Rabbits were immunized orally with 3 doses of live noninvasive, Shigella flexneri strain 2457-0. Sixty days after the third oral dose a chronically isolated ileal loop was created surgically in each rabbit. The local IgA and IgG anti-shigella responses in secretions and sera were followed with a sensitive enzyme-linked immunosorbent assay. A significant local IgA memory response was found in the secretions of the orally-primed rabbits. Parenteral immunization alone results ...
Rabbits were immunized orally with 3 doses of live noninvasive, Shigella flexneri strain 2457-0. Sixty days after the third oral dose a chronically isolated ileal loop was created surgically in each rabbit. The local IgA and IgG anti-shigella responses in secretions and sera were followed with a sensitive enzyme-linked immunosorbent assay. A significant local IgA memory response was found in the secretions of the orally-primed rabbits. Parenteral immunization alone results ...
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