| Influence of Bone Remodeling Inhibition on the Development of Experimental Stress Fractures |
SEP 2001 |
38 pages |
| Authors:
Robert Boyd; Mitchell B. Schaffler; HENRY FORD HEALTH SCIENCES CENTER DETROIT MI
|
 | Stress fractures result from repetitive loading and have been regarded as a mechanical fatigue-driven process. However, data suggests that increased remodeling precedes the occurrence of bone microdamage and stress fractures, suggesting a central role for increased intracortical remodeling in the pathogenesis of stress fractures. Our ongoing experiments test the hypothesis by pharmacological inhibition of bone remodeling will slow the subsequent accumulation of microdamage, diminishing the severity of the stress fracture. ... |
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| Phase II: Understanding Factors Related to Prostate, Lung, and Colorectal Screening Among African American Men |
FEB 2001 |
336 pages |
| Authors:
Marvella Ford; HENRY FORD HEALTH SCIENCES CENTER DETROIT MI
|
| The study aims were to: (1) use a randomized trial to evaluate an ongoing innovative intervention designed to facilitate screening adherence among African American men aged 55(+) years in the screening arm of the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial and (2) develop a survey to assess perceptions of cancer screening among African American men. No statistically significant differences were found in age, education or income between ... |
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| Molecular Epidemiology of Breast Cancer: Establishment of an at Risk Cohort and Methods to Improve the Collection and Use of Risk Factor Data |
OCT 2000 |
186 pages |
| Authors:
Christine C. Johnson; HENRY FORD HEALTH SCIENCES CENTER DETROIT MI
|
| The objective of our research program was to develop a research infrastructure for studies defining molecular markers and their interaction with other factors as risk indicators for development of breast cancer among women with benign breast disease (BBD). We estimated the incidence of breast cancer development in African American and Caucasian women with biopsy-proven BBD and collected and archived in a specimen bank samples of benign breast disease lesions and ... |
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| Influence of Bone Remodeling Inhibition on the Development of Experimental Stress Fractures |
SEP 2000 |
9 pages |
| Authors:
Robert D. Boyd; Mitchell B. Schaffler; HENRY FORD HEALTH SCIENCES CENTER DETROIT MI
|
| Stress fractures result from repetitive loading and have been regarded as a mechanical fatigue-driven process. However, histopathological data and experimental data from our laboratory suggests that increased remodeling precedes the occurrence of bone microdamage and stress fractures, suggesting a central role for increased intracortical remodeling in the pathogenesis of stress fractures. Thus, we propose that stress fracture occurs through a positive feedback mechanism, in which increased mechanical usage stimulates focal ... |
|
| Influence of Bone Remodeling Inhibition on the Development of Experimental Stress Fractures |
SEP 2000 |
|
| Authors:
Robert D. Boyd; Mitchell B. Schaffler; HENRY FORD HEALTH SCIENCES CENTER DETROIT MI
|
 | Stress fractures result from repetitive loading and have been regarded as a mechanical fatigue-driven process. However, histopathological data and experimental data from our laboratory suggests that increased remodeling precedes the occurrence of bone microdamage and stress fractures, suggesting a central role for increased intracortical remodeling in the pathogenesis of stress fractures. Thus, we propose that stress fracture occurs through a positive feedback mechanism, in which ... |
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| NMR with Combined Antiangiogenic and Radiation Therapies - Breast Cancer |
MAY 2000 |
14 pages |
| Authors:
Stephen Brown; HENRY FORD HEALTH SCIENCES CENTER DETROIT MI
|
| The original goal of the present study was to determine optimal strategies for combining radiation and antiangiogenic therapies in spontaneous murine tumors and to evaluate the potential of Nuclear Magnetic Resonance (NMR) blood flow, arterial spin tagging, and oxygen measurements, (19)F oximetry, to guide the planning of combined treatment. Antiangiogenic therapy was found to have only minimal effect in the tumor model. In contrast, we ... |
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| African American Men in the PLCO Trial: Developing and Testing Methods to Increase Retention |
FEB 2000 |
312 pages |
| Authors:
Marvella E. Ford; HENRY FORD HEALTH SCIENCES CENTER DETROIT MI
|
| The specific aims of this randomized trial are to evaluate the efficacy of an innovative intervention in retaining African American men in the screening arm of the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial at the Henry Ford Health System site, and to develop a culturally appropriate measurement instrument to assess perceptions of cancer screening. The study population consists of African American men aged 55 and older living ... |
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| Molecular Epidemiology of Breast Cancer: Establishment of an at Risk Cohert and Methods to Improve the Collection and Use of Risk Factor Data |
OCT 1999 |
161 pages |
| Authors:
Christine C. Johnson; HENRY FORD HEALTH SCIENCES CENTER DETROIT MI
|
| The aim of the research program we are developing is to define molecular markers and their interaction with other risk factors as risk indicators for development of breast cancer among women with benign breast disease (BBD). Our specific aims are: 1. Estimate the incidence and time span of breast cancer development in a large cohort of African American and Caucasian women with biopsy-proven BBD; 2. Collect ... |
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| Influence of Bone Remodeling Inhibition on the Development of Experimental Stress Fractures |
SEP 1999 |
6 pages |
| Authors:
Mitchell B. Schaffler; Robert D. Boyd; HENRY FORD HEALTH SCIENCES CENTER DETROIT MI
|
| Stress fractures result from repetitive loading and have been regarded as a mechanical fatigue-driven process. However histopathological data and experimental data from our laboratory suggests that increased remodeling precedes the occurrence of bone microdamage and stress fractures suggesting a central role for increased intracortical remodeling in the pathogenesis of stress fractures. Thus we propose that stress fracture occurs through a positive feedback mechanism in which ... |
|
| Molecular Epidemiology of Breast Cancer: Establishment of An At Risk Cohort and Methods to Improve the Collection and Use of Risk Factor Data |
OCT 1998 |
89 pages |
| Authors:
Christine C. Johnson; HENRY FORD HEALTH SCIENCES CENTER DETROIT MI
|
| The aim of the research program we are developing is to define molecular markers and their interaction with other risk factors as risk indicators for development of breast cancer among women with benign breast disease (BBD). Our specific aims are: (1) Estimate the incidence and time span of breast cancer development in a large cohort of African American and Caucasian women with biopsy-proven BBD; (2) Collect and archive in a ... |
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| A Comparison of Breast Cancer Treatment Regimens by Demographic Characteristics |
OCT 1998 |
22 pages |
| Authors:
Marianne E. Ulcickas-Yood; HENRY FORD HEALTH SCIENCES CENTER DETROIT MI
|
| The purpose of this study was to measure ethnic differences in treatment and survival between African American (AA) and European American (EA) women with breast cancer. This annual report presents results of the survival analysis. We abstracted data on cases of breast cancer diagnosed in members of an HMO in metropolitan Detroit between 1986-1996 (N=886) and followed these cases for survival through April 1997 (N=137 deaths). AA women were diagnosed ... |
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| Molecular Epidemiology of Breast Cancer: Establishment of an at Risk Cohort and Methods to Improve the Collection and Use of Risk Factor Data |
OCT 97 |
45 pages |
| Authors:
Christine C. Johnson; HENRY FORD HEALTH SCIENCES CENTER DETROIT MI
|
| The aim of the research program we are developing is to define molecular markers and their interaction with other risk factors as risk indicators for development of breast cancer among women with benign breast disease (BBD). Our specific aims are: (1) Estimate the incidence and time span of breast cancer development in a large cohort of African American and Caucasian women with biopsy-proven BBD; (2) Collect and archive in a ... |
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| High Fidelity Electronic Display of Digital Mammographs |
OCT 1997 |
33 pages |
| Authors:
Michael J. Flynn; HENRY FORD HEALTH SCIENCES CENTER DETROIT MI
|
| We are investigating photoemissive structures which can achieve the required display performance of digital mammography. A thin glass faceplate supported by a glass microcapillary array is being studied. The objectives of this project we are modeling the performance , constructing a test fixture, designing an emissive structure, and obtaining preliminary experimental data. We are investigating photoemissive structures which can achieve the required display performance of digital mammography. A thin glass ... |
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