This contract effort focused on the development of an automated, cartridge-based genotyping system that integrates a multiplex polymerase chain reaction (PCR) assay with a semiconductor microarray that uses electrochemical detection to identify biothreat agents. The DX-100 Genotyping Cartridge System has three subcomponents: a disposable cartridge, the cartridge processing instrument, and a personal computer. The alpha prototype is compact and solid state (no optics) and has a simple three step operation: ...
The funded proposal had several objectives. The first objective is to expand the fabrication and utilization of large arrays of individually addressable, nanometerscale ultramicroelectrodes (nanodes). The second objective was to expand on the current suite of immunochemical assays that can be monitored by electrochemical, visible, or fluorescent means for a wide range of chemical and biological warfare agents. Thirdly, we were to determine if various particle size (viral, spore, cell) ...
The phase I SBIR grant had two primary objectives. The first objective was to demonstrate the fabrication of large arrays of individually addressable, nanometerscale ultramicroelectrodes (nanodes). The second objective was to develop model immunochemical assays that can be monitored by electrochemical means for a wide range of chemical and biological warfare agents. Attaining these technical objectives would demonstrate the feasibility of using integrated circuit sensor devices for multiplexed assays. We ...
Reports by Corporate Author
