development of Novel Technetium-99m-Labeled Steroids as Estrogen-Responsive Breast Cancer Imaging Agents |
JUN 2007 |
33 pages |
| Authors:
Robert N. Hanson; NORTHEASTERN UNIV BOSTON MA
|
| The goal of this project was the preparation and evaluation of new technetium-99m labeled compounds via utilization of their rhenium surrogates. An initial series of rhenium tricarbonyl complexes of estradiol were prepared using Stille coupling methods at the 17-alpha position of estradiol. While the compounds were chemically stable and retain modest affinity for the estrogen receptor compared to estradiol (2-10%), their ability to stimulate or inhibit estrogen function in cells ... |
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| Characterizing the Dynamic Response of the Estrogen Receptor to Agonists and Antagonists by Multi-frequency Electron Spin Resonance Spin-Labeling |
MAY 2007 |
8 pages |
| Authors:
David E. Budil; Robert N. Hanson; NORTHEASTERN UNIV BOSTON MA
|
| The overall objective of this project is to characterize the detailed structural and dynamic response of the estrogen receptor ligand binding domain (ER-LBD) to a variety of ligands ranging from strong estrogens to strong antiestrogens using electron spin labeling. The technical aims for the initial period involved developing site-directed spin-labeled mutants of the ER-LBD and synthesizing new spin-labeled ligands for the proposed studies. We have optimized cell culture production of ... |
|
| Metamaterials for Antenna Technologies |
15 SEP 2006 |
56 pages |
| Authors:
Sridar Sriniva; NORTHEASTERN UNIV BOSTON MA
|
| This project was centered around research and development of next generation metamaterials that are needed in radar technologies. Results were obtained in metamaterials that display negative refraction properties. New metamaterial designs were developed and new phenomena arising from the negative refraction properties were demonstrated . The work in this area has led to some major results, reported in 10 published papers. |
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| Prostate Activated Prodrugs and Imaging Agents |
MAY 2006 |
25 pages |
| Authors:
Graham B. Jones; NORTHEASTERN UNIV BOSTON MA
|
| The goal of this project is to demonstrate that enzymatically active PSA in the prostatic microenvironment can be used to locally activate either prodrugs or imaging systems. The substrate chosen was a 3 component system composed of a peptide sequence with affinity for PSA, an imaging agent / cytotoxic drug, and a deactivating bridge-linker, which electronically incapacitates the imaging agent /cytotoxin. On PSA mediated release, the peptide sequence is designed ... |
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| Synthesis and Screening of Novel Substituted Biphenyl Proteomimetics as Potential Anti-Estrogenic Agents for the Treatment of Hormone-Responsive Breast Cancer |
JUL 2005 |
7 pages |
| Authors:
Robert N. Hanson; NORTHEASTERN UNIV BOSTON MA
|
| The goal of this project was to identify one or more novel compounds that would inhibit estrogen receptor coactivator binding proteins. The specific aims involved preparing the requisite aryl halide and boronic acid intermediates, coupling to generate the small biphenyl library and evaluating the compounds in a competitive binding assay. Molecular modeling would be used to help design the compounds and to interpret the results. Molecular modeling suggested that the ... |
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| Prostate Activated Prodrugs and Imaging Agents |
MAY 2005 |
25 pages |
| Authors:
Graham B. Jones; NORTHEASTERN UNIV BOSTON MA
|
| The goal of this project is to demonstrate that enzymatically active PSA in the prostatic microenvironment can be used to locally activate either prodrugs or imaging systems. The substrate chosen was a 3 component system composed of a peptide sequence with affinity for PSA, an imaging agent / cytotoxic drug, and a deactivating bridge-linker, which electronically incapacitates the imaging agent cytotoxin. On PSA mediated release, the peptide sequence is designed ... |
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| Autoignition and Burning Speeds of JP-8 Fuel at High Temperatures and Pressures |
25 AUG 2004 |
42 pages |
| Authors:
Mohamad Metghalchi; NORTHEASTERN UNIV BOSTON MA
|
| MIL-T-83133C grade JP-8 is of interest to the U.S. Army as the single fuel for the battlefield. The conversion to JP-8 occurred primarily to improve the safety of aircraft, although the single fuel for the battlefield concept (and the similarity of jet fuel to diesel fuel) is centered on the use of aviation kerosene in all Air Force and Army aircraft and ground vehicles. Detailed chemical kinetic mechanisms that describe ... |
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| Strongly Modulated Photonic Crystal With Tailor Made Negative Refractive Index |
10 MAY 2004 |
10 pages |
| Authors:
P. Vodo; V. Parimi; W. T. Lu; S. Sridhar; NORTHEASTERN UNIV BOSTON MA
|
| Negative refraction and left-handed electromagnetism in a metallic photonic crystal (PC) wedge are demonstrated in free space for both transverse magnetic and electric mode propagation. The experimental results are in excellent agreement with numerical calculations based on the band structure with no fit parameters used in modeling. The results demonstrate precision control on the design and fabrication of the PC to achieve tailor-made refractive indices between -0.6 to +1. |
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| Prostate Activated Prodrugs and Imaging Agents |
MAY 2004 |
13 pages |
| Authors:
Graham B. Jones; NORTHEASTERN UNIV BOSTON MA
|
| The goal of this project is to demonstrate that enzymatically active prostate specific antigen (PSA) in the prostatic microenvironment can be used to locally activate either prodrugs or imaging systems. The substrate chosen was a 3 component system composed of a peptide sequence with affinity for PSA, an imaging agent and a deactivating bridge-linker, which electronically incapacitates the imaging agent. On PSA mediated release, the peptide sequence is designed to ... |
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| Synthesis of Estrogen Receptor Beta Selective 17-Substituted Estradiols for the Treatment of Prostate Cancer |
FEB 2004 |
7 pages |
| Authors:
Pakamas Tongcharoensirikul; NORTHEASTERN UNIV BOSTON MA
|
| Recent evidence of the presence of ER alpha and ER beta messages in prostatic tissues has appeared recently. Evidence suggested that Estrogen Receptor beta (ER beta) is down regulated during the precancerous prostate intraepithelium neoplasia (PIN) and reappear during the metastatic PC alpha. The applicant has proposed to synthesized novel selective ER beta agonist based on the lead structure l7betaEstradiol, the Estrogen Receptor endogeneous ligand. The applicant has successfully synthesized ... |
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| Quantitative Characterization of Pulmonary Pressure-Volume Curve for Improved Care of Acute Lung Injury |
SEP 2003 |
153 pages |
| Authors:
Uichiro Narusawa; NORTHEASTERN UNIV BOSTON MA
|
| Based on the analyses of over seventy existing pressure- volume (pV) curves, continuous (tangent-hyperbolic or error function) pV model equations are confirmed to represent clinical pV curves accurately and also quantify differences and similarities among various p-V data sets effectively. A mechanistic model of the total respiratory system (TRS) is constructed, based on the principle of statistical mechanics applied to TRS as an ensemble of a large number of elements, ... |
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| Terrestrial Ambulatory Robots |
JUN 2003 |
8 pages |
| Authors:
Frank Kirchner; NORTHEASTERN UNIV BOSTON MA
|
| Direct new technical developments are reported in the following sections with respect to the last report. We have been focused to prepare the system for evaluation on the SWRI Test site. In order to be able to perform as much testing as possible we have worked on 2 main aspects: Software: New behaviors have been implemented that allow the system to overcome more and difficult obstacles. A behavior to attach ... |
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| Development of Artificial Y-Type Hexaferrites |
01 MAY 2003 |
2 pages |
| Authors:
C. Vittoria; NORTHEASTERN UNIV BOSTON MA
|
| We have developed a technique to orient particles of Y-type hexaferrite in which the c-axis of the particles are oriented perpendicular to a plane As such, that plane becomes necessarily the easy plane of magnetization. For microwave device application the easy plane of magnetization is chosen as the plane to deposit a metallic microstrip and related circuit patterns. The technique entails the rotation of an external magnetic field in the ... |
|
| Prostate Activated Prodrugs and Imaging Agents |
MAY 2003 |
10 pages |
| Authors:
Graham B. Jones; NORTHEASTERN UNIV BOSTON MA
|
| The goal of this project is to demonstrate that enzymatically active prostate specific antigen (PSA) in the prostatic microenvironment can be used to locally activate either prodrugs or imaging systems. The substrate chosen was a 3 component system composed of a peptide sequence with affinity for PSA, an imaging agent / cytotoxin and a deactivating bridge-linker, which electronically incapacitates the imaging agent. On PSA mediated release, the peptide sequence is ... |
|
| Quantitative Characterization of Pulmonary Pressure-Volume Curve for Improved Care of Acute Lung Injury |
MAR 2003 |
108 pages |
| Authors:
Uichiro Narusawa; NORTHEASTERN UNIV BOSTON MA
|
| Continuous (sigmoidal (tangent-hyperbolic) and error-function) p-V model equations with four parameters are shown to represent clinical p-V curves accurately. The magnitudes of the four parameters, coupled with the normalized p-V equation, distinguish p-V data sets effectively. A mechanistic model of the total respiratory system is developed for the inflation process, relating characteristics of the p-V model equation to the internal respiratory conditions such as alveolar recruitment and elastic distension of ... |
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| Solid Phase Peptide Synthesis of Antimicrobial Peptides for cell Binding Studies: Characterization Using Mass Spectrometry |
NOV 2002 |
23 pages |
| Authors:
Paul Vouros; Terrance Black; NORTHEASTERN UNIV BOSTON MA
|
| The ultimate goal of the project is to synthesize three specific peptides (cercropin Pl, cercropin A and PGQ) in order to determine their anti- microbial activity. To expedite this goal, mass spectrometry was used to identify products of the solid phase synthesis and thereby optimize synthetic conditions. Three different analytical approaches - MALDI-TOF, LC-electrospray ionization (ESI), ion trap MS and direct infusion ESI Ion Trap MS - were examined. Of ... |
|
| Evolution of Software via Adaptive Programming |
OCT 2002 |
26 pages |
| Authors:
Karl Lieberherr; NORTHEASTERN UNIV BOSTON MA
|
| Adaptive Programming (AP) is a technology that improves the separation of traversal-related concerns by separating the concerns of where-to- go, what-to-do and when-to-do. The three concerns can be understood using the terminology of Aspect-Oriented Programming (AOP): pointcuts, advice and introductions. The concern what-to-do can be implemented as an advice and concern when-to-do as a pointcut. The concern where-to-go specifies a set of introductions that implement a set of traversal methods. ... |
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| Solid Phase Combinatorial Approach to Estradiol Tamoxifen/Raloxifene Hybrids: Novel Chemotherapeutic/Prophylactic Selective Estrogen Receptor Modulators |
JUL 2002 |
13 pages |
| Authors:
Robert N. Hanson; NORTHEASTERN UNIV BOSTON MA
|
| The objective of this project is the development of new chemotherapeutic agents for the treatment of hormone-responsive breast cancer using a solid phase approach to synthesize new agents having features common to both steroids and antiestrogens. Previously we functionalized the carboxy resin with both the E-and Z-tributylstannylvinyl estradiol, and prepared an initial series of iodophenoxyalkylamines that will be coupled to the resin-bound steroid. Coupling reactions with the Z-stannylvinyl estradiol were ... |
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| A Structure Based, Solid-Phase Synthesis Approach to the Development of Novel Selective Estrogen Receptor Modulatory Steroids |
JUL 2002 |
142 pages |
| Authors:
Robert N. Hanson; NORTHEASTERN UNIV BOSTON MA
|
| The overall objective of this project was the development of new chemotherapeutic agents for the treatment of hormone-responsive breast cancer. The specific aims included: (1) the preparation of polymer-bound steroidal starting materials; (2) elaboration via acylation/amidation reactions; (3) biological evaluation of the new compounds; and (4) identification of leads for subsequent optimization. We prepared the polymer-bound estradiol derivatives and prepared several preliminary series of derivatives. We compared the solid-phase and ... |
|
| Nonlinear Adaptive Control of AC Electric Drives |
31 MAR 2002 |
11 pages |
| Authors:
Gilead Tadmor; Aleksandar Stankovic; NORTHEASTERN UNIV BOSTON MA
|
| The use of energy dynamics/dissipative design is one unifying theme for the various projects carried under this grant, exploring the scope of quadratically dissipative design, design based on shaping Hamiltonian dynamics and design for systems with non-quadratic energy structures. Specific projects involved the permanent magnet synchronous, switch reluctance, induction and DC motors, power electronics devices, including a three phase synchronous rectifiers, the series resonant converter, voltage source inverters, and power ... |
|
| 3-D Computational Sensors for Advanced Low Power Visual Processing |
MAR 2002 |
76 pages |
| Authors:
Lisa Mcllrath; James Burns; Craig Keast; Craig lewis; Andrew Loomis; NORTHEASTERN UNIV BOSTON MA
|
| This report describes work performed in a collaborative effort between Northeastern University, MIT, and MIT Lincoln Laboratory to develop three-dimensional integrated circuit process technology and designs to enable advanced low power computational image sensors. The 3D development program was funded under DARPA contract DAAK60-96-K-0204 from June 4, 1996 through September 30, 2000. During the course of the program, over twenty people from these three institutions participated in circuit design, algorithm ... |
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| Options for statistical classification of buried objects from spatially sampled time or frequency domain EMI data. |
OCT 2001 |
|
| Authors:
E. L. Miller; NORTHEASTERN UNIV BOSTON MA
|
| Methods for classifying objects based on spatially sampled electromagnetic induction data taken in the time or frequency domain are developed and analyzed. To deal with nuisance parameters associated with the position of the object relative to the sensor as well as the object orientation a computationally tractable physical model explicit in these unknowns is developed. The model is also parameterized by a collection of decay constants (or equivalently Laplace-plane poles) ... |
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| A Structure Based, Solid Phase Synthesis Approach to the Development of Novel Selective Estrogen Receptor Modulatory Steroids |
JUL 2001 |
68 pages |
| Authors:
Robert N. Hanson; NORTHEASTERN UNIV BOSTON MA
|
| The objective of this project is the development of new chemotherapeutic agents for the treatment of hoemone-responsive breast cancer using a structure-based solid phase synthesis approach. During the past year we have utilized our functionalized resin to prepare a second series of carboxamido-phenylvinyl estradiols. The compounds were characterized by NMR and analyzed by computational methods. The new agents were evaluated for estrogen receptor binding affinity and in vivo efficacy. The ... |
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| Solid-Phase Combinatorial Approach to Estradiol Tamoxifen/Raloxifene Hybrids: Novel Chemotherapeutic/Prophylactic Selective Estrogen Receptor Modulators (SERM) |
JUL 2001 |
46 pages |
| Authors:
Robert N. Hanson; NORTHEASTERN UNIV BOSTON MA
|
| The objective of this project is the development of new chemotherapeutic agents for the treatment of hormone-responsive breast cancer using a solid phase approach to synthesize new agents having features common to both steroids and antiestrogens. During the past year we have functionalized the carboxy resin with both the E-and Z-tributylstannylvinyl estradiol. We have prepared and characterized the initial series of iodophenoxyalkylamines that will be coupled to the resin-bound steroid. ... |
|
| Molecular Analysis of the Common Signaling Mechanism of Neuronal Death Induced by Glutamate and Mutated Huntington |
MAR 2001 |
31 pages |
| Authors:
Ya F. Liu; NORTHEASTERN UNIV BOSTON MA
|
| The goal of this project is to characterized common moledular mechanism of neuronal toxicity mediated by glutamate and polyglutamine-expanded huntingtin. Our results show that activation of mixed-lineage kinase and its down-stream signaling pathway is involved in neuronal toxicity mediated by glutamate and by the mutated huntingtin. We also observed that PSD-95, a scaffold protein that binds to glutamate receptors links glutamate receptor to mixed lineage kinase to induce neuronal toxicity. ... |
|
| Extending UML to Support Ontology Engineering for the Semantic Web |
2001 |
16 pages |
| Authors:
Kenneth Baclawski; Mieczyslaw K. Kokar; Paul A. Kogut; Lewis Hart; Jeffrey Smith; III Holmes William S.; Jerzy Letkowski; Michael L. Aronson; NORTHEASTERN UNIV BOSTON MA
|
| There is rapidly growing momentum for web enabled agents that reason about and dynamically integrate the appropriate knowledge and services at run-time. The World Wide Web Consortium and the DARPA Agent Markup Language (DAML) program have been actively involved in furthering this trend. The dynamic integration of knowledge and services depends on the existence of explicit declarative semantic models (ontologies). DAML is an emerging language for specifying machine-readable ontologies on ... |
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| A Structure Based, Solid Phase Synthesis Approach to the Development of Novel Selective Estrogen Receptor Modulatory Steroids |
JUN 2000 |
71 pages |
| Authors:
Robert Hanson; NORTHEASTERN UNIV BOSTON MA
|
| The objective of this project is the development of new chemotherapeutic agents for the treatment of hormone responsive breast cancer using a structure-based, solid-phase synthesis approach. We have successfully linked an activated derivative of estradiol to a solid support and converted it to two different series of estrogen receptor ligands. We have begun the biological evaluation of these compounds and initail results suggest that ... |
|
| Towards Modeling the Magnetospheric Space Plasma Environment |
JUL 1999 |
141 pages |
| Authors:
Michael Silevitch; Elena Villalon; NORTHEASTERN UNIV BOSTON MA
|
| The research described in this report was focused into three related areas: (a) A study of nonadiabatic particle orbits and the electrodynamic structure of the coupled magnetosphere-ionosphere arc system. (b) An examination of electron acceleration and pitch angle scattering due to wave-particle interaction in the ionosphere and radiation belts. (c) A study of ionospheric modification research and the experimental results of Oedipus C satellite. |
|
| Detection of DNA Adducts in Human Breast Tissue |
JUL 1999 |
45 pages |
| Authors:
Roger Giese; NORTHEASTERN UNIV BOSTON MA
|
| Cancer of the breast and other tissues may be initiated or promoted by DNA adducts. Some of these adducts may be unknown at the present time, and differ from one individual to another both qualitatively and quantitatively. This makes it important to detect the entire spectrum of DNA adducts in breast and other tissues. Analytical methodology is not available for this at the present time, ... |
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| Detection of DNA Adducts in Human Breast Tissue |
JUL 1998 |
23 pages |
| Authors:
Roger W. Giese; NORTHEASTERN UNIV BOSTON MA
|
| The purpose of this project is to optimize and apply new methodology for the detection of unknown DNA adducts in breast and, for comparison, other human tissues. In this methodology the DNA adducts are labeled with a fluorescent dye to enhance their detection. Although the first dye tested (IMI1) was not fully stable, this problem was overcome by preparing IMI2. High dye Purity is required, and this was accomplished for ... |
|
| Detection of DNA Adducts in Human Breast Tissues |
JUL 1997 |
29 pages |
| Authors:
Roger Giese; NORTHEASTERN UNIV BOSTON MA
|
| The purpose of this project is to optimize and apply new methodology for the detection of unknown DNA adducts in breast and, for comparison, other human tissues. Current methodology for this purpose has shortcomings, and breast cancer may be initiated by unknown DNA adducts. Initially the methodology will be applied to nonpolar adducts, and later it can be expanded. The concept for the new methodology is the same as 32P-postlabeling, ... |
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| Spatial Frameworks for Perceived Environments |
17 FEB 97 |
45 pages |
| Authors:
David J. Bryant; NORTHEASTERN UNIV BOSTON MA
|
| Research examined mental representation of spatial information. Spatial frameworks are based on an egocentric reference frame, and intrinsic computation on a object centered frame. Research documented the use of spatial frameworks in memory for observed and modeled scenes, but intrinsic computation for memory of diagrams. Intrinsic computation was also used in perception of models and diagrams. Reference frame is under strategic control - instructions can alter the representation of diagrams ... |
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| Spatial Frameworks for Perceived Environments |
17 FEB 97 |
46 pages |
| Authors:
David J. Bryant; NORTHEASTERN UNIV BOSTON MA
|
| Research examined mental representation of spatial information. Spatial frameworks are based on an egocentric reference frame, and intrinsic computation on an object centered frame. Research documented the use of spatial frameworks in memory for observed and modeled scenes, but intrinsic computation for memory of diagrams. Intrinsic computation was also used in perception of models and diagrams. Reference frame is under strategic control; instructions to use one or the other guides ... |
|
| Automatic Target Detection And Recognition: A Wavelet Based Approach |
25 JAN 97 |
73 pages |
| Authors:
A. J. Devaney; R. Raghavan; H. Lev-Ari; E. Manolakos; M. Kokar; NORTHEASTERN UNIV BOSTON MA
|
| Wavelet based target detection and identification algorithms for radar applications are presented and tested and evaluated on computer simulated data. The algorithms make use of a scale sequential and/or scale recursive paradigm where computations are performed within and across scales in a multiresolution analysis (MRA) of the sensor data relative to a compactly supported discrete orthonormal wavelet basis. It is argued that such procedures are computationally efficient and offer promise ... |
|
| On the Modelling of Space Plasma Dynamics and Structure |
NOV 95 |
151 pages |
| Authors:
Jay Albert; Stephen Anderson; Michael Silevitch; Elena Villalon; NORTHEASTERN UNIV BOSTON MA
|
| The research described in this report was focused into two related areas. These were: (A) A study of nonadiabatic particle orbits and the electrodynamic structure of the coupled magnetosphere ionosphere auroral arc System. (B) An examination of electron acceleration and pitch angle scattering due to wave actions in the ionosphere and radiation belts. |
|
| Linear and Reentrant CFA S for In Situ Measurements and Comparison with Numerical Simulations and Study of Noise Mechanisms |
29 SEP 95 |
28 pages |
| Authors:
Chan; NORTHEASTERN UNIV BOSTON MA
|
| We have performed in situ measurements in two low frequency CFAs to study several basic physics issues which may lead to CFA noise reduction. Our measurements include the local radio-frequency (RF) fields, electron density profiles, electron energy distributions and noise spectrums in both the linear CFA and the reentrant CFA. Comprehensive electron density measurements of the interaction region as well as parametric comparisons such as gain versus sole voltage, beam ... |
|
| Object Oriented Segmentation of Images |
21 DEC 94 |
19 pages |
| Authors:
Jayant Shah; NORTHEASTERN UNIV BOSTON MA
|
| The central theme of this research project is recovery of object shapes from noisy images. The main mathematical techniques are energy functionals and gradient descent. The goal is to construct vertically integrated models capable of incorporating constraints imposed by various objectives such as noise suppression, boundary detection, shape description and object recognition. The difficulty with this approach is that these functionals are very hard to implement on account of their ... |
|
| Novel Reagents for Chemical Vapor Deposition of Intermetallic Alloys |
31 OCT 94 |
11 pages |
| Authors:
Rein U. Kirss; NORTHEASTERN UNIV BOSTON MA
|
| Reactions of Hf(CH2SiMe3)4 with AlMe3 proceeded by formation of covalently bonded heterobimetallic intermediates with no alkyl exchange. Reaction with A1H3.NMe3 yielded A1(Ch2SiMe3)3. NMe3 and 'Hf(CH2SiMe3)H3'. Carbon blocks coated with this mixture produced a HfAlC2 coating which was effective in protecting the substrate from air oxidation at high temperatures. |
|
| Novel Reagents for Chemical Vapor Deposition of Intermetallic Alloys |
31 OCT 94 |
11 pages |
| Authors:
Rein U. Kirss; William Feighery; Jozsef Kreisz; Lamartine Meda; Douglas Gordon; NORTHEASTERN UNIV BOSTON MA
|
| Reactions of Hf(CH2SiMe3)4 with AlMe3 proceed by formation of covalently bonded heterobimetallic intermediates with no alkyl exchange. Reaction with AlH3:NMe3 yielded Al(CH2SiMe3)3. NMe3 and 'Hf(CH2SiMe3)H3'. Carbon blocks coated with this mixture produced a HfAlC2 coating which was effective in protecting the substrate from air oxidation at high temperatures. jg |
|
| A Multiscale, Statistically-Based Inversion Scheme for Linearized Inverse Scattering Problems |
13 SEP 1994 |
51 pages |
| Authors:
Eric L. Miller; Alan S. Willsky; NORTHEASTERN UNIV BOSTON MA
|
| The application of multiscale and stochastic techniques to the solution of a linearized inverse scattering problem is presented. This approach allows for the explicit and easy handling of many difficulties associated with problems of this type. Regularization is accomplished via the use of a multiscale prior stochastic model which offers considerable flexibility for the incorporation of prior knowledge and constraints. We use the relative error covariance matrix (RECM), introduced in ... |
|
| Control Oriented System Identification |
AUG 93 |
7 pages |
| Authors:
Clas A. Jacobson; NORTHEASTERN UNIV BOSTON MA
|
| The research goals for this grant were to obtain algorithms for control oriented system identification is to construct dynamical models of systems based primarily on measured data that are compatible with robust control design techniques. The research carried out under this grant has continued the research on control oriented identification originated by the PI and his collaborators, has extended control oriented identification methods to new classes of dynamical systems and ... |
|
| On the Dynamics of Space Plasma |
01 SEP 92 |
|
| Authors:
Jay Albert; Chung Chan; Michael Silevitch; Elena Villalon; NORTHEASTERN UNIV BOSTON MA
|
| The research was focused into three related areas. These were: A) An examination of stochastic electron acceleration mechanisms in the ionosphere and the resulting dynamics of magnetospheric (i.e., Radiation Belt) particles and waves; B) A study of nonadiabatic particle orbits and the electrodynamic structure of the coupled magnetosphere-ionosphere auroral arc system; C) An experimental investigation of the wake signatures created by a solid body immersed in a flowing plasma. ... |
|
| Signal-toNoise-Ratio Equations for a Heterodyne Laser Radar. |
JUL 1992 |
|
| Authors:
C. A. Dimarzio; S. C. Lindberg; NORTHEASTERN UNIV BOSTON MA
|
|
| EM Properties of High Tc Superconductors |
JUN 92 |
|
| Authors:
S. Sridhar; NORTHEASTERN UNIV BOSTON MA
|
| The aim of this contract was to study the factors influencing microwave properties o high TC superconductors, via fundamental measurements on high quality thin film and single crystal materials. Two principal lines of investigation were pursued: In single crystals of Y,Ba2CU307-6 (Tc=93K) ultrasensitive rf methods were used to stud the penetration depth A, lower critical fields Hc1 and vortex pinning forces. The penetration depth and surface resistance were found to ... |
|
| A Model for Spatially Correlated Radar Clutter. |
MAR 1991 |
|
| Authors:
R. S. Raghavan; NORTHEASTERN UNIV BOSTON MA
|
|
| Center for the Study of Rhythmic Processes |
01 DEC 90 |
|
| Authors:
N. Kopell; NORTHEASTERN UNIV BOSTON MA
|
| The Center for the Study of Rhythmic Processes continued its work on Central Pattern Generators (CGPs), notably on the vertebrate spinal CPG for undulatory locomotion, and the invertebrate crustacean stomatogastric ganglion (STG). For the lamprey, a primitive vertebrate, experiments were designed and performed involving transduction of mechanical motion to neural activity; these experiments were combines with mathematical theory to help understand the relation of structure to function in that network. ... |
|
| Center for the Study of Rhythmic Processes |
01 DEC 90 |
|
| Authors:
N. Kopell; NORTHEASTERN UNIV BOSTON MA
|
| The Center for the Study of Rhythmic Processes began operation in the academic year 1986-1989 and was supported as a Center of Excellence through June 1990. The Center gathered together mathematicians and biologists to work on problems involving neural control of rhythmic motor behavior. There were two main problems addresses during this time. One was the structure and function of the intersegmental coordinating system of the vertebrate spinal cord, using ... |
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| Active Probing of Space Plasmas |
01 SEP 89 |
|
| Authors:
Chang Chan; Michael B. Silevitch; Elena Villalon; NORTHEASTERN UNIV BOSTON MA
|
| During the course of the research period our efforts were focused on the following areas: 1) An examination of stochastic acceleration mechanisms in the ionosphere; 2) A study of nonequilibrium dynamics of the coupled magnetosphere - ionosphere system; and 3) Laboratory studies of active space experiments. Reprints include: Dynamics of charged particles in the near wake of a very negatively charged body -- Laboratory experiment and numerical simulation; Laboratory study ... |
|
Reports by Corporate Author
