| Research Studies on Electromagnetically Induced Transparency |
20 Jan 2010 |
94 pages |
| Authors:
S E Harris; LELAND STANFORD JUNIOR UNIV CA
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 | The overall theme of this work has been the development and utilization of new sources of radiation that produce time energy entangled biphotons that are both much longer and much shorter than those that now exist. We have learned to produce biphotons with temporal lengths greater than 500 nanoseconds and linewidths smaller than the natural linewidth of target atoms. We have demonstrated the use of telecommunication light modulators to modulate ... |
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| Site-Specific Differentiation of Fibroblasts in Normal and Scleroderma Skin |
Jun-2009 |
13 pages |
| Authors:
Howard Y Chang; LELAND STANFORD JUNIOR UNIV CA
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| The results from year 2 of funding applied novel biomarkers to address whether systemic sclerosis, a fibrosing disorder, involves changes in cell positional identity. Long noncoding RNAs are the predominant position specific output of the HOX loci, and their misexpression in systemic sclerosis suggests that altered fibroblast positional identity is involved. |
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| Chemical Modeling for Large-Eddy Simulation of Turbulent Combustion |
31-Mar-2009 |
41 pages |
| Authors:
Heinz Pitsch; LELAND STANFORD JUNIOR UNIV CA
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| In the present project the focus was on developing advanced combustion models for large-eddy simulations (LES) and to develop automatic chemistry reduction techniques and reduced chemical mechanisms for JP-8 surrogate fuels. The aim of the combustion LES modeling part was to advance the models for non-premixed and premixed combustion towards a generalized combustion model that covers all combustion regimes. Towards this end, for the premixed regime, a dynamic model for ... |
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| Imaging Heat Shock Protein 90 (Hsp90) Activity in Hormone-Refractory Prostate Cancer |
Mar-2009 |
14 pages |
| Authors:
Gang Niu; LELAND STANFORD JUNIOR UNIV CA
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| During the first year of the funding period, we have labeled 1, 3-propoyldiamine modified geldanamycin with both fluorescent core (FITC in this case) and radioisotopes. Unfortunately, in vitro cell experiments failed to disclose the ability of FITC-GM to monitor Hsp90 activity changes after heat stimulation in prostate cancer cell lines. Small molecular Hsp90 inhibitors, at least GM derivatives, showed reasonable tumor accumulation after being labeled with 64Cu. However, in vitro ... |
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| Site-Specific Differentiation of Fibroblasts in Normal and Scleroderma Skin |
01-Jun-2008 |
26 pages |
| Authors:
Howard Y Chang; LELAND STANFORD JUNIOR UNIV CA
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| The results from year I of funding suggest that appropriate markers and technologies are in place for systematic investigation of the positional identity of fibroblasts both in normal and diseased tissues. Because long noncoding RNAs are the predominant position specific output of the HOX loci they may constitute excellent markers for testing the idea that scleroderma involves altered fibroblast positional identity. |
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| Selective Androgen Receptor Down-Regulators (SARDs): A New Prostate Cancer Therapy |
OCT 2007 |
29 pages |
| Authors:
Rumi S. Bhattacharyya; LELAND STANFORD JUNIOR UNIV CA
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| The androgen receptor (AR) plays a key role in the development and progression of prostate cancer Targeting the AR for down-regulation would be a useful strategy for treating prostate cancer, especially hormone-refractory or androgen independent prostate cancer (AIPC). In the present study we showed that the antiestrogen Fulvestrant (ICI 182,780, ICI) effectively suppressed AR expression in several human prostate cancer cells including androgen-independent cells In LNCaP cells, ICI (10 microM) ... |
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| PTEN Regulates Beta-Catenin in Androgen Signaling: Implication in Prostate Cancer Progression |
01 MAR 2007 |
52 pages |
| Authors:
Zijie Sun; LELAND STANFORD JUNIOR UNIV CA
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| The androgen-signaling pathway is essential in male sexual development and in normal and malignant prostate cell growth and survival. PI3K/Akt plays a critical role in prostate cancer cell growth and survival. Recent studies demonstrate that the effect of PI3K/Akt in prostate cells is mediated through androgen signaling. The PI3K inhibitor LY294002 and a tumor suppressor PTEN negatively regulate the PI3K/Akt pathway and repress the androgen receptor (AR) activity. However the ... |
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| Accelerating Electronic Tag Development for Tracking Free-Ranging Marine Animals at Sea |
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15 pages |
| Authors:
Barbara A Block; LELAND STANFORD JUNIOR UNIV CA
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| This project developed, tested, and deployed archival and satellite tags for the Tagging of Pacific Pelagics (TOPP). Our efforts centered both on improving existing technologies and on developing new tools. These new tools have provided TOPP the tools necessary to address fundamental questions in biological oceanography concerning the distribution and critical, habitats of pelagic organisms. We developed a GPS tag using Fastloc technology making it possible to study animal movements ... |
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