| Measurements of T2 of Electron Spins at Bound Donor Sites in Si:P |
17 NOV 2005 |
6 pages |
| Authors:
W. G. Clark; Karoly Holczer; Stuart Brown; Eli Yablonovitch; CALIFORNIA UNIV LOS ANGELES
|
 | The goal of the project was to establish the limitations on the transverse spin relaxation of bound donors in dilute semiconductors, in particular in Si:P. The experiments were undertaken in two steps, first using the existing pulsed EPR spectrometer in Prof. Holczer's laboratory, and then extending to longer times after obtaining an upgrade in hardware from Bruker Biospin Corporation. |
|
| Development of STEAP-Based Vaccines for the Treatment of Prostate Cancer |
NOV 2005 |
19 pages |
| Authors:
Maria Garcia-Hernandez; CALIFORNIA UNIV LOS ANGELES
|
| Six-Transmembrane Epithelial Antigen of the Prostate (STEAP) has been considered an attractive target, because it is overexpressed in human prostate cancer tissues. Recently two hSTEAP peptides have been selected for their capacity to bind and stabilize HLA-A*0201 molecules. In addition peptide-specific human CTL cell lines recognized hSTEAP-expressing cells, lysing them. These findings suggest that STEAP is a promising antigen for tumor immunotherapy. In this study we determined the effectiveness of ... |
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| SMAD-Mediated Signaling During Prostate Growth and Development |
OCT 2005 |
10 pages |
| Authors:
Charles F. Shuler; Nobuyuki Shiomi; Sharon Stewart; CALIFORNIA UNIV LOS ANGELES
|
| The binding of TGF-Beta family molecules to their receptors on the surfaces of cells initiates a signaling pathway within the cells. The Smad family of molecules mediates the propagation of the intracellular signal from the receptor for TGF-Beta. Two different Smad molecules are essential to propagating this signal, Smad 2 and Smad 3. It has been shown that Smad 2 expression is altered in prostate cancer and adult normal prostate ... |
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| Interrogating Androgen Receptor Mediated Gene Expression and Tumor Progression by Molecular Imaging |
OCT 2005 |
74 pages |
| Authors:
Michael F. Carey; CALIFORNIA UNIV LOS ANGELES
|
| This final report summarizes our work on the effectiveness of a new adenovirus based optical imaging vector designed to detect MAP kinase levels in living subjects. The vector was injected into human tumors implanted into SCID mice. Animals were injected with D-luciferin and imaged in a Xenogen IVIS device. The vector was able to detect enhanced MAPK levels stimulated by Epidermal Growth Factor in prostate cancer tumors of xenograft animals. ... |
|
| The Mechanistic Role of Iodine in Breast Carcinogenesis |
OCT 2005 |
13 pages |
| Authors:
Keisuke S. Iwamoto; CALIFORNIA UNIV LOS ANGELES
|
| There is both considerable interest and ignorance in the possible role of iodine in the etiology and prognosis of breast cancer. This project is the first step in elucidating a mechanistic role for iodine in breast carcinogenesis. The data that we have been able to generate to date suggest that our hypothesis is correct; namely, using transgenic human breast cancer cells (MCF7) overexpressing the sodium/iodide symporter (NIS) and/or lactoperoxidase (LPO), ... |
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| Increasing Adherence to Follow-Up of Breast Abnormalities in Low-Income Korean American Women: A Randomized Controlled Trial |
SEP 2005 |
9 pages |
| Authors:
Annette Maxwell; CALIFORNIA UNIV LOS ANGELES
|
| The purpose of this study is to design an intervention to assist Korean American (KA) women who require follow-up diagnostics after routine breast cancer screening who have missed their first follow-up appointment (at-risk women). We have conducted exploratory one-to-one interviews with health care providers who serve KA women with abnormal mammograms and with KA women who have been referred for follow-up diagnostics. We have designed an intervention that will utilize ... |
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| Molecular Mechanism of Nkx3.1 Deregulation and Its Function in Murine Pten Prostate Cancer Model |
SEP 2005 |
48 pages |
| Authors:
Jing Jiao; CALIFORNIA UNIV LOS ANGELES
|
| Both PTEN and Nkx3.1 play important role in prostate cancer control. Preliminary results from Pten prostate model indicated that reduced Nkx3.1 expression is correlated with Cre-mediated Pten deletion. The goal of this study is to investigate how these two proteins interplay in prostate cancer development. We generated and characterize the primary cell lines from Pten prostate cancer model, which will facilitate us to study the molecular mechanism of Nkx3.1 deregulation ... |
|
| The Origin and Significance of Mammary Intraductal Foam Cells |
SEP 2005 |
7 pages |
| Authors:
Sanford H. Barsky; CALIFORNIA UNIV LOS ANGELES
|
| Intraductal "foam cells" are the most commonly encountered cells in spontaneous nipple discharge, aspirates, and lavage, and frequently surround DCIS and other intraductal proliferations. The origin of these cells is thus of potential importance, but is not presently understood. This project tested the hypothesis that these intraductal macrophages take origin from bone marrow-derived hematopoietic precursors. The central work tests the idea by transfer of bone marrow from C57BL/6 mice recombinantly ... |
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| Identification of Small Non-Peptidic Ligands that Bind the Scf-beta-TRCP Ubiquitin Ligase to Target to ER for Ubiquitination and Degradation |
AUG 2005 |
55 pages |
| Authors:
Kathleen M. Sakamoto; CALIFORNIA UNIV LOS ANGELES
|
| Breast cancer is the most common cancer diagnosed among women. Breast cancer cells often require activation of the estrogen-specific steroid hormone receptor by estrogen to proliferate, and it is well known that steroid hormone receptor signaling plays a pivotal role in progression of breast cancer disease. We hypothesize that a completely novel conceptual approach known as Protac (Proteolysis Targeting Chimeric Molecule) will lead to the ubiquitination and degradation of targeted ... |
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| Quality of Breast Cancer Care: The Role of Hispanic Ethnicity, Language and Socioeconomic Position |
JUN 2005 |
7 pages |
| Authors:
Diana Tisnado; Katherine L. Kahn; CALIFORNIA UNIV LOS ANGELES
|
| Socioeconomic position (SEP) refers to a range of dimensions that describe position in society, poverty, deprivation, wealth, occupation and social status. The goal of the proposed work is to inform our understanding of racial and ethnic dispanties in breast cancer care and the impact of SEP and linguistic barriers. We received approval from the Contracting Specialist to begin work in July 2004. This first year of work was spent obtaining ... |
|
| Accelerated Development of a High Field Single Electron Spin Microscope |
30 APR 2005 |
9 pages |
| Authors:
Karoly Holczer; CALIFORNIA UNIV LOS ANGELES
|
| This program has significantly accelerated the construction of a Single Electron Spin Microscope (SESM) - by this time practically completed - and the ideas proposed has been successfully realized. In this final report we emphasize those aspects of the SESM construction where funding provided under this pilot project made a substantial difference in the planning and design phase of the development even if additional funds were required for the eventual ... |
|
| A PSCA Promoter Based Avian Retroviral Transgene Model of Normal and Malignant Prostate |
01 Apr 2005 |
7 pages |
| Authors:
Robert Reiter; CALIFORNIA UNIV LOS ANGELES
|
| The molecular and cellular origins of prostate cancer are poorly understood. Recent evidence from our laboratory suggests that prostate cancer may arise from a basal/luminal precursor cell marked by cell surface expression of PSCA. The evidence supporting this hypothesis is that (1) PSCA marks an intermediate cell population that co-expresses basal and luminal cell cytokeratins (2) this cell population is does not express p63 and is androgen receptor positive, all ... |
|
| Arginase: A Novel Proliferative Determinant in Prostate Cancer |
APR 2005 |
22 pages |
| Authors:
Wayne W. Grody; CALIFORNIA UNIV LOS ANGELES
|
| This project is an investigation of the involvement of the enzyme arginase type II (All) in the pathogenesis and growth of prostate cancer. Having cloned the All gene in our laboratory, we unexpectedly discovered that it is expressed at high levels in the normal prostate and even higher in neoplastic prostate samples. The purpose of the present research funded by USAMRMC is to examine the expression of All in a ... |
|
| Automated Incremental Design of Flexible Intrusion Detection Systems on FPGAs |
FEB 2005 |
19 pages |
| Authors:
Zacahry Z. Baker; Viktor K. Prasanna; CALIFORNIA UNIV LOS ANGELES
|
| Intrusion detection for network security is a computeintensive application demanding high system performance. This paper presents a variety of strategies we have developed for the automatic synthesis of highly efficient intrusion detection systems. We create FPGA architectures using a high-level, graph-based partitioning methodology. We provide a library of performancecustomized architectures, which, through more efficient communication and extensive reuse of hardware components, provide dramatic increases in area- time performance. This paper ... |
|
| Integrating Molecular Imaging Approaches to Monitor Prostate Targeted Suicide and Anti-angiogenic Gene Therapy |
Feb 2005 |
76 pages |
| Authors:
Makoto Sato; CALIFORNIA UNIV LOS ANGELES
|
| To develop safe and efficient gene therapy protocol for advanced stages of prostate cancer, we aimed to combine the selective suicide and anti-angiogenic gene therapy approaches into an effective targeted treatment for prostate cancer. We propose to incorporate a strong and tissue-specific two-step transcriptional amplification(TSTA) system to mediate prostate-targeted thymidine kinase (sr39tk) gene expression in prostate cancer cells. This targeted vector can be also utilized as a positron emission tomography ... |
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| Role of Nuclear Receptor Cofactors in Hormone Refractory Prostate Cancer |
JAN 2005 |
10 pages |
| Authors:
Charlie D. Chen; CALIFORNIA UNIV LOS ANGELES
|
| Previously we discovered that a modest increase in androgen receptor (AR) expression is sufficient and necessary for hormone refractory (HR) prostate cancer progression. Together with published results of common AR overexpression in HR clinical tumor samples, our results indicate that AR overexpression is a cause for HR disease. We also demonstrated that the canonical transcriptional activity of AR is required in this process. Since the AR transcriptional function is mediated ... |
|
| Mechanism of Ovarian Epithelial Tumor Predispostion in Individuals Carrying Germline BRCA1 Mutations |
JAN 2005 |
32 pages |
| Authors:
Louis Dubeau; CALIFORNIA UNIV LOS ANGELES
|
| Women with germline mutations in BRCA1 are strongly predisposed to cancers of the ovary and fallopian tubes. Given the strong link between menstrual activity and risk of ovarian cancer in the general population, we hypothesized that BRCA1 might predispose to ovarian cancer indirectly, by influencing ovarian granulosa cells, which play an important role in controlling menstrual cycle progression. We used the Cre-lox system to inactivate the mouse Brca1 gene in ... |
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| Imaging Metastatic Prostate Cancer After Genetic Manipulation of Transcriptional Memory Regulators EZH2 and EED |
JAN 2005 |
6 pages |
| Authors:
Lily Wu; CALIFORNIA UNIV LOS ANGELES
|
| This project is intended to explore the role of polycomb group protein EZH2 and its binding partner EED in metastatic prostate cancer. Both proteins will be introduced and overexpressed independently overexpressed in prostate cancer xenograft models by lentiviral transduction. Concordantly, the effects of reduced EZH2 or EED expression will be evaluated by RNAi technology. The growth and progression of the tumors will be monitored by optical imaging. The hypothesis is ... |
|
| Identification and Characterization of the Ligand of Prostate Specific Membrane Antigen |
JAN 2005 |
11 pages |
| Authors:
Gopalakrishnapillai Anilkumar; CALIFORNIA UNIV LOS ANGELES
|
| Prostate Specific Membrane Antigen (PSMA) is a transmembrane protein expressed predominantly in prostate' epithelial cells. The expression of PSMA increases several fold in cancer cells, and recently it was shown that, PSMA is involved in the modulation of invasiveness of prostate cancer cells. The objective of this project was to identify a potential ligand for PSMA. For this purpose, we have employed the yeast two-hybrid system using different regions of ... |
|
| Radiation-Induce Immune Modulation in Prostate Cancer |
JAN 2005 |
87 pages |
| Authors:
William H. McBride; CALIFORNIA UNIV LOS ANGELES
|
| This proposal is designed to determine if radiation therapy inhibits presentation of prostate tumor antigens through the endogenous pathway by dendritic cells (DC) and to devise strategies to overcome this inhibition. This functional immune suppression following radiation therapy is not associated with cell killing but rather by interference with antigen processing. In this regard it is very different from the conventional view of immune suppression associated with lymphocyte sensitivity to ... |
|
| Study of the Formation Mechanism of Self-Assembled Quantum Dot Arrays with a Focus on Alloying and Nucleation Control |
14 DEC 2004 |
35 pages |
| Authors:
Ya-Hong Xie; HyungJun Kim; ZuoMing Zhao; Bin Shi; Jian Liu; CALIFORNIA UNIV LOS ANGELES
|
| The objective of the research project is to further the understanding of key materials science with regard to the formation mechanism of semiconductor self assembled quantum dots via epitaxy. During the funding period of 3+ years, we have made significant progress in that direction. We have conducted in-depth study on the following specific topics: the importance of alloying during epitaxial growth of SAQDs; the function of buried misfit dislocation in ... |
|
| The Meaning of Incontinence and Impotence for Low Income African American and Latino Men with Prostate Cancer |
DEC 2004 |
6 pages |
| Authors:
Sally L. Maliski; CALIFORNIA UNIV LOS ANGELES
|
| Two common side effects of prostate cancer treatments are incontinence and impotence, both of which can affect the quality of a man's life. Hence, it is important to discuss these possible side effects when men are making treatment decisions and to help them cope with the symptoms if they occur. This study will describe the meaning of treatment-related incontinence and impotence for low-income African American and Latino men. Participants will ... |
|
| Elucidation of a Novel Cell Death Mechanism in Prostate Epithelial Cells |
DEC 2004 |
30 pages |
| Authors:
Linda G. Baum; CALIFORNIA UNIV LOS ANGELES
|
| Tumor cell resistance to apoptosis and immune attack are obstacles to effective prostate cancer therapy. Androgen dependent LNCaP prostate cancer cells are sensitive to apoptosis induced by galectin-l, a human lectin that is abundant in prostate stroma. In contrast, androgen independent LNCaP, DU145 and PC-3 cells are resistant to galectin-l induced death and express galectin-l on the cell surface. Galectin-l binds to specific saccharide ligands on LNCaP cells to trigger ... |
|
| Role of PSMA in Aberrant Cell Cycle Progression in Prostate Cancer |
DEC 2004 |
62 pages |
| Authors:
Ayyappan K. Rajasekaran; CALIFORNIA UNIV LOS ANGELES
|
| Prostate specific membrane antigen (PSMA) is a well-studied, highly restricted prostate epithelial cell membrane antigen. In contrast to other highly restricted prostate-related antigens such as prostate specific antigen (PSA) and prostatic acid phosphatase (PAP), which are secretory proteins, PSMA is an integral membrane protein. In addition to its prostate specificity, PSMA is expressed by a very high proportion of prostate cancers (Pca), expression is further increased in higher grade cancers, ... |
|
| Flavonoids and DNA Repair in Prostate Cancer |
DEC 2004 |
13 pages |
| Authors:
Susanne M. Henning; CALIFORNIA UNIV LOS ANGELES
|
| Oxidative DNA damage has been closely linked to cancer development. An active DNA repair system is critical to prevent the occurrence of mutations leading to carcinogenesis. It was the objective of this investigation to test the hypothesis that natural products such as flavonoids are able to stimulate the repair of oxidative DNA damage. For this purpose LNCaP prostate tumor cells were exposed to FeSO4 to induce oxidative DNA damage (8-hydroxydeoxyguanosine ... |
|
| Identification of a Protein for Prostate-Specific Infection |
DEC 2004 |
5 pages |
| Authors:
Shen Pang; CALIFORNIA UNIV LOS ANGELES
|
| In this proposal, we will identify and clone a protein that can be used to generate infection-specific gene therapy vector. We expect that using this protein to modify various gene therapy vectors, we can specifically deliver cytotoxic genes into prostate cancer cells using systemic treatment, and eventually eradicate metastatic prostate cancer cells in patients. During the first year, we have generated the cDNA expression library (Task 1). We have picked ... |
|
| Interrogating Androgen Receptor Mediated Gene Expression and Tumor Progression by Molecular Imaging |
OCT 2004 |
11 pages |
| Authors:
Michael F. Carey; CALIFORNIA UNIV LOS ANGELES
|
| This annual report contains data demonstrating the effectiveness of a new adenovirus based optical imaging vector. The vector was injected into human tumors implanted into SCID mice. Animals were injected with D-luciferin and imaged in a Xenogen IVIS device. The vector was able to detect enhanced MAPK levels stimulated by Epidermal Growth Factor in prostate cancer tumors of xenograft animals. The vector was also able to detect inhibition by the ... |
|
| Targeting the Estrogen Receptor for Ubiquitination and Degradation in Breast Cancer Cells |
OCT 2004 |
68 pages |
| Authors:
Kathleen M. Sakamoto; CALIFORNIA UNIV LOS ANGELES
|
| The ubiquitin-proteasome pathway involves the assembly of a multiubiquitin chain on a substrate, which then targets the appended protein for degradation by the 26S proteasome. In this application, we propose to develop a suite of heterobifunctional compounds known as Protacs (for Proteolysis - Targeting Chimeric Molecules) that can be used to target the degradation of any protein in the cell by artificially tethering it to a ubiquitin ligase. Specifically, we ... |
|
| The UCLA-Community Breast Cancer Collaborative Clinical Translational Research Program |
OCT 2004 |
10 pages |
| Authors:
John A. Glaspy; CALIFORNIA UNIV LOS ANGELES
|
| The purpose of this proposal was to develop a consortium of community physicians committed to study novel approaches to the treatment and prevention of breast cancer, provide them with a clinical trials infrastructure linked to an academic center with expertise in basic research and the design and regulation of clinical investigation and to form partnerships with the pharmaceutical industry to facilitate the rapid translation of novel therapeutic approaches to breast ... |
|
| Non-Invasive Gene Therapy of Experimental Parkinson's Disease |
SEP 2004 |
33 pages |
| Authors:
William M. Pardridge; CALIFORNIA UNIV LOS ANGELES
|
| Neurotoxins can cause serious derangements in brain biochemistry that can compromise the cognitive and motor function of the individual. In the present studies an anima! model of neurotoxin exposure is used, wherein the neurotoxin, 6-hyrdoxydopamine, is injected into a specific region of the rat brain called the medial forebrain bundle, followed approximately 4 weeks later by a biochemical picture resembling Parkinson's disease (PD). On the side of the brain where ... |
|
| Targeting Angiogenic Factors Contributing to Etiology and Progression of Human Ovarian Cancer |
SEP 2004 |
26 pages |
| Authors:
Richard J. Pietras; CALIFORNIA UNIV LOS ANGELES
|
| Development of ovarian cancer depends, in part, on formation of an adequate blood supply. Tumor angiogenesis is essential for cancer growth, and vascular endothelial growth factor (VEGF) is critical to stimulate growth of vascular endothelial cells. VEGF is produced by ovarian cancers, with secretion markedly increased in ovarian cancers with HER-2 oncogene overexpression. Herceptin antibody to HER-2 receptor has direct antitumor effects, but the antibody also reduces VEGF secretion from ... |
|
| The Origin and Significance of Mammary Intraductal Foam Cells |
SEP 2004 |
6 pages |
| Authors:
Sanford H. Barsky; CALIFORNIA UNIV LOS ANGELES
|
| Intraductal "foam cells" are the most commonly encountered cells in spontaneous nipple discharge, nipple aspirate fluid and ductal lavage yet their origin and significance remain a mystery. They frequently surround DCIS and other intraductal proliferations but their presence has been regarded as a nuisance since they often hide the diagnostically more important epithelial cells. Our previous immunocytochemical studies with macrophage (CD68, lysozyme), epithelial (cytokeratin, estrogen receptor) and myoepithelial (smooth muscle ... |
|
| Increasing Adherence to Follow-Up of Breast Abnormalities in Low-Income Korean American Women: A Randomized Controlled Trial |
SEP 2004 |
13 pages |
| Authors:
Annette E. Maxwell; CALIFORNIA UNIV LOS ANGELES
|
| The purpose of this study is to design an intervention to assist Korean American women who have been identified with a potential breast abnormality through the Breast Cancer Early Detection Program (BCEDP) and who have missed their first follow-up appointment (at risk women). Intervention activities will include reminder phone calls or home visits by a trained peer counselor to explain the importance of follow-up procedures, emotional support, help with transportation ... |
|
| The Role of Myoepithelial Maspin in Breast Carcinoma Progression, Diagnosis, and Screening |
AUG 2004 |
206 pages |
| Authors:
Sanford H. Barsky; CALIFORNIA UNIV LOS ANGELES
|
| In glandular organs, precancerous state precedes invasive carcinoma. In the breast this state is recognized as DCIS and consists of an epithelial cell proliferation confined by myoepithelial cells. Our laboratory has established cell line/xenografts of myoepithelial cells. Our myoepithelial cell lines inhibit invasion and motility of breast carcinoma lines in vitro largely through maspin. The overall hypothesis of this proposal was how does myoepithelial maspin regulate breast (DClS) carcinoma progression ... |
|
| Antiangiogenic Steroids and Growth Factor Receptors in Human Breast Cancer Therapy |
AUG 2004 |
11 pages |
| Authors:
Richard J. Pietras; CALIFORNIA UNIV LOS ANGELES
|
| With 2,000,000 new cases worldwide annually, breast cancer is the most common malignancy in women. Genesis of these cancers depends, in part, on formation of a good blood supply, a process termed angiogenesis. Vascular endothelial growth factor (VEGF) stimulates growth of endothelial cells, and this critical protein is produced by breast cancers. High levels of VEGF secretion occur in tumors expressing EGF and HER-2 growth factor receptors. Anti-bodies to HER-2 ... |
|
| Membrane Estrogen and HER-2 Receptors in Human Breast Cancer |
JUL 2004 |
86 pages |
| Authors:
Richard J. Pietras; CALIFORNIA UNIV LOS ANGELES
|
| Patients with breast cancers that express estrogen receptor (ER) commonly receive antiestrogen therapy. The efficacy of this treatment depends on tight regulation of breast growth by estrogen. However, as breast cancers progress, they often become resistant to estrogens, and%most patients no longer respond to antiestrogen therapy. New antiestrogen treatment options are needed, and alternative therapies may derive from findings showing that some ER molecules occur in plasma membranes of breast ... |
|
| Functional Analysis of Oncogene Akt: Its Role in Tumorigenesis in Vivo and Cell Cycle Progression in Vitro |
JUL 2004 |
18 pages |
| Authors:
Bangyan Stiles; Hong Wu; CALIFORNIA UNIV LOS ANGELES
|
| Breast cancer is the most common malignancy in women. The recently identified tumor suppressor gene PTEN has turned out to be a promising candidate for mammary tumorigenesis. Mice heterozygous for Pten develops mammary tumors starting from 6 weeks. The goal of this project is to determine the role of AKT, a major downstream target of PI3K pathway, in PTEN mediated mammary tumor development. To study the function of AKT in ... |
|
| Fermi Electronics: A Means of Correlating and Canceling Shot Noise From Solid State Devices |
08 JUN 2004 |
48 pages |
| Authors:
Elliot R. Brown; CALIFORNIA UNIV LOS ANGELES
|
| This project has developed a formalism for computing the shot noise in resonant- tunneling structures having an arbitrary number of quantum wells. It is based on the electrostatic feedback effect in quantum-well structures and is the first known shot noise formalism that treats the electrostatic and quantum effects in a self-consistent fashion. Simulation results are analyzed and compared to experimental results for an InGaAs/AlAs double-barrier structure, which is the fastest ... |
|
| Endothelial Genes |
JUN 2004 |
13 pages |
| Authors:
Mai N. Brooks; CALIFORNIA UNIV LOS ANGELES
|
| Breast cancer growth and metastasis are dependent on angiogenesis. Multiple angiogenic peptides have been identified and sequenced. These include basic and acidic fibroblast growth factor (bFCF and aFGF), vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), transforming growth factor- alpha and beta (TGF-alpha and TGF-beta), hepatocyte growth factor (HGF), tumor necrosis factor-alpha (TNF-alpha), interleukin-8 (IL-8), granulocyte colony stimulating factor (G-CSF), E-selectin, angiogenin, platelet-derived endothelial cell growth factor (PD-ECGF), placental ... |
|
| Quality of Breast Cancer Care: The Role of Hispanic Ethnicity, Language, and Socioeconomic Position |
JUN 2004 |
10 pages |
| Authors:
Diana Tisnado; Katherine L. Kahn; CALIFORNIA UNIV LOS ANGELES
|
| Socioeconomic position (SEP) refers to a range of dimensions that describe absolute and relative position in society including income, education, poverty, deprivation, and social status. The ultimate goal of the proposed work is to inform our understanding of racial and ethnic disparities in breast cancer care and the contribution of SEP and linguistic barriers, particularly for Hispanic women. This work has the potential to contribute to our understanding of disparities ... |
|
| PIAS Proteins in Androgen Signaling nd Prostate Cancer |
JUN 2004 |
14 pages |
| Authors:
Ke Shuai; CALIFORNIA UNIV LOS ANGELES
|
| It has been well established that androgen receptor (AR) plays an important role in prostate cancer. Previous studies have suggested that the PIAS (protein inhibitor of activated STAT) family may be involved in the regulation of AR-mediated gene activation. The overall goal of this proposal is to study the role of PIAS proteins in androgen signaling and prostate tumor progression. |
|
| Laser Transmission Through Cirrus Clouds |
31 MAY 2004 |
5 pages |
| Authors:
Kuo-Nam Liou; CALIFORNIA UNIV LOS ANGELES
|
| Laser transmission model development. We developed a number of 2D radiative transfer models based on the successive-order-of-scattering approach for the computation of airborne high-energy laser transmission and backscattering through homogeneous and inhomogeneous thin cirrus clouds in both plane-parallel and spherical geometries. These models took into account the relative positions of aircraft, target, and cirrus clouds in the atmospheres. We investigated the sensitivity of laser transmission and backscattering on variation of ... |
|
| Modulation of VEGF Bioavailability in Breast Tumors by Direct MMP cleavage |
MAY 2004 |
11 pages |
| Authors:
Sunyoung Lee; Luisa Iruela-Arispe; CALIFORNIA UNIV LOS ANGELES
|
| VEGF-A is one of the most relevant mediators of capillary morphogenesis during development and a key stimulator of tumor-induced angiogenesis. hVEGF-A exists in five forms, VEGF(exp 121), VEGF(exp 145), VEGF165, VEGF(exp 189), and VEGF(exp 205), as a result of alternative splicing from a single gene. These various isoforms differ in their affinity for extracellular matrix (ECM) proteins(all except for VEGF(exp 121) bind to ECM components upon secretion) and regulate vascular ... |
|
| Integral Invariant Signatures |
May 2004 |
13 pages |
| Authors:
Siddharth Manay; Byuny-Woo Hong; Anthony J Yezzi; Stefano Soatto; CALIFORNIA UNIV LOS ANGELES
|
| For shapes represented as closed planar contours, we introduce a class of functionals that are invariant with respect to the Euclidean and similarity group, obtained by performing integral operations. While such integral invariants enjoy some of the desirable properties of their differential cousins, such as locality of computation which allows matching under occlusions and uniqueness of representation in the limit, they are not as sensitive to noise in the data. ... |
|
| Angiogenesis Inhibitors in Breast Cancer |
APR 2004 |
10 pages |
| Authors:
Alfonso Luque; Luisa Iruela-Arispe; CALIFORNIA UNIV LOS ANGELES
|
| ADAMTSl/METHl is a secreted protease that belongs to the metallospondin/ADAMTS sub-family of the zinc-metalloprotease superfamily. This family is characterized by proteins that contain a modular structure that includes A, Disintegrin-like, Metalloprotease, and type-1 ThromboSpondin domains. ADAMTSl has been shown to inhibit both endothelial cell proliferation in vitro, as well as angiogenesis in vivo. We have investigated the role of ADAMTSl and its proteolytic activity, through the creation of a catalytically ... |
|
| Arginase: A Novel Proliferative Determinant in Prostate Cancer |
APR 2004 |
25 pages |
| Authors:
Wayne W. Grody; CALIFORNIA UNIV LOS ANGELES
|
| This project is an investigation of the involvement of the enzyme arginase type II (All) in the pathogenesis and growth of prostate cancer. Having recently cloned the All gene in our laboratory, we unexpectedly discovered that it is expressed at high levels in the normal prostate and even higher in neoplastic prostate samples. The purpose of the present research funded by USAMRMC is to examine the expression of All in ... |
|
| A PSCA Promoter Based Avian Retroviral Transgene Model of Normal and Malignant Prostate |
APR 2004 |
7 pages |
| Authors:
Robert Reiter; CALIFORNIA UNIV LOS ANGELES
|
| The molecular and cellular origins of prostate cancer are poorly understood. Recent evidence from our laboratory suggests that prostate cancer may arise from a basal/luminal precursor cell marked by cell surface expression of PSCA. The evidence supporting this hypothesis is that (1) PSCA marks an intermediate cell population that co-expresses basal and luminal cell cytokeratins (2) this cell population does not express p63 and is androgen receptor positive, all hallmarks ... |
|
| Microlocalization and Quantitation of Risk Associated Elements in Gleason Graded Prostate Tissue |
MAR 2004 |
12 pages |
| Authors:
Curtis Eckhert; CALIFORNIA UNIV LOS ANGELES
|
| Epidemiological and laboratory studies show that boron, selenium and zinc reduce prostate cancer risk whereas calcium and cadmium increase risk. The objective of this proposal is to determine the concentration and location of these elements in normal and tumor tissue. Specific aims include: (1) preparation of four grades of prostate tissue, (2) determination of tissue concentrations of: B, Ca, Cd, Se, and Zn; and (3) determination of tissue and cellular ... |
|
| Mechanisms and Refinements of PSCA Directed Antibody Therapy |
MAR 2004 |
7 pages |
| Authors:
Robert E. Reiter; CALIFORNIA UNIV LOS ANGELES
|
| Prostate cancer is the second leading cause of cancer-related death in American men. New treatments are needed. Prostate stem cell antigen (PSCA) is a cell surface protein over expressed by a 40% of localized and as many as 80- 100% of metastatic prostate cancers. A monoclonal antibody generated in our lab against PSCA inhibits growth and metastasis of prostate cancer in animal models, but the mechanism of action is not ... |
|
| Molecular Engineering of Vector-Based Oncolytic and Imaging Approaches for Advanced Prostate Cancer |
FEB 2004 |
47 pages |
| Authors:
Lily Wu; CALIFORNIA UNIV LOS ANGELES
|
| Hormone refractory and metastatic prostate cancer are not well understood. Better animal models, diagnostic and treatment modalities are sorely needed for these advanced stages of disease. We have coupled non-invasive optical imaging to develop metastatic prostate cancer animal models, and vector- based diagnostic and therapeutic approaches. A highly potent and prostate- specific transcriptional regulatory system (TSTA) has been utilize dot restrict the expression of our adenoviral vector specifically to prostate ... |
|
Reports by Corporate Author
