| Role of Crk Adaptor Proteins in Cellular Migration and Invasion in Human Breast Cancer |
Mar-2009 |
55 pages |
| Authors:
Kelly E Fathers; MCGILL UNIV MONTREAL (QUEBEC)
|
 | The Crk adaptor proteins (CrkI, CrkII and CrkL) play an important role during cellular signalling by mediating the formation of protein complexes. We examined how the loss of Crk would affect tumor progression using RNA interference, as well as examining the consequences of Crk over-expression. For each cancer cell line tested, loss of Crk expression corresponded with a significant decrease in cell migration, invasion, and adhesion, demonstrating that Crk adaptor ... |
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| The Law of Neutrality in Outer Space |
01-Sep-2008 |
125 pages |
| Authors:
Robert W Jarman; MCGILL UNIV MONTREAL (QUEBEC)
|
| Satellite telecommunications, global navigation and remote sensing systems are key drivers in the ongoing transformation of an industrial based global economic order to one increasingly dominated by information services. A growing number of States are establishing an independent presence in outer space and all States (and indeed, individuals) can access a broad range of affordable space-related products and services (e.g., Google Earth imagery, GPS receivers, and global voice and data ... |
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| Implementing International Standards for "Continuing Supervision" |
01-Jun-2008 |
117 pages |
| Authors:
Spencer; Ronald L Jr; MCGILL UNIV MONTREAL (QUEBEC)
|
| The Outer Space Treaty established the obligation to provide continuing supervision of its national space activities by the appropriate state. The implementation of this obligation remains a matter of state discretion. Since this Treaty came into force the world has evolved to become reliant on space based utilities to enable the global economy and state governance. Today, space faring states are increasingly dependent upon the supervision practices of other states ... |
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| Role of Crk Adaptor Proteins in Cellular Migration and Invasion in Human Breast Cancer |
01-Mar-2008 |
51 pages |
| Authors:
Kelly E Fathers; MCGILL UNIV MONTREAL (QUEBEC)
|
| The Crk adaptor proteins (CrkI, CrkII and CrkL) play an important role during cellular signalling by mediating the formation of protein-protein complexes and are involved in cellular migration, invasion, and adhesion. Targeting CrkI and CrkII in breast cancer cell lines by RNA interference demonstrated that loss of Crk expression corresponded with a significant decrease in cell migration and invasion. This implies that Crk adaptor proteins play an important role in ... |
|
| Mammary Gland Tumor Development in Transgenic Mice Overexpressing Different Isoforms of the CDP/Cux Transcription Factor |
MAR 2008 |
20 pages |
| Authors:
Chantal Cadieux; MCGILL UNIV MONTREAL (QUEBEC)
|
| Short CUX1 isoforms were found to be overexpressed in breast cancer cell lines, in human breast tumors and in uterine leiomyomas, suggesting that these proteins play a key role in tumor development and progression. My project consists in analyzing the effect of these CUX1 isoforms on mammary gland development and tumorigenesis. Also, I will work on the identification of targets of CUX1 that mediate its oncogenic properties. So far, I ... |
|
| Orbital Debris: Technical and Legal Issues and Solutions |
AUG 2006 |
121 pages |
| Authors:
Michael W. Taylor; MCGILL UNIV MONTREAL (QUEBEC)
|
| This thesis examines the current technological and legal issues concerning orbital debris (space debris). The unique physical characteristics of the space environment are identified and explained. The thesis then explores the causes of orbital debris and examines the risk posed by debris to the most frequently used orbital areas. Significant environmental, legal, political, and economic consequences of orbital debris are described. The current technical and legal controls on the creation ... |
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| Nuclear Receptor Interactions in Breast Cancer: The Role of Kinase Signaling Pathways |
JUL 2006 |
9 pages |
| Authors:
Filippa Pettersson; MCGILL UNIV MONTREAL (QUEBEC)
|
| Retinoids and rexinoids are vitamin A derivatives, which cause growth inhibition and/or apoptosis in various cell types, including some breast cancer cells. Retinoids bind and activate the nuclear receptor RAR, whereas rexinoids specifically bind to the related receptor RXR. While retinoids like RA inhibit the growth of estrogen receptor (ER) positive and not ER negative breast cancer cells, rexinoids appear to have activity in both ER positive and ER negative ... |
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| Contribution of Protein Tyrosine Phosphateses to the Ontogeny and Progression of Chronic Myeloid Leukemia |
APR 2006 |
9 pages |
| Authors:
Michel Tremblay; MCGILL UNIV MONTREAL (QUEBEC)
|
| The JAK and STAT families of signal transduction molecules play a critical role in the pathogenesis of chronic myeloid leukemias (CML). Inappropriate STAT1 and STAT5 activation have been observed in the Philadelphia chromosome-positive CML cell lines K562 and BV17, yet low levels of JAK1 tyrosine phosphorylation were observed suggesting that BCR/Abl directly tyrosine phosphorylates and activates STATs. The protein tyrosine phosphatases TC-PTP and PTP1B are negative regulators of JAK/STAT signaling ... |
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| ERalpha and ErbB-2 Cross-talk in Mammary Tumorigenesis and Metastasis |
APR 2006 |
12 pages |
| Authors:
William J. Muller; MCGILL UNIV MONTREAL (QUEBEC)
|
| The induction of human breast cancer involves the complex interplay of hormones and growth factor receptors. The major focus of our DOD sponsored research program is to investigate the interaction of the ER and erbB-2 receptor in the induction of breast cancer. In addition, we studied the involvement of ErbB-2 coupled signaling pathways such as c-Src in ER induced mammary tumorigenesis. To accomplish this, we derived and characterized transgenic mice ... |
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| Significance of ERa and c-Src Interaction in the Progression of Hormone Independent Breast Cancer |
DEC 2005 |
25 pages |
| Authors:
William J. Muller; MCGILL UNIV MONTREAL (QUEBEC)
|
| We have shown previously that c-Src null epithelial cells are unable to respond to estrogenic stimulation [1]. In addition, c-Src recruitment to ErbB-2 catalytic domain could be involved in the hormone independent response of ErbB-2 induced mammary tumorigenesis [2]. In order to assess whether ablation of c-Src can influence the ability of mammary epithelial cells to respond to hormonal stimulation, we are currently generating a mouse strain homozygous for the ... |
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| Quantum-Dot Based Automated Screen of Sentinel Lymph Nodes for Metastatic Breast Cancer |
OCT 2005 |
6 pages |
| Authors:
John F. Presley; MCGILL UNIV MONTREAL (QUEBEC)
|
| We are developing an automated technique for scanning lymph nodes for small numbers of breast cancer cells using a mouse model. This technique involves the use of standard primary antibodies for tumor specific antigens and quantum-dot conjugates in place of chemical fluorophores combined with exhaustive confocal z-sectioning and computer analysis. We have verified that the quantum dot conjugates using antibodies to Brst and cytokeratin are functional in frozen sections from ... |
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| Mesenchymal Stem Cells for Vascular Target Discovery in Breast Cancer-Associated Angiogenesis |
SEP 2005 |
84 pages |
| Authors:
Jacques Galipeau; MCGILL UNIV MONTREAL (QUEBEC)
|
| Cancer growth and spread is dependent on new blood vessel formation, i.e. angiogenesis. A tumor mass cannot develop into a life-threatening condition without angiogenesis. Obstructing the recruitment of new blood vessels to the tumor through administration of antiangiogenic agents will hinder cancer progression. We propose the use of marrow stromal cells (MSCs) for an investigative gene discovery program to identify new genes involved in blood vessel formation. MSCs, a normal ... |
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| Quantum-Dot-Based Automated Screen of Sentinel Lymph Nodes for Metastatic Breast Cancer |
OCT 2004 |
6 pages |
| Authors:
John F. Presley; MCGILL UNIV MONTREAL (QUEBEC)
|
| We are developing an automated technique for scanning lymph nodes for small numbers of breast cancer cells using a mouse model. This technique involves the use of standard primary antibodies for tumor specific antigens and quantum-dot conjugates in place of chemical fluorophores combined with exhaustive confocal z-sectioning and computer analysis. We have verified that the quantum dot conjugates using antibodies to Brst and cytokeratin are functional in frozen sections from ... |
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| Mesenchymal Stem Cells for Vascular Target Discovery in Breast Cancer- Associated Angiogenesis |
SEP 2004 |
44 pages |
| Authors:
Jacques Galipeau; MCGILL UNIV MONTREAL (QUEBEC)
|
| Cancer growth and spread is dependent on new blood vessel formation, i.e. angiogenesis. A tumor mass cannot develop into a life-threatening condition without angiogenesis. Obstructing the recruitment of new blood vessels to the tumor through administration of antiangiogenic agents will hinder cancer progression. We propose the use of marrow stromal cells (MSCs) for an investigative gene discovery program to identify new genes involved in blood vessel formation. MSCs, a normal ... |
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| Soluble Erythropoietin Receptor for Gene Therapy of Breast Cancer |
SEP 2004 |
7 pages |
| Authors:
Nicoletta Eliopoulos; MCGILL UNIV MONTREAL (QUEBEC)
|
| Breast cancer is the most common malignancy in women. When the cancer remains localized, long-term survival is possible following surgery to remove the primary tumor. However, when the cancer metastasizes, death occurs for most patients. The progression and metastasis of breast cancer is dependent on angiogenesis. Tumors continuously dispense angiogenic signals. One such signal is erythropoietin (Epo). The general idea of the authors' gene therapy approach is that breast cancer ... |
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| The Air Bridge Denial Program and the Shootdown of Civil Aircraft Under International Law |
AUG 2004 |
133 pages |
| Authors:
Darren C. Huskisson; MCGILL UNIV MONTREAL (QUEBEC)
|
| In August 2003, the United States resumed the sharing of real-time intelligence with Columbia, information that will be used by Columbia to shoot down aircraft engaged in drug trafficking. A similar program with Peru may restart soon, Such operations are part of the Air Bridge Denial Program (ABDP), a program that has been operating since the early l990s designed to cut off the flow of drug out of the Andean ... |
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| Nuclear Receptor Interactions in Breast Cancer: The Role of Kinase Signaling Pathways |
JUL 2004 |
22 pages |
| Authors:
Filippa Petterson; MCGILL UNIV MONTREAL (QUEBEC)
|
| Retinoids are vitamin A derivatives, which cause growth inhibition, differentiation and/or apoptosis in various cell types, including some breast cancer cells. In general, estrogen receptor (ER)-positive cells are retinoic acid (RA) sensitive, whereas ER-negative cells are resistant. In this report, I show that ER-negative MDA-MB-231 cells are strongly growth inhibited by retinoids in combination with a PKC inhibitor. While neither RA nor GF109203X (GF) has a significant growth inhibitory effect ... |
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| ER(alpha) and ErbB-2 Cross-Talk in Mammary Tumorigenesis and Metastasis |
APR 2004 |
11 pages |
| Authors:
William J. Muller; MCGILL UNIV MONTREAL (QUEBEC)
|
| The interaction between growth factor and steroid hormone receptors may play a critical role in the breast cancer progression. The principle objective of this proposal is to elucidate the in vivo importance of cross-talk between estrogen and ErbB-2 signaling pathways. We first plan to establish transgenic mice that express both an constitutively active estrogen receptor and its co-activator in the mammary epithelium. To accomplish this objective, we will derives eparate ... |
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| Pilot Study to Measure the Effects of NSAID Use on Angiogenesis and Apoptosis in Female Invasive Breast Cancer |
SEP 2003 |
7 pages |
| Authors:
John B. Richardson; M. C. Guiot; V. Tagalakis; E. Zorychta; MCGILL UNIV MONTREAL (QUEBEC)
|
| To examine the effects of NASIDs on invasive breast cancer we are performing a immunohistochemical analysis on 220 cases of breast cancer from Saskatchewan which has provided a complete drug history of each patient. We are assessing the tumors for COX 1 and COX 2, angiogenesis, estrogen receptor, proliferative index and the degree of apoptosis. Previous work has shown that some breast cancers over express cyclooxygenases COX 1 and 2 ... |
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| Locating a Prostate Cancer Susceptibility Gene on the X Chromosome by Linkage Disequilibrium Mapping Using Three Founder Populations in Quebec and Switzerland |
MAR 2002 |
8 pages |
| Authors:
William D. Foulkes; MCGILL UNIV MONTREAL (QUEBEC)
|
| The funded proposal has not yet been activated at all sites. Approval was given to commence the research at the McGill University hospital site only. IRB approval was obtained from in Switzerland and Chicoutimi and we are working on obtaining the appropriate documents for the final review. Realistically, we anticipate that within the next 6 weeks, we will have obtained the documents needed for approval by Army. Prevalent cases were ... |
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| Non-Uniform Spatial Sampling in EEG Source Analysis |
25 OCT 2001 |
|
| Authors:
C. G. Benar; J. Gotman; MCGILL UNIV MONTREAL (QUEBEC)
|
 | We investigate in this paper the non-uniform sampling of EEG dipolar potentials and its impact on source analysis. We suppose some a priori knowledge on the approximate location of the dipole, We show that, in a noise-free situation, the electrode spacing needs to be around 3cm in the region of the dipole only, whereas it can drop to 8cm in remote regions. |
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| High Throughput Challenges in Molecular Cell Biology: The CELL MAP |
25 OCT 2001 |
|
| Authors:
John Bergeron; Miche Desjardins; David Y. Thomas; Robert E. Kearney; MCGILL UNIV MONTREAL (QUEBEC)
|
| The complete elucidation of the protein complement of all compartments of the eukaryotic cell is under way. This poses logistical problems in sample preparation and high throughput but exhaustive characterization. Using examples of protein characterization of organelles by mass spectrometry and the validation of protein function by DNA chips fl engineering and bioinformatics challenges in proteomics and genomics will be illustrated. |
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| Biology of Somatostatin and Somatostatin Receptors in Breast Cancer |
SEP 2001 |
12 pages |
| Authors:
Yogesh C. Patel; MCGILL UNIV MONTREAL (QUEBEC)
|
| The twelve tasks comprising this four year project were completed and a' full report submitted in September 2000. However, in the course of these studies three new leads were pursued as three separate tasks (Tasks 13, 14, 15) which were not part of the original contract but because of their importance were nonetheless developed substantially and also reported upon in September 2000. We then requested and received approval for a ... |
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| Novel Transcriptional Interactions Between the Estrogen and Retinoic Acid Receptors in Human Breast Cancer Cells |
JUN 2001 |
18 pages |
| Authors:
Caroline Rousseau; Wilson Miller; MCGILL UNIV MONTREAL (QUEBEC)
|
| The purpose of this research was to investigate the specific mechanisms by which transcriptional pathways may become more responsive to retinoids in cells that express the estrogen receptor (SR). To determine which region of ER is required for retinoid sensitivity, several deletion mutants of ER were subcloned into a retroviral vector and stable ER-deletion mutant human breast cancer cell lines were derived. Studies with these stable cell lines indicate that ... |
|
| Locating a Prostate Cancer Susceptibility Gene on the X Chromosome by Linkage Disequilibrium Mapping Using Three Founder Populations in Quebec and Switzerland |
MAR 2001 |
10 pages |
| Authors:
William D. Foulkes; MCGILL UNIV MONTREAL (QUEBEC)
|
| The funded proposal has not yet been activated. We have obtained DOD- endorsed ethical approval at McGill University, but because we are waiting for ethical approval at the other 2 sites we cannot begin. The need to obtain ethical approval at all sites within the McGill University Hospitals system led to much longer delays than anticipated as four separate ethics board had to approve the DoD-endorsed documents. This endeavour took ... |
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| Biology of Somatostatin and Somatostatin Receptors in Breast Cancer |
SEP 2000 |
97 pages |
| Authors:
Yogesh C. Patel; MCGILL UNIV MONTREAL (QUEBEC)
|
| Breast tumors show rich expression of multiple SSTR subtypes and may be amenable to treatment with selective SST compounds. All five SSTRs variably inhibit cell growth. When studied as individual subtypes expressed in host cells, SSTR3 is the only isoform that induces apoptosis whereas SSTR1,2,4 and 5 promote cell growth arrest with SSTR5 exerting the most potent effect. Both apoptotic and cytostatic signalling are dependent on receptor-mediated activation of SHP-1. ... |
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| The Influence of BRCA1 and BRCA2 Mutations on Prognosis in Breast Cancer Occuring in Ashkenazi Women: A Historical Cohort Approach |
AUG 2000 |
69 pages |
| Authors:
William Foulkes; MCGILL UNIV MONTREAL (QUEBEC)
|
| Using a historical approach, we studied the clinicopathological features of hereditary breast cancer (BC) and related this to the outcome following the BC diagnosis. We ascertained all self-reporting Ashkenazi Jewish (AJ) women diagnosed with primary invasive BC from 1980 to 1995. Diagnostic, treatment and follow-up information was extracted from the medical chart and the pathology blocks (PB) were re-examined by one pathologist. Slides were prepared for immunohistochemistry (IHC) and DNA ... |
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| Prognostic Significance of Loss-of-Heterozygosity of the CUTL1 Putative Tumor Suppressor Gene in Breast Cancers |
AUG 2000 |
|
| Authors:
Alain Nepveu; MCGILL UNIV MONTREAL (QUEBEC)
|
| We have defined a second region of LOH on the long arm of chromosome 7, within 7q22. 18% of spontaneous breast cancers were found to exhibit LOH of 7q22. The centromeric endpoint of the deletion was mapped to the CUTL1 gene, between introns 6 and 20. We found no correlation between LOH at 7q22 and tumor type or grade, ER or PR expression, nodal status, or age of onset. However, ... |
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| Characterization of Uterine Derived Growth Inhibitor (UDGI): A Novel Growth Inhibitor of Estrogen Receptor Negative Breast Cancer Cells |
JUN 2000 |
|
| Authors:
Hung Huynh; MCGILL UNIV MONTREAL (QUEBEC)
|
| We report the cloning and characterization of a novel cDNA, 0KL38. OKL38 gene expression was induced by pregnancy and hormone associated with pregnancy such as hCG. OKL38 expression was low in breast cancer cell lines and barely detectable in DMBA-induced breast tumours. Transfection of human MCF-7 breast cancer cells with OKL38 cDNA lead to reduction in proliferation and tumour formation in nude mice. The data suggest that the OKL38 may ... |
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| Novel Transcriptional Interactions Between the Estrogen and Retinoic Acid Receptors in Human Breast Cancer Cells |
JUN 2000 |
|
| Authors:
Caroline Rousseau; Wilson Miller; MCGILL UNIV MONTREAL (QUEBEC)
|
| The purpose of this research is to investigate the specific mechanisms by which transcriptional pathways may become more responsive to retinoids in cells that express estrogen receptor (ERalpha). Understanding how the steroid hormone receptors interact to control transcription and inhibit growth of cancer cells will suggest directions for the use of retinoids or may provide the foundation for target-oriented therapies in breast cancer. To determine which region of the ER ... |
|
| Biology of Somatostatin and Somatostatin Receptors in Breast Cancer |
SEP 1999 |
138 pages |
| Authors:
Yogesh C. Patel; MCGILL UNIV MONTREAL (QUEBEC)
|
| Analysis of SSTR1-5 mRNA expression by semiquantitative RT-PCR in two separate batches of primary ductal NOS breast cancer (n, N 48 and 50) has revealed a strong positive correlation (p , 0.001) between SSTR3 expression and tumor grade suggesting that SSTR3 induction in high grade tumors may represent a compensatory mechanism for regulating proliferative activity through apoptosis. Expression of SSTR1, 2, and 4 strongly correlates with estrogen ... |
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| Prognostic Significance of Loss-of-Heterozygosity of the CUTL1 Putative Tumor Suppressor Gene in Breast Cancers |
JUL 1999 |
|
| Authors:
Alain Nepveu; MCGILL UNIV MONTREAL (QUEBEC)
|
| A fraction (approx. 18%) of spontaneous breast cancers exhibited LOH of 7q22, and the smallest deleted region included the CUTL1 gene. We found no correlation between LOH at 7q22 and tumor type or grade, ER or PR expression, nodal status, or age of onset. However, the average sizes of breast tumors with or without LOH at 7q22 were 4.99 and 2.93 cm respectively. We conclude that LOH of 7q22 will ... |
|
| Novel Transcriptional Interactions Between the Estrogen and Retinoic Acid Receptors in Human Breast Cancer Cells |
JUN 1999 |
|
| Authors:
Caroline Rousseau; MCGILL UNIV MONTREAL (QUEBEC)
|
| The purpose of this research is to investigate the specific mechanisms by which transcriptional pathways may become more responsive to retinoids in cells that express estrogen receptor (ER alpha). Understanding how the steroid hormone receptors interact to control transcription and inhibit growth of cancer cells will suggest directions for the use of retinoids, or may provide the foundation for target-oriented therapies in breast cancer. To determine which region of the ... |
|
| Characterization of Uterine Derived Growth Inhibitor: A Novel Growth Inhibitor of Estrogen Receptor |
JUN 1999 |
|
| Authors:
Hung T. Huynh; MCGILL UNIV MONTREAL (QUEBEC)
|
| We reported the purification of UDGI, a uterine derived growth inhibitor. UDGI protein shares 98% identity to ps20 growth inhibitor isolated from urogenital sinus mesenchymal cells. Although purified UDGI potently inhibited breast cancer cell growth, recombinant UDGI exhibited mild inhibition. UDGI antibody recognized native UDGI from uterine fluid and conditioned media of UDGI-transfectant cells with molecular mass of 24. 27 and 29 kDa. UDGI cDNA was isolated from a rat ... |
|
| Biology of Somatostatin and Somatostatin Receptors in Breast Cancer |
SEP 1998 |
187 pages |
| Authors:
Yogesh C. Patel; MCGILL UNIV MONTREAL (QUEBEC)
|
| Fifty additional primary human breast tumor samples were analysed for SSTR1-5 mRNA and shown to be all receptor positive. Mean SSTR mRNA level was the highest for SSTR3 followed by SSTR1, SSTR2, SSTR5, and SSTR4. Statistical analysis showed a negative correlation between SSTR2 and tumor size, a positive correlation between SSTR2 and estrogen receptors (ER), and a trend towards a positive correlation between SSTR2 and progesterone receptor, SSTR1 and ER, ... |
|
| Prognostic Significance of Loss-of-Heterozygosity of the CUTL1 Putative Tumor Suppressor Gene in Breast Cancers |
JUL 1998 |
18 pages |
| Authors:
Alain Nepveu; MCGILL UNIV MONTREAL (QUEBEC)
|
| Previous studies suggested that the human Cut gene, CUTL1, could function as a tumor suppressor gene whose deletion and/or mutation may be involved in breast cancer. During this past year, we have determined the complete CUTL1 exon/intron structure. This effort allowed us to determine that three polymorphic markers on 7q22 were located within the boundaries of the CUTL1 gene. As a first step to verify ... |
|
| Biology of Somatostatin and Somatostatin Receptors in Breast Cancer |
SEP 97 |
74 pages |
| Authors:
Yogesh C. Patel; MCGILL UNIV MONTREAL (QUEBEC)
|
| The longterm goal of our work is to elucidate the pattern of expression of the five somatostatin receptor (SSTR1-5) isoforms in breast cancer, to determine which SSTR subtypes and signalling mechanisms mediate the antiproliferative effects of somatostatin (SST), whether the available SST analogs are effective in binding to these antiproliferative SSTR subtypes, and whether the pattern of SSTR expression in tumors can provide an independent prognostic marker. Towards these goals, ... |
|
| Artificial Phosphoesterase: A Binuclear Approach |
JUN 1997 |
19 pages |
| Authors:
Jik Chin; MCGILL UNIV MONTREAL (QUEBEC)
|
| Work has been done on developing both mononuclear and dinuclear metal complexes for hydrolyzing phosphate esters. What is learned from the study of mononuclear metal complexes can be used to develop more reactive dinuclear metal complexes. |
|
| Logical/Linear Operators in Early Vision |
14 JUN 96 |
23 pages |
| Authors:
Steven W. Zucker; MCGILL UNIV MONTREAL (QUEBEC)
|
| We propose a research program to investigate new techniques for computing image descriptions in early vision. The program will incorporate computational, physiological and psychophysical aspects. Research will be focused on the certain non-linearities that we have discovered can play an important role in improving the robustness of edge, line, and curve detection. These non-linearities are totally different from those previously studied in early vision. We embody them in what we ... |
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| Gravity Segregation of Complex Intermetallic Compounds in Liquid Aluminum-Silicon Alloys. |
1995 |
|
| Authors:
S. G. Shabestari; J. E. Gruzleski; MCGILL UNIV MONTREAL (QUEBEC)
|
| Primary crystals of intermetallics that are rich in iron, manganese, and chromium form at temperatures above the liquidus, and because their density is higher than that of liquid aluminum, they cause liquid segregation in the melt. segregation may occur either in the mold at slow cooling rates or in the bulk liquid in furnaces or ladles. the kinetics of settling of these intermetallic compounds in a melt of al-12.5 pct ... |
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| Crystallization Behavior of Iron-Containing Intermetallic Compounds in 319 Aluminum Alloy |
1994 |
|
| Authors:
L. Anantha Narayanan; F. H. Samuel; J. E. Gruzleski; MCGILL UNIV MONTREAL (QUEBEC)
|
| The crystallization behavior of iron-containing intermetallic compounds in industrial grade 319 aluminum alloy has been investigated by means of thermal analysis and metallography. in the absence of manganese, the iron compound crystallizes in the beta phase, at all cooling rates ranging from 0.1 degrees per second to 20 degrees per second under normal casting temperatures (750 degrees c). however, when the melt is superheated to a high temperature (about 200 ... |
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| Fine Fibres by Melt Extraction. |
1994 |
|
| Authors:
J. Stroem-Olsen; MCGILL UNIV MONTREAL (QUEBEC)
|
| Methods for manufacturing fine fibres of metals and ceramics below 20 micrometers diameter are described. some analysis of the fabrication process is given as well as a description of properties of the fibres. a brief account is also given of selected applications of the materials. keywords:, composite materials, fibers, magnetic alloys, permalloy fibers, melt extractions, metglas 2605-s2 fibers, nanocrystals, vitrovac 6025z fibers. |
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| Grain Refinement of Aluminium by TiC. |
1994 |
|
| Authors:
P. S. Mohanty; J. E. Gruzleski; MCGILL UNIV MONTREAL (QUEBEC)
|
| This paper concerned mmc in some important way and contained information about, utilized, or discussed these subjects: basic topics:, composite materials, dr mmc, mmc materials and material types:, (tic)p/al, al alloys, al matrix, al4c3 formations, c particulates, crystals, particulates, ti3al crystals, tic particulates, tic/al material characteristics and data fields:, thermodynamic stability parameter values relevant to the data:, 1100 c - 1200 c, 1200 c - 1300 c, 1300 c - ... |
|
| Effect of Modification on Aluminium Matrix of Al-Si-Mg Alloys. |
1994 |
|
| Authors:
F. Paray; J. E. Gruzleski; MCGILL UNIV MONTREAL (QUEBEC)
|
| This paper concerned mmc in some important way and contained information about, utilized, or discussed these subjects: basic topics:, composite materials, data materials and material types:, 356 matrix, al matrix, al-si alloys material characteristics and data fields:, alloy data, hardness, hardness data, homogeneity, matrix data, yield strength, yield strength data parameter values relevant to the data:, 100 c - 200 c, heat treatment effects testing and test conditions:, hardness tests, ... |
|
| Thermodynamic Modelling of Wetting at Silicon Nitride/Ni-Cr-Si Alloy Interfaces. |
1994 |
|
| Authors:
Ali M. Hadian; Robin A. L. Drew; MCGILL UNIV MONTREAL (QUEBEC)
|
| Through thermodynamic modelling of the reaction at ceramic-metal interface, wetting of a sintered silicon nitride was investigated with a series of ni-based brazing alloys without addition of active elements. the thermodynamic calculations showed that ni-cr-si alloys with ni/cr ratio of 3.5 and x(sub si) |
|
| Cholinergic Neurotransmission: Function and Dysfunction, International Cholinergic Symposium (8th) Held at Montreal (Quebec) on 26-30 July 1992 |
31 DEC 92 |
|
| Authors:
Augusto C. Cuello; Giancarlo Pepeu; MCGILL UNIV MONTREAL (QUEBEC)
|
|
| Volume Resistivity and Mechanical Properties of Electrically Conductive Long Fiber Composites, |
MAY 1992 |
|
| Authors:
M. E. Weber; M. R. Kamal; MCGILL UNIV MONTREAL (QUEBEC)
|
| The use of polymers for packaging or electronic housing applications is ever-increasing, due to their low cost, good strength, and light weight. Electronic enclosures must be conductive in order to shield the electrical components from electromagnetic interference. In general, polymers in their unmodified state are non-conductive, but the addition of a conductive reinforcement can impart conductivity. Conductive long fibers would be attractive due to their excellent mechanical properties and ability ... |
|
| Greenland Sea Ice Anomalies During 1901-1984 and their Relation to an Interdecadal Arctic Climate Cycle, |
MAR 1992 |
|
| Authors:
L. A. Mysak; D. K. Manak; R. K. Marsden; MCGILL UNIV MONTREAL (QUEBEC)
|
| Two ice data sets from the Greenland and neighboring seas have been analyzed to determine interannual and decadal time scale sea ice extent anomalies during this century. Sea ice concentration data on a 1 deg x 1 deg grid for 1953-19 the presence of a large positive anomaly in the Greenland Sea during the 1960s which coincided with the Great Salinity Anomaly, a low-salinity water mass that traveled cyclonically around ... |
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| A Coupled, Zonally Averaged Atmosphere-Ocean Model: Variability of the Thermohaline Circulation, |
MAR 1992 |
|
| Authors:
Thomas F. Stocker; Daniel G. Wright; Lawrence A. Mysak; MCGILL UNIV MONTREAL (QUEBEC)
|
| Two experiments with a recently developed zonally averaged climate model which includes the ocean's thermohaline circulation are performed. The first experiment simulates a global thermohaline circulation in which deep water is formed in the North Atlantic, flows as a deep current into the Pacific basin and then upwells. The water is returned as a near-surface flow through the Indian Ocean into the South Atlantic Gordon, 1986. The present model reproduces ... |
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| Evaluation of the Metallurgical Effects of Strontium on Cast 6000 Series Aluminum Alloys |
92 |
|
| Authors:
M. H. Mulazimoglu; B. M. Closset; J. E. Gruzleski; MCGILL UNIV MONTREAL (QUEBEC)
|
| The effect of Sr addition on cast AA 6201 and AA 6063 alloys has been investigated. Acicular AlFeSi intermetallic phases were changed to Chinese Script form Al8Fe2Si in commercial 6201 and 6063 and in synthetic 6201 alloys. Sr was found to be a weak grain refiner. Heat treatment characteristics were not affected significantly by Sr addition, but it slowed Mg2Si precipitation during artificial aging in slowly cooled alloys. |
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