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LA JOLLA INST FOR ALLERGY AND IMMUNOLOGY LA JOLLA CA DIVISION OF VACCINE DISCOVERY


Click on the titles below to find US government-authored or -collected reports written by LA JOLLA INST FOR ALLERGY AND IMMUNOLOGY LA JOLLA CA DIVISION OF VACCINE DISCOVERY

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Predicting the Interplay of Epitope Recognition and Evolution in RNA Viruses Under Immune Pressure 30-Apr-2008 13 pages
Authors:  Bjoern Peters; Alesandro Sette; Martin Blythe; LA JOLLA INST FOR ALLERGY AND IMMUNOLOGY LA JOLLA CA DIVISION OF VACCINE DISCOVERY
The full text of this report is available for sale.RNA viruses can rapidly mutate, causing therapeutics and vaccines to loose their effectiveness. The long-term goal of this project is to predict such mutations, in order to anticipate their effect and design better therapeutics and vaccines. In the funding period reported here, the specific goal was to build a predictive model of viral escape from immune pressure exerted by monospecific T cells in vitro. This goal was achieved: a general ...


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