| Interferon Antagonism as a Common Virulence Factor of Hemorrhagic Fever Viruses |
Feb-2009 |
19 pages |
| Authors:
Adolfo G Sastre; Connie S Schmaljohn; MOUNT SINAI MEDICAL CENTER OF THE CITY OF NEW YORK
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 | We examined the ability of viruses in the Hantavirus and Nairovirus genera of the family Bunyaviridae to interfere with host signaling pathways involved in innate immunity. For the nairovirus, Crimean Congo hemorrhagic fever virus (CCHFV), we found that the viral polymerase gene contains a predicted ovarian tumor (OTU) protease domain that functions to deconjugate ubiquitin and interferon stimulated gene product 15 (ISG15) from host proteins. Both ubiquitin and ISG15 reversibly ... |
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| Emotional, Biological, and Cognitive Impact of a Brief Expressive Writing Intervention for Women at Familial Breast Cancer Risk |
Jun 2006 |
5 pages |
| Authors:
Heiddis Valdimarsdottir; MOUNT SINAI MEDICAL CENTER OF THE CITY OF NEW YORK
|
| Women at familial breast cancer risk have highly inflated perceptions of their risk of developing the disease high levels of cancer-specific distress and lower levels of natural killer cell activity (NKCA) than women without familial breast cancer risk. The proposed study will examine the impact of an expressive writing intervention on emotional biological and cognitive processes among women at familial breast cancer risk. This intervention has been shown to have ... |
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| Gene-Environment Interaction and Breast Cancer on Long Island, NY |
14 SEP 2005 |
7 pages |
| Authors:
Susan L. Teitelbam; MOUNT SINAI MEDICAL CENTER OF THE CITY OF NEW YORK
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| This research project will build upon the Long Island Breast Cancer Study Project (LIBCSP), a large population based, case-control study of the environment and breast cancer. Participants completed an in-person interviewer-administered interview, donated blood and urine samples and had home environment samples (dust, soil and water) collected. For this study, 200 cases and 200 controls who donated urine samples will be selected and their urine samples will be analyzed for ... |
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| Mitotic Spindle Directed Therapeutics for Early Stage Breast Carcinoma |
SEP 2005 |
10 pages |
| Authors:
Sucharita J. Mistry; MOUNT SINAI MEDICAL CENTER OF THE CITY OF NEW YORK
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| For the proposed studies, we used a recombinant adenovirus that carries anti-stathmin ribozyme, Rz184, for inhibiting stathmin expression in breast cancer cells. We used a bicistronic expression vector, pAdCMV5- IRES-GFP, that contains an adenovirus origin of replication and 2.5 kilobases of human adenovirus type 5 (AdS) DNA for efficient homologous recombination. This vector also contains an internal ribosome entry site (IRES) element derived from the encephalomyocarditis virus that permits the ... |
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| One-Carbon Metabolism and Breast Cancer Survival in a Population-Based Study |
01 JUN 2005 |
8 pages |
| Authors:
Jia Chen; MOUNT SINAI MEDICAL CENTER OF THE CITY OF NEW YORK
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| The 5-year survival rate for breast cancer (BC) among U.S. women has increased from 75% during 1974-76 to 85% during 1989-95. Despite such marked improvement, BC is still the leading cause of cancer mortality among women 20-59 years of age and the second leading cause of cancer mortality among all women. Disease-free survival after BC treatment is likely predicted by both tumor characteristics and host factors. The clinical and pathologic ... |
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| Emotional, Biological, and Cognitive Impact of a Brief Expressive Writing Intervention for African American Women at Familial Breast Cancer Risk |
JUN 2005 |
6 pages |
| Authors:
Heiddie Valdimarsdottir; Dana Bovbjerg; MOUNT SINAI MEDICAL CENTER OF THE CITY OF NEW YORK
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| Women at familial breast cancer risk have highly inflated perceptions of their risk of developing the disease, high levels of cancer specific distress, and lower levels of natural killer cell activity (NKCA) than women without familial breast cancer risk. To date, little research has been done on women of African descent with family histories of breast cancer, despite the fact that they may be at particularly high risk for chronic ... |
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| Genetic Influences on Toxicity and Prognosis in Women Treated With Breast-Conserving Surgery and Radiation Therapy |
AUG 2003 |
7 pages |
| Authors:
Christine B. Ambrosone; MOUNT SINAI MEDICAL CENTER OF THE CITY OF NEW YORK
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| Women with earlier stage breast cancer who receive breast conserving surgery and radiation therapy have a generally good prognosis. However, among 15-20% of these women, breast cancer recurs, and a similar proportion of women also experience severe toxicity with radiation therapy. It is possible that inter-individual differences in capabilities of both tumor and normal cells to protect themselves from radiation-induced damage, and to repair that damage if it does occur, ... |
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| Novel Technology for Cloning Prostate Cancer Cell Markers |
FEB 2002 |
21 pages |
| Authors:
F. C. Bancroft; MOUNT SINAI MEDICAL CENTER OF THE CITY OF NEW YORK
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| The purpose of the project is to employ probes isolated from the LNCaP series of human prostate cancer cells, to probe human cDNA microarrays, so as to investigate genes differentially expressed among these cell lines; prepare from the LnCaP series, particularly the C4-2B cells representing the most advance cancer stage, RNA corresponding to a purified "membrane fraction", expected to contain the mRNAs for cell surface markers or secretory proteins; and ... |
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| Novel Technology for Cloning Prostate Cancer Cell Merkers |
FEB 2001 |
12 pages |
| Authors:
F. C. Bancroft; MOUNT SINAI MEDICAL CENTER OF THE CITY OF NEW YORK
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| Purpose of project is to clone, isolate and characterize protein markers specifically expressed by advanced stage, androgen-independent prostate cancers. Two types of markers with this specificity are targeted: proteins secreted specifically by advanced stage prostate cancer cells, potentially useful in serum-based assays for these tumors; markers expressed specifically on the surface of these cells, potentially useful as advanced prostate cancer. Work during the period covered included: (1) Incorporation of the ... |
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| Novel Technology for Cloning Prostate Cancer Cell Markers |
AUG 1999 |
10 pages |
| Authors:
F. C. Bancroft; MOUNT SINAI MEDICAL CENTER OF THE CITY OF NEW YORK
|
| The purpose of the research is to clone, isolate and characterize protein markers that are specifically expressed by advanced stage, androgen- independent prostate cancers. Two types of markers with this specificity are expected to be identified: (1) proteins secreted specifically by advanced stage prostate cancer cells, potentially useful in serum-based assays designed to specifically detect this class of tumors; and (2) markers expressed specifically on ... |
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| Regulation Of The Tumor Suppressor Activity Of p53 In Human Breast Cancer |
SEP 1998 |
24 pages |
| Authors:
James J. Manfredi; MOUNT SINAI MEDICAL CENTER OF THE CITY OF NEW YORK
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| This research is centered on testing the hypothesis that there are novel mechanisms in human breast cancer involving functional inactivation of wild-type p53 besides such direct genetic alteration. The immediate goal of this research is to characterize cellular activities which affect the ability of p53 to bind to DNA in a sequence-specific manner. The long term goal is to determine the relevance of such regulators in human breast cancer. Human ... |
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| Mechanisms of Breast Carcinogenesis Involving Wild-Type p53 |
SEP 1998 |
8 pages |
| Authors:
James J. Manfredi; MOUNT SINAI MEDICAL CENTER OF THE CITY OF NEW YORK
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| This research application is centered on testing the hypothesis that there are mechanisms of carcinogenesis involving functional inactivation of wild-type p53 besides direct genetic alteration in human breast cancer. - The goal of this proposal is to identify mechanisms and clone genes which encode proteins which act on wild-type p53 and functionally inactivate it. Technical objectives include: (1) Determine the mechanisms by which rat embryo fibroblasts acquire resistance to the ... |
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| Characterization and Consequences of Estrogen Receptor Exon Five Deletion |
SEP 95 |
18 pages |
| Authors:
Irina Erenburg; Schacter; MOUNT SINAI MEDICAL CENTER OF THE CITY OF NEW YORK
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| Normal breast growth and development is dependent on estrogen signaling through the estrogen receptor (ER). In addition to its normal function, many studies have conclusively demonstrated the involvement of estrogen as a mitogen in breast tumors. The recent identification of estrogen receptor mRNA splice isoforms has lead to the hypothesis that de-regulation of ER pre-mRNA splicing contributes to the etiology of breast cancer. Data in this report begin to clarify ... |
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