| Molecular Biology and Prevention of Endometrial Cancer |
01-Jul-2009 |
7 pages |
| Authors:
George L Maxwell; HENRY M JACKSON FOUNDATION ROCKVILLE MD
|
 | To increase our understanding of the molecular aberrations associated with endometrial carcinogenesis and the biologic mechanisms underlying the protective effect of oral contraceptive (OC) therapy. Methods: 1) Oligonucleotide microarray analysis was performed on a panel of endometrial cancers. 2) A subset of adenocarcinoma cases from the International DES Registry (IDESR) was analyzed for MSI 3) A case-control study of the CASH database was performed to evaluate the relationship between progestin ... |
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| Amphetamine Challenge: A Marker of Brain Function that Mediates Risk for Drug and Alcohol Abuse |
May-2009 |
8 pages |
| Authors:
Frances H Gabbay; HENRY M JACKSON FOUNDATION ROCKVILLE MD
|
| People differ in their susceptibility to abuse alcohol and drugs, and the conditions that lead to abuse and dependence are not the same in everyone. Some people are susceptible because they experience particularly positive effects from alcohol and drugs; often, the same people have problems controlling their behavior. They are impulsive; they seek out novel and exciting experiences; and they may be influenced by other rewards, such as those associated ... |
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| Stress-Induced Neurodegeneration: Mechanisms and Interventions |
JAN 2000 |
48 pages |
| Authors:
James L. Meyerhoff; HENRY M JACKSON FOUNDATION ROCKVILLE MD
|
| Soldiers face a broad range of occupational/environmental threats which are hazardous to central nervous system (CNS) function. One of these, exposure to prolonged, extreme stress, has been recently associated with neuronal loss. Vietnam veterans with PTSD have decreased hippocampal volume on MRI, as well as decreased scores on standardized tests of memory. Short term (recent) memory function has been localized to the hippocampus. Humans exposed ... |
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| Evaluation of the Health Risks of Embedded Depleted Uranium (DU) shrapnel on Pregnance and Offspring Development |
OCT 1999 |
3 pages |
| Authors:
Kimberly A. Benson; HENRY M JACKSON FOUNDATION ROCKVILLE MD
|
| This part of the medical research on "Evaluation of the Health Risks of Embedded Depleted Uranium D (DU) Shrapnel on Pregnancy and Offspring Development" was unable to be completed because the depleted uranium was not available. |
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| Use of Cytokines to Prevent Breast Cancer Growth and Progression |
AUG 1999 |
21 pages |
| Authors:
Philip M. Grimley; HENRY M JACKSON FOUNDATION ROCKVILLE MD
|
| Interferon-alpha/beta (IFN-alpha/beta) and prolactin (PRL) are natural ligands relevant to breast cancer progression: IFN-alpha/beta inhibits proliferation while PRL stimulates growth. The IFN alpha/beta antiproliferative action is mediated by STAT I in a transcriptional holocomplex with STAT2 and ISGF3 gamma -p48). #1We investigated a negative regulator of -p48 function, designated "TKO". Proteins in a cytosol fraction enriched for "TKO" were resolved by 2D PAGE. The ... |
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| Taxol and LPS Modulation of c-kit and nm23 Expression in Macrophages andNormal vs. Malignant Breast Cancer Cell Lines |
JUL 1999 |
60 pages |
| Authors:
Stefanie N. Vogel; HENRY M JACKSON FOUNDATION ROCKVILLE MD
|
| Taxol is a microtubule poison that has been used successfully in refractory breast cancer. Apart from its well characterized anti-mitotic effects, Taxol shares with bacterial lipopolysaccharide (LPS) the capacity to elicit microtubule-independent, intracellular signaling in murine macrophages leading to expression of many genes. This IDEA grant proposed to test the ability of Taxol to up-regulate expression of two genes, nm23 and c-kit, whose expression ... |
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| The Role of the Suppressor, Rsu-1, in Regulation of Ras Signal Transduction in Breast Cancer Cells |
JUL 1999 |
17 pages |
| Authors:
Mary L. Cutler; HENRY M JACKSON FOUNDATION ROCKVILLE MD
|
| Epidermal growth factor (EGF) family of ligands bind to a number of related receptors and stimulate mitogenesis in mammary cells. Signal transduction downstream of the EGF family of receptors involves activation of the GTPase Ras and its effectors. Rsu-1, a cDNA identified as an inhibitor of Ras-induced transformation, was RA-epitope tagged and introduced into expression vectors. The HA-Rsu-1 vectors were transfected into MCF7 breast carcinoma cell ... |
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| Evaluation of the Health Risks of Embedded Depleted Uranium (DU) shrapnel on Pregnancy and Offspring Development |
OCT 1998 |
36 pages |
| Authors:
Kimberly A. Benson; HENRY M JACKSON FOUNDATION ROCKVILLE MD
|
| Our laboratory is currently assessing the toxicity of embedded depleted uranium on the female rat This research is intended to answer questions that have arisen following Operation Desert Storm During this conflict a number of. U.S. military personnel were wounded by depleted uranium fragments. Many of these fragments were not removed because the removal procedure would produce excessive tissue damage. Uranium bioassays taken over a year ... |
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| Role of Pregnancy Specific Glycoproteins in Breast Cancer Development |
SEP 1998 |
11 pages |
| Authors:
Gabriela S. Dveksler; HENRY M JACKSON FOUNDATION ROCKVILLE MD
|
| Pregnancy specific glycoproteins (PSGs) are secreted proteins of unknown function that belong to the carcinoembryonic antigen gene family (CEA). CEA is a commonly used tumor marker for adenocarcinomas. Expression of PSGs in normal breast tissue is undetectable by current techniques but they have been shown to be expressed in certain tumors including breast ductal and lobular carcinomas by immunohystochemistry. Because polyclonal anti-PSG antibodies can cross react with other members of ... |
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| The Role of the Suppressor, Rsu-1, in Regulation of Ras Signal Transduction in Breast Cancer Cells |
JUL 1998 |
15 pages |
| Authors:
Mary Cutler; HENRY M JACKSON FOUNDATION ROCKVILLE MD
|
| Epidermal growth factor (EGF) family of ligands bind to a number of related receptors and stimulate mitogenesis in mammary cells. Signal transduction downstream of the EGF family of receptors involves activation of the GTPase Ras and its effectors. RSU-1, a cDNA identified as an inhibitor of Ras-induced transformation, was HA-epitope tagged and introduced into expression vectors. The HA-RSU-1 vectors were transfected into MCF7 and MCFlOA cell lines. Transfectants were selected ... |
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| Taxol and LPS Modulation of c-kit and nm23 Expression in Macrophages and Normal vs. Malignant Breast Cancer Cell Lines |
JUL 1998 |
54 pages |
| Authors:
Stephanie N. Vogel; HENRY M JACKSON FOUNDATION ROCKVILLE MD
|
| Taxol is a microtubule poison that has been used successfully in refractory breast cancer. Apart from its well characterized anti-mitotic effects, Taxol shares with bacterial lipopolysaccharide (LPS) the capacity to elicit microtubule-independent, intracellular signaling in murine macrophages that activate kinase cascades that lead to expression of many genes. This IDEA grant proposed to test the ability of Taxol to up-regulate expression of two genes, nm23 and c-kit, whose expression is ... |
|
| WDMET Numeric and Descriptive Data User Interface Development Project CD-ROM) |
29 JUN 1998 |
|
| Authors:
HENRY M JACKSON FOUNDATION ROCKVILLE MD
|
 | File characteristics: Software and database. Physical description: 1 CD-ROM disc; col. System Requirements: WordPerfect; Bitmap Images; Playtime 74 minutes; 600MB. The TRAUMABASE project ending in 1990 attempted to develop a hypertext style interface to access the unique multimedia WDMET data set on combat trauma. Data were reentered and a visual interface was completed. There were no links to multimedia as originally envisioned and the browser lacked good search capabilities. The ... |
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| The Role of the RAS Tumor Suppressor, Lysyl Oxidase, in Breast Cancer Development and Progression |
NOV 1997 |
37 pages |
| Authors:
Sara Contente; HENRY M JACKSON FOUNDATION ROCKVILLE MD
|
| This project sought to analyze, in breast cell lines and normal and neoplastic human breast tissue, the pattern and level of expression lysyl oxidase messenger RNA. Lysyl oxidase expression acts as a suppressor of the transforming activity of the ras oncogene in mouse cells. The expression of normal ras was also determined. Reverse transcriptase-polymerase chain reaction (RT-PCR) for cellular RNA, and in situ RT-PCR on sections of fixed, paraffin- embedded ... |
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| Heat Tolerance and Exertional Heat Illness in Female Military Recruits |
OCT 97 |
34 pages |
| Authors:
C. B. Wenger; HENRY M JACKSON FOUNDATION ROCKVILLE MD
|
| We studied healthy recruits (controls), and recruits with exertional heat illness (EHI) during basic training. We copied pertinent clinical and training records on all identified EHI cases during this reporting period, numbering approximately 100 cases-fewer than usual but the 1997 hot season was cooler than usual until mid-August. Unlike past years, when most EHI cases occurred during the first 4 weeks of training, and while running, 40% of EHI cases ... |
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| Support of USARIEM Postpartum Soldier Research Study |
SEP 1997 |
133 pages |
| Authors:
Joseph Dettori; Kathleen A. Westphal; Anthony Pusateri; Alana Cline; Paul Smith; HENRY M JACKSON FOUNDATION ROCKVILLE MD
|
| Pregnant and postpartum soldiers have unique needs that require adjustments in the demands placed on them in a military environment. This prospective cohort study was undertaken to examine the effects of pregnancy on the health, fitness and nutritional status of postpartum soldiers. We studied 468 females in three different groups: a nonpregnant active duty group (NPAD, n=2 15), a postpartum family member group (PPFM, n=126), and a postpartum active duty ... |
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| Role of Pregnancy Specific Glycoproteins in Breast Cancer Development |
SEP 97 |
11 pages |
| Authors:
Gabriela S. Dveksler; HENRY M JACKSON FOUNDATION ROCKVILLE MD
|
| Pregnancy specific glycoproteins (PSGs) are secreted proteins of unknown function that belong to the carcinoembryonic antigen gene family (CEA). CEA is a commonly used tumor marker for adenocarcinomas. Expression of PSGs in normal breast tissue is undetectable by current techniques but they have been shown to be expressed in certain tumors including breast ductal and lobular carcinomas by immunohytochemistry. Because polyclonal anti-PSG antibodies can cross react with other members of ... |
|
| Use of Cytokines to Prevent Breast Cancer Growth and Progression |
AUG 1997 |
24 pages |
| Authors:
Philip M. Grimley; HENRY M JACKSON FOUNDATION ROCKVILLE MD
|
| The current project extends two sets of observations: (1) Original work from our laboratories which showed that a cytoplasmic extract from transformed cells (TKO) interrupts the Stat1 signal transduction pathway of IFN- alpha/beta 28; and (2) published work of others showing that human breast cancer cells can secrete PRL and thus might autonomously activate Stat 1 by tyrosine phosphorylation. |
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| Taxol and LPS Modulation of c-kit and nm23 Expression in Macrophages and Normal vs. Malignanat Breast Cancer Cell Lines |
JUL 1997 |
20 pages |
| Authors:
Stefanie N. Vogel; HENRY M JACKSON FOUNDATION ROCKVILLE MD
|
| Taxol is a microtubule poison that has been used successfully in refractory breast cancer. Apart from its well characterized anti-mitotic effects, Taxol shares with bacterial lipopoly- saccharide (LPS) the capacity to elicit microtubule-independent, intracellular signaling pathways in murine macrophages that activate a serine/threonine and tyrosine kinase cascade that leads to expression of many genes. This IDEA grant proposed to test the ability of Taxol to up-regulate expression of two genes, ... |
|
| Heat Tolerance and Exertional Heat Illness in Female Military Recruits |
OCT 96 |
102 pages |
| Authors:
Bruce C. Wenger; HENRY M JACKSON FOUNDATION ROCKVILLE MD
|
| We studied healthy Marine recruits (controls), and recruits with exertional heat illness (EHI) or dilutional hyponatremia (patients) during basic training. With swallowed telemetry devices, we recorded core-temperature (Tcore) of 380 male and 350 female recruits during training events with high incidence of EHI, to define norms for comparison with presenting Tcore of EHI patients. With a computerized cognitive assessment battery we established norms for controls, and demonstrated acute impairment in ... |
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| Use of Cytokines to Prevent Breast Cancer Growth and Progression |
AUG 96 |
18 pages |
| Authors:
Phillip M. Grimley; HENRY M JACKSON FOUNDATION ROCKVILLE MD
|
| Goals of this project include: (I) characterization of a novel transcriptional knock out (TKO) factor which negatively regulates signal activation t)y type I interferons (!FN-cxJ% in breast cancer cells; and L)2 analysis of signal interactions of IFN-aI% and prolactin (pRL) in breast cancer cells. W Improved purification of ThO from suspension cultures of huanan cancer cells has been achieved: a single fimctionally active polypeptide of -20 kDa has been isolated. ... |
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| WDMET Numeric and Descriptive Data User Interface Development Project |
JUL 1996 |
102 pages |
| Authors:
Richard K. Pruett; HENRY M JACKSON FOUNDATION ROCKVILLE MD
|
| The TRAUMABASE project ending in 1990 attempted to develop a hypertext style interface to access the unique multimedia WDMET data set on combat trauma. Data were reentered and a visual interface was completed. There were no links to multimedia as originally envisioned and the browser lacked good search capabilities. The TRAUMABASE data set currently exist in a Macintosh based 4th Dimension database, a set of ASCII delimited text files, and ... |
|
| Support of USARIEM Postpartum Soldier Research Study |
MAR 96 |
26 pages |
| Authors:
Joseph Dettori; HENRY M JACKSON FOUNDATION ROCKVILLE MD
|
| It is estimated approximately 9% of Army women are pregnant at any one time. Shortly after delivery, postpartum soldiers are expected to return to full duty, meet body fat standards and pass the APFT. It has never been determined when prepregnancy work capacity or fitness levels return in postpartum women, either civilian or military. Surprisingly little is reported about the risk of injury, bone health, weight loss, and calcium and ... |
|
| Use of Cytokines to Prevent Breast Cancer Growth and Progression |
31 AUG 95 |
13 pages |
| Authors:
Philip M. Grimley; HENRY M JACKSON FOUNDATION ROCKVILLE MD
|
| This project aims to characterize a novel transcriptional knock out polypeptide (TKO) which we identified in breast cancer cells and which competitively interrupts molecular events in the ISGF3 signaling pathway for interferons-a/Beta (IFNalpha). The TKO action is of clinical significance since IFNs-alpha/Beta are antiproliferative cytokines with significant potential for therapy of stage II or disseminated breast cancer. Improved chromatographic purification of TKO has been achieved during the initial phase of ... |
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| Research Programs in Tropical and Infectious Diseases |
26 JUL 95 |
331 pages |
| Authors:
Bryce Redington; Joe P. Bryan; Larry Laughlin; HENRY M JACKSON FOUNDATION ROCKVILLE MD
|
| Between December 1, 1989 and May 31, 1995 a number of research projects were accomplished in Belize. The area that was most thoroughly studied was that of hepatitis. In response to reports of a number of cases of hepatitis around a banana plantation in 1990. a serosurvey of workers and their families was conducted. This revealed that up to 70% of workers had been infected with hepatitis B and almost ... |
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| Research Programs in Tropical and Infectious Diseases. |
26 JUL 1995 |
25 pages |
| Authors:
Joe P. Bryan; Larry Laughlin; Bryce Redington; HENRY M JACKSON FOUNDATION ROCKVILLE MD
|
| During the period February 11. 1994-May 31. 1995 faculty and students at Uniformed Services University of the Health Sciences along with members of the staff of the Epidemiology Research Center in Belize accomplished five studies. A study of risk factors and social correlates of malaria among Mayan Indians in Belize who experience very high rates of malaria each year revealed that housing is not mosquito resistant. personal protective measures are ... |
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| Human Immunodeficiency Virus (HIV) Research - AIDS |
30 NOV 94 |
206 pages |
| Authors:
John W. Lowe; Francine McCutchan; John McNeil; Ellen Namie; Richard Daniella; HENRY M JACKSON FOUNDATION ROCKVILLE MD
|
| A comprehensive MIV Research Program continued into its seventh year of scientific endeavors through a Cooperative Agreement between the United States Army Medical Research and Materiel Command and the Henry M. Jackson Foundation for the Advancement of Military Medicine. The primary mission of the program remains constant: to reduce and prevent HIV-infection among military medical beneficiaries. Five structural Program Areas produce the science to achieve this mission: Preventive Vacdnes, Behavioral ... |
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| Research Program in Tropical Infectious Diseases |
10 FEB 94 |
72 pages |
| Authors:
Bryce C. Redington; HENRY M JACKSON FOUNDATION ROCKVILLE MD
|
| The Memorandum of Understanding between the Ministry of Health of Belize and USUHS was signed in December 1989. Two USUHS MTM&H students conducted-research and obtained clinical experience in country. In August 1990, Jorge Palanco, MD received the MPH from USUHS. The renovation of the CML was completed in October 1990. The dedication of the CML and the ERC took place in November 1990. The preliminary analysis of the sera obtained ... |
|
| Human Immunodeficiency Virus Research Program |
30 NOV 93 |
179 pages |
| Authors:
John W. Lowe; HENRY M JACKSON FOUNDATION ROCKVILLE MD
|
| A comprehensive HIV Research Program continued into its sixth year of scientific endeavors with new direction and focus guided by a Cooperative Agreement between the U.S. Army Medical Research, Development, Acquisition and Logistics Command (Provisional), and the Henry M. Jackson Foundation, signed on April 1, 1993. During this six month reporting period intensive planning represented a major effort; nevertheless, each program area continued its research mission. Significant results during this ... |
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| Human Immunodeficiency Virus (HIV) Research (AIDS) |
15 JUL 93 |
391 pages |
| Authors:
Bryce Redington; John W. Lowe; Jacquelyn Burns; HENRY M JACKSON FOUNDATION ROCKVILLE MD
|
| A comprehensive HIV Research Program conducted studies in the areas or Vaccines and Immunotherapy/Immunoprophylaxis, Epidemiology/Natural History, Behavioral Medicine, Chemotherapy/Chemoprophylaxis, Retroviral Biology, Animal models, Diagnostics and opportunistic Infections. Research was directed towards ameliorating the effects of HIV infections within the US Armed Forces. Program priorities were early stage disease over late stage disease; interventions over descriptive studies; and primary anti-retroviral therapy over treatment/ prophylaxis of opportunistic infection or symptomatic therapy of ... |
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| Research Program in Tropical Infectious Diseases |
15 DEC 92 |
40 pages |
| Authors:
Bryce Redington; Richard E. Krieg; Llewellyn Legters; HENRY M JACKSON FOUNDATION ROCKVILLE MD
|
| Research progressed in fevers of unknown origin, leishmaniasis and mosquito larval ecology. New initiatives included investigations of hepatitis incidence and vaccine trials in the BDF and mosquito surveillance and pesticide screening. Manuscripts on malaria vectors and hepatitis have been accepted for publication. Two USUHS medical students conducted research and obtained clinical experience in Belize. Three Belizean physicians completed USUHS MPH and MTM and H graduate programs. ERC personnel attended three ... |
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| Research Program In Tropical Infectious Diseases |
15 DEC 91 |
|
| Authors:
Bryce C. Redington; HENRY M JACKSON FOUNDATION ROCKVILLE MD
|
| Research progressed on the causes of fevers of unknown origin, leishmaniasis and mosquito larval ecology. New initiatives included investigations of outbreaks of hepatitis and gastroenteritis. Manuscripts on gastroenteritis and hepatitis were-prepared and submitted for presentation and publication. Suspected cases of tick-borne fever in an archaeological team were investigated. Five USUHS medical students conducted research and obtained clinical experience in Belize. Three Belizean physicians entered USUHS MPH and MTM and H ... |
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| Hepatic Function in Hemorrhagic Shock |
15 NOV 91 |
|
| Authors:
William R. Drucker; Frederick J. Pearce; HENRY M JACKSON FOUNDATION ROCKVILLE MD
|
| For the wounded soldier in combat, the time between his injury and treatment can be quite long and variable depending on the combat circumstance. The duration and severity of this hypotensive period are critical factors in determining his responsiveness to resuscitative efforts when aid does arrive. Due to the venous nature of the bulk of its blood flow, the liver is particularly susceptible to decreases in its blood flow and ... |
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| Human Immunodeficiency Virus (HIV) Research (AIDS) |
28 FEB 91 |
123 pages |
| Authors:
Bryce C. Redington; Martha B. Shaw; HENRY M JACKSON FOUNDATION ROCKVILLE MD
|
| This grant was awarded to fund clinical and laboratory research on therapeutic regimens which show promise of ameliorating the effects of HIV infection. Midway through the five year grant, an organizational structure is in place to conduct both basic and applied research of HIV. In late 1980 a few cases of a devastating disease that attacked the body's immune system and its ability to fight disease were identified in the ... |
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| Research Program in Tropical Infectious Diseases |
14 DEC 90 |
|
| Authors:
Bryce C. Redington; Jose A. Lopez; Llewellyn J. Legters; Richard E. Krieg; HENRY M JACKSON FOUNDATION ROCKVILLE MD
|
| The Memorandum of Understanding between the Ministry of Health of Belize and USUHS was signed in December 1989. Two USUHS MTM&H students conducted research and obtained clinical experience in country. In August 1990, Jorge Palanco, MD received the MPH from USUHS. The renovation of the CML was completed in October 1990. The dedication of the CML and the ERC took place in November 1990. The preliminary analysis of the sera ... |
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| Molecular Studies of Cytokine Induction |
31 MAY 90 |
|
| Authors:
Carl W. Dieffenbach; HENRY M JACKSON FOUNDATION ROCKVILLE MD
|
| While many of the molecular events in viral replication are well studied, the mechanisms by which viral infections trigger such constitutional symptoms as fever and malaise are unknown. We investigate the hypothesis that these viral constitutional symptoms can be triggered by the accumplation and release of dsRNA arising from viral replication. Total lung RNA from mice acutely infected with influenza virus but not from sham-infected mice was shown to induce ... |
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