| Regulatory T Cells and Host Anti-CML Responses |
01-Jun-2008 |
9 pages |
| Authors:
Wong; K K Jr; CITY OF HOPE NATIONAL MEDICAL CENTER DUARTE CA
|
 | CD4+CD25+FoxP-3+ regulatory T-cells (Tregs) suppress immune responses to "self" antigens, but also have been shown to suppress host anti-tumor responses in several human malignancies, including breast, gastrointestinal, and ovarian cancer. Identification of CML Tregs as suppressors of host anti-CML responses could have a significant impact upon CML treatment strategies. Methods are currently available to selectively suppress Tregs, and subsequently boost host anti-CML responses. We have examined the CD4+CD25+FoxP-3+ regulatory T-cell ... |
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| Training Program in Breast Cancer Research |
OCT 2005 |
20 pages |
| Authors:
John Shively; CITY OF HOPE NATIONAL MEDICAL CENTER DUARTE CA
|
| The objective of the City of hope breast cancer training program is to develop a new generation of basic and clinical scientists trained to do research on breast cancer and its prevention. The program will draw predoctoral trainees from the CoH graduate school and post doctoral trainees from the basic sciences and clinical oncology disciplines at CoH. Those who show a genuine interest in breast cancer research, as determined by ... |
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| Training Program in Breast Cancer Research |
OCT 2004 |
15 pages |
| Authors:
John Shively; CITY OF HOPE NATIONAL MEDICAL CENTER DUARTE CA
|
| The objective of the City of hope breast cancer training program is to develop a new generation of basic and clinical scientists trained to do research on breast cancer and its prevention. The program will draw predoctoral trainees from the CoH graduate school and post doctoral trainees from the basic sciences and clinical oncology disciplines at CoH. Those who show-a genuine interest in breast cancer research, as determined by a ... |
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| Anti-Angiogenic Gene Therapy of Prostate Cancer with Lentiviral Vectors |
JUL 2004 |
12 pages |
| Authors:
Jiing-Kuan Yes; CITY OF HOPE NATIONAL MEDICAL CENTER DUARTE CA
|
| Tumor progression induces the growth of endothelial cells by releasing angiogenic factors. This is accompanied by down-regulation of local tissue inhibitors of endothelian cell proliferation such as angiostatin and endostatin. Both proteins target normal endothelial cells and effectively regress large tumors in animals. However, animal studies demonstrate that an effective treatment requires long-term administration of angiogenesis inhibitors. Thus, delivery of angiogenesis inhibitor genes to tumor sites should increase local concentration ... |
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| Anti-Angiogenic Gene Therapy of Prostate Cancer with Lentiviral Vectors |
JUL 2003 |
21 pages |
| Authors:
Jiing-Kuan Yee; CITY OF HOPE NATIONAL MEDICAL CENTER DUARTE CA
|
| Tumor progression induces the growth of endothelial cells by releasing angiogenic factors. This is accompanied by down-regulation of local tissue inhibitors of endothelian cell proliferation such as angiostatin and endostatin. Both proteins target normal endothelial cells and effectively regress large tumors in animals. However, animal studies demonstrate that an effective treatment requires long-&term administration of angiogenesis inhibitors. Thus, delivery of angiogenesis inhibitor genes to tumor sites should increase local concentration ... |
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| Training Program in Breast Cancer Research |
OCT 2002 |
16 pages |
| Authors:
Susan E. Kane; CITY OF HOPE NATIONAL MEDICAL CENTER DUARTE CA
|
| The objective of the City of Hope (COH) Breast Cancer Training Program is to develop a new generation of basic and clinical scientists trained to do research on breast cancer and its prevention. The Program will draw predoctoral trainees from the COH Graduate School and postdoctoral trainees from the basic sciences and clinical oncology disciplines at COH. Those who show a genuine interest in breast cancer research, as determined by ... |
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| Anti-Angiogenic Gene Therapy of Prostate Cancer With Lentiviral Vectors |
JUL 2002 |
34 pages |
| Authors:
Jiing-Kuan Yee; CITY OF HOPE NATIONAL MEDICAL CENTER DUARTE CA
|
| Tumor progression induces the growth of endothelial cells by releasing angiogenic factors. This is accompanied by down-regulation of local tissue inhibitors of endothelian cell proliferation such as angiostatin and endostatin. Both proteins target normal endothelial cells and effectively regress large tumors in animals. However, animal studies demonstrate that an effective treatment requires long-term administration of angiogenesis inhibitors. Thus, delivery of angiogenesis inhibitor genes to tumor sites should increase local concentration ... |
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| Training Program in Breast Cancer Research |
OCT 2001 |
17 pages |
| Authors:
Susan E. Kane; CITY OF HOPE NATIONAL MEDICAL CENTER DUARTE CA
|
| The objective of the City of Hope (COH) Breast Cancer Training Program is to develop a new generation of basic and clinical scientists trained to do research on breast cancer and its prevention. The Program will draw predoctoral trainees from the COH Graduate School and postdoctoral trainees from the basic sciences and clinical oncology disciplines at COH. Those who show a genuine interest in breast cancer research, as determined by ... |
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| Role of the Steroid and Xenobiotic Receptor (SXR) in Drug Resistant Breast Cancer |
OCT 2001 |
5 pages |
| Authors:
Susan E. Kane; CITY OF HOPE NATIONAL MEDICAL CENTER DUARTE CA
|
| The rationale for the work in this proposal was based on the observations that: 1) SXR, a recently-characterized member of the nuclear steroid receptor family, is expressed to varying degrees in normal and neoplastic breast tissues; 2) the anticancer agent Taxol acts as a ligand for SXR and can activate the transcriptional activity of SXR in the context of an SXR-reporter gene construct; 3) Taxol activation of SXR in primary ... |
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| Electrochemical Treatment of Breast Cancer with Direct Current |
JUN 1999 |
76 pages |
| Authors:
Nayana L. Vora; CITY OF HOPE NATIONAL MEDICAL CENTER DUARTE CA
|
| To test two hypotheses of using electrochemical treatment (EChT) for cancer therapy: (1) both anodes and cathodes should be inserted inside the tumor; (2) tumor responses are dependent on electrode spacing and dose. Rat breast cancers were initiated by injecting 1 x 10(exp 6) MTF-7 cells to the rat right mammary gland fat pad. Rats were randomly divided into experimental groups when the tumors were grown ... |
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| Nucleoprotein-Based Nanoscale Fabrication |
31 DEC 1998 |
5 pages |
| Authors:
Steven S. SMith; D. J. Baker; J. A. Wendel; A. Laayoun; L. Niu; D. S. Joy; CITY OF HOPE NATIONAL MEDICAL CENTER DUARTE CA
|
| We have provided a clear demonstration of each of the essential scientific principles governing this approach to macromolecular assembly. First, we have shown that the coupling reaction between methyltransferases and 5-FdC in DNA provides a mechanism for stable attachment of methyltransferases and chimeric methyltransferase fusion proteins in a pre-selected arrangement along a DNA molecule. In the course of this work we discovered that the FdC dramatically slows the rate of ... |
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| Electrochemical Treatment of Breast Cancer with Direct Current |
MAR 1998 |
23 pages |
| Authors:
Chung-Kwang Clou; CITY OF HOPE NATIONAL MEDICAL CENTER DUARTE CA
|
| Electrochemical treatment (ECT) of cancer is a promising new method which delivers direct current (dc) into tumor tissue by inserting electrodes (anodes and/or cathodes) to induce tumor regression. The purpose of this study is to evaluate the effectiveness of ECT and tissue responses to anode and cathode. Methods: (I) Tumor tissue responses to ECT: 1 x 10 rat breast cancer cells (MTF-7) were injected subcutaneously ... |
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| Performance Report on Grant N00014-90-J-1648 (City of Hope National Medical Center, Duarte, California) |
12 JUL 91 |
5 pages |
| Authors:
Thomas G. Burke; CITY OF HOPE NATIONAL MEDICAL CENTER DUARTE CA
|
| Research efforts during the past four months of this project have been concentrated in two areas: (1) testing of tripolyphosphate as a possible agent useful in optimizing the oxygen binding affinities of hemoglobin contained in liposome-encapsulated hemoglobin (LEH) and (2) the synthesis of LR16. As described in previous reports, the LR16 agents that we initially proposed to use to optimize the oxygen binding properties of LEH is capable of diffusing ... |
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| Evaluation of Liposome-Encapsulated Hemoglobin/LR16 Formulation as a Potential Blood Substitute |
15 MAR 91 |
6 pages |
| Authors:
Thomas G. Burke; CITY OF HOPE NATIONAL MEDICAL CENTER DUARTE CA
|
| During the last four months of our project entitled 'Evaluation of Liposome-Encapsulated Hemoglobin/LR16 Formulation as a Potential Blood Substitute', efforts have been made in the following four areas: (1) the resynthesis of LR16; (2) physical characterization of LEH/LR16 formulations; (3) design and development of membrane-impermeable LR16 analogues; and (4) preparations for small animal testing of surrogate blood preparations. The work completed in each of these areas is outlined below. ... |
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| Evaluation of Liposome-Encapsulated Hemoglobin/LR16 Formulation as a Potential Blood Substitute |
90 |
9 pages |
| Authors:
Thomas G. Burke; CITY OF HOPE NATIONAL MEDICAL CENTER DUARTE CA
|
| Reducing the oxygen affinity of liposome-encapsulated hemoglobin (LEH) to a physiologically useful range is a key step in the development of an LEH product that may potentially be used as a blood replacement fluid. Our approach to this challenge is a pharmacological one, that being the development of drug molecules capable of lowering the oxygen affinity of purified hemoglobin. In our initial proposal, we presented data which demonstrated the ability ... |
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| Animal Models for the Prevention of Acute and Chronic Graft-versus-Host Disease |
MAR 84 |
|
| Authors:
Michael T. Gallagher; Lawrence D. Petz; CITY OF HOPE NATIONAL MEDICAL CENTER DUARTE CA
|
 | These studies considered the effect on monoclonal antibodies to several T-cell differentiation antigens on graft-versus-host disease in a murine model of bone marrow transplantation. The monoclonal antibodies were used for in vitro treatment of bone marrow and/or spleen cells prior to transplantation and were also used to treat established graft-versus-host disease by in vivo injections. The results increase our understanding of transplantation biology and can form the basis for clinical ... |
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| Animal Models for the Prevention of Acute and Chronic Graft-vs-Host Disease |
SEP 82 |
|
| Authors:
Michael T. Gallagher; Lawrence D. Petz; CITY OF HOPE NATIONAL MEDICAL CENTER DUARTE CA
|
| One of the purposes of the work was to develop a better understanding of the mechanism whereby pre-treatment of a mixture of bone marrow and spleen cells (which are used in a murine model of bone marrow transplantation) with rabbit antisera against murine lymph node tissue could effect not only acute graft-versus-host disease mortality but also chronic graft-versus-host disease mortality. The second major objective of the research was to evaluate ... |
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| Blood Preservation Study |
30 APR 1979 |
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| Authors:
E. Beutler; CITY OF HOPE NATIONAL MEDICAL CENTER DUARTE CA
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| Although the 21 day shelf life of red cells stored in acid-citrate- dextrose or citrate-phosphate-dextrose solution represents a workable system for blood storage, it is unsatisfactory in three major respects: (1) A shelf life of only 21 days makes the stockpiling of blood impossible. (2) While blood is considered to be usable until the 21st day of storage, only about 70% of the red cells in 21 day-old units are ... |
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