The purpose of this research is to determine which steps in the metastatic process are affected by the metastasis suppressor gene, BRMS1. Stable b-Gal expressing MDA-MB-231 and MDA-MB-231/BRMS1 cell lines were used to identify 2 steps in the metastatic process inhibited by BRMS1. It was found that BRMS1-expression (I) reduced the numbers of solitary cells that survive initial arrest in the lung (4 hours) and (2) reduced the numbers of ...
An essential requirement in understanding how genes contribute to genetic disease is the thorough knowledge of the mechanisms controlling gene expression at the level of transcription. In this project we are identifying and functionally characterizing the NF1 regulatory region, and evaluating the molecular mechanisms that regulate NF1 transcription during normal cellular differentiation and the events leading to NF1 -related neoplasia. Overlapping regions of the NFl proximal promoter have been cloned ...
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