| Inspired Biological Engineering: Detection and Production of Polarized Light by Animals |
26-May-2009 |
16 pages |
| Authors:
Thomas W Cronin; MARYLAND UNIV BALTIMORE COUNTY BALTIMORE MD
|
 | In the course of this project, we met all of our initially stated objectives. Our research involved ongoing collaborations with colleagues at UMBC, the Marine Biological Laboratory, the University of Queensland, the University of California, Arizona State University, and the University of Pennsylvania. We regularly exchanged visits with our major collaborator and subcontractor, Nader Engheta of the University of Pennsylvania, to discuss our results and the construction of synthetic polarizers ... |
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| Rational Selection of Tailored Amendment Mixtures and Composites for In Situ Remediation of Contaminated Sediments |
Dec 2008 |
63 pages |
| Authors:
Upal Ghosh; Brian E Reed; Seokjoon Kwon; Jeff Thomas; Todd Bridges; Daniel Farrar; Victor Magar; Laura Levine; MARYLAND UNIV BALTIMORE COUNTY BALTIMORE MD
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| Emerging laboratory-scale research by our group and others has shown that contaminant transport pathways and bioavailability can be interrupted in-situ by modifying and enhancing the contaminant assimilation capacity of natural sediments. This is achieved by adding amendments such as activated carbon for binding persistent organic pollutants and natural minerals such as apatites, zeolites, or bauxite for the binding of toxic metals in sediments. This research was focused on advancing in-situ ... |
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| Miniature and Low-cost Wireless Sensor Platform for Environmental Monitoring |
Sep-2007 |
87 pages |
| Authors:
Yordan Kostov; Govind Rao; Upal Ghosh; MARYLAND UNIV BALTIMORE COUNTY BALTIMORE MD
|
| A sensor platform with DO, pH, and turbidity sensors was developed. It was equipped with pH and oxygen sensitive fluorescent foils. The foils were attached outside of the waterproof case and read through optical window. They had also antibiofouling protection, which allowed them to operate for extended period of time. A microcontroller switched the channels and collected the reading of O2, pH, and turbidity every 15 minutes, than transmitted it ... |
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| Theoretical Study of an Actively Mode-Locked Fiber Laser Stabilized by an Intracavity Fabry-Perot Etalon: Linear Regime |
01-Jul-2007 |
11 pages |
| Authors:
Moshe Horowitz; Yurij Parkhomenko; Curtis R Menyuk; Thomas F Carruthers; MARYLAND UNIV BALTIMORE COUNTY BALTIMORE MD
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| We study theoretically the effect of an intracavity etalon on actively mode-locked fiber lasers by solving the master equation for the laser when nonlinearity in the laser is negligible. The first-order dispersion of the material inside the etalon can increase the pulse duration by a factor of 10. The minimum pulse duration is obtained when the relative frequency offset between the free spectral range of the etalon and the modulation ... |
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| Novel MHC Class II Breast Cancer Vaccine Using RNA Interference (RNAi) to Down Regulate Invariant Chain (Ii) |
01-May-2007 |
218 pages |
| Authors:
James A Thompson; MARYLAND UNIV BALTIMORE COUNTY BALTIMORE MD
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| Our goal is to induce a strong CD4+ T cell response against tumor antigens by preferentially presenting endogenous tumor antigens via class II major histocompatibility complex molecules (MHC II). MHC II can present endogenous tumor antigens if expressed in the absence of Invariant chain (II). We have up-regulated MHCII and down regulated II without affecting MHC II expression in tumor cells. Using the key transcription factor class II trans-activator (CIITA) ... |
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| Immune Suppression and Inflammation in the Progression of Breast Cancer |
MAR 2007 |
24 pages |
| Authors:
Stephanie K. Bunt; MARYLAND UNIV BALTIMORE COUNTY BALTIMORE MD
|
| Epidemiological and experimental evidence supports the concept that chronic inflammation promotes the development and progression of cancers; however, the mechanisms underlying this relationship are poorly understood. We have demonstrated previously that secretion of the pro-inflammatory cytokine interleukin 1beta (IL-1beta) from 4T1 mammary carcinoma cells (4T1/IL-1beta) promotes tumor progression and decreases the survival of tumor-bearing animals. Tumor progression in many patients and experimental animals with cancer is frequently associated with the ... |
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| A Novel Therapeutic Vaccine for Metastatic Mammary Carcinoma: Focusing MHC/Peptide Complexes to Lipid Rafts |
NOV 2006 |
90 pages |
| Authors:
Brian P. Dolan; MARYLAND UNIV BALTIMORE COUNTY BALTIMORE MD
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| Genetic engineering of tumor cells to express MHC class ll and subsequent use of said cells for treatment of established and metastatic tumors has yielded promising results in animal models for treatment of breast cancer. It is widely believed that the vaccine efficacy is due to the ability of such tumor cells to present tumor-specific antigens to 004+ T helper cells which activate the immune system to eradicate tumors. Next ... |
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| Novel MHC Class II Breast Cancer Vaccine Using RNA Interference (RNAi) to Down Regulate Invariant Chain (li) |
MAY 2006 |
42 pages |
| Authors:
James A. Thompson; MARYLAND UNIV BALTIMORE COUNTY BALTIMORE MD
|
| Our goal is to induce a strong CD4+ T cell response against tumor antigens by preferentially presenting endogenous tumor antigens via class II major histocompatibility complex molecules (MHC II). MHC II can present endogenous tumor antigens if expressed in the absence of Invariant chain (Ii). We have up-regulated MHCII and down regulated Ii without affecting MHC II expression in tumor cells. Using the key transcription factor class II trans-activator (CIITA) ... |
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| Pulse Compression using a Tapered Microstructure Optical Fiber |
APR 2006 |
12 pages |
| Authors:
Jonathan Hu; Brain S. Marks; Curtis R. Menyuk; Jinchae Kim; Thomas F. Carruthers; Barbara M. Wright; Thierry F. Taunay; E. J. Friebele; MARYLAND UNIV BALTIMORE COUNTY BALTIMORE MD
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| We calculate the pulse compression in a tapered microstructure optical fiber with four layers of holes. We show that the primary limitation on pulse compression is the loss due to mode leakage. As a fiber's diameter decreases due to the tapering, so does the air-hole diameter, and at a sufficiently small diameter the guided mode loss becomes unacceptably high. For the four-layer geometry we considered, a compression factor of 10 ... |
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| STAT6 Deletion Enhances Immunity to Mammary Carcinoma |
JUN 2005 |
133 pages |
| Authors:
Suzanne Ostrand-Rosenberg; MARYLAND UNIV BALTIMORE COUNTY BALTIMORE MD
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| The Stat6 (signal transducer activator of transcription) gene is essential for the production of IL-4 an U 13, two cytokines that govern the activation of CD4+ T helper type 2 (Th2) cells. We hypothesized that mice with a deleted Stat6 gene (Stat6(exp -/-)) would have enhanced tumor immunity because they would preferentially make tumor-reactive Th1 cells, which are thought to facilitate the activation of CD8+ cytotoxic T cells (Tc), thereby ... |
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| Development and Evaluation of Novel Implantable Nanosensors for Real- Time Monitoring of Individual Cells and Cellular Signaling |
03 JAN 2005 |
17 pages |
| Authors:
B. M. Cullum; S. Ostrand-Rosenberg; T. Alexander; MARYLAND UNIV BALTIMORE COUNTY BALTIMORE MD
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| The goal of this project was to develop and demonstrate the potential of a versatile class of nano-biosensors capable of being implanted within individual living cells for the direct conversion of biochemical signaling events into electronic information. In order to monitor the various biochemical species responsible for intracellular signaling (e.g., proteins), with minimal stress to the cell during analysis, we are developing nanobead sensors between 200 and 500 nm in ... |
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| Enhancing P3P Framework through Policies and Trust |
2005 |
16 pages |
| Authors:
Pranam Kolari; Li Ding; Lalana Kagal; Shashidhara G. Anupam Joshi; Tim Finin; MARYLAND UNIV BALTIMORE COUNTY BALTIMORE MD
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| The Platform for Privacy Preferences (P3P) is a W3C standard that web sites can use to describe their privacy practices. The presence of P3P policies enables users to configure web browsers to constrain what they can and cannot do when visiting web sites. It's a good idea that unfortunately is rarely used. The authors identify two reasons for this: (i) the languages available to define a user's privacy preferences are ... |
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| Undergraduate Training Program in Breast Cancer Research |
JUN 2004 |
8 pages |
| Authors:
Suzanne Ostrand-Rosenberg; MARYLAND UNIV BALTIMORE COUNTY BALTIMORE MD
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| The goal of this Training Program is to direct talented undergraduates into careers in breast cancer research. The program, called Breast Cancer Undergraduate Research Experience (BCURE), is a joint program between The University of Maryland Baltimore County (UMBC) and the University of Maryland, Baltimore Medical School (UM,B). The centerpiece of BCURE is a full- time, 10-week summer research experience in the laboratory of an established investigator (mentor) working in breast ... |
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| Automated System for Text Detection Individual Video Images |
JUL 2003 |
14 pages |
| Authors:
Yingzi Du; Chein-I Chang; Paul D. Thouin; MARYLAND UNIV BALTIMORE COUNTY BALTIMORE MD
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| Text detection in video images is a challenging research problem because of the poor spatial resolution and complex background, which may contain a variety of colors. An automated system for text detection in video images is presented. It makes use of four modules to implement a series of processes to extract text regions from video images. The first module, called the multistage pulse code modulation (MPCM) module, is used to ... |
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| High Performance Local Area Networks |
MAY 2003 |
41 pages |
| Authors:
Gary M. Carter; MARYLAND UNIV BALTIMORE COUNTY BALTIMORE MD
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| The potential use of optical switching to keep data in the optical domain will be used for the interconnection of local and metropolitan optical networks. Keeping data in the optical domain over various optical networks leads to new design challenges as the variability of path leads to a variability of impairments. This work accomplished experiments at 10, 20, and 40 Gbps on the ATDNET which is a metropolitan network. The ... |
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| Standard, Mixed & Non-Conforming HP Finite Elements for Problems in Mechanics |
02 OCT 2001 |
12 pages |
| Authors:
Manil Suri; MARYLAND UNIV BALTIMORE COUNTY BALTIMORE MD
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| Numerical analysis of a linearized formulation for three-dimensional buckling and stress-stiffening phenomena showed that an algorithm implemented in the commercial finite element code STRESS CHECK is robust. An hp method was formulated and implemented for computing the response of woven composite (3) Domain decomposition/concatenation hp methods were analyzed. Locking-free robust hp mixed methods for elasticity were developed. |
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| Conference on p and hp Finite Element Methods: Mathematics and Engineering Practice. Summaries of Papers |
27 JUL 2001 |
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| Authors:
Manil Suri; MARYLAND UNIV BALTIMORE COUNTY BALTIMORE MD
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| Dynamic and Quasi-Static Multiaxial Response of Ceramics and Constitutive/Damage Modeling |
02 JAN 2001 |
15 pages |
| Authors:
Akhtar S. Khan; MARYLAND UNIV BALTIMORE COUNTY BALTIMORE MD
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| Acoustic emission (AE) waveforms were recorded during compression of the ceramic Alumina AD995. The frequency contents of the wave form were determined using FFT technique. It was found that signals which represented damage/crack growth had frequencies between 39 and 80 kHz. Experiments were also performed on post-shocked AD995 specimens. Significant differences were observed which demonstrated that AE technique could be used for damage evolution determination. |
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| On Mining Web Access Logs |
MAY 2000 |
8 pages |
| Authors:
Anupam Joshi; Raghu Krishnapuram; MARYLAND UNIV BALTIMORE COUNTY BALTIMORE MD
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| The proliferation of information on the world wide web has made the personalization of this information space a necessity. One possible approach to web personalization is to mine typical user profiles from the vast amount of historical data stored in access logs. In the absence of any a priori knowledge, unsupervised classification or clustering methods seem to be ideally suited to analyze the semi-structured log data of user accesses. In ... |
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| Tumor-Specific Immunotherapy of Mammary Cancer |
APR 2000 |
84 pages |
| Authors:
Suzanne Ostrand-Rosenberg; MARYLAND UNIV BALTIMORE COUNTY BALTIMORE MD
|
| For many patients with mammary cancer the primary tumor can be successfully treated by surgical removal, however the long-term prognosis is not favorable because of the high frequency of metastatic disease, which is not treatable by current approaches. Our goal is to develop vaccination strategies to minimize metastatic disease. We postulate that an improvement in the generation of mammary carcinoma-specific CD4+ T lymphocytes will facilitate development of CD8+ T cell ... |
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| Molecular Basis of Prostate-Specific Androgen-Independent Expression of a Homeobox Gene (Prostate) |
OCT 1999 |
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| Authors:
Charles Bieberich; MARYLAND UNIV BALTIMORE COUNTY BALTIMORE MD
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 | The goal of the work supported by this grant is to characterize the molecular basis of prostate specificity and androgen independence of the hoxb-13 gene with a view towards developing new treatments for advanced prostate cancer. To date, we have succeeded in generating a physical map of both the mouse and human hoxb-13 loci, and have sublconed regions both upstream and downstream of the coding region of both genes. Two ... |
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| Multi-Photon Entanglement and Quantum Teleportation |
JUL 1999 |
32 pages |
| Authors:
Yanhua Shih; MARYLAND UNIV BALTIMORE COUNTY BALTIMORE MD
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| The project 'Multi-Photon Entanglement and Quantum Teleportation' concerns a series of experimental and theoretical investigations on multi-photon entangled states and the applications, for example, quantum teleportation. The objective of this re search is to probe the foundations of quantum theory of entanglement and its fundamental roles in quantum computing and quantum information processing. This research will definitely benefit many scientific and engineering discipline applications. This report is for the first ... |
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