| Effects of a Viral Peptide (Nef) on Growth and Metastasis of Human Breast Cancer |
Sep 2009 |
14 pages |
| Authors:
Harvey L Bumpers; MOREHOUSE SCHOOL OF MEDICINE ATLANTA GA
|
 | We have shown that a novel peptide from HIV-1 Nef (NefM1) induces apoptosis through the CXCR4 receptor. We would like to exploit this as a cancer therapeutic agent. Breast cancer cell lines, MDA-MB231 (231), MDAMB468 (468), MCF-7, DU4475, and HMEC were each evaluated for their response to NefM1. Apoptosis was assessed using TUNEL staining and caspase-3 activation. The presence of CXCR4 receptors on the tumor cells was determined using immunohistochemistry ... |
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| Mitochondrial DNA Mutations in Epithelial Ovarian Tumor Progression |
Dec 2007 |
19 pages |
| Authors:
Felix O Aikhionbare; MOREHOUSE SCHOOL OF MEDICINE ATLANTA GA
|
| Early diagnosis is one of the greatest challenges facing clinicians in the treatment of epithelial ovarian cancer. As a result of mitochondria role in apoptosis and ROS, it have been implicated in carcinogenesis. In this study we detected sequence variants in two fragments of mitochondrial DNA obtained from 68 epithelia ovarian cancer tissues spanning 5317 to 7608 and 8282 to 10110 base pair, including NADH subunits 2, 3, CO I,II,III, ... |
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| The Role & Action of Prohibition, an Antiproliferative Gene, in Ovarian Cancer |
APR 2007 |
10 pages |
| Authors:
Winston E. Thompson; MOREHOUSE SCHOOL OF MEDICINE ATLANTA GA
|
| The experiments proposed in this application aim at understanding the mechanisms by which prohibitin induces growth arrest in ovarian cancer. We hypothesize that the prohibitin gene product will substantially induce arrest in ovarian cancer cells and enhance differentiation. Accordingly, we will characterize the expression pattern and function of this gene. In specific aim 1, we will define the spatial, temporal and stage specific cellular expression pattern of prohibitin in normal ... |
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| Study of Prostate Cancer Screening and Mortality in Black and White Men in the Five Atlanta Area SEER Counties |
OCT 2002 |
35 pages |
| Authors:
Nabih R. Asal; MOREHOUSE SCHOOL OF MEDICINE ATLANTA GA
|
| A case-control study is being implemented in the Five Metropolitan Atlanta SEER Counties to determine if screening with the prostate specific antigen and the digital rectal examination reduce mortality from prostate cancer in black and white men. 566 Prostate cancer death (221 Blacks and 345 Whites of the required sample of 170 Black and 280 White men) occurring to residents of the five counties during 1998-2001 have been identified, reviewed, ... |
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| The Breast Health Intervention Evaluation Study |
AUG 2001 |
86 pages |
| Authors:
Daniel S. Blumenthal; MOREHOUSE SCHOOL OF MEDICINE ATLANTA GA
|
| The Breast Health Intervention Evaluation (BRIE) Study evaluated the relative effectiveness of three different approaches to breast health messages--a fear appeal, a positive affect appeal, and an affectivity neutral, cognitive appeal. The three interventions were structured as three 10-12 minute videotaped presentations targeting 450 African American women residing in three rural communities in Georgia (150/community). Each site received all three intervention approaches which were randomly assigned within the site sample. ... |
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| Breast Health Belief System Study |
AUG 2001 |
146 pages |
| Authors:
Mary P. Williams; MOREHOUSE SCHOOL OF MEDICINE ATLANTA GA
|
| The Breast Health Belief Systems Study was designed to test the saliency of integrating elements of study participants' belief system about breast cancer to increase early breast cancer screening practices. The study targeted African American women living in rural Georgia. The study consisted of three phases: One - an ethnographic survey to determine the scope and depth of beliefs and practices regarding breast cancer; Two used the data gathered from ... |
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| Managing Multiple Risk Factors for Cardiovascular Disease Through Anger/ Hostility Control and Medicine |
MAR 2001 |
181 pages |
| Authors:
Charlie M. Lollis; MOREHOUSE SCHOOL OF MEDICINE ATLANTA GA
|
| Despite the decrease in coronary heart disease mortality over the past 30 years, coronary heart disease (CHD) continues to reign as the leading cause of death in men and women. Cardiovascular disease, including CHD, kills nearly 500,000 American women each year and black women generally have a higher prevalence of CHD risk factors and a higher death rate at a younger age than white women (Haan, 1996). Risk factors are ... |
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| The Breast Health Intervention Evaluation Study |
AUG 2000 |
8 pages |
| Authors:
Daniel Blumenthal; MOREHOUSE SCHOOL OF MEDICINE ATLANTA GA
|
| The Breast Health Intervention Evaluation Study will evaluate the relative effectiveness of three different affective approaches to breast health messages--a fear appeal, a positive appeal, and an effectively neutral, cognitive appeal. The three interventions will be structured as three 10-12 minute videotaped presentations targeting 450 African American women residing in three rural communities in Georgia (150/community). Each site will provide the intervention within a 60-minute workshop format. Workshops will be ... |
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| The Breast Health Intervention Evaluation Study |
AUG 1999 |
21 pages |
| Authors:
Daniel S. Blumenthal; MOREHOUSE SCHOOL OF MEDICINE ATLANTA GA
|
| The Breast Health Intervention Evaluation Study will evaluate the relative effectiveness of three different approaches to breast health messages-- a fear appeal, a positive affect appeal, and an affectively neutral cognitive appeal. The three interventions will be structured as three 10-12 minute videotaped presentations targeting 450 African American women residing in three rural communities in Georgia (150/community). Each site will receive one of the three ... |
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| Breast Health Belief Systems Study |
AUG 1999 |
72 pages |
| Authors:
Mary P. Williams; MOREHOUSE SCHOOL OF MEDICINE ATLANTA GA
|
| The Morehouse School Medicine is conducting the Breast Health Belief Systems Study, a multi-institutional project. This study was designed to address the issues surrounding constructing effective health promotion messages in regard to breast cancer for African American women who live in the rural South. The hypothesis underlying this research is that a breast health promotion approach that is based in specific belief systems among three disparate ... |
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| Breast Health Education Study |
NOV 1998 |
49 pages |
| Authors:
Beverly D. Taylor; MOREHOUSE SCHOOL OF MEDICINE ATLANTA GA
|
| Morebouse School of Medicine has developed a Breast Health Education Study that focuses on two groups: (1) minority, underserved women who are residents of Atlanta Housing Authority communities, and (2) primary care physicians and other health care providers who care for the medically underserved. The study seeks to determine and validate the efficacy of community-based educational program initiatives in promoting breast health in ... |
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| Managing Multiple Risk Factors |
SEP 1998 |
18 pages |
| Authors:
Charlie M. Lollis; MOREHOUSE SCHOOL OF MEDICINE ATLANTA GA
|
| Current research provides evidence that a higher prevalence of obesity, a more centralized fat pattern and a clustering of cardiovascular risk factors (i.e., overweight/obesity, hypertension, hyperinsulinemia, insulin resistance, dyslipidemia, neurohumoral activation and anger/hostility) contribute to the racial differences in cardiovascular risk and events among women. High levels of socioeconomic stress, higher dietary fat intake and sedentary lifestyle are more prevalent among black than white women. The proposed study will address ... |
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| Breast Health Belief Systems Study |
AUG 1998 |
44 pages |
| Authors:
Mary P. Williams; MOREHOUSE SCHOOL OF MEDICINE ATLANTA GA
|
| Morehouse School of Medicine (MSM) conducts the Breast Health Belief Systems Study that seeks to accomplish three specific goals: (1) qualitatively analyze intracultural variations in knowledge, attitudes, and beliefs regarding breast disease among 73 low-SE S, African American rural women who have received a diagnosis of breast cancer, (2) provide breast health information on an interpersonal level to a total of 600 demographically similar women (200 at each of 3 ... |
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| The Breast Health Intervention Evaluation Study |
AUG 1998 |
16 pages |
| Authors:
Daniel S. Blumenthal; MOREHOUSE SCHOOL OF MEDICINE ATLANTA GA
|
| The Breast Health Intervention Evaluation Study will evaluate the relative effectiveness of three different approaches to breast health messages-- a fear appeal, a positive affect appeal, and an effectively neutral cognitive appeal. The three interventions will be structured as three 10-12 minute videotaped presentations targeting 450 African American women residing in three rural communities in Georgia (150/community). Each site will receive one of the three intervention approaches, randomly selected, to ... |
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| The Breast Health Intervention Evaluation Study |
SEP 97 |
29 pages |
| Authors:
Daniel S. Blumenthal; MOREHOUSE SCHOOL OF MEDICINE ATLANTA GA
|
| The Breast Health Intervention Evaluation (BRIE) Study will evaluate the relative effectiveness of three different approaches to breast health messages--a fear appeal, a positive affect appeal, and an affectively neutral, cognitive appeal. The three interventions will be structured as three 10-12 minute videotaped presentations targeting 450 African American women residing in three rural communities in Georgia (150/community). Each site will receive one of the three intervention approaches, randomly selected, to ... |
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| Breast Health Education Study |
JUL 97 |
132 pages |
| Authors:
Beverly D. Taylor; MOREHOUSE SCHOOL OF MEDICINE ATLANTA GA
|
| Morehouse School of Medicine has developed a Breast Health Education Study that focuses on two groups: 1.) minority, underserved women who are residents of Atlanta Housing Authority communities, and 2.) primary care physicans and other health care providers who care for the medically underserved. The study seeks to determine and validate the efficacy of community based educational program initiatives in promoting breast health in this population by educating and motivating ... |
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| Breast Health Education Study |
AUG 96 |
41 pages |
| Authors:
Beverly D. Taylor; MOREHOUSE SCHOOL OF MEDICINE ATLANTA GA
|
| The purpose of the currently fluided project is: to seek to determine and validate the efficacy of a community-based educational program initiative in promoting breast health in minority and medically underserved women by educating and motivating them to seek mammograms and perform breast self examination on a regular basis. The study focuses on two groups to achieve its goals: (1) minority and underserved women, in the metropolitan Atlanta area, and ... |
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| Symposium on Career Opportunities in Biomedical and Public Health Sciences for Minorities |
MAY 96 |
60 pages |
| Authors:
Walter W. Sullivan; MOREHOUSE SCHOOL OF MEDICINE ATLANTA GA
|
| This report chronicles activities of the Minority Health Professions Foundation's tenth symposium on Career Opportunities in Biomedical and Public Health Sciences. The Symposium was held in Los Angeles, California, April 3-5, 1996, with thirteen hundred thirty-two (1332) minority students in attendance. The Symposium was designed to influence minority students to pursue a career in a biomedical or public health science. Students were treated to plenary speakers and workshop speakers who ... |
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| Breast Health Education Study |
30 JUL 95 |
88 pages |
| Authors:
Beverly D. Taylor; MOREHOUSE SCHOOL OF MEDICINE ATLANTA GA
|
| Morehouse school of Medicine had developed a Breast Health Study that focuses on two groups: (1) minority, underserved women who are residents of Atlanta Housing Authority communities, and (2) primary care physicians and other health care providers who care for the medically underserved. The study seeks to determine and validate the efficacy of community-based educational program initiatives in promoting breast health in this population by educating and motivating target women ... |
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| Biochemical Testing of Potentially Hazardous Chemicals for Toxicity Using Mammalian Liver Cell Cultures |
09 APR 92 |
51 pages |
| Authors:
Curtis L. Parker; MOREHOUSE SCHOOL OF MEDICINE ATLANTA GA
|
| This proposal dealt with the testing of selected chemicals for their possible toxic effects on humans through the use of established mouse (HEPA-2) and human (HEP-G2) liver cell lines. The objective of the work was to eliminate the use of long-term more costly animal models to assess chemical toxicity. These established liver cell lines were chosen or use in this project because they are well characterized biochemically, and continue to ... |
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| Use of Liposomes for Directed Drug Delivery Against Entamoeba histolytica |
20 JAN 90 |
20 pages |
| Authors:
Gordon B. Bailey; MOREHOUSE SCHOOL OF MEDICINE ATLANTA GA
|
| The ability of purified glycosphingolipids to enhance liposome stimulated Entamoeba histolytica actin polymerization was assessed as a means to define the specificity of mammalian cell membrane lipid glycan recognition by this parasite. Synthetic liposomes containing a variety of individual glycosphingolipids bearing neutral, straight chain oligomeric glycans with galactose or N-acetylgalactosamine termini stimulated rapid (90 sec) polymerization of amoeba actin. Glycans with terminal N-acetylgalactosamine residues were not, or only weakly, stimulatory. ... |
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