| Molecular Basis of Autophagic Cell Death in Prostate Cancer |
Mar-2009 |
28 pages |
| Authors:
Ramesh Kaini; NEW MEXICO UNIV ALBUQUERQUE
|
 | To understand the molecular basis of autophagy in prostate cancer, I am trying to isolate pure autophagosomes from autophagic cell survival and autophagic cell death Prostate cancer cell model and profile proteins and lipids to identify autophagy abundant/specific proteins and lipid molecule that are essential for functional autophagy in prostate cancer. I established EGFP.LC3 stably expressing LNCaP cell line and characterized the autophagic activity by western blot, translocation assay and ... |
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| Evaluation of Genomic Instability in the Abnormal Prostate |
Dec-2008 |
94 pages |
| Authors:
Christina Haaland-Pullus; Jeffrey K Griffth; NEW MEXICO UNIV ALBUQUERQUE
|
| The aim of this study is to investigate field effect in prostate cancer, the relationship between tumor and nearby histologically normal tissues compared to truly disease free prostate tissue. Identification of changes within tumor adjacent tissues has two possible clinical implications: prognosis and diagnosis. Several tools are being used to investigate this effect, specifically the assessment of telomere length, allelic imbalance, and methylation status, all markers of genomic instability. Microarray ... |
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| Evaluation of Genomic Instability in the Abnormal Prostate |
Dec-2007 |
55 pages |
| Authors:
Christina Haaland-Pullus; Jeffrey K Griffith; NEW MEXICO UNIV ALBUQUERQUE
|
| The aim of this study is to investigate the field effect in prostate cancer, the relationship between tumor and nearby histologically normal tissues compared to truly disease free prostate tissue. Identification of changes within tumor adjacent tissues has two possible clinical implications: prognosis and diagnosis. Several tools are being used to investigate this effect, specifically the assessment of telomere length, allelic imbalance, and methylation status, all markers of genomic instability. ... |
|
| Motivational Interviewing in the Prevention of Alcohol Abuse |
AUG 2007 |
123 pages |
| Authors:
Theresa B. Moyers; NEW MEXICO UNIV ALBUQUERQUE
|
| This study represented an effort to test whether standard training strategies, commonly used effectively in civilian providers, were effective in training Air Force Behavioral Health Providers in a specific empirically based treatment (EBT): motivational interviewing (MI). Employing a randomized, controlled design, providers were randomized to receive either standard training in MI or an enriched training option. The standard training option was a 2-day workshop on MI, while the enriched option ... |
|
| Basic Research Leading to Compact, Portable Pulsed Power |
31 MAR 2007 |
34 pages |
| Authors:
Edl Schamiloglu; Karl Schoenbach; Robert Vidmari; NEW MEXICO UNIV ALBUQUERQUE
|
| Pulsed power is a technology that is suited to drive electrical loads requiring very large power pulses in short bursts (high-peak power). Certain applications require technology that can be deployed in small spaces under stressful environments, e.g., on a ship, vehicle, or aircraft. In 2001, the U.S. Department of Defense (DoD) launched a long-range (five-year) Multidisciplinary University Research Initiative (MURI) to study fundamental issues for compact pulsed power. This research ... |
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| Prognostic Significance of Telomere Attrition in Ductal Carcinoma in Situ of the Breast |
FEB 2007 |
21 pages |
| Authors:
Jeffrey K. Griffith; NEW MEXICO UNIV ALBUQUERQUE
|
| We are using an innovative quantitative assay for telomere DNA content (TC) developed and characterized by the PI to test the hypothesis that TC predicts the likelihood of disease recurrence in women with DCIS. In Year One we collaborated to determine whether TC measured in bulk DCIS tumor tissue is comparable to that measured in tumor epithelial cells purified by laser-capture microscopy. In 7/10 instances TC in microdissected specimens was ... |
|
| The Role of CXCR4 and Arrestins in Breast Cancer Signaling and Apoptosis |
FEB 2007 |
167 pages |
| Authors:
Brant M. Wagener; NEW MEXICO UNIV ALBUQUERQUE
|
| This work focuses on how arrestin regulates trafficking and signaling of the N-formyl peptide receptor (FPR), a G protein-coupled receptor (GPCR). GPCRs are involved in almost all physiologic processes and numerous pathologic processes. There is an intimate relationship between GPCR trafficking and signaling that controls many cellular processes. However, the protein-protein interactions that control post-endocytic trafficking and signaling of GPCRs are poorly understood. Our previous reports demonstrated that three events ... |
|
| Evaluation of Genomic Instability in the Abnormal Prostate |
DEC 2006 |
47 pages |
| Authors:
Christina Haaland-Pullus; Jeffrey K. Griffith; NEW MEXICO UNIV ALBUQUERQUE
|
| The aim of this study is to investigate the field effect in prostate cancer, the relationship between tumor and nearby histologically normal tissues compared to truly disease free prostate tissue. Identification of changes within tumor adjacent tissues has two possible clinical implications: prognosis and diagnosis. Several tools are being used to investigate this effect, specifically the assessment of telomere length, allelic imbalance, and methylation status, all markers of genomic instability. ... |
|
| Effect of Palm Cooling with Negative Pressure on Heat Balance During Exercise in a Hot, Dry Environment |
15 NOV 2006 |
78 pages |
| Authors:
Suzanne Schneider; Rob Robergs; Steve Verney; Fabiano Amorium; Paulette Yamada; NEW MEXICO UNIV ALBUQUERQUE
|
| Military personnel often must work in hot environments, increasing the risk of hyperthermia. Our purpose was to evaluate a new rapid thermal exchange device (RTX) in slowing the development of hyperthermia and associated symptoms to 3 other conditions [hand immersed in water bath (WB), water-perfused vest (VEST), and a no- cooling condition (NC)] in subjects exercising in a hot environment (42C, 30% rh) wearing summer fatigues, a backpack and body ... |
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| Mutations in PUMA Gene Cause Prostate Cancer Development and Aggressiveness |
NOV 2006 |
11 pages |
| Authors:
Chien-An Hu; NEW MEXICO UNIV ALBUQUERQUE
|
| In the first year of this project, we surveyed the PUMA gene expression using RT-PCR amplification of RNA isolated from three PCa cell models, LNCaP, DU145 and PC3, BPH (benign prostate hyperplasia) cells or normal prostate tissues. Our results showed that expression of PUMA was relatively high in normal prostate tissues/cells but was significantly reduced in two PCa cell models, DU145 and PC3. In addition, to survey the PUMA gene ... |
|
| Role of the 5HT3 Receptor in Alcohol Drinking and Aggression Using a Transgenic Mouse Model |
01 SEP 2006 |
37 pages |
| Authors:
Andrea M. Allan; NEW MEXICO UNIV ALBUQUERQUE
|
| We hypothesized that over-expression of 5-HT3 receptors decreases alcohol consumption because the presence of an increased number of 5-HT3 receptors increased the potentiation of dopamine release at lower alcohol concentrations. Thus, the animal requires less alcohol to obtain the same behavioral effect. Thus, the lower level of alcohol consumption seen in the 5-HT3 receptor over-expressing mice may be the result of increased inhibitory control over alcohol consumption We found that ... |
|
| MiPRI Collaboration on High Power Microwave and Vacuum Electronics Source Research |
01 AUG 2006 |
16 pages |
| Authors:
Edl Schamiloglu; Ron Gilgenbach; Y. Y. Lau; Rick Temkin; NEW MEXICO UNIV ALBUQUERQUE
|
| High Power Microwave (HPM) and Vacuum Electronics (VE) sources have been studied in support of Air Force needs, under the auspices of the MiPRI initiative, a congressionally mandated program. A consortium of three universities led by the University of New Mexico and including the University of Michigan and MIT have teamed up to perform research on two sources of current interest to the Air Force: i) the relativistic magnetron operating ... |
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| The Role of Telomeric Repeat Binding Factor 1 (TRF1) in Telomere Maintenance and as a Potential Prognostic Indicator in Human Breast Cancer |
APR 2006 |
15 pages |
| Authors:
Kimberly S. Bulter; Jeffrey K. Griffith; NEW MEXICO UNIV ALBUQUERQUE
|
| The aims of this study are to (i) determine the relationships between the telomere binding protein Telomere Repeat Binding Factor i (TRF1) and other telomere binding proteins, (ii) establish the potential is TRF1 as a surrogate marker for telomere content (TC) and as a potential clinical marker and (iii) characterize the relationship between is the telomere binding protein TRF1 and TC. Through examining the role is TRF1 in telomere length ... |
|
| Evaluation of Genomic Instability as an Early Event in the Progression of Breast Cancer |
APR 2006 |
98 pages |
| Authors:
Christopher M. Heaphy; Jeffrey K. Griffith; NEW MEXICO UNIV ALBUQUERQUE
|
| We have shown in retrospective studies that loss of telomere content (TC) has potential value in predicting clinical outcome in breast cancer. However, an alternative marker for TC, which could be assessed in samples with small numbers of cells, such as fine needle aspirates, with commonly used methods is desirable. The aim of this study is to demonstrate that measurement of allelic imbalance (AI), which could be easily adapted to ... |
|
| An Optoelectronics Research Center |
08 MAR 2006 |
96 pages |
| Authors:
S. R. Brueck; NEW MEXICO UNIV ALBUQUERQUE
|
| The research description contains 5 tasks divided into two general areas The first area is the area of nanomatenals and nanophotonics Two tasks are described there, the first being to understand and develop applications for a new class of nanostructured thin films, the second exploring circumstances in which metal films can transmit a high fraction of an incident electromagnetic wave. The second area of research is in new optoelectronic materials. ... |
|
| Computation in the Wild: Moving Beyond the Metaphor |
MAR 2006 |
28 pages |
| Authors:
NEW MEXICO UNIV ALBUQUERQUE
|
| This report presents an overview of the research performed and technical results of the "Computation in the Wild: Moving Beyond the Metaphor" project, which was part of the DARPA TASK program. The work was performed between September 2000 and September 2005, at the Department of Computer Science at the University of New Mexico. The goal of the work was to demonstrate concrete examples and develop theoretical models of the metaphor ... |
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| Prognostic Significance of Telomere Attrition in Ductal Carcinoma in Situ of the Breast |
FEB 2006 |
9 pages |
| Authors:
Jeffrey K. Griffith; NEW MEXICO UNIV ALBUQUERQUE
|
| The investigators employed an innovative, quantitative assay for telomere DNA content (TC) that was developed and characterized by the Principal Investigator to test the hypothesis that TC can be used to predict the likelihood of disease progression in women with Ductal Carcinoma in Situ (DCIS). The first step in this investigation was to determine whether TC measured in bulk DCIS tumor tissue is comparable to that measured in tumor epithelial ... |
|
| Inhalation of Uranium Oxide Aerosois: CNS Deposition, Neurotoxicity, and Role in Gulf War Illness |
OCT 2005 |
46 pages |
| Authors:
Johnnye L. Lewis; Graham Bench; Fletcher F. Hahn; NEW MEXICO UNIV ALBUQUERQUE
|
| This study investigates the potential for inhaled uranium oxide (UO) aerosols to penetrate the nose-brain barrier, directly enter the central nervous system (CNS), distribute within the CNS, and result in slowly developing neurotoxicity. Inhalation exposures to depleted uranium (DU) may have occurred during the GW in several scenarios of varying duration and airborne uranium concentration. Nasal inflammation could alter sensitivity to uranium uptake. Nephrotoxic and pulmonary effects are evaluated to ... |
|
| Prognostic Value of Allelic Imbalance in Prostate Biopsy |
SEP 2005 |
10 pages |
| Authors:
Jeffrey K. Griffith; NEW MEXICO UNIV ALBUQUERQUE
|
| The novel concept that is being tested in this project is that allelic imbalance (AI) in tissue obtained at prostate biopsy can serve as a sensitive and independent marker for staging and predicting disease recurrence in prostate cancer. The two aims of the project are (1) to determine whether the number of sites of AI in biopsy predicts pathological staging following prostatectomy, and (2) to determine the independence, positive and ... |
|
| The Man Who Tamed Mexico's Tiger: General Joaquin Amaro and the Professionalization of Mexico's Revolutionary Army |
01 MAY 2005 |
267 pages |
| Authors:
Robert Carriedo; NEW MEXICO UNIV ALBUQUERQUE
|
| This thesis focuses on the military career of General Joaquin Amaro, the officer most responsible for professionalizing the Mexican military after the tumultuous years of the Mexican Revolution. After 1917, with the most violent phase of the Revolution over, the military forces that crushed Mexican President Porfirio Diaz's Federal Army proved to be a two-edged sword. While effective in overthrowing Diaz, Mexico's revolutionary armies neither disbanded nor submitted themselves to ... |
|
| The Role of CXCR4 and Arrestins in Breast Cancer Signaling and Apoptosis |
FEB 2005 |
7 pages |
| Authors:
Brant M. Wagener; NEW MEXICO UNIV ALBUQUERQUE
|
| G protein--coupled receptors (GPCR) are a family of receptors that are involved in all physiologic and many pathologic processes. Recently, they have been described as playing a critical role in breast cancer metastasis. As all GPCRs interact with arresting, we have sought to better understand the role of arrestin interaction with GPCRs particularly in the process of apoptosis. Previously published data has described the initiation of apoptosis when GPCRs are ... |
|
| Characterization of Instrument Effects in Imaging and Non-Imaging Polarimeters |
DEC 2004 |
15 pages |
| Authors:
J. S. Tyo; NEW MEXICO UNIV ALBUQUERQUE
|
| The purpose of this one-year effort was to identify and investigate some important effects that the optical systems have on the performance of imaging and non-imaging polarimeters. During our period of performance we concentrated on two primary areas; 1) Characterization of the effects of systematic errors in the polarization optics of non-imaging polarimeters through measurements and comparing these results to previous theory; and 2) Investigation of the effects of focal ... |
|
| Effects of Chronic Alcohol Exposure on Kainate Receptor-Mediated Neurotransmission in the Hippocampus |
SEP 2004 |
141 pages |
| Authors:
C. F. Valenzuela; NEW MEXICO UNIV ALBUQUERQUE
|
| Alcohol-related medical disorders affect many organs and systems of the body, including the central nervous system (CNS). As with other drugs of abuse, long-term alcohol ingestion results in the development of tolerance, addiction, and dependence. Alcohol produces these effects by altering the actions of neurotransmitters and their receptors in the brain. Chronic ethanol exposure has complex and long-lasting effects on the function and/or expression of a myriad of neurotransmitter receptors ... |
|
| Prenatal Alcohol Exposure Damages Brain Signal Transduction System |
SEP 2004 |
73 pages |
| Authors:
Kevin K. Caldwell; NEW MEXICO UNIV ALBUQUERQUE
|
| This final report details the results of our studies. The proposal's overall goal is to uncover biochemical mechanisms that underlie learning and memory. These studies have yielded novel information about the effects of fear conditioning on brain phospholipase C-Betala (PLC-Betala), indicating that PLC- Betala may play an important role in the biochemical processes underlying fear- conditioned learning and memory formation. We have uncovered the molecular basis of the observed association ... |
|
| Control of Breast Carcinoma Angiogenesis by Nutrient Stress Mechanisms |
AUG 2004 |
41 pages |
| Authors:
Steve Abcouwer; NEW MEXICO UNIV ALBUQUERQUE
|
| We found that expression of the pro-angiogenic gene vascular endothelial growth factor (VEGF) by breast cancer cell lines is responsive to endoplasmic reticulum (ER) stress and deprivation of nutrients, including glucose and amino acids. This means that VEGF expression in solid tumors may be increased not just by hypoxia, but also by deficient delivery of other nutrients. We have published three manuscripts on this subject. However, we have been unable ... |
|
| Non-Invasive Diagnosis of Androgen Sensitivity in Human Prostate Tumors |
FEB 2004 |
37 pages |
| Authors:
Laurel O. Sillerud; NEW MEXICO UNIV ALBUQUERQUE
|
| We characterized human prostate tumors by histology and quantitative NMR spectroscopy to determine if altered prostate gene expression produced NMR detectable changes in several metabolites (e.g., citrate, traicylglycerols, taurine, tyronsine). These may provide sensitive and specific predictors of the presence, and the androgen sensitivity, of prostatic adenocarcinoma. Our investigations provided a sound biochemical basis for the application of non invasive, in vivo NMR spectroscopy to assess tumor differentiation and androgen ... |
|
| Investigations into the Application of Cumulant Functions in Operations Research and Stochastic Modeling |
2004 |
34 pages |
| Authors:
Amara Nance; NEW MEXICO UNIV ALBUQUERQUE
|
|
| Role of the 5HT3 Receptor in Alcohol Drinking and Aggression Using a Transgenic Mouse Model |
SEP 2003 |
98 pages |
| Authors:
Andrea M. Allan; NEW MEXICO UNIV ALBUQUERQUE
|
| Alcohol use has been identified as an important factor in aggressive, or violent, behavior in humans. Alcohol not only increases the incidence but also the severity of violent attacks. Several clinical studies have reported the observation that highly aggressive individuals display a serotonin-deficient trait. A number of studies indicate that the 5HT(sub 3) receptor system mediates alcohol consumption and the subjective effects of alcohol. The 5HT(sub 3) receptor is unique ... |
|
| 99HRT Prenatal Alcohol Exposure Damages Brain Signal Transduction Systems |
SEP 2003 |
36 pages |
| Authors:
Kevin K. Caldwell; NEW MEXICO UNIV ALBUQUERQUE
|
| This report details our progress during the third year of a three- year proposal. The proposal's overall goal is to uncover biochemical mechanisms that underlie learning and memory. These studies have yielded novel information about the effects of fear conditioning on brain phospholipase C-Betala (PLC- Betala), indicating that PLC-bla may play an important role in the biochemical processes underlying fear-conditioned learning and memory formation. We have uncovered the molecular basis ... |
|
| Motivational Interviewing in the Prevention of Alcohol Abuse |
AUG 2003 |
11 pages |
| Authors:
Theresa Moyers; NEW MEXICO UNIV ALBUQUERQUE
|
| Motivational interviewing (MI) is a brief counseling method that has been shown to reduce alcohol abuse and alcohol-related problems. This project focuses on the training of AF behavioral health providers in the motivational interviewing method, with behavioral coding to assess the success and cost- effectiveness of the training. In addition, this project will assess the impact of such enhanced training on the overall level of alcohol- related events. Sixty behavioral ... |
|
| Selective Inhibitors of 17beta-Hydroxysteroid Dehydrogenase |
JUL 2003 |
45 pages |
| Authors:
David L. Vander; NEW MEXICO UNIV ALBUQUERQUE
|
| Human Type I 17 Beta-HSD, also known as 17 Beta-estrndiol dehydrogenase, catalyzes the reduction of the weak estrogen, estrone, to the strong estrogen, 17 Beta estradiol, which is the biologically active estrogen involved in the development of human breast cancer. Type I 17Beta-HSD is therefore a very attractive target for drug development. Objectives: Recently, we developed a new class of dehydrogenase inhibitors that are targeted at the NAD(P)/NAD(P)H binding sites ... |
|
| Tradeoffs in Polarimeter Design |
MAR 2003 |
39 pages |
| Authors:
J. S. Tyo; NEW MEXICO UNIV ALBUQUERQUE
|
| This presentation concerns system dimensionality, which includes applications and methods, data collection strategies, which includes serial vs. parallel, rotating vs. non-rotating optics, active vs. passive, and system optimization. |
|
| Role of the 5HT(3) Receptor in Alcohol Drinking and Aggression Using a Transgenic Mouse Model |
SEP 2002 |
11 pages |
| Authors:
Andrea M. Allan; NEW MEXICO UNIV ALBUQUERQUE
|
| Alcohol use has been identified as an important factor in aggressive or violent behavior in humans In its 10th Special Report to the U.S. Congress on Alcohol and Health (June 2000) the Public Health Service stated that one in four victims of violent crime described their attacker as having consumed alcohol prior to committing the crime. When the victim was a current or former intimate partner, the incidence increased to ... |
|
| Prenatal Alcohol Exposure Damages Brain Signal Transduction Systems |
SEP 2002 |
16 pages |
| Authors:
Kevin K. Caldwell; NEW MEXICO UNIV ALBUQUERQUE
|
| This report details our progress during the second year of a three- year proposal. The proposal's overall goal is to uncover biochemical mechanisms that underlie learning and memory deficits resulting from fetal alcohol exposure (FAE). We have made three important novel observations: First, we found that FAE increases the amount of PLC activity associated with extracellular signal- regulated kinase 2 (ERK2) in the hippocampal formation isolated from control animals. Second, ... |
|
| Motivational Interviewing in the Prevention of Alcohol Abuse |
AUG 2002 |
6 pages |
| Authors:
Theresa Moyers; NEW MEXICO UNIV ALBUQUERQUE
|
| Motivational interviewing (MI) is a brief counseling method that has been shown to reduce alcohol abuse and alcohol-related problems. This project focuses on the training of Air Force behavioral health providers in the motivational interviewing method, with behavioral coding to assess the success and cost-effectiveness of the training. In addition, this project will assess the impact of such enhanced training on the overall level of alcohol-related events. Initial human subjects ... |
|
| Synthesis of Selective Inhibitors of 17beta-Hydroxysteroid Dehydrogenase |
JUL 2002 |
13 pages |
| Authors:
Jeremy P. Barlow; David L. Vander Jagt; NEW MEXICO UNIV ALBUQUERQUE
|
| Estradiol works at the level of the genetic material of the breast epithelial cells to control a wide range of genes that determine how fast the cell will grow. Breast cancer cells often remain sensitive to estradiol subsequent to becoming cancer cells. Type I l7beta- hydroxysteroid dehydrogenase (HSD) is the enzyme responsible for reducing the hormone estrone to estradiol in the epithelial cells of the breast. In many cases of ... |
|
| A.Telomere DNA Content, Telomerase and c-Myc Amplification in Breast Carcinoma |
JUL 2002 |
27 pages |
| Authors:
Colleen A. Fordyce; Jeffrey K. Griffith; NEW MEXICO UNIV ALBUQUERQUE
|
| The difference between metastatic and localized breast cancer are not known. However, genetic instability is a poor prognostic factor in many types of cancer, implying that processes that lead to the gain, loss, or rearrangement of genomic DNA are important in the evolution of cancer. Telomeres are protein-DNA Complexes that cap the ends of linear chromosomes, protecting them from degradation and fusion. In most cells a number of processes lead ... |
|
| Length-Dependence of Intramolecular Electron Transfer in Sigma-Bonded Rigid Molecular Rods: An ab initio Molecular Orbital Study |
10 JAN 2002 |
|
| Authors:
Ranjit Pati; Shashi P. Karna; NEW MEXICO UNIV ALBUQUERQUE
|
 | The dependence of electron transfer (ET) coupling element, V?sub AB!, on the length of rigid-rod-like systems consisting of bicyclo1.1.1pentane (BCP), cubane (CUB), and bicyclo2.2.2octane (BCO) monomers, has been investigated with the use of ab initio Hartree-Fock (HF) method employing Marcus-Hush two-state (TS) model. The value of V?sub AB! decreases exponentially with increase in the number of the cage units of the sigma-bonded molecules. The calculated decay constant, beta, shows good ... |
|
| 99HRT Effects of Chronic Alcohol Exposure on Kainate Receptor-Mediated Neurotransmission in the Hippocampus |
SEP 2001 |
20 pages |
| Authors:
C. F. Valenzuela; NEW MEXICO UNIV ALBUQUERQUE
|
| We have been testing the hypothesis that chronic alcohol exposure alters expression and/or function of kainate receptors (KA-Rs) in the hippocampus. These receptors have been shown to control hippocampal excitability and an ethanol-induced upregulation of kA-Rs could contribute to the hyperexcitability associated to alcohol withdrawal. We have exposed adult male rats to a liquid diet containing ethanol for 16 days. We have euthanized these rats on the last day of ... |
|
| High Power Microwave Research, Atmospheric Plasma Phenomena, Ultra- Wideband Propagation and Generation |
SEP 2001 |
9 pages |
| Authors:
William Prather; David W. Scholfield; John M. Gahi; NEW MEXICO UNIV ALBUQUERQUE
|
| The primary objectives of this effort were to investigate gas breakdown, plasma antennas, and laser induced plasmas in the atmosphere. The contractor investigated the electrical breakdown of different types of gas under very fast transient voltage excitation. The research addresses different types of gas under different conditions of pressure, temperature, and electrical field stress as expressed on a Paschen curve. The contractor also investigated the feasibility of generating and shaping ... |
|
| Telomere DNA Content, Telomerase, and c-Myc Amplification in Breast Carcinoma |
JUL 2001 |
6 pages |
| Authors:
Colleen Fordyca; Jeffrey Griffith; NEW MEXICO UNIV ALBUQUERQUE
|
| The genetic differences between aggressive metastatic and localized breast cancer are not known. However genetic instability is a poor prognostic factor in many types of cancer, implying that processes that lead to the gain, loss, or rearrangement of genomic DNA are important in the evolution of cancer. Telomeres are protein-DNA complexes that cap the ends of linear chromosomes, protecting them from degradation and fusion. In most cells a number of ... |
|
| Synthesis of Selective Inhibitors of 17beta-Hydroxysteroid Dehydrogenase |
JUL 2001 |
8 pages |
| Authors:
Jeremy P. Barlow; David L. Vander Jagt; NEW MEXICO UNIV ALBUQUERQUE
|
| Estradiol works at the level of the genetic material of the breast epithelial cells to control a wide range of genes that determine how fast the cell will grow. Breast cancer cells often remain sensitive to estradiol subsequent to becoming cancer cells. Type I l7beta-hydroxysteroid dehydrogenase (HSD) is the enzyme responsible for reducing the hormone estrone to estradiol in the epithelial cells of the breast. In many cases of breast ... |
|
| Raman Shifting High Power Near Infrared Laser Radiation |
10 JUN 2001 |
20 pages |
| Authors:
Wolfgang Rudolph; Jack McIver; NEW MEXICO UNIV ALBUQUERQUE
|
| Raman scattering for efficient wavelength conversion of mid infrared radiation was investigated theoretically and experimentally. Conversion efficiencies as high as 70% were observed with stimulated Raman scattering in H2. Several conversion schemes were analyzed theoretically and their applicability for the conversion of iodine lasers was investigated. The most efficient configuration uses a synchronously pumped Raman laser. For this technique, the single pulse of the iodine laser must be converted into ... |
|
| Parallelization of Two- and Three-Dimensional Fast Fourier Transforms |
FEB 2001 |
12 pages |
| Authors:
Paul Bennett; NEW MEXICO UNIV ALBUQUERQUE
|
| Large computational programs employing multi-dimensional spectral techniques for numerical modeling or image processing rely heavily on the use of Fast Fourier Transforms (FFTs). This report describes work performed to port Numeric Algorithms Group, Ltd. (NAG) two-dimensional and three-dimensional FFTs to the IBM SP-l distributed parallel computing platform to transform arrays of almost any dimension upon many processors, while achieving significant speed-up factors. A description of the parallelization strategies used, observed ... |
|
| Multiplex PCR-Based Determination of Genetic Polymorphisms Involved in the Etiology of Breast Cancer |
SEP 2000 |
14 pages |
| Authors:
John R. Herron; Cosette Wheeler; NEW MEXICO UNIV ALBUQUERQUE
|
| Breast cancer incidence rates for New Mexico's women have risen rapidly over the last two decades, particularly in Hispanics for whom breast cancer mortality rates have doubled. Despite this fact, the causes of breast cancer in this minority population have not been adequately characterized; thus, hampering interventions to reverse these trends. We have proposed to develop novel methods to evaluate allelic polymorphisms potentially associated with breast and other forms of ... |
|
| Delays and Refusal in Treatment for Breast Cancer Among Native American and Hispanic Women with Breast Cancer |
AUG 2000 |
44 pages |
| Authors:
Elba Saavedra; Elias Duryea; NEW MEXICO UNIV ALBUQUERQUE
|
| The aim of this study was to describe the factors associated with delays in breast cancer treatment among New Mexico Hispanic, Native American and non-Hispanic white women. Scope: The study is currently enrolling a total of 70 participants, 35 patients and 35 caregivers identified by the patient This ethnographic study will gather data on the psychosocial, cultural, attitudinal, spiritual and demographic variables associated with delays and refusals in breast cancer ... |
|
| Ultralow Threshold Semiconductor Lasers Based on Gain without Inversion |
SEP 1999 |
38 pages |
| Authors:
Kevin Malloy; NEW MEXICO UNIV ALBUQUERQUE
|
| Quantum interference effects in semiconductors for use in the active regions of low threshold lasers. Quantum interference lies behind electromagnetic induced transparencies and gain without inversion in three level systems. Achieving this behavior in reduced dimensionality semiconductor quantum systems opens a host of potential applications and devices. Experiments in atomic systems and modeling of semiconductors has established the conditions and configurations necessary for these phenomena. The initial portion of our ... |
|
| Delays and Refusals in Treatment for Breast Cancer Among Native Americanand Hispanic Women With Breast Cancer |
AUG 1999 |
9 pages |
| Authors:
Elba Saavedra; Elias Duryea; NEW MEXICO UNIV ALBUQUERQUE
|
| The aim of this study is to describe the factors associated with delays in breast cancer treatment among New Mexico Hispanic, Native American and non-Hispanic white women. Scope: The study is enrolling a total of 70 participants, 35 patients and 35 caregivers identified by the patient. This ethnographic study will gather data on the psychosocial, cultural, attitudinal, spiritual and demographic variables associated with delays in ... |
|
| The TI:Sapphire Ring Laser Gyroscope |
07 JAN 1999 |
153 pages |
| Authors:
Matthew J. Bohn; NEW MEXICO UNIV ALBUQUERQUE
|
| This dissertation studied the Ti:sapphire laser as a pulsed ring laser gyroscope. Several new cavity designs were demonstrated, including a saturable absorber mode-locked laser gyroscope, a linear cavity laser, a Kerr- lens mode-locked femtosecond laser gyroscope, and a solid-state mutual Kerr-lens mode-locked ring gyroscope. A solid-state ring laser gyroscope using a dye-jet saturable absorber was studied for the first time. This laser produced the lowest beat frequencies recorded in a ... |
|
| Single Display Groupware: A Model for Co-Present Collaboration |
DEC 1998 |
9 pages |
| Authors:
Jason Stewart; Benjamin B. Bederson; Allison Druin; NEW MEXICO UNIV ALBUQUERQUE
|
| We introduce a model for supporting collaborative work between people that are physically close to each other. We call this model Single Display Groupware (SDG). In this paper, we describe this model, comparing it to more traditional remote collaboration. We describe the requirements that SDG places on computer technology, and our understanding of the benefits and costs of SDG systems. Finally, we describe a prototype SDG system that we built ... |
|
Reports by Corporate Author
