| LPP is Required for TGF-Beta Induced Motility and Invasion of Neu/ErbB-2 Expressing Breast Cancer Cells |
Sep 2012 |
14 pages |
| Authors:
Elaine Ngan; Betty Diamond; MCGILL UNIV MONTREAL (CANADA)
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 | Overexpression of the ErbB2 receptor tyrosine kinase is associated with metastatic breast cancer progression and is correlated with poor patient prognosis. Numerous cell-based and transgenic mouse models have demonstrated that ErbB2 and TGF Beta signaling cooperatively promote breast cancer cell aggressiveness and metastasis. Nonetheless, the mechanisms underlying the synergy between these two pathways remain unclear. In the present study, we demonstrate that Lipoma Preferred Partner (LPP) is indispensable for mediating ... |
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| Investigating the Role of Fatty Acid Metabolism and DecR1 Expression ErbB2-Driven Mammary Tumorigenesis and Metastasis Using a Transgenic Mouse Model Approach |
Jul 2011 |
13 pages |
| Authors:
Jason Turpin; MCGILL UNIV MONTREAL (CANADA)
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| Cancer cell metabolism has become an increasingly active area of research in recent years, elucidating the importance of Warburg metabolism and its role in tumorigenesis. Fatty acid oxidation is diminished in favor of synthesis during the tumorigenic process. DecR1 is a fatty acid oxidation protein that is frequently downregulated in models of breast cancer. Using a mouse model approach, expression of DecR1 in mammary epithelial cells results in a delay ... |
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| Uncovering the Hidden Molecular Signatures of Breast Cancer |
May 2011 |
21 pages |
| Authors:
Robert Lesurf; MCGILL UNIV MONTREAL (CANADA)
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| It is well understood that breast cancer is a heterogeneous disease, consisting of at least five transcriptional subtypes described by distinct, but poorly understood, molecular profiles. As the cause, aggressiveness, and outcome vary greatly between patients, it is essential to characterize the different ways in which the disease can grow and spread. Transcriptional subtyping operates by capturing the loudest molecular events within a tumor. While these events are both biologically ... |
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| Multi-Wavelength InAs Quantum Dot Microtube Lasers on Si |
06 SEP 2010 |
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| Authors:
Zetian Mi; MCGILL UNIV MONTREAL (CANADA)
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 | In this report, we summarize our work on the design, fabrication, and characterization of multi-wavelength rolled-up quantum dot tube lasers and coherent light sources on GaAs and InP substrates. We also describe the controllable transfer of rolled-up quantum dot tube cavities on Si or any other foreign substrates using fiber abrupt taper assisted transfer technique. The design and fabrication of electrically injected rolled-up quantum dot tube lasers is also presented. ... |
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| Effects of Cumulus Convection on Rapidly Intensifying Cyclones |
30 SEP 1998 |
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| Authors:
M. K. Yau; R. R. Rogers; MCGILL UNIV MONTREAL (CANADA)
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| To explain the inter actions between convective processes and larger scale marine weather systems, to increase our understanding of the processes affecting the size distribution of cloud droplets in maritime clouds, and to study atmospheric processes through application of new methods of remote sensing. To investigate the effects of convection and cloud microphysics on rapidly intensifying oceanic cyclones. To determine how mixing affects cloud dropsize distribution in the presence of ... |
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Reports by Corporate Author
