| An Experimental System to Evaluate LOH in Prostate Cancer |
JUL 2004 |
12 pages |
| Authors:
William M. Strauss; COLORADO UNIV AT BOULDER
|
 | The goal of this grant is to establish a new biological system for studying the progression of prostate cancer. We propose a technology we have previously developed to help define X-chromosome inactivation to increase our understanding of the molecular biology of prostate cancer. Using a mouse model, our goal is to induce functional Loss of Heterozygosity (LOH) on a particular chromosome at various specified time during development or life span. ... |
|
| Internal Consistency of Meteorological Data Obtained with a Volume- Imaging, Multi-Receiver Radar Wind Profiler |
26 MAY 2004 |
6 pages |
| Authors:
Andreas Muschinski; COLORADO UNIV AT BOULDER
|
| The main goals of this project ("Internal consistency of meteorological data obtained with a volume-imaging, multi-receiver radar wind profiler) were (1) to identify as clearly as possible the mathematical relationships between radar wind profiler (RWP) signals and the turbulent atmospheric field in the radar resolution volume; and (2) to develop dynamical and other conservation equations for those properties of the turbulence field that we identify in Part (1). The mathematical ... |
|
| Incidence of Development Impact Fees: Theory and Evidence |
23 JAN 2004 |
139 pages |
| Authors:
Phillip D. Prosseda; COLORADO UNIV AT BOULDER
|
| This dissertation investigates the incidence of development impact fees from both a theoretical and empirical perspective. A model of two communities with existing immobile residents and open land for new residents is developed. New residents may choose to live in either community and do so to maximize utility. The Pareto efficient and competitive outcomes are characterized and conditions for an efficient outcome under competition are established. The properties of the ... |
|
| Pentachlorophenol Hydroxylase: Analysis of Catalytic Abilities and Evolution of a Better Enzyme |
19 JAN 2004 |
4 pages |
| Authors:
Shelley D. Cople; COLORADO UNIV AT BOULDER
|
| Sphingobium chlorophenolicum is a Gram-negative soil bacterium that can mineralize pentachlorophenol (PCP), although degradation is slow and the bacterium cannot tolerate high levels of PCP. The rate of degradation is limited by the first enzyme in the pathway, PCP hydroxylase, which is a very poor catalyst. We have used DNA shuffling to produce mutant enzymes with modestly improved catalytic activities. We discovered that the reason for our limited success was ... |
|
| State-to-State Thermal/Hyperthermal Collision Dynamics of Atmospheric Species |
09 JAN 2004 |
10 pages |
| Authors:
David J. Nesbitt; COLORADO UNIV AT BOULDER
|
| Direct absorption IR laser methods developed under AFOSR support have been used to study state-to-state reactive scattering dynamics under single collision conditions. Efforts over this past granting period have led to significant progress in several areas: i) H atom abstraction dynamics in prototypic atom + diatom (e.g. X + HD --> Hx(v,J) + atom + triatom (e.g. X + H2O --> Hx(v,J) + OH(v,N)) and atom + polyatom (e.g. X ... |
|
| Ultrafast Soft X-Ray Laser Probing of Core Level Molecular Dynamics |
15 DEC 2003 |
13 pages |
| Authors:
Stephen R. Leone; Veronica M. Bierbaum; COLORADO UNIV AT BOULDER
|
| This research program explores time-resolved dynamics of molecular systems using femtosecond core level photoelectron spectroscopy. Ultrafast soft x-ray laser pump/probe studies reveal time-dependent binding energies and atomic core level-shifts in the molecules during chemical rearrangements by detecting the changes in photoelectron spectra as a function of internuclear separation in dissociative states in real time. A new apparatus introduces high order harmonics of a laser in the soft x-ray region of ... |
|
| Selection of Aptamers for CED-9/Bc1-2 Family Cell Death Regulators and Their Application in Study of Apoptosis Regulation and Drug Design for Breast Cancer |
JUL 2003 |
13 pages |
| Authors:
Ding Xue; COLORADO UNIV AT BOULDER
|
| Programmed cell death (apoptosis) plays an essential role in maintaining the physiological balance of appropriate cell numbers by opposing uncontrolled cell proliferation. The pathway of programmed cell death appears to be highly conserved from C. elegans to humans, suggesting that studies of programmed cell death in C. elegans can provide important information for understanding how cell death is regulated and executed in humans. Moreover, novel means developed in C. elegans ... |
|
| Breast Cancer Therapeutics, Environmental Estrogens, and the Estrogen Receptor (ER); Characterization of the Diverse Ligand Binding Properties of the ER |
JUL 2003 |
29 pages |
| Authors:
Deborah S. Wuttke; COLORADO UNIV AT BOULDER
|
| The estrogen receptor (ER) is found in the nucleus of several tissues, including breast, bone, liver, the organs of the reproductive system, and the cardiovascular system. The ER binds several types of compounds, including compounds that are quite distinct form its natural ligand. Estrogens bind to and activate the ER, which leads to the stimulation of transcription of genes containing an estrogen responsive element (ERE). Antiestrogens and partial antiestrogens bind ... |
|
| An Experimental System to Evaluate LOH in Prostate Cancer |
JUL 2003 |
13 pages |
| Authors:
William M. Strauss; COLORADO UNIV AT BOULDER
|
| The goal of this grant is to establish a new biological system for studying the progression of prostate cancer. We propose a technology we have previously developed to help define X-chromosome inactivation to increase our understanding of the molecular biology of prostrate cancer. Using a mouse model, our goal is to induce functional Loss of Heterozygosity (LOH) on a particular chromosome at various specified times during development or life span. ... |
|
| Real-Time Measurements of Reactive Chlorine and Carbon Dioxide in Rocket Plumes |
23 APR 2003 |
27 pages |
| Authors:
Darin W. Toohey; COLORADO UNIV AT BOULDER
|
| The objectives of this work were to measure reactive chlorine (Cl, ClO, and Cl2O2) and carbon dioxide (CO2) and to examine the mechanisms of ozone loss in the plumes of various rockets as part of an ongoing investigation of the impacts of rocket emissions on stratospheric ozone. This work has demonstrated that ozone losses in rocket plumes proceed at rates that can be explained by standard' ozone loss chemistry involving ... |
|
| State-to-State Thermal/Hyperthermal Collision Dynamics of Atmospheric Species |
30 JAN 2003 |
15 pages |
| Authors:
David J. Nesbitt; COLORADO UNIV AT BOULDER
|
| Direct absorption IR laser methods developed under AFOSR support have been used to study state-to-state reactive scattering dynamics under single collision conditions. Efforts over this past year have led to significant progress in several areas: i) H atom abstraction dynamics in prototypic atom+diatom (e.g. X+HD->HX(v,J)+D), atom+triatom (e.g. X+H2O->HX(v,J)+OH(v,N) and atom+polyatom (e.g. X+CH3-CH3) reaction systems; ii) application of novel slit discharge concentration modulation methods for ultrasensitive IR laser based detection of ... |
|
| Stratospheric Laser Propagation |
OCT 2002 |
4 pages |
| Authors:
Robert R. Beland; COLORADO UNIV AT BOULDER
|
| The University of Colorado simulated the evolution of the twopoint coherence function of a plane wave propagating through globally intermittent turbulence. The specific parameters of the probability-density function used were taken from stratospheric experiments. The contractor found that including the large-scale variability of the inner scale requires to carefully define the non- intermittent case. The results show that the coherence of propagation through intermittency, which is known to be strictly ... |
|
| Moral and Legal Issues Surrounding Terminal Sedation and Physician Assisted Suicide |
23 SEP 2002 |
105 pages |
| Authors:
Constance R. Bradley; COLORADO UNIV AT BOULDER
|
| Assisted suicide has been an issue for terminally ill patients for many years. This is because patients who suffer from terminal illnesses are forced to make difficult choices at the end of their lives. Currently, a terminally ill patient has three options in dealing with the extreme physical pain of his or her illness. First, he or she can choose being heavily medicated, which alleviates pain but significantly reduces awareness. ... |
|
| Three Corner Satellite |
SEP 2002 |
38 pages |
| Authors:
Elaine Hansen; Dave Beckwith; Brian Egaas; Steve Levin- Stankevich; Jennifer Michels; COLORADO UNIV AT BOULDER
|
| As part of the overall Three Corner Satellite (3CS) project within the University Satellite Program, the development and testing of the science Imaging System and the End-to-End Data System (EEDS) were undertaken at the University of Colorado in conjunction with team members from Arizona and New Mexico. This report describes the overall satellite project and the details of the development of the Imaging System and the EEDS. The Three Corner ... |
|
| Political Shocks and Abnormal Returns During the Taiwan Crisis: An Event Study Analysis |
15 AUG 2002 |
61 pages |
| Authors:
Geoffrey M. Steeves; COLORADO UNIV AT BOULDER
|
| The size and significance of a political shock's impact on financial markets is seldom fully understood. Often the effects of a shock are underestimated, affecting markets more significantly than expected. Likewise, these event's impacts can be overestimated, a phenomenon perhaps perpetuated by the media, which may cause people to view a political shock as more severe than it might be otherwise. Focusing on the 1996 Taiwan Crisis, by means of ... |
|
| Understanding Single-Stranded Telomere End Binding by an Essential Protein |
AUG 2002 |
75 pages |
| Authors:
Emily M. Anderson; Deborah S. Wuttke; COLORADO UNIV AT BOULDER
|
| Cdcl3p is an essential protein from S. cerevisiae that binds to the single-stranded ends of telomeres with high specificity and affinity. Cdcl3p perform functions in concert with two protein complexes - protecting the end of the chromosome from degradation and regulating telomere length through the enzyme telomerase. Cdcl3p binds yeast single-stranded telomeric DNA (sstelo DNA) in vitro with high affinity (K(sub d)=0.3 nM). The modular DNA-binding domain of the protein ... |
|
| Breast Cancer Therapeutics, Environmental Estrogens, and the Estrogen Receptor (ER); Characterization of the Diverse Ligand Binding Properties of the ER |
JUL 2002 |
15 pages |
| Authors:
Deborah S. Wuttke; COLORADO UNIV AT BOULDER
|
| The estrogen receptor (ER) is found in the nucleus of several tissues, including breast, bone, liver, the organs of the reproductive system, and the cardiovascular system. The ER binds several types of compounds, including compounds that are quite distinct from its natural ligand. Estrogens bind to and activate the ER, which leads to the stimulation of transcription of genes containing an estrogen responsive element (ERE). Antiestrogens and partial antiestrogens bind ... |
|
| Selection of Aptamers for CED-9/Bcl-2 Family Cell Death Regulators and Their Application in Study of Apoptosis Regulation and Drug Design for Breast Cancer |
JUL 2002 |
9 pages |
| Authors:
Ding Xue; Chonglin Yang; Berry Hatton; COLORADO UNIV AT BOULDER
|
| A central issue in cancer biology is how a tissue maintains appropriate cell numbers. Apoptosis plays an essential role in controlling cell numbers by inducing the deaths of extra cells. The Bcl-2 family proteins are conserved apoptosis regulators. Overexpression of bcl-2 can cause B-cell lymphoma and likely other human cancers, including breast cancer. How Bcl-2 family proteins act to regulate apoptosis is poorly understood. The major goal of this project ... |
|
| Photoelectron Spectroscopy and Dynamics of Adsorbates on Clusters |
30 JUN 2002 |
7 pages |
| Authors:
Wiiliam C. Lineberger; COLORADO UNIV AT BOULDER
|
| A simple sputter source of thermal silicon carbide cluster anions has been developed and tested. Vibrationally resolved photoelectron spectra have been obtained for a number of anions of the form Si(sub n)C(sub m(-)), with n + m <- 8. Full interpretation of the spectra requires accurate calculation of the anion structure, carried out in collaboration with Gordon (ISU) and Burggraf (AFIT). The first fully analyzed spectra and calculations for asymmetric ... |
|
| Parallel Fabrication and Optoelectronic Characterization of Nanostructured Surfaces |
30 JUN 2002 |
6 pages |
| Authors:
Kenneth Douglas; Thomas A. Winningham; COLORADO UNIV AT BOULDER
|
| Among the more notable accomplishments during the course of this contract we identify the following results: (1) We have used diblock copolymers to transfer nanoscale periodic patterns to substrates. The nanopatterns have been transferred both in the form of etched holes and in arrays of metal dots. This has been performed without the need for silicon nitride layers or multi- layered resists. (2) We have conducted experiments using a closed-loop ... |
|
| Ultrafast Laser Studies of Molecular Rydberg Wave Packets |
24 JUN 2002 |
4 pages |
| Authors:
Stephen R. Leone; COLORADO UNIV AT BOULDER
|
| Wave packet preparation and probing is investigated in molecules, with particular emphasis on the formation of Rydberg wave packets. A new apparatus has been developed to investigate Rydberg state excitation with ultrafast lasers. It consists of an ultrafast laser system, a cw dye laser for launch state preparation, and an electron time of flight spectrometer. Three photon plus one photon two-color photoionization of Kr has been achieved, with apparent resulting ... |
|
| Global Media and Public Affairs Communications in a New Era of Defense: The War Against Terrorism |
02 APR 2002 |
176 pages |
| Authors:
Michele M. Tasista; COLORADO UNIV AT BOULDER
|
| The Sept. 11, 2001, terrorist attacks and subsequent conflict in Afghanistan culminated a 30-year escalation of terrorism and efforts to counter it, an undeclared war that has unfolded principally on the information battlefield. Though terrorists habitually denounce the elements of modernity and globalization, they manipulate the transnational media to commit and communicate their violence and virulent rhetoric. This qualitative study considers the information battle field in the war against terrorism ... |
|
| Vertical Coupling and Variability in the Tropical Atmosphere/Ionosphere System |
31 MAR 2002 |
5 pages |
| Authors:
Jeffrey M. Forbes; COLORADO UNIV AT BOULDER
|
| The main objective of this research was to understand the processes that dynamically couple the troposphere at equatorial tropical latitudes with the overlying thermosphere-ionosphere. and identify those aspects of ionospheric variability which may be directly attributable to these processes. Using a combination of data analyses and numerical simulations, a new understanding of the excitation mechanisms, propagation characteristics, and lower thermosphere perturbations relating to tropospherically-excited Kelvin waves and nonmigrating tides has ... |
|
| Developing and Understanding Methods for Large Scale Nonlinear Optimization |
DEC 2001 |
7 pages |
| Authors:
Robert B. Schnabel; Richard H. Byrd; COLORADO UNIV AT BOULDER
|
| Our main activity in this grant has been the development and testing of techniques for solving global optimization problems for determining the structure of proteins and polymers. The problem is to find the lowest energy configuration of a protein or other polymer. This problem is a global optimization problem because it has a huge number of local minimizers. In addition, locating the lowest (global) minimizer is very difficult. For proteins, ... |
|
| Short Period Group Velocity Measurements and Maps in Central Asia |
Oct 2001 |
13 pages |
| Authors:
A L Levshin; M H Ritzwoller; M P Barmin; J L Stevens; COLORADO UNIV AT BOULDER
|
| The purpose of this study is to improve group velocity maps designed to advance the detection and discrimination capabilities for the area encompassed by western China, northern India, and Pakistan. These maps may be used to construct sharply tuned phase-matched filters for extracting weak surface wave signals from background noise and to make better estimates of surface wave spectral magnitudes for small events. We are working now to obtain a ... |
|
| Validation and Generation of Reference Events by Cluster Analysis |
Oct 2001 |
11 pages |
| Authors:
E R Engdahl; Eric A Bergman; COLORADO UNIV AT BOULDER
|
| High-resolution cluster analysis (multiple-event relocation) of earthquakes and other seismic sources is developed as a tool for assembling catalogs of reference events, especially those whose locations can be determined with an accuracy of 5 km or better [Ground Truth (GT) 5]. We use the Hypocentroidal Decomposition (HDC) method of Jordan and Sverdrup (1981), which is well suited to the rigorous statistical analysis required for this task. Candidate reference events typically ... |
|
| Capturing Uncertainties in Source-Specific Station Corrections Derived from a 3-D Model |
Oct 2001 |
10 pages |
| Authors:
N M Shapiro; M H Ritzwoller; M P Barmin; P B Weichman; L F Tenorio; W C Navidi; COLORADO UNIV AT BOULDER
|
| Uncertainties in Source-Specific Station Corrections (SSSCs) arise from several sources. If the SSSCs are constructed directly from empirical travel times, there are errors caused by origin time and hypocenter location errors, measurement errors, and phase misidentification. If a 3-D model is used either to interpolate an empirical surface or to compute the SSSC directly, then uncertainties in the 3-D model will also introduce errors in the SSSC. In order to ... |
|
| Understanding Single-Stranded Telomere End Binding by an Essential Protein |
AUG 2001 |
14 pages |
| Authors:
Emily Anderson; COLORADO UNIV AT BOULDER
|
| Telomeres are the nucleoprotein structures that cap the ends of eukaryotic chromosomes. Telomere length is controlled by the enzyme telomerase and a suite of telomere binding proteins. Anomalous telomeric replication and regulation are implicated in most forms of cancer, while telomeric shortening contributes to cellular aging. Cdc13p is an essential protein from S. cerevisiae that binds to the single-stranded ends of telomeres with high specificity and affinity. Genetically, Cdc13p has ... |
|
| Breast Cancer Therapeutics, Environmental Estrogens, and the Estrogens Receptor (ER); Characterization of the Diverse Ligand Binding Properties of the ER |
JUL 2001 |
21 pages |
| Authors:
Deborah S. Wuttke; COLORADO UNIV AT BOULDER
|
| The estrogen receptor (ER) is found in the nucleus of several tissues, including breast, bone, liver, the organs of the reproductive system, and the cardiovascular system. The ER binds several types of compounds, including compounds that are quite distinct from its natural ligand. Estrogens bind to and activate the ER, which leads to the stimulation of transcription of genes containing an estrogen responsive element (ERE). Antiestrogens and partial antiestrogens bind ... |
|
| Collaborative Experiment for Pulsed Radar Visualization of Water Flow Paths in Snow |
22 DEC 2000 |
17 pages |
| Authors:
M. W. Williams; W. T. Pfeffer; M. Knoll; COLORADO UNIV AT BOULDER
|
| Movement of liquid water through snowpacks is one of the least understood aspects of snow hydrology Richter-Menge and Colbeck 1991. It has an important influence on the timing and magnitude of snowmelt hydrographs Caine 1992 and on biogeochemical and geomorphological processes Williams and Melack. 1989: Caine. 1995. Adapting more physically-based approaches to understand and model flow through a snowpack should permit wider applications of operational snowpack models to more sites ... |
|
| Ion and Neutral Dynamics of Ceramic Materials Formation and Atmospheric Chemistry |
27 NOV 2000 |
20 pages |
| Authors:
Stephen R. Leone; Veronica M. Bierbaum; COLORADO UNIV AT BOULDER
|
| An ultrafast x-ray laser system and experimental apparatus have been fully constructed, calibrated and characterized. A titanium sapphire ultrafast laser is tightly focused into a rare gas jet, where high harmonics of the laser are created. A single harmonic can be isolated with a grazing-incidence grating and focused on to a gaseous sample to induce photoionization. Ejected electrons are energy analyzed using a magnetic bottle time-of-flight spectrometer. Harmonics up to ... |
|
| Ion Dynamics Related to Hypersonics |
27 NOV 2000 |
17 pages |
| Authors:
Stephen R. Leone; Veronica M. Bierbaum; COLORADO UNIV AT BOULDER
|
| This research has focused on systems with particular relevance to atmospheric chemistry and combustion processes In particular, the mobilities of cluster ions drifting in helium and in nitrogen buffer gas have been measured and the rotational state dependent velocity distributions and rotational alignment of the molecular nitrogen cation have been characterized. The reaction dynamics of the vibrationally excited nitrogen cation have been probed for reactions ... |
|
| Natural Hazards Observer, Volume XXV No. 2, November 2000 |
NOV 2000 |
28 pages |
| Authors:
COLORADO UNIV AT BOULDER
|
| The Natural Hazards Research and Applications Information Center was founded to strengthen communication among researchers and the individuals and organizations concerned with mitigating natural disasters. The center is funded by the National Science Foundation, Federal Emergency Management Agency, National Oceanic and Atmospheric Administration, U.S. Geological Survey, U.S. Army Corps of Engineers, U.S. Environmental Protection Agency, U.S. Department of Transportation, U.S. Bureau of Reclamation, National ... |
|
| Mechanisms for Breast Cancer Cell Resistance to Doxorubicin and Solutions to Resistance and Side Effects |
OCT 2000 |
17 pages |
| Authors:
Tad H. Koch; COLORADO UNIV AT BOULDER
|
| The anthracyclines, doxorubicin and epidoxorubicin, continue to be important drugs for the treatment of breast cancer. Recent studies refocus attention to anthracycline-alkylation and crosslinking of DNA as important toxic events triggering cell death. The long term goals of the proposed research are to establish the mechanism for the crosslinking, to produce new mechanism-based anthracycline derivatives which will be active against resistant breast cancer, and to develop a delivery vehicles for ... |
|
| Genetic and Molecular Analysis of Suppressors of Ras Mutations |
SEP 2000 |
13 pages |
| Authors:
Dennis Eastburn; Derek Sieburth; COLORADO UNIV AT BOULDER
|
| RAS GENES ENCODE SMALL GTPase proteins, which when mutated, have been shown to result in breast cancer as well as cancers in a variety of other tissues. The study of Caenorhabditis elegans and other model systems has demonstrated that Ras is part of a conserved Ras/MAPK signaling pathway involved in many aspects of development and cell regulation. The C. elegans vulva is induced by an EGF like signal that activates ... |
|
| Estimates Of Pn And Sn Across Eurasia |
Sep 2000 |
11 pages |
| Authors:
Michael H Ritzwoller; Mikhail P Barmin; Anatoli L Levshin; Antonio Villasenor; E R Engdahl; COLORADO UNIV AT BOULDER
|
| As an intermediate step to producing a integrated P and S model of the crust and upper mantle beneath most of Eurasia to predict regional station specific travel time correction surfaces, we present maps of isotropic Pn and Sn velocities across Eurasia. These maps are constructed using a groomed version of the ISC/NEIC data that are described, in part, by Engdahl et al. (1998). The locations and origin times of ... |
|
| Identification and Validation of Reference Events Within the Area Being Regionally Monitored by IMS Stations in Asia and North Africa |
Sep 2000 |
8 pages |
| Authors:
E R Engdahl; Eric A Bergman; COLORADO UNIV AT BOULDER
|
| High-resolution cluster analysis is applied to explosions and earthquake sequences in Asia and North Africa for which one or more of the associated events is known to an accuracy of 5 km or better (GT5). In particular, we analyze phase data reported to the ISC and NEIC for the 1997 Ghaen-Birjand earthquake sequence in eastern Iran and the 1997 Jiashi swarm in western China. In both cases, reference event data ... |
|
| Isotropic and Nonisotropic Components of Earthquakes and Nuclear Explosions on the Lop Nor Test Site |
Sep 2000 |
10 pages |
| Authors:
A L Levshin; M H Ritzwoller; B G Bukchin; A Z Mostinsky; A A Egorkin; COLORADO UNIV AT BOULDER
|
| We test the hypothesis that the existence of an observable isotropic component of the seismic moment tensor can be used as a discriminant to distinguish nuclear explosions from shallow earthquakes. We do this by applying the method described by Bukchin et al., (2000) to a set of data recorded between 1990 and 1996 following events (seven nuclear explosions and three earthquakes) that occurred on the Lop Nor test site in ... |
|
| Understanding Single-Stranded Telomere End Binding by an Essential Protein |
AUG 2000 |
16 pages |
| Authors:
Emily Anderson; Deborah Wuttke; COLORADO UNIV AT BOULDER
|
| Telomeres are the nucleoprotein structures that protect the ends of eukaryotic chromosomes. Telomere length regulation is controlled by the enzyme telomerase and a suite of telomere binding proteins. Anomalous telomeric replication and regulation are implicated in most forms of cancer, while telomeric shortening contributes to cellular aging. Cdcl3p is an essential protein from S. cerevisiae that binds to the single-stranded ends of telomeres with high specificity and affinity. Genetically, Cdcl3p ... |
|
| Breast Cancer Therapeutics, Environmental Estrogens, and the Estrogen Receptor (ER); Characterization of the Diverse Ligand Binding Properties of the ER |
JUL 2000 |
8 pages |
| Authors:
Deborah Wuttke; COLORADO UNIV AT BOULDER
|
| The estrogen receptor (ER) is found in the nucleus of several tissues, including breast, bone, liver, the organs of the reproductive system, and the cardiovascular system. The ER binds several types of compounds, including compounds that are quite distinct from its natural ligand. Estrogens bind to and activate the ER, which leads to the stimulation of transcription of genes containing an estrogen responsive element (ERE). ... |
|
| Quasi-Optical Transceivers for Wireless Communications |
27 APR 2000 |
7 pages |
| Authors:
Zoya Popovic; COLORADO UNIV AT BOULDER
|
| During the duration of this award we have demonstrated the following: (1) the first quasi-optical bidirectional amplifier array; (2) the array was used in a communication system and shown to have improved performance related to multipath fading due to built-in angle diversity; (3) the first quasi-optical isolator with no ferrite components, operating at X-band; (4) a two-stage quasi- optical lens amplifier array with improved feed efficiency and a ... |
|
| Characterization of sur-2, a Novel Ras-Mediated Signal Transduction Component in C. elegans |
APR 2000 |
11 pages |
| Authors:
Andrew G. Spencer; COLORADO UNIV AT BOULDER
|
| Alterations in the cellular genome affecting the expression or function of genes controlling cell growth or differentiation are the mechanism underlying the genesis of all cancers. Human cancers often require mutations in genes called proto-oncogenes which mutate to oncogenes (or cancer genes). A subset of proto-oncogenes comprise the RAS signal transduction pathway. Vulval development in the nematode worm C. elegans is controlled by a RAS ... |
|
| Ceramic Coatings on Metals Using Atomic Layer Controlled Chemical Vapor Deposition (ASSERT-96) |
16 FEB 2000 |
9 pages |
| Authors:
Steven M. George; COLORADO UNIV AT BOULDER
|
| The ASSERT research projects that have focused on thin film growth on various substrates examined the adsorption and desorption kinetics of tetrakis and dimethylamine on TiN surfaces. The competition between TDMAYT and DMA for surface sites during TiN growth with TDMAT is a model system to understand reaction product inhibition that affects the conformal deposition of TiN. Studied the adsorption and decomposition of 1,4-disilabutane (DSB) and ... |
|
| Mechanisms for Breast Cancer Cell Resistance to Doxorubicin and Solutions to Resistance and Side Effects (97 Breast) |
OCT 1999 |
21 pages |
| Authors:
Tad Koch; COLORADO UNIV AT BOULDER
|
| Recent studies indicate that doxorubicin alkylates DNA through catalytic production of formaldehyde and utilization of formaldehyde for attaching itself to 0-bases. This discovery prompted the synthesis of anthracycline-formaldehyde conjugates as improved anti-tumor dmgs. The first conjugate, Doxoform, was equally toxic to both sensitive and resistant breast cancer cells but is predicted to be hydrolytically too unstable. The second conjugate, Epidoxoform, from reaction of epidoxorubicin with formaldehyde was synthesized and characterized ... |
|
| Meso-Optics Based WDM Receiver |
OCT 1999 |
8 pages |
| Authors:
Jon Sauer; COLORADO UNIV AT BOULDER
|
| The broad goal was to advance the state-of-the art in WDM receiver technology. The approach was to use microcavity resonators since they should enable devices to be very small, rapidly tunable, and with high optical performance characteristics. In order to achieve this goal, design tools -- Maxwell equation solvers -- needed to be developed capable of handling long time spans in complex, 3D geometries currently demonstrated ... |
|
| Genetic and Molecular Analysis of Suppressors of Ras Mutations |
OCT 1999 |
38 pages |
| Authors:
Derek Sieburth; COLORADO UNIV AT BOULDER
|
| The goal of this research is to understand the regulation of Ras- mediated signaling in C. elegans vulva! development. We describe the identification and characterization of a novel gene, sur-8, that functions to regulate a receptor tyrosine kinase-Ras-MAp kinase- mediated signal transduction pathway during C. elegans vulval development. Mutations in sur-8 were identified as suppressors of an activated let-60 ras mutation. Our genetic analysis indicates that ... |
|
| Oligosaccharide Markers for Prognosis of Low-Risk Breast Cancer |
SEP 1999 |
33 pages |
| Authors:
David Pettijohn; COLORADO UNIV AT BOULDER
|
| The general goal of this study was to determine if there are specific combinations of oligosaccharide markers on ductal breast carcinoma cells that are useful in predicting the post surgical prognosis of low-risk node-negative breast cancer patients. A related goal was to define the expression of relevant glycosyltransferase genes that control the expression of unusual tumor- associated oligosaccharides found on breast cancer cells. ... |
|
| Turbulent Dissipation in Frontal Zones from Hot-Wire Measurements in theMICROFRONTS Experiment |
SEP 1999 |
8 pages |
| Authors:
William Blumen; COLORADO UNIV AT BOULDER
|
| Measurements of turbulent dissipation of kinetic energy have been taken of synoptic and small scale density frontal passages during the MICROFRONTS (MARCH 1999, Kansas) field program. It is revealed that there is a significant increase of turbulent kinetic energy during each-passage of the frontal transition zone. Data analyses suggest a linear relationship between the frontal width and the enhanced kinetic energy dissipation rate. A theoretical ... |
|
| Automatic Construction of Accurate Models of Physical Systems |
18 AUG 1999 |
7 pages |
| Authors:
Elizabeth Bradley; COLORADO UNIV AT BOULDER
|
| System identification (SID) is the task of deducing the internal dynamics of a black box system solely from observations of its outputs. This is an essential first step in a variety of engineering problems; most traditional control theoretic methods, for example, require an accurate ordinary differential equation (ODE) model. Accuracy is not the only requirement, however; for efficiency reasons, engineers work hard to construct minimal models; ODEs that ignore unimportant ... |
|
| Developing and Understanding Methods for Large-Scale Nonlinear Optimization |
16 AUG 1999 |
8 pages |
| Authors:
Robert B. Schnabel; Richard H. Byrd; COLORADO UNIV AT BOULDER
|
| The most important contribution under this grant has been a vast improvement in the ability of large-scale global optimization methods to solve very difficult molecular configuration problems. The improvements are shown both in the size and in the complexity of the problems that can now be solved. At the beginning of this research period, we and others were just beginning to solve molecular cluster problems with up to hundreds of ... |
|
Reports by Corporate Author
