| Determination of the Role of Estrogen Receptors and Estrogen Regulated Genes in B cell Autoreactivity. Addendum |
Jul 2012 |
32 pages |
| Authors:
Betty Diamond; FEINSTEIN INST FOR MEDICAL RESEARCH MANHASSET NY
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 | Systemic lupus erythematosus is an autoimmune disease that occurs preferentially in women. We have developed a murine model in which BALB/c non-spontaneously autoimmune mice harbor a transgene encoding the heavy chain of an anti-DNA antibody. Using this model, we have shown that B cell expression of the estrogen receptor (ER) mediates an estrogeninduced loss of B cell tolerance. This occurs through a reduced B cell receptor (BCR) signal strength in ... |
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| Determination of the Role of Estrogen Receptors and Estrogen Regulated Genes in B Cell Autoreactivity |
Jul 2011 |
32 pages |
| Authors:
Betty Diamond; FEINSTEIN INST FOR MEDICAL RESEARCH MANHASSET NY
|
| Systemic lupus erythematosus is an autoimmune disease that occurs preferentially in women. We have developed a murine model in which BALB/c non-spontaneously autoimmune mice harbor a transgene encoding the heavy chain of an anti-DNA antibody. Using this model, we have shown that B cell expression of the estrogen receptor (ER) mediates an estrogen-induced loss of B cell tolerance. This occurs through a reduced B cell receptor (BCR) signal strength in ... |
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| Treatment of TBI and Concomitant Hemorrhage with Ghrelin |
Jul 2011 |
10 pages |
| Authors:
Rongqian Wu; Lei Qi; Xioaxuan Cui; FEINSTEIN INST FOR MEDICAL RESEARCH MANHASSET NY
|
| Novel therapeutic advances in the field of trauma management depend upon animal models that can accurately predict the clinical efficacy of interventions. In the battlefield, traumatic brain injury (TBI) and hemorrhagic shock often occur concomitantly due to multiple injuries. In this project, we determined the long-term effect of ghrelin, a 'gut-brain' hormone, in a highly military relevant experimental rat model of TBI combined with uncontrolled hemorrhagic shock. Our results showed ... |
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| Induction of a Pregnancy-Like Mammary Gland Differentiation by Docosapentaenoic Omega-3 Fatty Acid |
SEP 2010 |
24 pages |
| Authors:
Eric Y. Shi; FEINSTEIN INST FOR MEDICAL RESEARCH MANHASSET NY
|
| The protective effect of early pregnancy against breast cancer can be attributed to the transition from undifferentiated cells in the nulliparous to the differentiated mature cells during pregnancy. Considerable evidences suggest strongly that the n-3 polyunsaturated fatty acid (PUFA) content of adipose breast tissue is inversely associated with an increased risk of breast cancer. Here we report that there was a decrease in n-6/n-3 PUFA ratio and a significant increase ... |
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| Treatment of TBI and Concomitant Hemorrhage with Ghrelin |
Jul 2010 |
11 pages |
| Authors:
Rongqian Wu; FEINSTEIN INST FOR MEDICAL RESEARCH MANHASSET NY
|
| TBI and hemorrhagic shock, the most common causes of trauma deaths, often occur concomitantly due to multiple injuries. Hemorrhagic shock markedly exacerbates secondary damage in the traumatically injured brain and doubles TBI mortality. Therefore, a therapeutic intervention to treat posttraumatic hypotension and prevent secondary ischemia would be a powerful tool to improve outcome after brain injury. Ghrelin is a ?gut-brain? hormone mostly produced by the stomach. In this project, we ... |
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| Determination of the Role of Estrogen Receptors and Estrogen Regulated Genes in B Cell Autoreactivity |
Jul 2010 |
9 pages |
| Authors:
Betty Diamond; FEINSTEIN INST FOR MEDICAL RESEARCH MANHASSET NY
|
| Systemic lupus erythematosus (SLE) is an autoimmune disease that occurs preferentially in women. In murine models of SLE, it is clear that increased or sustained high physiologic levels of estradiol can accelerate onset of disease and exacerbate disease severity. We have shown that estradiol alters B cell maturation in vivo but does so in a genetically restricted fashion. We have also shown that estradiol can act directly on B cells ... |
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| Induction of a Pregnancy-Like Mammary Gland Differentiation by Docosapentaenoic Omega-3 Fatty Acid |
SEP 2009 |
23 pages |
| Authors:
Eric Y. Shi; FEINSTEIN INST FOR MEDICAL RESEARCH MANHASSET NY
|
| The protective effect of early pregnancy against breast cancer can be attributed to the transition from undifferentiated cells in the nulliparous to the differentiated mature cells during pregnancy. Considerable evidences suggest strongly that the n-3 polyunsaturated fatty acid (PUFA) content of adipose breast tissue is inversely associated with an increased risk of breast cancer. Here we report that there was a decrease in n-6/n-3 PUFA ratio and a significant increase ... |
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| Determination of the Role of Estrogen Receptors and Estrogen Regulated Genes in B Cell Autoreactivity |
Jul-2009 |
16 pages |
| Authors:
Betty Diamond; FEINSTEIN INST FOR MEDICAL RESEARCH MANHASSET NY
|
| Systemic lupus erythematosus (SLE) is an autoimmune disease that occurs preferentially in women. In murine models of SLE, it is clear that increased or sustained high physiologic levels of estradiol can accelerate onset of disease and exacerbate disease severity. We have shown that estradiol alters B cell maturation in vivo but does so in a genetically restricted fashion. We have also shown that estradiol can act directly on B cells ... |
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| Determination of the Role of Estrogen Receptors and Estrogen Regulated Genes in B Cell Autoreactivity |
Jul 2008 |
14 pages |
| Authors:
Betty Diamond; FEINSTEIN INST FOR MEDICAL RESEARCH MANHASSET NY
|
| Systemic lupus erythematosus (SLE) is an autoimmune disease that occurs preferentially in women. In murine models of SLE it is clear that increased or sustained high physiologic levels of estradiol can accelerate onset of disease and exacerbate disease severity. We have shown that estradiol alters B cell maturation in vivo but does so in a genetically restricted fashion. We have also shown that estradiol can act directly on B cells ... |
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| Stimulation of Estrogen Receptor Signaling in Breast Cancer by a Novel Chaperone Synuclein Gamma |
JUN 2007 |
35 pages |
| Authors:
Y. E. Shi; FEINSTEIN INST FOR MEDICAL RESEARCH MANHASSET NY
|
| The association between SNCG expression and the progression of steroid dependent cancers of breast and ovary promoted us to investigate the role of SNCG in regulation of ERalpha. SNCG strongly stimulated the ligand-dependent transcriptional activity of ERalpha in breast cancer cells. A notable finding relevant to this study is that SNCG acting as a chaperone for ER strongly stimulated the ligand-dependent transcriptional activity of ERalpha ligand-dependent cell growth and ligand-dependent ... |
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| Anti-HMGB1 Antibodies and Alpha-7 Agonists as Experimental Therapeutics as BW Countermeasures |
10 NOV 2006 |
4 pages |
| Authors:
Kevin Tracey; FEINSTEIN INST FOR MEDICAL RESEARCH MANHASSET NY
|
| Biological warfare agents cause lethality by activating systemic inflammation. After infection, cells of the innate immune system, including macrophages release soluble factors like TNF, HMGB1 in addition to other proinflammatory cytokines that cause shock and widespread tissue injury. We originally identified a cytokine role for HMGB1, a protein known previously as a transcription factor, and have since focused our efforts on studying the role of this mediator in the pathogenesis ... |
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| Stimulation of Estrogen Receptor Signaling in Breast Cancer by a Novel Chaperone Synuclein Gamma |
JUN 2006 |
10 pages |
| Authors:
Y. E. Shi; FEINSTEIN INST FOR MEDICAL RESEARCH MANHASSET NY
|
| The association between SNCG expression and the progression of steroid dependent cancers of breast and ovary promoted us to investigate the role of SNCG in regulation of ERalpha. SNCG strongly stimulated the ligand-dependent transcriptional activity of ERalpha in breast cancer cells. A notable finding relevant to this study is that SNCG, acting as a chaperone for ER, strongly stimulated the ligand-dependent transcriptional activity of ERalpha, ligand-dependent cell growth, and ligand-dependent ... |
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