| Physiologic Waveform Analysis for Early Detection of Hemorrhage during Transport and Higher Echelon Medical Care of Combat Casualties |
Nov 2012 |
84 pages |
| Authors:
Ramakrishna Mukkamala; MICHIGAN STATE UNIV EAST LANSING
|
 | Early detection of hemorrhage is crucial for managing combat casualties. However, mean arterial blood pressure (ABP) and other vital signs are late indicators of a bleed. By contrast, cardiac output (CO), stroke volume (SV), ventricular end-diastolic volume (EDV), and autonomic nervous system (ANS) activity can provide timely warning of blood loss. However, existing methods for their measurement are invasive and/or require an operator. On the other hand, a peripheral ABP ... |
|
| Mechanical Behaviour of Bolted Joints Under Impact Rates of Loading |
Jan 2012 |
85 pages |
| Authors:
Andrew VanderKlok; MICHIGAN STATE UNIV EAST LANSING
|
| Bolted joints are extensively used in many automotive and aeronautical sectors where two members are bolted together. This particular method of fastening is vastly used in many industrial disciplines as it serves as an easy and non-destructive method to join and subsequently disassemble a complex structure. Since, bolted joints constitute an integral part of many structural components, this directly implicates the necessity to investigate the mechanical response of the bolted ... |
|
| Physiologic Waveform Analysis for Early Detection of Hemorrhage during Transport and Higher Echelon Medical Care of Combat Casualties |
Nov 2011 |
101 pages |
| Authors:
Ramakrishna Mukkamala; MICHIGAN STATE UNIV EAST LANSING
|
| Early detection of hemorrhage is crucial for managing combat casualties. However, mean arterial blood pressure (ABP) and other vital signs are late indicators of a bleed. By contrast, cardiac stroke volume (SV), cardiac end-diastolic volume (EDV), and autonomic nervous system (ANS) activity can provide timely warning of blood volume loss. However, existing methods for their measurement are invasive and/or require a point-of-care operator. On the other hand, a peripheral ABP ... |
|
| Unraveling the Molecular Mechanism(s) Underlying Er+/PR-Breast Tumorigenesis Using a Novel Genetically Engineered Mouse Model |
Nov 2011 |
51 pages |
| Authors:
Hua Xiao; MICHIGAN STATE UNIV EAST LANSING
|
| Estrogen-receptor alpha (ER )-positive and progesterone receptor negative (ER+/PR-) breast ductal carcinomas comprise approximate15- 25% of human breast cancers. However, molecular mechanisms underlying the development of this subtype of breast cancer remain poorly understood. This project is to study the molecular mechanism(s) underlying ER+/PR- breast tumorigenesis. Specifically, we proposed to determine genetic and epigenetic alterations in the initiation and progression of ER+/PR- mammary tumors arising in Tip30-/-/MMTV-Neu mice. We demonstrated ... |
|
| A Role for MEK-Interacting Protein 1 In Hormone Responsiveness of ER Positive Breast Cancer Cells |
Oct 2011 |
39 pages |
| Authors:
Susan E Conrad; MICHIGAN STATE UNIV EAST LANSING
|
| MEK Partner 1 (MP1 or MAPKSP1) is a scaffold protein that functions in multiple signaling pathways that play important roles in breast cancer, and is expressed in both ER-positive and negative breast cancer cell lines. We investigated MP1 function in these cells using RNA interference to silence the MP1 gene. MP1 gene silencing resulted in detachment and apoptosis of ER-positive breast cancer cell lines, but not ER-negative breast cancer or ... |
|
| Solving Differential Equations with Random Ultra-Sparse Numerical Discretizations |
29 Sep 2011 |
8 pages |
| Authors:
David M Bortz; Andrew J Christlieb; MICHIGAN STATE UNIV EAST LANSING
|
| We proposed a novel approach which employs random sampling to generate an accurate non-uniform mesh for numerically solving Partial Differential Equation Boundary Value Problems (PDE-BVPs). From a uniform probability distribution U over a 1D domain, we considered a M discretization of size N where MN. The statistical moments of the solutions to a given BVP on each of the M ulta-sparse meshes provide insight into identifying highly accurate non-uniform meshes. ... |
|
| Seismic and Geophysical Characterization of Northern Asia |
Sep 2011 |
12 pages |
| Authors:
Kevin G Mackey; Hans E Hartse; Kazuya Fujita; Michael E Pasyanos; Michael L Begnaud; MICHIGAN STATE UNIV EAST LANSING
|
| We are continuing our research effort to improve the seismic calibration of northern Asia. In conjunction with colleagues from the Geophysical Survey of Russia, we conducted a noise survey and station installation in the Amur region, south of the city of Blagoveschensk. For the noise study, four locations, each separated by about one kilometer, were surveyed. The general region was found to be rather noisy, with higher frequencies (1-20 Hz) ... |
|
| A Toolchain for the Detection of Structural and Behavioral Latent System Properties |
19 Mar 2011 |
18 pages |
| Authors:
Adam C Jensen; Betty H Cheng; Heather J Goldsby; Edward C Nelson; MICHIGAN STATE UNIV EAST LANSING
|
| The cost to repair a requirements-based defect in software-based systems increases substantially with each successive phase of the software lifecycle in which the error is allowed to propagate. While tools exist to facilitate early detection of design flaws, such tools do not detect flaws in system requirements thus allowing such flaws to propagate into system design and implementation. This paper describes an experience report using a toolchain that supports structural ... |
|
| Unraveling the Molecular Mechanism(s) Underlying ER+/PR- Breast Tumorigenesis Using a Novel Genetically Engineered Mouse Model |
SEP 2010 |
17 pages |
| Authors:
Hua Xiao; MICHIGAN STATE UNIV EAST LANSING
|
| Estrogen-receptor alpha (ERalpha)-positive Progesterone receptor negative (ER+/PR-) breast ductal carcinomas comprise approximate 15-25% of human breast cancers. However, molecular mechanisms underlying the development of this subtype of breast cancer remain poorly understood. This project is to study the molecular mechanism(s) underlying ER+/PR- breast tumorigenesis. Specifically, we proposed to determine genetic and epigenetic alterations in the initiation and progression of ER+/PR- mammary tumors arising in Tip30-/-/MMTV-neu mice. We previously demonstrated that ... |
|
| Mechanical Behavior and Fatigue Studies of Rubber Components in Army Tracked Vehicles |
13 Aug 2010 |
40 pages |
| Authors:
H R Brown; J L Bouvard; D Oglesby; E Marin; D Francis; A Antonyraj; H Toghiani; P Wang; M F Horstemeyer; M P Castanier; MICHIGAN STATE UNIV EAST LANSING
|
| Overview of report: Monotonic approach: Internal state variable (ISV) model for metals; ISV modeling strategy moved to glassy polymers and current efforts to apply ISV modeling strategy to elastomers. Fatigue approach: Researchers have historically separated fatigue crack initiation and propagation, (McDowell et al., 2003) refined the earlier crack stages into incubation and microstructurally and physically small crack growth, greatly increasing accuracy. Microstructure has been incorporated into the multistage modeling for ... |
|
| Data Representation: Learning Kernels from Noisy Data and Uncertain Information |
17 JUL 2010 |
7 pages |
| Authors:
Rong Jin; Anil K. Jain; MICHIGAN STATE UNIV EAST LANSING
|
| Identifying appropriate data representation is critical to many decision making problems. In this project, we focus on learning kernel-based data representation from noisy data and uncertain information. Unlike conventional approaches that represent objects by vectors, kernel representation defines a pairwise similarity between two objects, and is convenient for representing complex objects like graphs. Although many studies are devoted to learning kernel representation, none of them addresses the challenge of learning ... |
|
| A Role for MEK-Interacting Protein 1 in Hormone Responsiveness of ER Positive Breast Cancer Cells |
01 JUL 2010 |
14 pages |
| Authors:
Susan E. Conrad; MICHIGAN STATE UNIV EAST LANSING
|
| We have identified a novel role for the small scaffold protein MP1 in the survival of ER-positive breast cancer cell lines. Blocking MP1 expression using siRNA leads to apoptotic cell death in ER-positive MCF-7, LCC9 and T47D cells, but not in ER-negative MDA-MB-231, SKBr3 and BT-549 cell, or in non-tumorigenic 184B5 cells. Inhibition of MP1 expression in MCF-7 cells resulted in decreased ER expression and activity, and decreased AKT phosphorylation. ... |
|
| Analysis of Digitized Seismograms from Russian Geophysical Survey Stations of Soviet Peaceful Nuclear Explosions |
30-Sep-2009 |
11 pages |
| Authors:
Kevin G Mackey; Hans E Hartse; MICHIGAN STATE UNIV EAST LANSING
|
| Throughout the 1970s and 1980s, the permanent seismic stations of the Soviet Union recorded over 100 peaceful nuclear explosions (PNEs) detonated within the Soviet Union. These records represent a large data set that has not been fully utilized. Digitization and analysis of the historic seismograms has allowed the extension of long-range PNE profile data into geographic regions not previously covered. Although the resolution of the profiles is limited by the ... |
|
| Unraveling the Molecular Mechanism(s) Underlying ER+/PR- Breast Tumorigenesis Using a Novel Genetically Engineered Mouse Model |
Sep 2009 |
8 pages |
| Authors:
Hua Xiao; MICHIGAN STATE UNIV EAST LANSING
|
| Estrogen-receptor alpha (ER?)-positive Progesterone receptor negative (ER+/PR-) breast ductal carcinomas comprise approximate 15-25% of human breast cancers. However, molecular mechanisms underlying the development of this subtype of breast cancer remain poorly understood. Using genetically-engineered Tip30 knockout mice generated in our laboratory, we previously demonstrated that Tip30 deletion results in development of tumors in several tissues and ductal hyperplasia in the mammary glands. This project is to study the molecular mechanism(s) ... |
|
| A Role for MEK-Interacting Protein 1 in Hormone Responsiveness of ER Positive Breast Cancer Cells |
Jul 2009 |
17 pages |
| Authors:
Susan E Conrad; MICHIGAN STATE UNIV EAST LANSING
|
| Our results have revealed a critical and previously unreported role for the small scaffold protein MP1 in the survival of ER-positive, but not ER-negative breast cancer cell lines. Blocking MP1 expression using siRNA leads to apoptotic cell death in ER-positive MCF-7, LCC9 and T47D cells, but not in ER-negative MDA-MB-231, SKBr3 and BT-549 cells. Overexpression of MP1 may also be toxic to ER-positive cells, since MCF-7 derivatives expressing ectopic MP1 ... |
|
| Development of a New Measure of Polychronicity |
Apr-2009 |
37 pages |
| Authors:
Elizabeth M Poposki; Frederick L Oswald; Randy J Brou; MICHIGAN STATE UNIV EAST LANSING
|
| This paper describes the development of a new measure of polychronicity, an individual differences construct indicating a preference for performing multiple tasks at once as opposed to performing only one task at a time. Although empirical research to date has found mixed results with respect to polychronicity's association with multitasking and other related variables, polychronicity remains conceptually promising as a predictor of multitasking-related variables. Following a brief review of past ... |
|
| RF Polymers II |
17-Mar-2009 |
17 pages |
| Authors:
Leo Kempel; Shanker Balasubramaniam; MICHIGAN STATE UNIV EAST LANSING
|
| Design of polymer composites with specific engineered electromagnetic properties are of use in a variety of physical electromagnetic systems above 100 MHz. In physical electromagnetic systems, e.g., GPS, radomes, WiFi, etc., proper choice of the material can be transformative in that it can yield considerably better performance. Of interest to us is the possible development of low loss magneto-dielectric composites. This project investigates various aspects of material systems, starting with ... |
|
| Analysis of Digitized Seismograms from Russian Geophysical Survey Stations of Soviet Peaceful Nuclear Explosions |
30-Sep-2008 |
4 pages |
| Authors:
Kevin G Mackey; MICHIGAN STATE UNIV EAST LANSING
|
| Throughout the 1970s and 1980s, the permanent seismic stations of the Soviet Union recorded over 100 Peaceful Nuclear Explosions (PNEs) detonated within the Soviet Union. These records have not been analyzed using modern digital methods and remain in Russian Archives. We have started a new initiative in collaboration with the Institute of Petroleum Geology and Geophysics (IPGG) of the Siberian Branch of the Russian Academy of Sciences (RAS) in Novosibirsk ... |
|
| Seismic Characterization of Northeast Asia |
Sep 2008 |
11 pages |
| Authors:
Kevin Mackey; Lee Steck; Kazuya Fujita; Hans Hartse; Richard Stead; MICHIGAN STATE UNIV EAST LANSING
|
| Our project of seismic characterization of northeast Asia has continued on a multi-faceted approach concentrating on eastern Russia, including field deployments, data synthesis and interpretation, database integration, and travel-time tomography. For field efforts, we deployed four remote seismic stations in the Seimchan-Buyunda basin in the Magadan region to get a better idea of baseline seismicity. Several events per day were recorded over approximately 40 days of station operation; the detection ... |
|
| Grid-Free Electrostatic Plasma Simulations |
09-Jul-2008 |
10 pages |
| Authors:
Andrew Christlieb; MICHIGAN STATE UNIV EAST LANSING
|
| This report summarizes work done between September 2007 and June 2008 related to the development of a set of grid-free simulation tools for problems in plasma dynamics. As noted in the abstract on page one, the research objectives are: (1) to develop a grid-free field solver, fluid model, and kinetic model, (2) to evaluate these tools in comparison with traditional mesh-based methods, and (3) to demonstrate the capability of the ... |
|
| A Role for MEK-Interacting Protein 1 (MP1) in Hormone Responsiveness of Estrogen Receptor-Positive Breast Cancer Cells |
Jul-2008 |
12 pages |
| Authors:
Susan E Conrad; MICHIGAN STATE UNIV EAST LANSING
|
| The goals of this research are to test the hypothesis that the small scaffold protein MP1 is required for ER function and proliferation of ER- positive breast cancer cells and to characterize the ER/MP1 complex. MP1 expression was inhibited in several breast cancer cell lines by transfection with MP1-targeting siRNAs. The results obtained demonstrate that MP1 is required for the survival of ER-positive MCF-7 cells but not ER-negative MDA-MB-231 cells. ... |
|
| Optimizing Dynamic Resource Allocation in Teamwork |
FEB 2008 |
18 pages |
| Authors:
Steve W. Kozlowski; Richard P. DeShon; MICHIGAN STATE UNIV EAST LANSING
|
| The proposed research was designed to extend prior AFOSR sponsored research (DeShon, Kozlowski et al., 2004) to model optimal human resource allocation to account for learning, performance, and adaptation for complex and dynamic tasks incorporating individual and team goals. Phase 1 was intended to implement an optimal, multiple-criterion (individual and team goals) reinforcement learning model that would compare human performance to optimal model performance. Phase 2 was intended to extend ... |
|
| Seismic Characterization of Northeast Asia |
Sep 2007 |
11 pages |
| Authors:
Kevin G Mackey; Hans E Hartse; Lee K Steck; Richard J Stead; Charlotte A Rowe; Kazuya Fujita; Luiza Gutirrez; MICHIGAN STATE UNIV EAST LANSING
|
| Our project of seismic characterization of northeast Asia continues on a multi-faceted approach concentrating on eastern Russia. The field work aspects of the project have included temporary station deployments, new permanent seismic station installations, and calibration of existing digital stations. Seismic station deployments include a 5 station temporary deployment in the Stanovoi Range in southern Yakutia/northern Amur region and two stations deployed in the vicinity of Yakutsk. The station deployments ... |
|
| Improved Control Authority in Flexible Structures Using Stiffness Variation |
JUN 2007 |
11 pages |
| Authors:
Ranjan Mukherjee; Steven W. Shaw; MICHIGAN STATE UNIV EAST LANSING
|
| This research investigated control authority enhancement in structural systems through methodical stiffness variation. Our early work focused on stiffness variation in a cantilever beam under the application of a buckling-type end force and control designs based on switching of the end force. Towards the end of the project, our modeling, control, and experimental methods were extended to truss-like structures. An important extension of the work was tuning of beam-type MEMS ... |
|
| Designing of Bulk Nano-Structures with Enhanced Thermoelectric Properties |
23 APR 2007 |
20 pages |
| Authors:
Mercouri Kanatzidis; Timothy Hogan; Chris Murray; MICHIGAN STATE UNIV EAST LANSING
|
| We discovered a grand homologous series which may help in the future to systematically identify thermoelectric materials with high performance. Namely, the series Am[M1+1Se2+1]2m[M21+nSe2+31+n] (A = alkali metal, M = Pb, Bi) has structure-predicting properties. The modular construction of these structures from evolving building blocks permits many of the criteria necessary for good thermoelectrics to be met. K2Bi8Se13 is a member of this series and was found to be a ... |
|
| SYRUS: Understanding and Predicting Multitasking Performance |
Feb 2007 |
31 pages |
| Authors:
Frederick L Oswald; D Z Hambrick; L A Jones; Sonia S Ghumman; MICHIGAN STATE UNIV EAST LANSING
|
| This report is organized as follows: First, a broad definition of multitasking performance is offered and important considerations related to this definition. Second, an outline of the many task and environmental characteristics that potentially influence multitasking performance in critical ways is suggested. Third, specific cognitive and non-cognitive variables are identified as prime candidates for predicting multitasking performance, and specific research-based predictions follow. Fourth, related to the previous point, a summarization ... |
|
| Advance Care Planning: Experience of Women With Breast Cancer |
JUL 2006 |
88 pages |
| Authors:
Ardith Z. Doorenbos; MICHIGAN STATE UNIV EAST LANSING
|
| Advance care planning (ACP) enables women with breast cancer to proactively document their end-of-life care preferences. The purpose of this study is to describe the prevalence and predictors of ACP documents and the desire for ACP information for women undergoing chemotherapy, and to test the effectiveness of an ACP intervention among women attending breast cancer support groups. Among the 236 women undergoing chemotherapy, 76 women (32%) had ACP documents. Increased ... |
|
| Team Adaptation to Structural Misalignment: Determinants of Alternative Change Mechanisms |
JUN 2006 |
|
| Authors:
Michael D. Johnson; John R. Hollenbeck; Daniel R. Ilgen; Dustin Jundt; D. S. Derue; Christopher Barnes; MICHIGAN STATE UNIV EAST LANSING
|
 | Structural Contingency Theory holds that teams perform best when their structure is aligned with their environment (Hollenbeck et al., 2002). Yet when teams perform poorly due to structural misalignment, they may focus on making changes to their personnel or processes rather than to their structure. This experiment examined whether teams decided to make changes in their structure, personnel, or processes when their structure was misaligned with their environment, and the ... |
|
| Adapting to Reductions in Team Size: An Examination of Three Structural Alternatives |
JUN 2005 |
56 pages |
| Authors:
D. S. Derue; John R. Hollenbeck; Daniel R. Ilgen; Michael D. Johnson; Dustin K. Jundt; MICHIGAN STATE UNIV EAST LANSING
|
| Research on downsizing in organizations has traditionally focused on the affective based reactions of survivors or the reactions of financial markets to downsizing announcements. Very little research has examined how organizational units adapt to downsizing. This paper investigates three structural approaches to downsizing in teams and directly tests the general proposition that the appropriateness of a specific structural alternative can only be understood by considering certain team compositional factors. Results ... |
|
| Reconfigurable and Adaptable Micro-Robots |
APR 2004 |
55 pages |
| Authors:
R. L. Tummala; R. Mukherjee; N. Xi; D. Aslam; S. Mahadevan; MICHIGAN STATE UNIV EAST LANSING
|
| This report documents the mechanical structure, kinematic models and control implementation of two micro-robots, called Flipper and Crawler, that can traverse both on walls and floors. They are battery powered and use specially designed feet using suction cups. The design of these feet is described in Section 2. The mechanical design was arrived at through extensive analysis. It has a biped structure with revolute and prismatic hip joints. The underactuated ... |
|
| Aerobic and Anaerobic Transformation of cis-Dichloroethene (cis-DCE) and Vinyl Chloride (VC): Steps for Reliable Remediation |
01-Dec-2003 |
85 pages |
| Authors:
James M Tiedje; Frank E Loeffler; Babu Z Fathepure; Erik A Petrovskis; MICHIGAN STATE UNIV EAST LANSING
|
| Considerable research has focused on the anaerobic transformation of PCE and TCE, two of the most common chlorinated solvents found in groundwater. However, relatively little is known about the types of microorganisms and specific environmental conditions associated with the dechlorination of dichloroethenes (DCEs) and vinyl chloride (VC). For the successful remediation of a contaminated site, the complete reduction to the environmentally benign products (e.g., ethene and inorganic chloride), or complete ... |
|
| Global Transsaccadic Change Blindness During Scene Perception |
SEP 2003 |
6 pages |
| Authors:
John M. Henderson; Andrew Hollingworth; MICHIGAN STATE UNIV EAST LANSING
|
| Each time the eyes are spatially reoriented via a saccadic eye movement, the image falling on the retina changes. How visually specific are the representations that are functional across saccades during active scene perception? This question was investigated with a saccade-contingent display- change paradigm in which pictures of complex real-world scenes were globally changed in real time during eye movements. The global changes were effected by presenting each scene as ... |
|
| Analysis of Progestin Effects on Hepatocyte Growth Factor Signaling Pathways in Relation to Proliferation and Alveolar Morphogenesis of Normal Mammary Epithelial Cells in Vitro |
APR 2003 |
12 pages |
| Authors:
Kyle T. Smith; MICHIGAN STATE UNIV EAST LANSING
|
| Progestin action in the normal adult mammary gland has a major role in the formation of the alveolar bud structure during development and pregnancy. We have determined that for P-induced proliferation and morphogenesis to occur, the presence of hepatocyte growth factor (HGF) is required. When added alone to mouse primary cultures from adult virgin mice, HGF induces proliferation and a ductal morphology. With the addition of P we observe increased ... |
|
| Bunching and Cooling of Radioactive Ions with REXTRAP |
24 JUN 2002 |
6 pages |
| Authors:
F. Amers; D. Beck; G. Bollen; O. Forstner; D. Habs; MICHIGAN STATE UNIV EAST LANSING
|
| The properties of radioactive ion beams produced by the present on-line target ion source technology are often not suitable for direct post acceleration. For that purpose pulsed and cooled beams of higher charged ions are required. In the case of REX-ISOLDE, the post accelerator at the CERN-ISOLDE radioactive beam facility, a unique system for beam preparation is used. It consists of a gas-filled cylindrical Penning trap (REXTRAP) for bunching and ... |
|
| A Subacute Care Intervention for Short Stay Cancer Surgery |
OCT 2001 |
143 pages |
| Authors:
Gwen K. Wyatt; MICHIGAN STATE UNIV EAST LANSING
|
| This study was designed to address the well-documented, but unmet, physical and psychological needs of women undergoing surgery for breast cancer. The purpose of this study was to support women during the immediate post-operative phase in order to facilitate return to pre-surgical quality of life and improved physical and psychological well-being, at a reasonable cost following short-stay surgery for breast cancer. |
|
| Seismic Calibration And Discrimination in Northeast Russia |
Oct 2001 |
11 pages |
| Authors:
Kevin Mackey; Kazuya Fujita; MICHIGAN STATE UNIV EAST LANSING
|
| In an effort to obtain ground truth (GT) classifications in support of nuclear explosion monitoring for continental regions of northeastern Russia, we relocated and assigned GT classifications to 118 seismic events reported in the International Seismological Centre (ISC) supplemented with previously unavailable local data. Of the relocated events, 26 events are classified as GT10. From these events, consistent patterns of residuals, essentially source-specific station corrections (SSSC's), show upper mantle velocities ... |
|
| Characterization of an In Vitro Human Breast Epithelial Organoid System |
AUG 2001 |
114 pages |
| Authors:
Chia-Cheng Chang; MICHIGAN STATE UNIV EAST LANSING
|
| The objectives of this study are: (1) to identify factors that regulate the growth and differentiation of organoids formed by two types of normal human breast epithelial cells (HBEC) in Matrigel; (2) to characterize the expression and function of estrogen receptors (ER) in normal and in vitro neoplastically transformed HBEC; and (3) to determine if a HBEC type with stem cell characteristics (Type I) is more susceptible to telomerase activation ... |
|
| Femtochemistry: 1999 Nobel Prize Symposium |
05 JUL 2001 |
16 pages |
| Authors:
Marcos Dantus; MICHIGAN STATE UNIV EAST LANSING
|
| Approximately fifteen years ago the AFOSR recognized the potential of using ultrafast lasers to study chemical reactions and funded Professor Zewail in his endeavor to unravel the essential chemical processes that occur during chemical reactions. In 1999, Professor Ahmed H. Zewail received the Nobel Prize in Chemistry for the development of Femtochemistry. At the 220 ACS National Meeting in Washington a symposium has been organized to honor Professor Zewail's accomplishments ... |
|
| Role of Era Splicing Variants in Regulation of Ap-1 Directed Gene Transcription in Breast Cancer Cells |
JUN 2001 |
57 pages |
| Authors:
Aliccia B. Bollig; Richard J. Miksicek; MICHIGAN STATE UNIV EAST LANSING
|
| This report presents results from functional analysis of estrogen receptor-alpha (ERa) mRNA splicing variants and offers insight into the nature of their transcriptional activity. Efforts to establish a cellular transactivating role for ERa mRNA splicing variants have identified three genes, which do not contain consensus EREs in their promoters, that are regulated by one or both of the isoforms, ERAE3 and ERAE5. Expression of a reporter gene driven by the ... |
|
| Improved Follow-up of Breast Abnormalities Through Comprehensive Breast Care in Women 40 to 70 Years of Age |
MAR 2001 |
658 pages |
| Authors:
Dorothy Pathak; MICHIGAN STATE UNIV EAST LANSING
|
| In 1999, we began a randomized study of 8 Family Practice residencies, to address previously documented inconsistencies regarding breast cancer screening and management of identified breast abnormalities. Residencies randomized to the intervention arm received a multi-component intervention addressing knowledge and management of breast cancer related issues and clinical breast exam (CBE) skills. Chart reminder systems included guidelines for appropriate follow-up of breast abnormalities. Physician's performance in clinical settings was assessed ... |
|
| A Subacute Care Intervention for Short-Stay Breast Cancer Surgery |
OCT 2000 |
84 pages |
| Authors:
Gwen K. Wyatt; Barbara Given; Charles Given; MICHIGAN STATE UNIV EAST LANSING
|
| The purpose of this study is to add to the scientific basis for providing subacute care in the home, by testing the effects of a post-operative nursing intervention designed to facilitate quality of life and physical/ psychological well-being after diagnosis and surgery for breast cancer. A randomized clinical trial with repeated measures is examining the effects of the intervention. The intervention participants (n=1OO) receive the targeted subacute care protocol in ... |
|
| Characterization of an In Vitro Human Breast Epithelial Organoid System |
AUG 2000 |
72 pages |
| Authors:
Chia-Cheng Chang; MICHIGAN STATE UNIV EAST LANSING
|
| The objectives of this study are 1) to identify factors that regulate the growth and differentiation of organoids formed by two types of normal human breast epithelial cells (HBEC) in Matrigel; 2) to characterize the expression and function of estrogen receptors (ER) in normal and in vitro neoplastically transformed HBEC; and 3) to determine if a HBEC type with stem cell characteristics (Type I) is more susceptible to telomerase activation ... |
|
| Role of ERa Splicing Variants in Regulation of AP-1 Directed Gene Transcription in Breast Cancer Cells |
JUN 2000 |
26 pages |
| Authors:
Aliccia Bollig; Richard J. Miksicek; MICHIGAN STATE UNIV EAST LANSING
|
| This report presents recently published results from biochemical analysis of estrogen receptor (ER) -alpha mRNA splicing variants (Molecular Endocrinology 14: 634-649, May 2000). Although most of the variants appear to be functionally impaired, analysis of two receptor isoforms demonstrates that they retain many of the activities of wild-type ER-alpha, including protein-protein interaction, DNA binding, ligand binding and nuclear localization. These results and additional unpublished results from reporter gene studies suggest ... |
|
| Responses of Decision Making Teams to Adaptive Architectures: A Final Report |
01 MAY 2000 |
38 pages |
| Authors:
John R. Hollenbeck; Daniel R. Ilgen; MICHIGAN STATE UNIV EAST LANSING
|
| The research reported here is part of a larger project designed to develop, assess and understand adaptive structures for command and control teams. Much of that project, the A2C2 project, uses a simulated command and control exercise (the Distributed Dynamic Decision-making Simulation (DDD)) and naval personnel who perform experimental exercises presented to them under controlled conditions. Our research is designed to focus on human behaviors ... |
|
| Improved Follow-Up of Breast Abnormalities Through Comprehensive Breast Care in Women 40 to 70 Years of Age |
MAR 2000 |
455 pages |
| Authors:
Dorothy R. Pathak; MICHIGAN STATE UNIV EAST LANSING
|
| To address inconsistencies among health care providers in breast cancer screening and management of abnormal findings, we randomized eight Family Practice residencies into control and intervention groups. The intervention has multiple components addressing skill, knowledge and management of breast cancer related issues. Additionally, a chart reminder system assists physicians in daily breast care management. Physician performance in clinical settings is assessed through chart audits. We ... |
|
| Asymmetry in Structural Movement: Challenges on the Road to Adaptive Organizational Structures |
2000 |
12 pages |
| Authors:
Henry Moomn; John R. Hollenbeck; Daniel R. Ilgen; Bradley West; Aleks Ellis; Stephen Humphrey; Christopher Porter; MICHIGAN STATE UNIV EAST LANSING
|
| The authors propose that all team based change is not the same. It is offered that change is generally more difficult from divisional to functional structures than it is from functional to divisional structures. We offer that successful change from divisional to functional structures is contingent upon individual differences. Additionally, we argue that successful change from functional to divisional structures is contingent upon team based behaviors. Results from 66 four-person ... |
|
| A Subacute Care Intervention for Short-Stay Breast Cancer Surgery |
OCT 1999 |
|
| Authors:
Gwen Wyatt; MICHIGAN STATE UNIV EAST LANSING
|
| The purpose of this study is to add to the scientific basis for providing subacute care in the home, by testing the effects of a post-operative nursing intervention designed to facilitate quality of life and physical/ psychological well-being after diagnosis and surgery for breast cancer. A randomized clinical trial with repeated measures is examining the effects of the intervention. The intervention participants (n=1OO) receive the targeted ... |
|
| Role of Stroma-Derived Extracellular Matrix in Regulation of Growth and Hormonal Responsiveness of Normal and Cancerous Human Breast Epithelium |
SEP 1999 |
69 pages |
| Authors:
Terry L. Woodward; Sandra Haslam; MICHIGAN STATE UNIV EAST LANSING
|
| Extra cellular matrix (ECM) proteins are critical for differentiation of normal mammary epithelial cells, but pronounced changes in ECM occurs during breast cancer. We have determined that estrogen receptor (ER)-positive breast cancer cells (MCF-7 and T47D) cultured on laminin have reduced, or lack, estrogen responses. Estrogen-induced proliferation was significantly reduced on LM but did occur on collagens, fibronectin, poly-L-lysine or vitronectin. laminin did not inhibit ... |
|
| Characterization of an In Vitro Human Breast Epithelial Organoid System |
AUG 1999 |
102 pages |
| Authors:
Chia-Cheng Chang; MICHIGAN STATE UNIV EAST LANSING
|
| The objectives of this study are: (1) to identify factors that regulate the growth and differentiation of organoids formed by two types of normal human breast epithelial cells (HBEC) in Matrigel; (2) to characterize the expression and function of estrogen receptors (ER) in normal and in vitro neoplastically transformed HBEC; and (3) to determine if a HBEC type with stem cell characteristics (Type I) is more ... |
|
| Information Technology Innovation in the U.S. Army: The Case of the Adoption, Adaptation, and Utilization of the Strategic Crisis Exercise Intranet |
1999 |
99 pages |
| Authors:
Linda C. Jantzen; MICHIGAN STATE UNIV EAST LANSING
|
| The U.S. Army has undergone dramatic changes in its structure and operating procedures in recent years as a result of the introduction of new information technologies. This study examines the adoption and adaptation of an information technology innovation in a U.S. Army organization. While previous studies have focused on the technologies themselves, this study investigates the process of innovation adoption, with special attention paid to how the technology and the ... |
|
Reports by Corporate Author
