| Prostate Cancer Survivors with Rising PSA and Their Spouses: Treatment Decision Making and Quality of Life |
Dec-2008 |
12 pages |
| Authors:
Michael A Diefenbach; MOUNT SINAI SCHOOL OF MEDICINE NEW YORK
|
 | This study involves patients and their spouses/partners who are attending two cancer centers: the Deane Prostate Health and Research Center in the Department of Urology at Mount Sinai Hospital New York City and the Department of Medical Oncology at Fox Chase Cancer Center Philadelphia. Patients will have been diagnosed with rising PSA but have no clinical evidence of cancer. Eligible patients and their spouse/partners who have agreed to participate (n ... |
|
| Diversity, Replication, Pathogenicity and Cell Biology of Crimean Congo Hemorrhagic Fever Virus |
Oct-2008 |
63 pages |
| Authors:
Adolfo Garcia-Sastre; MOUNT SINAI SCHOOL OF MEDICINE NEW YORK
|
| This research project was a result of a collaboration between three research groups aimed at elucidating basic replication processes of CCHFV with the expected outcome of providing basic research reagents and establishing the foundation of knowledge necessary for discovery of vaccines and antiviral therapeutics for Crimean Congo hemorrhagic fever. Our major findings during the total period of support were the following: We have cloned and expressed all proteins of CCHFV. ... |
|
| Immune Surveillance, Cytokines and Breast Cancer Risk: Genetic and Psychological Influences in African American Women |
Aug 2008 |
8 pages |
| Authors:
Dana H Bovbjerg; MOUNT SINAI SCHOOL OF MEDICINE NEW YORK
|
| Breast cancer cells are known to bear determinants that would allow tumor specific immune responses. However, initiation and amplification of such immune responses are critically dependent upon the balance in TH1 and TH2 cytokine profiles, as well as differences in proinflammatory responses. This molecular epidemiological study evaluates the impact that variability in cytokine profiles, (inferred from functional polymorphisms in cytokine genes), may have on breast cancer risk among urban African- ... |
|
| One-Carbon Metabolism and Breast Cancer Survival in a Population-Based Study |
01-Jun-2008 |
9 pages |
| Authors:
Jia Chen; MOUNT SINAI SCHOOL OF MEDICINE NEW YORK
|
| The 5-year survival rate for BC among US women has increased from 75% during 1974-76 to 85% during 1989-95. Despite such marked improvement BC is still the leading cause of cancer mortality among women 20 - 59 years of age and the second leading cause of cancer mortality among all women. Disease-free survival after BC treatment is likely predicted by both tumor characteristics and host factors. The clinical and pathologic ... |
|
| Increasing Early Detection of Prostate Cancer in African American Men through a Culturally Targeted Print Intervention |
Jun-2008 |
45 pages |
| Authors:
Hayley Thompson; MOUNT SINAI SCHOOL OF MEDICINE NEW YORK
|
| Prostate cancer (PCa) incidence and mortality is higher among African American (AA) men compared to all other groups. There is compelling evidence that higher mortality is due to the greater likelihood of AA men to be diagnosed with advanced-stage PCa. PCa scrnening specifically prostate-specific antigen test (PSA) and digital rectal exam (DRE) has been shown to increase early-stage diagnoses. Although several organizations recommend annual PCa screening starting at age 45 ... |
|
| Emotional, Biological and Cognitive Impact of a Brief Expressive Writing Intervention for Women at Familial Breast Cancer Risk |
Jun-2008 |
7 pages |
| Authors:
Heiddis Valdimarsdottir; Bovbjerg; Dana ; MOUNT SINAI SCHOOL OF MEDICINE NEW YORK
|
| Women at familial breast cancer risk have highly inflated perceptions of their risk of developing the disease, high levels of cancer-specific distress, and lower levels of natural killer cell activity (NKCA) than women without familial breast cancer risk. The proposed study will examine the impact of an expressive writing intervention on emotional, biological, and cognitive processes among women at familial breast cancer risk. This intervention has been shown to have ... |
|
| Characterization of the Hematopoietic Stem Cell in the Peripheral Blood of Patients with Idiopathic Myelofirosis |
Jun-2008 |
6 pages |
| Authors:
Ronald Hoffman; MOUNT SINAI SCHOOL OF MEDICINE NEW YORK
|
| The clinical course of patients with Philadelphia chromosome negative myeloproliferative disorder (MPD) is frequently complicated by thrombotic events. Post-natal vasculogenesis has been proposed to play a critical role in angiogenesis by acting through a hierarchy of endothelial progenitor cells (EPC). Some EPC have been shown to share a number of features associated with monocytes while other more primitive progenitor cells produce EC in vitro exclusively. The cells which share features ... |
|
| Gene-Environment Interaction and Breast Cancer on Long Island, NY |
01-May-2008 |
31 pages |
| Authors:
Susan L Teitelbaum; MOUNT SINAI SCHOOL OF MEDICINE NEW YORK
|
| This research project will build upon the Long Island Breast Cancer Study Project (LIBCSP), a large population-based, case-control study of the environment and breast cancer. Participants completed an in-person interviewer-administered interview, donated blood and urine samples and had home environment samples (dust, soil and water) collected. For this study, 200 cases and 200 controls who donated urine samples will be selected and their urine samples will be analyzed for a ... |
|
| Effect of COX-2 (PGE2) and IL-6 on Prostate Cancer Bone Metastases |
02-Feb-2008 |
35 pages |
| Authors:
Alice C Levine; MOUNT SINAI SCHOOL OF MEDICINE NEW YORK
|
| We hypothesized that (1) prostate cancer cells that express high levels of cyclooxygenase-2 (COX-2) and prostaglandin E2(PGE2) display enhanced bone targeting and (2) the level of expression of COX-2 and PGE2 in established bone metastases determines the overall bone response, with lower vs. higher levels inducing osteoblastic vs. osteolytic responses, respectively. We utilized two human prostate cancer cell lines (MDA-PCa-2B that expresses low levels of COX-2 and PGE2 and produces ... |
|
| Evaluating an Interactive, Multimedia Education and Decision Program for Early-Stage Prostate Cancer Patients in a Randomized Controlled Trial |
FEB 2008 |
10 pages |
| Authors:
Michael A. Diefenbach; MOUNT SINAI SCHOOL OF MEDICINE NEW YORK
|
| This 3-arm randomized controlled trial evaluates the efficacy of a CD-ROM based multimedia prostate cancer education system (PIES). PIES is an educational software that provides patients with information about prostate cancer and its treatment through an intuitive interface, using video, animation, text, and voice-over text. All text is tailored to a person's information seeking preference. Participants (N = 86) are patients diagnosed with localized prostate cancer who will be randomized ... |
|
| ATM Heterozygosity and the Development of Radiation-Induced Erectile Dysfunction and Urinary Morbidity Following Radiotherapy for Prostate Cancer |
Feb-2008 |
27 pages |
| Authors:
Jamie A Cesaretti; MOUNT SINAI SCHOOL OF MEDICINE NEW YORK
|
| The goal of this training grant project is to determine whether the prevalence of ATM carriers among prostate cancer patients treated with radiotherapy that develop erectile dysfunction and urinary morbidity is greater than the prevalence of ATM heterozygosity among patients that do not develop this complication. Regardless of the scientific outcome of the proposal the PI will be left with a vast experience in translational research from which to form ... |
|
| Restoration of Wild-Type Activity to Mutant p53 in Prostate Cancer: A Novel Therapeutic Approach |
01-Jan-2008 |
12 pages |
| Authors:
James J Manfredi; MOUNT SINAI SCHOOL OF MEDICINE NEW YORK
|
| A summary is presented of research performed during three years of a project to determine feasibility of approaches to restore wild-type transcriptional activity on mutant p53 proteins found in human prostate tumors. p53 mutant proteins that are specifically relevant to prostate cancer were examined to determine whether they are suitable targets for such an approach. Three specific aims were pursued. The first was characterizing the interaction of p53 with two ... |
|
| Prostate Cancer Survivors With Rising PSA and Their Spouses: Treatment Decision Making and Quality of Life |
01-Dec-2007 |
11 pages |
| Authors:
Michael A Diefenbach; MOUNT SINAI SCHOOL OF MEDICINE NEW YORK
|
| This study involves patients and their spouses/partners who are attending two cancer centers: the Deane Prostate Health and Research Center in the Department of Urology at Mount Sinai Hospital, New York City and the Department of Medical Oncology at Fox Chase Cancer Center, Philadelphia. Patients will have been diagnosed with rising PSA but have no clinical evidence of cancer. Eligible patients and their spouse/partners who have agreed to participate (n ... |
|
| Diversity, Replication, Pathogenicity and Cell Biology of Crimean Congo Hemorrhagic Fever Virus |
OCT 2007 |
13 pages |
| Authors:
Adolfo Garcia-Sastre; MOUNT SINAI SCHOOL OF MEDICINE NEW YORK
|
| This research project is a result of a collaboration between three research groups aimed at elucidating basic replication processes of CCHFV with the expected outcome of providing basic research reagents and establishing the foundation of knowledge necessary for discovery of vaccines and antiviral therapeutics for Crimean Congo hemorrhagic fever. Our major findings during the third year of support are the following: We have demonstrated that the isopeptidase activity associated with ... |
|
| Immune Surveillance, Cytokines and Breast Cancer Risk: Genetic and Psychological Influences in African American Women |
AUG 2007 |
8 pages |
| Authors:
Dana H. Bovbjerg; MOUNT SINAI SCHOOL OF MEDICINE NEW YORK
|
| Breast cancer cells are known to bear determinants that would allow tumor specific immune responses. However, initiation and amplification of such immune responses are critically dependent upon the balance in TH1 and TH2 cytokine profiles. This molecular epidemiological study evaluates the impact that variability in cytokine profiles, (inferred from functional polymorphisms in cytokine genes), may have on breast cancer risk among urban African-American women. In the first phase of the ... |
|
| One-Carbon Metabolism and Breast Cancer Survival in a Population-Based Study |
JUN 2007 |
8 pages |
| Authors:
Jia Chen; MOUNT SINAI SCHOOL OF MEDICINE NEW YORK
|
| The 5-year survival rate for BC among US women has increased from 75% during 1974-76 to 85% during 1989-95. Despite such marked improvement, BC is still the leading cause of cancer mortality among women 20-59 years of age and the second leading cause of cancer mortality among all women. Disease-free survival after BC treatment is likely predicted by both tumor characteristics and host factors. The clinical and pathologic parameters that ... |
|
| Increasing Early Detection of Prostate Cancer in African American Men through a Culturally Targeted Print Intervention |
MAR 2007 |
7 pages |
| Authors:
Hayley Thompson; MOUNT SINAI SCHOOL OF MEDICINE NEW YORK
|
| Prostate cancer (PCa) incidence and mortality is higher among African American (AA) men compared to all other groups. There is compelling evidence that higher mortality is due to the greater likelihood of AA men to be diagnosed with advanced-stage PCa. PCa screening specifically prostate-specific antigen test (PSA) and digital rectal exam (DRE), has been shown to increase early-stage diagnoses. Although several organizations recommend annual PCa screening starting at age 45 ... |
|
| Evaluating an Interactive, Multimedia Education and Decision Program for Early-Stage Prostate Cancer Patients in a Randomized Controlled Trial |
01 FEB 2007 |
8 pages |
| Authors:
Michael A. Diefenbach; MOUNT SINAI SCHOOL OF MEDICINE NEW YORK
|
| This 3-arm randomized controlled trial evaluates the efficacy of a CD-ROM based multimedia prostate cancer education system (PIES). PIES is an educational software that provides patients with information about prostate cancer and its treatment through an intuitive interface, using video, animation, text, and voice-over text. All text is tailored to a person's information seeking preference. Participants (N = 312) are patients diagnosed with localized prostate cancer who will be randomized ... |
|
| ATM Heterozygosity and the Development of Radiation-Induced Erectile Dysfunction and Urinary Morbidity Following Radiotherapy for Prostate Cancer |
FEB 2007 |
43 pages |
| Authors:
Jamie A. Cesaretti; MOUNT SINAI SCHOOL OF MEDICINE NEW YORK
|
| The goal of this training grant project is to determine whether the prevalence of ATM carriers among prostate cancer patients treated with radiotherapy that develop erectile dysfunction and urinary morbidity is greater than the prevalence of ATM heterozygosity among patients that do not develop this complication. Regardless of the scientific outcome of the proposal the PI will be left with a vast experience in translational research from which to form ... |
|
| Effect of COX-2 (PGE2) and IL-6 on Prostate Cancer Bone Mets |
FEB 2007 |
9 pages |
| Authors:
Alice C. Levine; MOUNT SINAI SCHOOL OF MEDICINE NEW YORK
|
| We hypothesize that (1) prostate cancer cells that express cyclooxygenase-2 (COX-2), prostaglandin E2(PGE2) and interleukin-6 (IL-6) display enhanced bone targeting and (2) the level of expression of COX-2, PGE2 and IL-6 in established bone metastases determines the overall bone response, with lower vs. higher cytokine levels inducing osteoblastic vs. osteolytic responses, respectively. We utilize two human prostate cancer cell lines (MDA-PCa-2B that expresses low levels of COX-2 and PGE2 and ... |
|
| Microtubule-Targeting Therapy for Prostate Cancer |
FEB 2007 |
30 pages |
| Authors:
George F. Atweh; MOUNT SINAI SCHOOL OF MEDICINE NEW YORK
|
| Prostate cancer is the most frequently diagnosed malignancy and the second leading cause of cancer-related deaths in men in the U.S. In the early stage of the disease, the treatments of choice are extensive surgery and/or radiation therapy. Although both treatment modalities are effective, they are associated with significant morbidity and mortality. When local therapies for prostate cancer fail and the disease progresses, systemic androgen ablation therapy, with or without ... |
|
| Restoration of Wild-Type Activity to Mutant p53 in Prostate Cancer: A Novel Therapeutic Approach |
JAN 2007 |
8 pages |
| Authors:
James J. Manfredi; MOUNT SINAI SCHOOL OF MEDICINE NEW YORK
|
| A summary is presented of research performed during the second year of a project to explore approaches to restore wild-type function on mutant p53 proteins found in human prostate tumors. p53 mutant proteins derived from prostate tumors are being characterized to determine their suitability. Three specific aims are being pursued. The first is characterizing the interaction of p53 with two distinct classes of its response elements. The second aim is ... |
|
| Construction of a Vesicular Stomatitis virus Expressing Both a Fusogenic Glycoprotein and IL-12: A Novel Vector for Prostate Cancer Therapy |
Jan-2007 |
11 pages |
| Authors:
Simon J Hall; MOUNT SINAI SCHOOL OF MEDICINE NEW YORK
|
| Introduction: Vesicular Stomatitis Virus (VSV) infection of malignant cells results in oncolysis, sparing normal cells due to inherent differences in the interferon response pathway. In this study we explored enhancing VSV-G by engineering it to express the fusogenic glycoprotein from the Newcastle Disease Virus (VSV-F) to induce inter-cellular membrane fusion producing syncytia, which are incompatible with cell survival. Materials and Methods: Studies initially compared effects of VSV and VSV-F in ... |
|
| Bone Geometry as a Predictor of Tissue Fragility and Stress Fracture Risk |
OCT 2006 |
76 pages |
| Authors:
Karl J. Jepsen; MOUNT SINAI SCHOOL OF MEDICINE NEW YORK
|
| Having a narrow tibia relative to body mass has been shown to be a major predictor of stress fracture risk and fragility. The reason for this phenomenon is not understood. Based on studies of genetically distinct inbred mouse strains, we found a reciprocal relationship between bone mass and bone quality, such that slender bones are associated with more damageable bone tissue. We postulate that a similar reciprocal relationship between bone ... |
|
| Diversity, Replication, Pathogenicity and Cell Biology of Crimean Congo Hemorrhagic Fever Virus |
OCT 2006 |
15 pages |
| Authors:
Adolfo Garcia-Sastre; MOUNT SINAI SCHOOL OF MEDICINE NEW YORK
|
| This research project is a result of a collaboration between three research groups aimed at elucidating basic replication processes of CCHFV with the expected outcome of providing basic research reagents and establishing the foundation of knowledge necessary for discovery of vaccines and antiviral therapeutics for Crimean Congo hemorrhagic fever. Our major findings during the second year of support are the following: We have mapped domains in the N and L ... |
|
| Genetic Factors in Breast Cancer: Center for Interdisciplinary Biobehavioral Research |
OCT 2006 |
45 pages |
| Authors:
Dana H. Bovbjerg; Christine Ambrosone; Heiddis Valdimarsdottir; Lina Jandorf; Margaret McGovern; Jim Godbold; MOUNT SINAI SCHOOL OF MEDICINE NEW YORK
|
| The Behavioral Center has three primary Objectives: 1) To support an integrated, interdisciplinary Program of Research consisting of three synergistic Research Projects each of which addresses an important issue in breast cancer genetic research with African American women that entails critical psychological or behavioral issues. Thus, our first purpose is to do outstanding research, with implications for our understanding of the etiology of breast cancer, as well as for our ... |
|
| Immune Surveillance, Cytokines and Breast Cancer Risk: Genetic and Psychological Influences in African American Women |
AUG 2006 |
6 pages |
| Authors:
Dana H. Bovbjerg; MOUNT SINAI SCHOOL OF MEDICINE NEW YORK
|
| Breast cancer cells are known to bear determinants that would allow tumor specific immune responses. However, initiation and amplification of such immune responses are critically dependent upon the balance in TH1 and TH2 cytokine profiles. This molecular epidemiological study evaluates the impact that variability in cytokine profiles, (inferred from functional polymorphisms in cytokine genes), may have on breast cancer risk among urban African-American women. In the first phase of the ... |
|
| Genetic Influence on Toxicity and Prognosis in Women Treated with Breast Conserving Surgery and Radiation Therapy |
JUL 2006 |
9 pages |
| Authors:
Christine B. Ambrosone; Jenny Chang-Claude; MOUNT SINAI SCHOOL OF MEDICINE NEW YORK
|
| Women with earlier stage breast cancer who receive breast conserving surgery and radiation therapy have a generally good prognosis. However, among 15-20% of these women, breast cancer recurs, and a similar proportion of women also experience severe toxicity with radiation therapy. It is possible that inter-individual differences in capabilities of both tumor and normal cells to protect themselves from radiation-induced damage, and to repair that damage if it does occur, ... |
|
| ATM Mutations and the Development of Severe Radiation-Induced Morbidity Following Radiotherapy for Breast Cancer |
JUL 2006 |
51 pages |
| Authors:
Barry S. Rosenstein; MOUNT SINAI SCHOOL OF MEDICINE NEW YORK
|
| The hypothesis being tested in this project is that a greater proportion of patients who develop radiation-induced subcutaneous late tissue morbidity possess a variant allele in the ATM gene compared with patients who do not suffer these complications. An additional objective is to determine the functional impact upon the protein encoded by the ATM gene for each genetic alteration identified and subsequent cellular radiosensitivity. The specific aims of this project ... |
|
| Screening for ATM Mutations in an African-American Population to Identify a Predictor of Breast Cancer Susceptibility |
JUL 2006 |
12 pages |
| Authors:
Barry S. Rosenstein; MOUNT SINAI SCHOOL OF MEDICINE NEW YORK
|
| The hypothesis being tested in this project is that a greater proportion of African-Americans with breast cancer harbor a specific germline genetic alteration in the ATM gene or possess a particular ATM haplotype compared to African-American women without breast cancer. An additional objective is to determine the functional impact upon the protein encoded by the ATM gene for each mutation identified. Specific Aims: The specific aims of this project are ... |
|
| Increasing Breast Cancer Surveillance Among African American Breast Cancer Survivors |
JUL 2006 |
27 pages |
| Authors:
Hayley Thompson; MOUNT SINAI SCHOOL OF MEDICINE NEW YORK
|
| Breast cancer survivors are at elevated risk for developing a new breast cancer compared to healthy women, and are at considerable risk for breast cancer recurrence. According to the American Society of Clinical Oncology, survivors should undergo careful breast cancer surveillance including annual mammography and breast self-exam. However, studies indicate that breast cancer surveillance among African American survivors, particularly mammography, is low, especially given the higher risk of survivors as ... |
|
| Restoration of Epithelial Polarity in Metastatic Tumors |
JUL 2006 |
6 pages |
| Authors:
Sergei Sokol; MOUNT SINAI SCHOOL OF MEDICINE NEW YORK
|
| Malignant properties of breast cancer cells are known to depend on their altered polarity and adhesion properties. LGL genes function by controlling normal epithelial polarity and suppressing tumors in the fruit fly. The LGL proteins were also proposed to decrease the frequency of epithelial tumor formation in mammals. To test this idea, we monitored LGL expression in epithelial cells undergoing malignant transformation to correlate it with increased cell motility and ... |
|
| One-Carbon Metabolism and Breast Cancer Survival in a Population-Based Study |
JUN 2006 |
8 pages |
| Authors:
Jia Chen; MOUNT SINAI SCHOOL OF MEDICINE NEW YORK
|
| The 5-year survival rate for BC among US women has increased from 75% during 1974-76 to 85% during 1989-95. Despite such marked improvement, BC is still the leading cause of cancer mortality among women 20-59 years of age and the second leading cause of cancer mortality among all women. Disease-free survival after BC treatment is likely predicted by both tumor characteristics and host factors. The clinical and pathologic parameters that ... |
|
| Gene-Environment Interaction and Breast Cancer on Long Island, NY |
MAY 2006 |
6 pages |
| Authors:
Susan Teitelbaum; MOUNT SINAI SCHOOL OF MEDICINE NEW YORK
|
| This research project will build upon the Long Island Breast Cancer Study Project (LIBCSP), a large population-based, case-control study of the environment and breast cancer. Participants completed an in-person interviewer-administered interview, donated blood and urine samples, and had home environment samples (dust, soil, and water) collected. For this study, 200 cases and 200 controls who donated urine samples will be selected and their urine samples will be analyzed for a ... |
|
| Role of Cdc25C Phosphatases in Human Breast Cancer |
MAY 2006 |
8 pages |
| Authors:
James J. Manfredi; MOUNT SINAI SCHOOL OF MEDICINE NEW YORK
|
| A summary is presented of research performed during the first year of a project to determine the role of Cdc25 phosphatases in human breast cancer. Three specific aims are being pursued. The first is to determine the role of Cdc25B in breast cancer proliferation. The second aim is examining whether alternative splicing of Cdc25C contributes to human breast cancer. The final aim is to explore a potential novel breast cancer ... |
|
| Transcriptional Regulation by KLF6, A Novel Tumor Suppressor Gene in Prostate Cancer, Through Interaction with HATS and HDACS |
MAR 2006 |
79 pages |
| Authors:
Scott L. Friedman; MOUNT SINAI SCHOOL OF MEDICINE NEW YORK
|
| KLF6 is a zinc finger transcription factor mutated in more than 50% of sporadic prostate cancers. Our studies have explored the role of acetylation of KLF6 and how its abrogation by mutation in human cancer may contribute to its dysregulation and emergence of prostate cancer. The KLF6 tumor suppressor protein normally inhibits cell growth by upregulating p21 (WAF1/CIP1) independent of p53 whereas most tumor derived mutations are no longer growth ... |
|
| Role of Cdc25C Phosphatases in Human Breast Cancer |
MAR 2006 |
8 pages |
| Authors:
James J. Manfredi; MOUNT SINAI SCHOOL OF MEDICINE NEW YORK
|
| A summary is presented of research performed during the first year of a project to determine the role of Cdc25 phosphatases in human breast cancer. Three specific aims are being pursued. The first is to determine the role of Cdc25B in breast cancer proliferation. The second aim is examining whether alternative splicing of Cdc25C contributes to human breast cancer. The final aim is to explore a potential novel breast cancer ... |
|
| Effect of COX-2 (PGE2) and IL-6 on Prostate Bone Metastases |
FEB 2006 |
9 pages |
| Authors:
Alice Levine; MOUNT SINAI SCHOOL OF MEDICINE NEW YORK
|
| We hypothesize that (1) prostate cancer cells that express cyclooxygenase-2 (COX-2), prostaglandin E2 (PGE2) and interleukin-6 (IL-6) display enhanced bone targeting and (2) the level of expression of COX-2, PGE2, and lL-6 in established bone metastases determines the overall bone response, with lower vs. higher cytokine levels inducing osteoblastic vs. osteolytic responses, respectively. We utilize two human prostate cancer cells lines (MDA-Pca 2b, osteoblastic response, low cytokine expression and PC-3ML, ... |
|
| Evaluating and Interactive, Multimedia Education and Decision Program for Early-Stage Prostate Cancer Patients in a Randomized Controlled Trial |
FEB 2006 |
8 pages |
| Authors:
Michael A. Diefenbach; MOUNT SINAI SCHOOL OF MEDICINE NEW YORK
|
| This 3-arm randomized controlled trial evaluates the efficacy of a CD-ROM based multimedia prostate cancer education system (PIES). PIES is an educational software that provides patients with information about prostate cancer and its treatment through an intuitive interface, using video, animation, text, and voice-over text. All text is tailored to a person's information seeking preference. Participants (N = 312) are patients diagnosed with localized prostate cancer who will be randomized ... |
|
| ATM Heterozygosity and the Development of Radiation-Induced Erectile Dysfunction and Urinary Morbidity Following Radiotherapy for Prostate Cancer |
FEB 2006 |
40 pages |
| Authors:
Jamie A. Cesaretti; MOUNT SINAI SCHOOL OF MEDICINE NEW YORK
|
| The goal of this training grant project is to determine whether the prevalence of ATM carriers among prostate cancer patients treated with radiotherapy that develop erectile dysfunction and urinary morbidity is greater than the prevalence of ATM heterozygosity among patients that do not develop this complication. Regardless of the scientific outcome of the proposal the PI will be left with a vast experience in translational research from which to form ... |
|
| Restoration of Wild-Type Activity to Mutant p53 in Prostate Cancer: A Novel Therapeutic Approach |
JAN 2006 |
8 pages |
| Authors:
James Manfredi; MOUNT SINAI SCHOOL OF MEDICINE NEW YORK
|
| A summary is presented of research performed during the first year of a project to determine feasibility of approaches to restore wild-type transcriptional activity on mutant p53 proteins found in human prostate tumors. p53 mutant proteins that are specifically relevant to prostate cancer are being examined to determine whether they are suitable targets for such an approach. Three specific aims are being pursued. The first is characterizing the interaction of ... |
|
| Construction of a Vesicular Stomatitis Virus Expressing Both a Fusogenic Glycoprotein and IL-12: A Novel Vector for Prostate Cancer Therapy |
JAN 2006 |
9 pages |
| Authors:
Simmon J. Hall; MOUNT SINAI SCHOOL OF MEDICINE NEW YORK
|
| Introduction: Vesicular Stomatitis Virus (VSV) infection of malignant cells results in oncolysis, sparing normal cells due to inherent differences in the interferon response pathway. In this study we explored enhancing VSV-G by engineering it to express the fusogenic glycoprotein from the Newcastle Disease Virus (VSV-F) to induce inter-cellular membrane fusion producing syncytia, which are incompatible with cell survival. Materials and Methods: Studies initially compared effects of VSV and VSV-F in ... |
|
| Construction of a Vesicular Stomatitis Virus Expressing Both a Fusogenic Glycoprotein and IL-12: A Novel Vector for Prostate Cancer Therapy |
JAN 2006 |
9 pages |
| Authors:
Simon J. Hall; MOUNT SINAI SCHOOL OF MEDICINE NEW YORK
|
| Vesicular Stomatitis Virus (VSV) infection of malignant cells results in oncolysis, sparing normal cells due to inherent differences in the interferon response pathway. In this study, we explored enhancing VSV-G by engineering it to express the fusogenic glycoprotein from the Newcastle Disease Virus (VSV-F) to induce inter-cellular membrane fusion producing syncytia, which are incompatible with cell survival. Studies initially compared effects of VSV and VSV-F in vitro in prostate cancer ... |
|
| Influence of Bone Remodeling Inhibition on the Development of Experimental Stress Fractures |
NOV 2005 |
84 pages |
| Authors:
Mitchell B. Schaffler; MOUNT SINAI SCHOOL OF MEDICINE NEW YORK
|
| Stress fractures result from repetitive loading and have been regarded as a mechanical fatigue-driven process. However, a number of studies indicate implicate increased bone remodeling in the pathogenesis of stress fractures. Our experiments tested the hypothesis that pharmacological inhibition of bone remodeling will slow the accumulation of microdamage and diminish the severity of the stress fracture. Using a bisphosphonate (BIS) to suppress remodeling in the rabbit tibial stress fracture model, ... |
|
| Phase I Trial of Adenovirus-Mediated IL-12 Gene Transduction in Patients with Recurrent Locally Advanced Prostate Cancer Following Therapy |
01 OCT 2005 |
29 pages |
| Authors:
Simon J. Hall; MOUNT SINAI SCHOOL OF MEDICINE NEW YORK
|
| Patients with radiorecurrent prostate cancer have few options. Gene therapy may define a treatment option of both local and systemic value. Pre-clinical studies using adenovirus-mediated (Ad.) transduction of IL-12 (Ad.mIL-12) in a metastatic model of prostate cancer resulted in local growth suppression, survival enhancement and inhibition of pre-established metastases. The basis for these activities include the induction of both innate (neutrophils & NKs) and acquired immunity (T cells). On the ... |
|
| Genetic Factors in Breast Cancer: Center for Interdisciplinary Biobehavioral Research |
OCT 2005 |
35 pages |
| Authors:
Dana H. Bovbjerg; Christine Ambrosone; Heiddis Valdimarsdottir; Margaret McGovern; Jim Godbold; Lina Jandorf; MOUNT SINAI SCHOOL OF MEDICINE NEW YORK
|
| The central goal of the Breast Cancer Behavioral Center is to further our understanding of the impact of biobehavioral factors on genetic aspects of breast cancer in African-American women. The Center has three aims: 1) To support an integrated, interdisciplinary, Program of Research consisting of three synergistic Research Projects (with 4 supporting Cores), each of which addresses an important cancer topic and includes psychological and/or behavioral issues. Thus, we have ... |
|
| Diversity, Replication, Pathogenicity and Cell Biology of Crimean Congo Hemorrhagic Fever Virus |
OCT 2005 |
35 pages |
| Authors:
Adolfo Garcia-Sastre; MOUNT SINAI SCHOOL OF MEDICINE NEW YORK
|
| This research project is a result of a collaboration between three research groups aimed at elucidating basic replication processes of CCHFV with the expected outcome of providing basic research reagents and establishing the foundation of knowledge necessary for discovery of vaccines and antiviral therapeutics for Crimean Congo hemorrhagic fever. Our major findings during the first year of support are the following: We have sequenced and cloned in expression vectors the ... |
|
| Bone Geometry as a Predictor of Tissue Fragility and Stress Fracture Risk |
OCT 2005 |
26 pages |
| Authors:
Karl J. Jepsen; MOUNT SINAI SCHOOL OF MEDICINE NEW YORK
|
| Having a narrow tibia relative to body mass has been shown to be a major predictor of stress fracture risk and fragility. The reason for this phenomenon is not understood. Based on studies of genetically distinct inbred mouse strains, we found a reciprocal relationship between bone mass and bone quality, such that slender bones are associated with more damageable bone tissue. We postulate that a similar reciprocal relationship between bone ... |
|
| Inherited Susceptibility to Breast Cancer in Healthy Women: Mutation in Breast Cancer Genes, Immune Surveillance, and Psychological Distress |
OCT 2005 |
11 pages |
| Authors:
Dana H. Bovbjerg; MOUNT SINAI SCHOOL OF MEDICINE NEW YORK
|
| The purpose of the research supported by this IDEA grant award was to test the possibility that variability in the strength of immune surveillance mechanisms against cancer (operationally defined by assessment of natural killer cell activity, or NKCA) may be a factor in determining the penetrance of mutations in breast cancer susceptibility genes. The following hypotheses were investigated: Hypothesis 1 -- Women with family histories of breast cancer are more ... |
|
| Analysis of Alk-1 Signaling in Endothelial Cells and its Role in Breast Tumor Angiogenesis. Addendum |
SEP 2005 |
13 pages |
| Authors:
Marcus Kretzschmar; Hans-Willem Snoeck; MOUNT SINAI SCHOOL OF MEDICINE NEW YORK
|
| The process of tumor angiogenesis i.e. the vascularization of the tumor mass by formation of new blood vessels is important for tumor growth and metastasis. Inhibition of tumor angiogenesis is therefore an important goal for therapeutic intervention in breast cancer. Understanding the regulation of tumor angiogenesis at the molecular level is a prerequisite for successful manipulation of this process. Angiogenesis is regulated by the coordinated action of various growth factors ... |
|
Reports by Corporate Author
