| Non-invasive MR-guided HIFU Therapy of TSC-Associated Renal Angiomyolipomas |
Jul 2012 |
9 pages |
| Authors:
Yu Li; CHILDREN'S HOSPITAL MEDICAL CENTER CINCINNATI OH
|
 | This report is a summary of our first year's work on the proposed research. During this period, our effort was focused on technological development for thermal ablation in mice. Our goal was to establish a small-animal MR-guided HIFU experimental system that enables simultaneous HIFU ablation and MR guidance. This goal was achieved and our experimental results demonstrated the basic function of the experimental system in in-vitro studies. We have laid ... |
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| Early Prediction of Lupus Nephritis Using Advanced Proteomics |
Jun 2012 |
65 pages |
| Authors:
Prasad Devarajan; CHILDREN'S HOSPITAL MEDICAL CENTER CINCINNATI OH
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| The purpose of this project is to identify initial biomarker patterns in SLE nephritis using screening proteomic profiling. Utility of one of the biomarkers (NGAL) in predicting worsening of global and renal SLE disease activity has been validated. We have identified novel urinary biomarkers that distinguish between class IV and class V lupus nephritis, including albumin fragments and -1 acid glycoprotein(AGP) by 2D gel electrophoresis, transferrin (Tf), ceruloplasmin (Cp), lipocalin-type ... |
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| Regulation and Function of TIFAB in Myelodysplastic Syndrome |
Jun 2012 |
24 pages |
| Authors:
Daniel Starczynowski; CHILDREN'S HOSPITAL MEDICAL CENTER CINCINNATI OH
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| Myelodysplastic syndromes (MDS) are clonal bone marrow failure (BMF) disorders defined by blood cytopenias due to ineffective hematopoiesis, genomic instability, and a predisposition to acute myeloid leukemia (AML). The most commonly recurring genomic alteration in MDS is deletion of chromosome 5q (del(5q)). MDS patients with an isolated del(5q) presenting with anemia, neutropenia, and elevated platelets associated with dysplastic megakaryocytes are considered to have 5q- syndrome. The majority of MDS patients ... |
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| Genetics of Eosinophilic Esophagitis |
Mar 2012 |
36 pages |
| Authors:
Marc Rothenberg; CHILDREN'S HOSPITAL MEDICAL CENTER CINCINNATI OH
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| Eosinophilic esophagitis (EE) is an emerging worldwide food allergic disorder associated with polysensitization to multiple food allergens, resulting in greatly restricted diets and chronic gastroesophageal reflux disease-like symptoms in many individuals. EE has a strong genetic component based on the frequent presence of a familial inheritance pattern, the high sibling risk ratio (80-fold) and the demonstration that a single nucleotide polymorphism (SNP) in the eotaxin-3 gene confers disease susceptibility. In ... |
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| Genome-Wide Association Study in African-Americans With Systemic Lupus Erythematosus |
Sep 2011 |
5 pages |
| Authors:
John Harley; CHILDREN'S HOSPITAL MEDICAL CENTER CINCINNATI OH
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| Systemic lupus erythematosus is a potentially deadly systemic autoimmune disease that disproportionately afflicts women and African-Americans. This project is designed to discover genes that increase the risk of lupus in African-Americans. Our goal was to expand the genotyping density in African- Americans (2000 cases and 2000 controls) to increase the number and distribution of genetic markers tested. The genotyping on samples collected in Oklahoma and Birmingham is virtually complete. The ... |
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| Role of Foxm1 in the Pathogenesis of Prostate Cancer |
Jul 2011 |
14 pages |
| Authors:
Tanya Kalinichenko; CHILDREN'S HOSPITAL MEDICAL CENTER CINCINNATI OH
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| The main purpose of our work is to understand the role of Foxm1 in the development of prostate cancer, provide information about molecular mechanisms whereby Foxm1 controls epithelial cell proliferation during PCa, and determine whether the inhibition of Foxm1 may potentially be beneficial during PCa therapy, therefore leading to the development of the novel therapeutic target for prostate cancer chemotherapy. During the second year of grant support, we demonstrated that ... |
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| Genetics of Eosinophilic Esophagitis |
Mar 2011 |
33 pages |
| Authors:
Marc E Rothenberg; CHILDREN'S HOSPITAL MEDICAL CENTER CINCINNATI OH
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| Eosinophilic esophagitis (EE) is an emerging worldwide food allergic disorder associated with polysensitization to multiple food allergens, resulting in greatly restricted diets and chronic gastroesophageal reflux disease-like symptoms in many individuals. EE has a strong genetic component based on the frequent presence of a familial inheritance pattern, the high sibling risk ratio (80-fold) and the demonstration that a single nucleotide polymorphism (SNP) in the eotaxin-3 gene confers disease susceptibility. In ... |
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| Early Prediction of Lupus Nephritis Using Advanced Proteomics |
JUN 2010 |
13 pages |
| Authors:
Prasad Devarajan; CHILDREN'S HOSPITAL MEDICAL CENTER CINCINNATI OH
|
| The purpose of this project is to identify initial biomarker patterns in SLE nephritis using screening proteomic profiling, and advanced proteomic profiling. Subject recruitment has been completed (150 children with SLE, out of which 75 have lupus nephritis). Utility of one of the biomarkers (NGAL) in predicting worsening of global and renal SLE disease activity has been validated. We found 2 proteins significantly over-expressed in Class IV vs Class V ... |
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| Early Prediction of Lupus Nephritis Using Advanced Proteomics |
JUN 2009 |
24 pages |
| Authors:
Prasad Devarajan; CHILDREN'S HOSPITAL MEDICAL CENTER CINCINNATI OH
|
| The purpose of this project is to identify initial biomarker patterns in SLE nephritis using screening proteomic profiling, and advanced proteomic profiling. Subject recruitment has been completed (150 children with SLE, out of which 75 have lupus nephritis). Utility of one of the biomarkers (NGAL) in predicting worsening of global and renal SLE disease activity has been validated. We found 2 proteins significantly over-expressed in Class IV vs Class V ... |
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| Inhibition of Rac GTPases in the Therapy of Chronic Myelogenous Leukemia |
Apr-2009 |
56 pages |
| Authors:
Jose Cancelas; CHILDREN'S HOSPITAL MEDICAL CENTER CINCINNATI OH
|
| Chronic myelogenous leukemia (CML) is a clonal myeloproliferative disease (MPD) characterized by the expression of the p210-BCR/ABL fusion gene [1]. This gene is produced by the reciprocal translocation (9; 22) (q34; q11) that juxtaposes the 3end of Abelson leukemia virus (ABL) gene with the 5' end of the breakpoint cluster region (Bcr) gene on chromosome 22. The transcript formed as a result encodes for the BCR/ABL fusion protein with constitutively ... |
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| Early Prediction of Lupus Nephritis Using Advanced Proteomics |
Jun-2008 |
29 pages |
| Authors:
Prasad Devarajan; CHILDREN'S HOSPITAL MEDICAL CENTER CINCINNATI OH
|
| The survival with Systemic Lupus Erythematosus (SLE) is closely linked to the early detection of kidney disease, making the discovery of currently elusive renal biomarkers crucial for the prognosis of SLE. A well-defined cohort of patients with SLE (n=150), disease and healthy controls were assembled and followed-for up to 1.5 years. By surface-enhanced laser desorption time to flight mass spectrometry (SELDI-TOF-MS) and matrix enhanced various TOFMS, we discovered a set ... |
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| Inhibition of Rac GTPases in the Therapy of Chronic Myelogenous Leukemia |
01-Apr-2008 |
77 pages |
| Authors:
CHILDREN'S HOSPITAL MEDICAL CENTER CINCINNATI OH
|
| Chronic myelogenous leukemia (CML) is a clonal myeloproliferative disease (MPD) characterized by the expression of the p210-BCR/ABL fusion gene [1]. This gene is produced by the reciprocal translocation (9; 22) (q34; q11) that juxtaposes the 3 end of Abelson leukemia virus (ABL) gene with the 5 end of the breakpoint cluster region (Bcr) gene on chromosome 22. The transcript formed as a result encodes for the BCR/ABL fusion protein with ... |
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| A Novel Strategy to Control and Prevent Norovirus Gastroenteritis |
01 NOV 2006 |
8 pages |
| Authors:
Xi Jiang; Pengwei Huang; Xizhi Feng; Ming Tan; Weiming Zhong; Tibor Farkas; Ardythe L. Morrow; Scott Thornton; CHILDREN'S HOSPITAL MEDICAL CENTER CINCINNATI OH
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| Norovirus (NV) gastroenteritis is an important disease of all ages and populations, including the military. The disease is difficult to control due to its widespread nature and lack of a treatment. NVs recently have been found to recognize human histo-blood group antigens (HBGAs) as receptors. The human HBGA system is highly polymorphic; NVs also are genetically diverse. This presentation summarizes our studies on the unique interaction of NVs with human ... |
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| Targeting Breast Cancer Cells for Destruction |
01 JUL 2006 |
54 pages |
| Authors:
Jun Ma; CHILDREN'S HOSPITAL MEDICAL CENTER CINCINNATI OH
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| The long-term objective of our work is to understand the actions of existing anti-cancer drugs and to investigate concepts leading to the design of new drugs to eradicate breast cancer. One of our long-standing research interests is in understanding the molecular principles that govern biological specificities. We have been studying both protein-protein interactions and protein-DNA interactions through a battery of different approaches including molecular, genetic, biochemical and structural approaches. The ... |
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| National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. Diagnosis and Staging Working Group Report |
09 SEP 2005 |
13 pages |
| Authors:
Alexandra H. Filipovich; Daniel Weisdorf; Steven Pavletic; Gerard Socie; John R. Wingard; Stephanie J. Lee; PAUL MARTIN; Jason Chien; Donna Przepiorka; Daniel Couriel; CHILDREN'S HOSPITAL MEDICAL CENTER CINCINNATI OH
|
| This consensus document is intended to serve 3 functions. First, it standardizes the criteria for diagnosis of chronic graft-versus-host disease (GVHD). Second, it proposes a new clinical scoring system (0-3) that describes the extent and severity of chronic GVHD for each organ or site at any given time, taking functional impact into account. Third, it proposes new guidelines for global assessment of chronic GVHD severity that are based on the ... |
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| Assessment of the Activation State of Rho Family GTP-Binding Proteins in Breast Cancer Cells and Specimens |
AUG 2004 |
114 pages |
| Authors:
Yi Zheng; CHILDREN'S HOSPITAL MEDICAL CENTER CINCINNATI OH
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| Rho GTPases are known to play roles in various aspects of cancer development. To establish a causal link between activation of individual Rho GTPases and certain aspects of breast cancer, we have started to search for a functional association of Rho GTPases with mitogenic conditions and various physiological or pathological situations that may be connected to mammary cell transformation. As stated in this final report, we have established a method ... |
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| Ron in Breast Development and Cancer |
OCT 2003 |
12 pages |
| Authors:
Susan B. Waltz; CHILDREN'S HOSPITAL MEDICAL CENTER CINCINNATI OH
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| The long-term objective of this project is to define the in viva role of the receptor tyronsine kinase Ron in mammary gland biology. Virtually nothing is known regarding the function of Ron in the breast. However, two recent studies have shown the Ron is over- expressed and highly phosphorylated in a significant fraction of human and feline breast cancers. To define the in vivo significance of Ron, mice were generated ... |
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| Social and Emotional Functioning of Children With NF-1 and Their Families; A Case Controlled Study |
JUN 2001 |
5 pages |
| Authors:
Robert B. Noll; CHILDREN'S HOSPITAL MEDICAL CENTER CINCINNATI OH
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| The first objective of this work is to evaluate the social, emotional, and behavioral quality of life (QOL) of children with NF and explore potential linkages between NF and QOL in these 3 domains. The second objective of this work is to evaluate parental distress, family functioning, and child rearing practices. It is hypothesized that the social and emotional status of children with NF plays an important role in predicting ... |
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Reports by Corporate Author
