| Age-Related DNA Methylation Changes and Neoplastic Transformation of the Human Prostate |
Jul-2009 |
22 pages |
| Authors:
Bernard Kwabi-Addo; HOWARD UNIV WASHINGTON DC
|
 | There is abundant evidence to suggest that DNA methylation changes may appear earlier during prostate cancer development than genetic changes, as well as more commonly and consistently. The purpose of the present study is to investigate whether aberrant methylation in normal prostate tissues may in itself be a pathologic event that increases with age. Using methylated CpG island amplification coupled with CpG promoter microarray, I have identified several novel genes ... |
|
| A Partnership Training Program in Breast Cancer Research Using Molecular Imaging Techniques |
Jul-2009 |
156 pages |
| Authors:
Paul C Wang; HOWARD UNIV WASHINGTON DC
|
| This partnership training program is between Howard University and the Johns Hopkins University to pursue breast cancer research using molecular imaging techniques. The program has two components: a research component and a broad training component. Six Howard faculty members and two research assistants were trained. Two collaborative research projects have completed: (1) Magnetic Resonance Imaging Enhancement by Tumor Cell Targeted Immunoliposome Complex Delivered Contrast Agent, and (2) Imaging the Effects ... |
|
| Radiometric Measurements on Ag/n-Si Composite Films for Detecting Radiation in the Earth's Atmospheric Windows |
20-Feb-2009 |
3 pages |
| Authors:
Bates; Clayton W Jr; HOWARD UNIV WASHINGTON DC
|
| The objectives of the research proposed in this 10-month effort were to assemble optical absorption and radiometric facilities for measuring the properties of Ag/n-Si composite films that are to be used as infrared detectors in the earth's atmospheric windows (1-2, 3-5, and 8-12 microns) from room temperature down to liquid nitrogen temperature and to begin making these measurements on films with specific microstructures. All of the equipment requested in the ... |
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| Mechanisms Down-Regulating Sprouty1, a Growth Inhibitor in Prostate Cancer |
Oct-2008 |
113 pages |
| Authors:
Bernard Kwabi-Addo; HOWARD UNIV WASHINGTON DC
|
| The Sprouty gene family negatively regulates growth factor-induced receptor tyrosine kinase signaling in human prostate cancer (PCa). The purpose of this study was to investigate the expression of Sprouty1 in PCa, determine its biological function and elucidate the molecular mechanism(s) regulating its expression in PCa. RESULTS: Using immunohistochemical and quantitative RT-PCR analysis, I have shown that Sprouty1 is down-regulated in PCa tissues compared to matched normal prostate tissues. Transient forced ... |
|
| A Partnership Training Program in Breast Cancer Research Using Molecular Imaging Techniques |
Jul-2008 |
113 pages |
| Authors:
Paul C Wang; HOWARD UNIV WASHINGTON DC
|
| In the third year, Howard faculty from Departments of Biology, Radiology, and Radiation Oncology at Howard University were further trained in molecular imaging through seminars and workshops, and by conducting two research projects with the faculty at the Johns Hopkins University. We have established three breast cancer tumor models, and further optimized the imaging probes for MRI and fluorescent optical imaging of breast cancers. We have determined how the interactions ... |
|
| Short-Term Exercise and Prostate Cancer Prevention in African American Men |
01-Apr-2008 |
12 pages |
| Authors:
Teletia R Taylor; HOWARD UNIV WASHINGTON DC
|
| This study seeks to examine the impact of exercise on serum factors related to prostate cancer in African-American men. Aims and Objectives: 1. To recruit 40 African-American men between the ages of 40 and 70 who are at increased risk for developing prostate cancer and randomize them into an exercise intervention or control group. 2. To examine the effect of 12 days of aerobic exercise over 4 weeks on PSA ... |
|
| Gesture Recognition Development for the Interactive Datawall |
JAN 2008 |
27 pages |
| Authors:
Naren Vira; HOWARD UNIV WASHINGTON DC
|
| Hand gestures provide a useful interface for humans to interact with not only other humans but also machines. Especially for a high degree-of-freedom manipulation tasks such as the operation of 3D objects in virtual scenes, the traditional interface composed of a keyboard and mouse is neither intuitive nor easy to operate. In collaborative environments using large screen displays for display of both 3D and 2D information, participants would benefit greatly ... |
|
| Mechanisms Down-Regulating Sprouty1, a Growth Inhibitor in Prostate Cancer |
OCT 2007 |
63 pages |
| Authors:
Bernard Kwabi-Addo; HOWARD UNIV WASHINGTON DC
|
| The Sprouty gene family negatively regulates growth factor-induced receptor tyrosine kinase signaling with a potential tumor suppressor function in cancer. I have demonstrated that Sprouty1 is down-regulated in human prostate cancer. The purpose of the present study is to elucidate the relative contribution of transcription regulation and epigenetic DNA methylation changes in regulating Sprouty1 expression in human prostate cancer. Using transient transfection analysis in prostate cancer cell lines; I have ... |
|
| Electronic Transport Control of Bi Nanowires |
07 SEP 2007 |
24 pages |
| Authors:
Tito E. Huber; HOWARD UNIV WASHINGTON DC
|
| Theoretical models of the effect of quantum confinement in nanowire arrays show that thermoelectric cooler efficiency can be enhanced several-fold using this strategy. Previous experimental studies of well characterized samples failed to show an enhancement of the thermopower, but the reason for this failure was not identified. We show that bismuth nanowires have, in addition to bulk electrons and holes, a third type of charge carriers (surface charges). The effect ... |
|
| A Partnership Training Program in Breast Cancer Research Using Molecular Imaging Techniques |
JUL 2007 |
55 pages |
| Authors:
Paul C. Wang; HOWARD UNIV WASHINGTON DC
|
| In the second year five faculty members and a research assistant were further trained in molecular imaging of breast cancer through seminars and workshops and are currently conducting two research projects with the faculty at Johns Hopkins University. We have perfected the technique of constructing a dual imaging probe for MRI and fluorescent imaging by linkage of near-infrared fluorescently labeled transferring on the surface of contrast agent encapsulated cationic liposomes. ... |
|
| Eosinophil Granular Protein(s) Modulate Tumor Metastasis Marker Gene Expression |
01 MAY 2007 |
44 pages |
| Authors:
Paulette Furbert-Harris; HOWARD UNIV WASHINGTON DC
|
| Multicellular tumor spheroids are a suitable tumor model system for investigating the effect of anti-cancer agents on tumor growth. The overall objective of the present investigation is to examine the effect of isolated eosinophil toxic granular protein(s) and cytokines IL-4, IL-10, IL-12, TNF+/- on markers of tumor growth and metastasis (e.g. erbB2, cyclin D1, cyclin E). Early studies concentrated on the development of the spheroid model. Optimization of spheroid size, ... |
|
| Short-Term Exercise and Prostate Cancer Prevention in African American Men |
APR 2007 |
7 pages |
| Authors:
Teletia R. Taylor; HOWARD UNIV WASHINGTON DC
|
| This study seeks to examine the impact of exercise on serum factors related to prostate cancer in African-American men. Aims and Objectives: I. To recruit 40 African-American men between the ages of 40 and 70 who are at increased risk for developing prostate cancer and randomize them into an exercise intervention or control group. 2. To examine the effect of 12 days of aerobic exercise over 4 weeks on PSA ... |
|
| UV Exposure, Vitamin D, and Prostate Cancer Risk in African Americans |
AUG 2006 |
20 pages |
| Authors:
Yasmine Kanaan; HOWARD UNIV WASHINGTON DC
|
| African American men have the highest incidence of prostate cancer compared to other ethnic groups. This cohort also tends to present at an advanced stage with aggressive histology and increased cancer-related mortality. There is accumulating evidence that vitamin D may be an important determinant of the occurrence and progression of prostate cancer. Because the prostate cancer mortality rate increases significantly as the availability of ultraviolet (UV) radiation exposure decreases, and ... |
|
| Anti-Estrogen Regulations of Macrophage Products that Influence Breast Cancer Cell Proliferation and Susceptibility to Apoptosis |
AUG 2006 |
8 pages |
| Authors:
Theodore Brenner; HOWARD UNIV WASHINGTON DC
|
| In June 2006, I applied for a final no-cost extension to complete Task 2c of the project which required more time than previously anticipated. Program was slow owing to difficulty in recruiting a qualified laboratory technician for a single year. During the spring and summer (2006). I trained an undergraduate student, Ms. Giaelle Burnett, who is now assisting me with cell culture, western blotting and RT-PCR. The project will be ... |
|
| A Partnership Training Program in Breast Cancer Research Using Molecular Imaging Techniques |
JUL 2006 |
48 pages |
| Authors:
Paul C. Wang; HOWARD UNIV WASHINGTON DC
|
| In the first year of this training grant, five faculty members from different departments at the Howard University were trained in molecular imaging with the faculty at the In Vivo Cellular Molecular Imaging Center at the Johns Hopkins University. Two research projects have started and progressed well. A Molecular Imaging Laboratory, a university core facility, has been established. Major optical imaging equipment, Xenogen IVIS 200, was acquired through this funding. ... |
|
| A Training Program in Breast Cancer Research Using NMR Techniques |
JUL 2006 |
86 pages |
| Authors:
Paul C. Wang; HOWARD UNIV WASHINGTON DC
|
| This is a six year training program in breast cancer research using NMR techniques. This program has supported seven predoctoral students and five postdoctoral students. All the trainees have learned the theory and instrumentation of MRI. They have been actively involved in one of the seven research projects: (1) NMR studies of phosphorus metabolites of breast cancer cells using an improved cell perfusion system (2) Segmentation of mammographic masses (3) ... |
|
| Computer-Aided Detection of Mammographic Masses in Dense Breast Images |
JUN 2006 |
56 pages |
| Authors:
Lisa M. Kinnard; HOWARD UNIV WASHINGTON DC
|
| This document describes the research tasks and educational activities in which the PI has been engaged during the second phase of this post-doctoral work. The PI has selected 300 dense breast masses for testing using an automated segmentation algorithm which combines region growing with cost function analysis. This method has been validated on all cases using overlap, accuracy, sensitivity, specificity, Dice Similarity Index, and kappa statistics by three expert radiologists. ... |
|
| A Partnership Training Program in Breast Cancer Diagnosis: Concept Development of the Next Generation Diagnostic Breast Imaging Using Digital Image Library and Networking Techniques |
MAY 2006 |
12 pages |
| Authors:
Mohamed F. Chouikha; HOWARD UNIV WASHINGTON DC
|
| In this partnership training program, experts from Georgetown and Howard Universities participated in training through seminars, specialized tutorials and workshops. Further, we developed a large digitized mammography database of African-American patients. The database was made accessible through the web to support breast cancer research. We have accomplished the objectives of this 4-year project and have reached our goal. As a result, a large number of Howard faculty investigators and students, ... |
|
| Short-Term Exercise and Prostate Cancer Prevention in African-American Men |
APR 2006 |
17 pages |
| Authors:
Teletia R. Taylor; HOWARD UNIV WASHINGTON DC
|
| This study seeks to examine the impact of exercise on serum factors related to prostate cancer in African-American men. Aims and Objectives: 2) To examine the effect of 12 days of aerobic exercise over 4 weeks on PSA levels in African American men. 3) To examine the effect of 12 days of aerobic exercise on free and total testosterone insulin IGF1 and SHBG levels in African American men. A total ... |
|
| Breast Cancer in African American Women: Molecular Analysis of Differences in Incidence and Outcomes |
OCT 2005 |
43 pages |
| Authors:
Agnes A. Day; John Stubbs; Rina Das; Marti Jett; HOWARD UNIV WASHINGTON DC
|
| The DOD funded HBCU/MI Partnership Training award entitled "Breast Cancer in African American Women: Molecular Analysis of Differences in Incidence and Outcomes" continues to provide quality research experiences to faculty and students and has developed into a highly rewarding collaboration that has expanded from the original 2 faculty at HUCC to include 6 experienced faculty and multiple students. At WRAIR, the original 2 has increased to include 3 new researchers ... |
|
| Strategies for Treatment of Bone Metastases from Breast Cancer |
OCT 2005 |
45 pages |
| Authors:
Rajagopalan Sridhar; HOWARD UNIV WASHINGTON DC
|
| The major goal of this project is to optimize the strategies for using radioactive strontium for palliation of bone pain due to breast cancer metastases. One approach is to determine ways of selectively increasing strontium uptake at the metastatic site. Bisphosphonates are useful in the treatment of osteoporosis and bone metastases. Bisphosphonates sequester calcium and strontium. Strontium was non toxic to human breast cancer cells. Bisphosphonates are charged molecules that ... |
|
| Anti-Estrogen Regulation of Macrophage Products That Influence Breast Cancer Cell Proliferation and Susceptibility to Apoptosis |
AUG 2005 |
22 pages |
| Authors:
Theodore A. Bremner; HOWARD UNIV WASHINGTON DC
|
| Macrophage function can be regulated by breast cancer cells to sustain an inflammatory microenvironment that promotes cancer cell proliferation and survival. MCF-7 cells suppress IL-10 expression by co-cultured macrophages. Activated and resting THP-1 macrophages were able to induce SNAIL expression in MCF-7 cells. SNAIL has been implicated in the epithelial-mesenchymal transition which precedes metastasis. These observations suggest that tumor-associated macrophages may promote progression-related gene expression at discrete steps in the ... |
|
| A Training Program in Breast Cancer Research Using NMR Techniques |
JUL 2005 |
69 pages |
| Authors:
Paul C. Wang; HOWARD UNIV WASHINGTON DC
|
| This is an extended 5th year of a training program. This program has supported four predoctoral students. One MD/PhD student suffered medical problem and his PhD thesis work has been delayed. The PI has filed a second extension of this grant in order to continue supporting the student and the research. All the trainees have continued to learn the theory and instrumentation of MRI. The trainees have attended the weekly ... |
|
| Psychological and Neuropsychological Predictors of Non-Compliance to Mammography Screening Among High-Risk African American Women |
APR 2005 |
17 pages |
| Authors:
Sharon L. Steele; Ometha Lewis-Jack; HOWARD UNIV WASHINGTON DC
|
| The breast cancer death rate is high for African American women compared to U.S. national figures and an explanation is that African American women are more likely to be diagnosed with advanced breast cancer disease. Regular mammography screenings reduce the number of deaths from breast cancer by helping to detect the disease at an early stage. Although effective, the number of women engaging in repeat screenings is low, and this ... |
|
| Real-Time Implementation of a Fuzzy Logic Controller for DC-DC Switching Converters |
11 FEB 2005 |
34 pages |
| Authors:
Ahmed Rubaai; HOWARD UNIV WASHINGTON DC
|
| This report presents a successful implementation of a fuzzy logic controller structure for dc-dc switching converters and evaluates experimentally its sensitivity for variable supply voltages and load resistance variations. The optimum topology of the controller structure is determined using experimental tests. An advanced test bed system is used to evaluate the robustness capacities of the controller under varying loading conditions and input voltage variations. The experiment is performed using a ... |
|
| Dietary Fat and Vitamin E in Prostate Cancer Risk Among African Americans and West Africans: A Case-Control Study |
FEB 2005 |
54 pages |
| Authors:
Flora A. Ukoli; Ernest Smith; Alecia Malin; Barbara Zhao; Usifo Osime; Steven Stain; HOWARD UNIV WASHINGTON DC
|
| The role of dietary fat and vitamin E in prostate cancer risk among African-Americans, African migrants and Africans is being investigated using a dietary assessment tool and by measuring plasma fatty acids and vitamin E in cases and controls. The FFQ appropriate for all three populations has been developed and continues to be in use for the Nigerian population. The BLOCK FFQ will be used for the Nashville population to ... |
|
| A Partnership Training Program in Breast Cancer Diagnosis: Concept Development of the Next Generation Diagnostic Breast Imaging Using Digital Image Library and Networking Techniques |
OCT 2004 |
19 pages |
| Authors:
Mohamed F. Chouikha; HOWARD UNIV WASHINGTON DC
|
| This program represents a training partnership between Howard University (HU) (Department of Electrical Engineering, Department of Systems and Computer Sciences, and Department of Radiology); and Georgetown University (Image Science and Information Systems, ISIS). In this partnership training program, we will train faculty and students in breast cancer imaging, digital image database library techniques and network communication strategy. Experts from Georgetown and Howard University will participate in training through seminars, specialized ... |
|
| Anti-Estrogen Regulation of Macrophage Products that Influence Breast Cancer Cell Proliferation and Susceptibility to Apoptosis |
AUG 2004 |
23 pages |
| Authors:
Theodore Bremner; HOWARD UNIV WASHINGTON DC
|
| We have characterized the regulation of gene expression in MCF-7 breast cancer cells and THP-l macrophages as a model of epithelial cell-stromal cell interaction in breast cancer progression. THP-1 macrophages enhanced the proliferation of MCF-7 cells, protected them against tamoxifen killing, and induced the expression of several MCF-7 angiogenesis-related genes, including IL-8 (interleukin-8), OPN (osteopontin), MDK (Midkine), TGFRl/2/3 (TGF receptors 1, 2, 3), and 1D3 (inhibitor of differentiation 3). Pre-treatment ... |
|
| A Training Program in Breast Cancer Research Using NMR Techniques |
JUL 2004 |
53 pages |
| Authors:
Paul C. Wang; HOWARD UNIV WASHINGTON DC
|
| This program has supported four predoctoral students (two students from the Electrical Engineering Department, one medical student and one MD/PhD student from Biochemistry) and three postdoctoral fellows. The new students have been introduced to the Biomedical NMR Laboratory and the Howard University Cancer Center. The trainees have continued to learn the theories and instrumentation behind nuclear MRI. The trainees have rotated through the mammography service in the Radiology Department to ... |
|
| Chemomodulation of Doxorubicin Pharmacodynamics |
JUL 2004 |
89 pages |
| Authors:
Rajagopalan Sridhar; HOWARD UNIV WASHINGTON DC
|
| The project aims to develop;strategies for using doxorubicin in the treatment of multidrug resistant advanced breast cancer while simultaneously minimizing the risk of cardiotoxicity. The wild type MCF-7 breast cancer cells and the multidrug resistant cell line designated as MCF7/ADR were genetically unrelated. This slowed the progress of our research. However, genetically related MCF-7 wild type and its genetically related multidrug resistant variant were acquired and used successfully in our ... |
|
| Computer-Aided Detection of Mammographic Masses in Dense Breast Images |
JUN 2004 |
52 pages |
| Authors:
Lisa M. Kinnard; HOWARD UNIV WASHINGTON DC
|
| This document describes the research tasks and educational activities in which the PI has been engaged during the first phase of this post-doctoral work. The Pr has selected 342 dense breast masses (175 cancer cases and 167 benign cases) for testing using an automated segmentation algorithm which combines region growing with cost function analysis. This method has been validated on 198 cases using overlap, accuracy, sensitivity and specificity statistics by ... |
|
| Psychological and Neuropsychological Predictors of Non-Compliance to Mammography Screening Among High-Risk African American Women |
APR 2004 |
26 pages |
| Authors:
Sharon L. Steele; HOWARD UNIV WASHINGTON DC
|
| The breast cancer death rate is high for African American women compared to U.S. National figures and an explanation is that African American women are more likely to be diagnosed with advanced breast cancer disease. Regular mammography screening reduce the number of deaths from breast cancer by helping to detect the disease at an early stage. Although effective, the number of women engaging in repeat screening is low, and this ... |
|
| Eosinophil Cell Lines in a Tri-Cell Multicellular Tumor Spheroid (MTS)/Endothelium Complex: Down Regulation of Adhesion and Integrin Molecules-Implications of Metastasis Inhibition |
OCT 2003 |
92 pages |
| Authors:
Paulette M. Furbert-Harris; HOWARD UNIV WASHINGTON DC
|
| Eosinophils are nonimmune inflammatory cells which are intricately involved in helminthic infections and allergic hypersensitivity reactions (1, 2). Activated eosinophils produce a host of mediators, including cytokines which can be both detrimental as well as helpful to the host (3, 4, 5). Cytokines such as IL-lalpha, IL-1beta and TNFalpha, also produced by eosinophils, upregulate adhesion molecule expression on both endothelial and tumor cells (6, 7). Increased expression of adhesion molecules ... |
|
| A Training Program in Breast Cancer Research Using NMR Techniques |
JUL 2003 |
26 pages |
| Authors:
Paul C. Wang; HOWARD UNIV WASHINGTON DC
|
| In the third year, this program has supported three graduate students (one from Electrical Engineering Department, one from Biochemistry Department, and one medical student) and two postdoctoral fellows (Radiology Department). The new medical student has been introduced to the Biomedical NMR Laboratory and the Howard University Cancer Center. The trainees have continued to learn the theory and instrumentation of nuclear magnetic resonance imaging and spectroscopy. The trainees have rotated through ... |
|
| Dietary Fat and Vitamin E in Prostate Cancer Risk Among African Americans and West Africans: A Case Control Study |
FEB 2003 |
50 pages |
| Authors:
Flora A. Ukoli; Aaron Jackson; Tanya Agurs-Collins; Kepher Makambi; Chiledum Ahaghotu; HOWARD UNIV WASHINGTON DC
|
| The role of dietary fat and vitamin B in prostate cancer risk among African-Americans. African migrants and Africans is being investigated using a dietary assessment tool and by measuring plasma fatty acids and vitamin B in cases and controls. The FFQ appropriate for all three populations has been developed and is in the process of being computerized. 39 potential cases have been accrued into the study and 9 of them ... |
|
| Relationships Between IGF-1, IGF-Binding Proteins and Diet in African American and Caucasian Men |
JAN 2003 |
33 pages |
| Authors:
Tanya Agurs-Collins; HOWARD UNIV WASHINGTON DC
|
| The study aims to determine racial differences between insulin-like growth factor-1 (lGF-1), insulin-like binding protein-1 (IGFBP-2), insulin-like binding protein-3 (IGFBP-3), prostate specific antigen (PSA), testosterone, body mass index (BMI), and diets high in calories, protein and fat. Specifically, the primary objectives are to: (1) define racial differences in serum levels of free and total IGF-1, IGFBP-2, IGFBP-3, and testosterone. (2) Define how diet and BMI impact serum levels of IGF-1, ... |
|
| Diet Genetic Polymorphisms and Breast Cancer in African-Americans |
OCT 2002 |
88 pages |
| Authors:
Lucille L. Adams-Campbell; HOWARD UNIV WASHINGTON DC
|
| Dietary fat and cooking practices, such as overcooking of meats that can lead to the formation of heterocyclic amines (HAAs) and polycyclic aromatics hydrocarbons (PAHs), differ by racial groups and culture. The project is a case control study designed to assess the role of dietary fat, cholesterol, cooking practices (e.g., of fatty foods that would increase HAAs and PAHs), smoking, and alcohol consumption as risk factors for breast cancer among ... |
|
| Chemomodulation of Doxorubicin Pharmacodynamics |
OCT 2002 |
39 pages |
| Authors:
Rajagopalan Sridhar; HOWARD UNIV WASHINGTON DC
|
| The wild type MCF7 human breast cancer cells and the multidrug resistant cell line designated as MCF7/ADR are reported to be genetically unrelated. Our attempts to produce stable multidrug resistant mutants from MCF7 were unsuccessful. However, we found reliable sources of wild type and related multidrug resistant breast cancer cell lines. This has further delayed our experiments. We are in the process of repeating our experiments with these genetically related ... |
|
| A Partnership Training Program in Breast Cancer Diagnosis: Concept Development of Next Generation Diagnostic Breast Imaging Using Digital Image Library and Networking Techniques |
OCT 2002 |
13 pages |
| Authors:
Mohamed F. Chouikha; S. C. Ben Lo; HOWARD UNIV WASHINGTON DC
|
| This ongoing training program consists of three components, namely: start up, training and research development stages. In the first year of this program, our main effort has been in providing facilities and students with series of lectures in breast imaging, coordination and digitization of mammograms aiming to establish and African-American women mammogram database, and design of a research mammographic workstation. Under this partnership arrangement, one Ph.D. student is working on ... |
|
| Breast Cancer in African American Women: Molecular Analysis of Differences in Incidence and Outcomes |
OCT 2002 |
139 pages |
| Authors:
Agnes Day; John Stubbs; Rina Dad; Marti Jett; HOWARD UNIV WASHINGTON DC
|
| Breast cancer mortality in higher among West African and African American women than it is among caucasian women in the United States, but the reasons for theses difference are not known. To devise effective methods for preventing breast cancer, we must understand which factors alone or in combination raise the risk of triggering a tumor, and which factors protect against the disease. Specific goals for the proposed research are to: ... |
|
| Correlation Between the Composition of Various Estrogen Receptors and Ligand Binding |
OCT 2002 |
11 pages |
| Authors:
Kate M. Baldwin; Indra Poola; HOWARD UNIV WASHINGTON DC
|
| Clinical data show that about 50% of the ER-positive patients respond to tamoxifen, the most widely used anti- estrogen. The factors that correlate with resistance/response to tamoxifen, or any other anti-estrogens, are largely not understood, but are likely to depend on the relative amounts of all ER forms present in the tumor tissue. Therefore, lack of knowledge of the correlation between the relative amounts of various ER isoforms with response ... |
|
| A Training Program in Breast Cancer Research Using NMR Techniques |
JUL 2002 |
17 pages |
| Authors:
Paul C. Wang; HOWARD UNIV WASHINGTON DC
|
| In the second year, this program has supported two graduate students (one from the Electrical Engineering Department and one from the Biochemistry Department) and three postdoctoral fellows (Radiology Department). This program supports the graduate students in the second year. The new postdoctoral fellows have been introduced to the Biomedical NMR Laboratory and the Howard University Cancer Center. The trainees have continued to learn the theory and instrumentation of nuclear magnetic ... |
|
| Pharmacists as Health Educators and Risk Communicators in the Prevention of Prostate Cancer |
APR 2002 |
42 pages |
| Authors:
Cynthia A. Warrick; HOWARD UNIV WASHINGTON DC
|
| The purpose of this study is to determine if and how pharmacists can play a significant part in the prevention of prostate cancer. The study is divided into three phases. Phase 1 (Year 1) involved the identification of community pharmacists who are willing to serve as health educators on prostate cancer in the community-pharmacy setting. Phase II is the design, pilot testing, and evaluation of a prostate cancer education and ... |
|
| High Temperature Superconductor RF Probes for Breast Cancer Research |
OCT 2001 |
38 pages |
| Authors:
Paul C. Wang; HOWARD UNIV WASHINGTON DC
|
| Nuclear magnetic resonance imaging and spectroscopy techniques have been used to study the breast cancer cells and tumor grown on animal. The goal of this study is to gain knowledge, which could be useful to improve the specificity of diagnosis and staging of breast cancer in clinic. Intrinsically, NMR techniques have weak signals, which limit the ultimate spatial resolution in image and sensitivity in spectrum. A high temperature superconductor RF ... |
|
| Diet, Genetic Polymorphisms and Breast Cancer in African-Americans |
OCT 2001 |
82 pages |
| Authors:
Lucile L. Adams-Campbell; HOWARD UNIV WASHINGTON DC
|
| Dietary fat and cooking practices, such as overcooking of meats that can lead to the formation of heterocyclic amines (HAAs) and polycyclic aromatic hydrocarbons (PAHs), differ by racial groups and culture. The project is a case control study designed to assess the role of dietary fat, cholesterol, cooking practices (i.e. of fatty foods that would increase HAAs and PAHs), smoking, and alcohol consumption as risk factors for breast cancer among ... |
|
| Modulation of Adhesion Molecule Expression on Prostate Tumor Cells after Co-Culture with Eosinophilic Cell Lines |
OCT 2001 |
|
| Authors:
Paulette M. Furbert-Harris; HOWARD UNIV WASHINGTON DC
|
 | We studied the effect of eosinophil 24hr. cultured supernatants and exogenous cytokines on growth and adhesion molecule expression on PC3, DU145 and LNCaP prostate cancer (Pca) cell lines. Hypo and hyperdense peripheral blood eosinophils (Eos) significantly inhibited LNCaP, PC3 and DU145 cell growth in vitro. This activity was enhanced by IL-S. DU145 and PC3 colony formation was inhibited by 50-75% by Eos cell lines, while peripheral blood Eos inhibited PC3 ... |
|
| National Hospital Discharge Survey Data Analysis of Breast Cancer Between African American and White Women |
AUG 2001 |
42 pages |
| Authors:
Kyungsook Kim; HOWARD UNIV WASHINGTON DC
|
| The present study estimated age-specific hospital admission rates for breast cancer in African American (AA) and White women through analyzing National Hospital Discharge Survey (NHDS) data from 1988 to 1994. Weighted linear regression was used to analyze trends. Specific standard errors for rates analyzed in the regression were produced using the SUDAAN program. The statistical significance of the weighted least squares test for trends is based on the two-sided z-test ... |
|
| A Training Program in Breast Cancer Research Using NMR Techniques |
JUL 2001 |
9 pages |
| Authors:
Paul C. Wang; HOWARD UNIV WASHINGTON DC
|
| In the first year, this program has supported two graduate students (one from EE Department and one from Biochemistry Department) and a postdoctoral fellow (Radiology Department). They have been introduced to the Biomedical NMR Laboratory and the Howard University Cancer Center. The trainees learned the theory and instrumentation of Nuclear Magnetic Resonance imaging and spectroscopy. The students have also rotated through the clinical services in the hospital to learn the ... |
|
| Growth Inhibition of Breast Tumor Cells by Hypodense and Normodense Eosinophilic Cell Lines |
JUL 2001 |
|
| Authors:
Paulette M. Furbert-Harris; HOWARD UNIV WASHINGTON DC
|
| We hypothesized that activated eosinophils (Eos) can inhibit the growth of breast tumor cells in vitro, and that this due in part to the action of released mediators. In this study we utilized Eos cell lines, previously developed from peripheral blood of allergic/asthmatic individuals, and newly developed sublines (FACS sorting of parent lines using antibodies to Eos markers). Using both monolayer culture and colony forming assays, we have demonstrated that ... |
|
| The Role of Terbium and Gadolinium in Reversal of Cisplatin Resistance in Cultured Human Breast Cancer Cells |
JUN 2001 |
6 pages |
| Authors:
Ann E. Allworth; HOWARD UNIV WASHINGTON DC
|
| This proposal was an innovative endeavor to unravel the intracellular signaling events that occur when terbium ions (Tb3+) or gadolinium ions (Gd3+) are added to cisplatin treatment of cisplatin resistant MDA-MB231 human breast cancer cells Preliminary data demonstrated that either trivalent lanthanide ion reverses the cellular phenotype of microtubules in resistant cells treated with cisplatin alone and mimics the phenotype seen when cisplatin sensitive MDA-MB231 cells are treated with cisplatin ... |
|
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