| Mechanism of Selenium Chemoprevention and Therapy in Prostate Cancer |
Nov 2009 |
14 pages |
| Authors:
Allen C Gao; CALIFORNIA UNIV DAVIS
|
 | Prevention trials demonstrated that selenium is a promising chemopreventive agent for prostate cancer. Selenium inhibited human prostate cancer cell growth, blocked cell cycle progression, and induced apoptotic cell death. We have demonstrated a novel mechanism of selenium anticancer action in which selenium markedly reduces androgen receptor (AR) expression and AR-mediated gene expression including prostate-specific antigen (PSA) in human prostate cancer cells in vitro and in vivo. Based on our novel ... |
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| Optimal Transmission Diversity for High-Speed Wireless Communication Systems Under Adverse Environment |
15-Jul-2009 |
15 pages |
| Authors:
Zhi Ding; CALIFORNIA UNIV DAVIS
|
| High speed wireless mobile communication systems have become increasingly important in battlefield command/control and in sensor network systems for national defense and security. The project investigates advanced design of bandwidth efficient retransmission diversity in multi-input multi- output (MIMO) wireless communication systems. We develop optimization techniques in (hybrid) ARQ and MIMO precoding for robust, progressive, adaptive, and scalable diversity. We focus on OFDM as the underlying broadband signal modulation. We present ... |
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| The Role of Autophagy with Arginine Deiminase as a Novel Prostate Cancer Therapy |
Jul-2009 |
31 pages |
| Authors:
Randle Kim; CALIFORNIA UNIV DAVIS
|
| Arginine deprivation by arginine deiminase (ADI) is a novel therapy that is effective against prostate cancers that lack argininosuccinate synthetase (ASS), the rate-limiting enzyme for de novo arginine synthesis. We show that in ASS negative CWR22Rv1 prostate cancer cells, ADI rapidly induced autophagy through AMPK/mTOR/S6K as well as ERK1/2 pathways in order to delay the onset of caspase-independent apoptosis. Inhibiting autophagy with chloroquine or Beclin1 siRNA accelerated and enhanced ADI-induced ... |
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| Studies in Reliability Economics and Reliability Modeling and Inference |
25-Aug-2008 |
11 pages |
| Authors:
Francisco J Samaniego; CALIFORNIA UNIV DAVIS
|
| Research accomplishments under ARO support can be grouped into seven problem areas. In *reliability economics*, we solved the important open problem of identifying optimal system designs relative to criterion functions based on both performance and cost. We also solved the related statistical estimation problem, allowing data-based approximations of optimal system designs. New results were obtained in *structural reliability*, and a research monograph in this area was completed. Sufficient conditions were ... |
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| Bacterial Chemotaxis to Naphthalene and Nitroarene Compounds |
31-Jul-2008 |
27 pages |
| Authors:
Rebecca E Parales; Piper Wood; Christine Rabinovitch; Juanito V Parales; CALIFORNIA UNIV DAVIS
|
| Bacteria that can both degrade and sense pollutants using chemotaxis may be more efficient in biodegradation. Ralstonia sp. U2 mineralizes naphthalene, and Acidovorax sp. JS42 utilizes the man-made compound 2-nitrotoluene (2NT). Capillary assays were performed with wild-type and catabolic and regulatory mutants of these strains. The results showed that wild-type Ralstonia sp. U2 is chemotactic to naphthalene, the chemotactic response is induced when cells are grown with naphthalene, and insertional ... |
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| International Congress on Biophotonics (1st) (ICOB 2008). Held in Sacramento, California on February 3-7, 2008 |
02-Jun-2008 |
4 pages |
| Authors:
Joanna Albala; CALIFORNIA UNIV DAVIS
|
| The NSF Center for Biophotonics Science & Technology (CBST) of UC Davis hosted the 1st International Congress on Biophotonics (ICOB) on February 3 7, 2008 in Sacramento, California. The purpose of the meeting was to gather thought leaders from around the world, representing academia (researchers and educators), industry, medicine, and government agencies to create a strategic roadmap for the future of biophotonics research, technology development and education. The rationale for ... |
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| A Semidefinite Programming Approach to Source Localization in Wireless Sensor Networks |
16-May-2008 |
6 pages |
| Authors:
Chen Meng; Zhi Ding; Soura Dasgupta; CALIFORNIA UNIV DAVIS
|
| We propose a novel approach to the source localization and tracking problem in wireless sensor networks. By applying minimax approximation and semidefinite relaxation, we transform the traditionally nonlinear and nonconvex problem into convex optimization problems for two different source localization models involving measured distance and received signal strength. Based on the problem transformation, we develop a fast low-complexity semidefinite programming (SDP) algorithm for two different source localization models. Our algorithm ... |
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| Cognitive Agents for Knowledge Discovery |
05 FEB 2008 |
5 pages |
| Authors:
V. R. Vemuri; CALIFORNIA UNIV DAVIS
|
| Discovery of new knowledge, that is, knowledge that we do not already possess, is the focus of this research. This problem can be formulated as an inverse problem, where the new knowledge can be represented by the parameters of a black box model. The solution can then be viewed as the culmination of a sequence of problem solving steps: search, composition, integration and discovery. A well designed cognitive agent capable ... |
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| Application of Hyperspectral Techniques to Monitoring and Management of Invasive Plant Species Infestation |
Jan-2008 |
190 pages |
| Authors:
Susan L Ustin; Edward T Tom; Carlos M Ramirez; Karen S Olmstead; Nina Noujdina; Shawn Kefauver; John Kefauver; Deanne DiPietro; Yen-Ben Cheng; Maragaret E Andrew; Mary Andrews; Emma Underwood; CALIFORNIA UNIV DAVIS
|
| This report summarizes and integrates the main findings, using several case studies to illustrate conclusions. Case studies include cheatgrass and Russian knapweed at Yakima Training Center, showing that multiple dates that combine different growing seasons improve map accuracy. Also included are maps for kudzu and Johnson lovegrass at Fort Benning, tamarisk at Yuma Proving Ground and phragmites at Aberdeen Proving Ground. Examples were chosen to illustrate a range of problems ... |
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| Power Control in Spectrum Overlay Networks: How to Cross a Multi-Lane Highway |
Jan-2008 |
5 pages |
| Authors:
Qing Zhao; Ananthram Swami; Wei Ren; CALIFORNIA UNIV DAVIS
|
| We consider power control in spectrum overlay networks (also referred to as opportunistic spectrum access) where secondary users identify and exploit instantaneous and local spectrum opportunities without causing unacceptable interference to primary users. We quantify the impact of the transmission power of secondary users on the occurrence of spectrum opportunities and the reliability of opportunity detection. We demonstrate that the probability of spectrum opportunity decreases exponentially with the transmission power ... |
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| Identifying Molecular Targets for Chemoprevention in a Rat Model. Addendum |
DEC 2007 |
7 pages |
| Authors:
Ralph W. deVere White; CALIFORNIA UNIV DAVIS
|
| The purpose of this grant was to determine the molecular events that occur in the dorsal and ventral lobes of the rat prostate gland after 20 weeks of exposure to PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine). Our Final Report was submitted July 2007 and summarized our data from the completion of Task 1 and Task 2 (published in Neoplasia). Task 3 was still pending at that time. This Final Addendum Report includes data from ... |
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| Characterization of MHC-Related Volatile Organic Compounds in Heterologous Expression Systems: Role of Infection in Odor Compound Generation |
25 NOV 2007 |
17 pages |
| Authors:
Cristina Davis; CALIFORNIA UNIV DAVIS
|
| Major histocompatibility complex (MHC) human leukocyte antigen (HLA) in humans plays significant role in mate selection and kin recognition mainly through apparition of organism specific odor recognized by other individuals. However a mechanism of the relationship between unique MHC genetic combination of an organism and generation of the specific organism odor is not understood. We are showing here that human B cells produce volatile organic (odor) compounds measurable by GC/MS ... |
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| Molecular Mechanisms of Nonlinearity in Response to Low Dose Ionizing Radiation |
12 OCT 2007 |
43 pages |
| Authors:
Zelanna Goldberg; David M. Rocke; CALIFORNIA UNIV DAVIS
|
| In this very new project we have begun a systematic evaluation of the molecular mechanisms of radiation adaptation. We have developed a wound-healing model that will provide a functional assessment of the promitogenic effects of low dose radiation exposure. We have begun detailed cell cycle analysis of low dose radiation exposure on human keratinocytes and fibroblasts as well as survival as says following priming and challenge doses of ionizing radiation. ... |
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| Castration Induced Neuroendocrine Mediated Progression of Prostate Cancer |
SEP 2007 |
61 pages |
| Authors:
Christopher P. Evans; CALIFORNIA UNIV DAVIS
|
| We have made headway into understanding the paracrine relationship between neuropeptide expressing, androgen-insensitive CaP cells and their ability to support the proliferation and migration of androgen sensitive CaP cells. Critically, we have identified src kinase as a molecule central to the process. We have been awarded a NIH CTEP phase II trial to study a novel, oral src kinase inhibitor AZD0530 in androgen-insensitive prostate cancer patients based upon our work. ... |
|
| Identifying Molecular Targets for Chemoprevention in a Rat Model |
01 JUN 2007 |
15 pages |
| Authors:
Ralph W. deVere White; CALIFORNIA UNIV DAVIS
|
| The purpose of this grant is to determine the molecular events that occur in the dorsal and ventral lobes of the rat prostate gland after 20 weeks of exposure to PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine). PhIP is a potent inducer of mutations in the rate prostate where we have previously shown that it forms bulky DNA adducts. The scope of this research includes: 1)Generation of a rat model, 2) Analysis of the rat ... |
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| State of the Science Meeting: Burn Care: Goals for Treatment and Research |
NOV 2006 |
158 pages |
| Authors:
Tina L. Palmieri; CALIFORNIA UNIV DAVIS
|
| The Burn State of the Science Research Conference achieved its stated purpose: the identification and prioritization of burn research goals for the next decade and the delineation of the resources needed to achieve those goals. Issues ranging from acute burn care through the rehabilitative period were addressed in a single forum and published in the Journal of Burn Care and Research. Although much progress has been made in burn management, ... |
|
| Improving Blood Monitoring of Enzymes as Biomarkers of Risk from Anticholinergic Pesticides and Chemical Warfare Agents |
OCT 2006 |
11 pages |
| Authors:
Barry W. Wilson; CALIFORNIA UNIV DAVIS
|
| Blood biomarkers are an important way to monitor exposure to anticholinergic pesticides and chemical warfare agents and to establish whether some personnel are at greater risk than others from exposure. Many clinical and research laboratories use the colorimetric Ellman assay based on the hydrolysis of acetylthiocholine. CHPPM (US Army Center for Health Promotion and Preventive Medicine) uses a slower delta pH method based on that of Michel to monitor 16,000 ... |
|
| Development of Bioacoustic Tools for Long-Term,Non-invasive Monitoring of Threatened and Endangered Birds |
14 JUL 2006 |
64 pages |
| Authors:
Brenda McCowan; Ann Bowles; CALIFORNIA UNIV DAVIS
|
| The project's objective was to develop quantitative bioacoustic techniques that can be used to monitor population densities and trends as well as assess the effects of military training and other anthropogenic activities on the population dynamics of threatened and endangered birds, and specifically the Mexican spotted owl. |
|
| Theoretical Modeling of Molecular Mechanisms, Time Scales, and Strains in Prion Diseases |
JUL 2006 |
74 pages |
| Authors:
Daniel L. Cox; Rajiv R. Singh; CALIFORNIA UNIV DAVIS
|
| We have obtained significant results modeling: (1) the structure of the minimal infectious prion oligomer as a domain swapped beta helical trimer; (2) metal binding to the prion protein showing results consistent with measured affinities and suggesting a detailed molecular role for the protection of the normal prion form against conversion to the infectious scrapies form when copper is bound to a particular site; (3) kinetics of yeast prion aggregation ... |
|
| Quasi-2D Unsteady Flow Procedure for Real Fluids (PREPRINT) |
17 MAY 2006 |
12 pages |
| Authors:
Bryan T. Campbell; Roger L. Davis; CALIFORNIA UNIV DAVIS
|
| The numerical solution techniques, including explicit, point-implicit, and fully implicit schemes, used in a new quasi two-dimensional procedure for the transient solution of real fluid flows in system lines and volumes are presented. The procedure is coupled with a real-fluid properties database so that both compressible and incompressible fluids may be considered using the same code. The procedure has been implemented n Matlab/Simulink? as well as Fortran95 to allow for ... |
|
| Short- and Long-Term Effects in Prostate Cancer Survival: Analysis of Treatment Efficacy and Risk Prediction |
01 MAR 2006 |
120 pages |
| Authors:
Alexander D. Tsodikov; CALIFORNIA UNIV DAVIS
|
| This project represents a successful effort to develop abstract statistical theory, computational algorithms, translate this methodology into stable shareware software products that can be used by the broad scientific community, put this product into the R-Projects nltm and rpNLTM that has become the dominant site for dissemination of cutting edge statistical procedures, and finally use and showcase all this arsenal to address real data and problems in prostate cancer. We ... |
|
| Prevention of Post-Radiotherapy Failure in Prostate Cancer by Vitamin D |
MAR 2006 |
38 pages |
| Authors:
Srinivasan Vijayakumar; CALIFORNIA UNIV DAVIS
|
| Prostate cancer patients receive either surgery or radiation therapy as treatment for cancer. Among patients receiving radiation therapy nearly 50% have an elevation of PSA within five years of treatment. These patients then receive hormone treatment. In this study we wish to test the theory that chemopreventive agents which shoe the ability to prevent or delay the growth of prostate cancer cells in the laboratory may also prevent or delay ... |
|
| Identifying Molecular Targets for Chemoprevention in a Rat Model |
DEC 2005 |
27 pages |
| Authors:
Ralph W. deVere White; CALIFORNIA UNIV DAVIS
|
| The purpose of this grant is to determine the molecular events that occur in the dorsal and ventral lobes of the rat prostate gland after 20 weeks of exposure to PhIP (2-amino-i -methyl-6-phenylimidazo[4,5-b]pyndene). PhIP is a potent inducer of mutations in the rat prostate where we have shown that it forms bulky DNA adducts. In addition it induces high levels of oxidative damage in the target tissues. The scope of ... |
|
| Contributions to Structural, Stochastic and Statistical Reliability |
07 NOV 2005 |
4 pages |
| Authors:
Francisco J. Samaniego; CALIFORNIA UNIV DAVIS
|
| This report summarizes the work completed by the Principal Investigator in several subfields of Reliability Theory proposed for study under the support of the afore-named ARO grant. Research advances in four specific areas are reported, and twelve research papers are cited for details. In structural reliability, new and useful properties of system signatures are developed. Examples include necessary and sufficient conditions on the signatures of two competing systems for the ... |
|
| Improving Blood Monitoring of Enzymes as Biomarkers of Risk from Anticholinergic Pesticides and Chemical Warfare Agents |
OCT 2005 |
13 pages |
| Authors:
Barry W. Wilson; CALIFORNIA UNIV DAVIS
|
| Blood biomarkers are an important way to monitor exposure to anticholinergic pesticides and chemical warfare agents and to establish whether some personnel are at greater risk than others from exposure. Many clinical and research laboratories use the colorimetric Ellman assay based on the hydrolysis of acetylthiocholine. CHFPM (US Army Center for Health Promotion and Preventive Medicine) uses a slower delta pH method based on that of Michel to monitor 16,000 ... |
|
| Castration-Induced Neuroendocrine Mediated Progression of Prostate Cancer |
SEP 2005 |
34 pages |
| Authors:
Christopher P. Evans; CALIFORNIA UNIV DAVIS
|
| This progress report highlights our past 12 months of work on understanding neuroendocrine differentiation in prostate cancer (CaP). We have made headway into understanding the paracrine relationship between neuropeptide expressing CaP cells and androgen-insensitive CaP cells. Specifically the ability for neuropeptide expressing CaP cells to support the proliferation and migration of the androgen sensitive CaP cells in an environment without androgens (castrate). The more detailed, in vivo experiments will provide ... |
|
| Producing a Mouse Model to Explore the Linkages Between Tocopherol Biology and Prostate Cancer |
JUL 2005 |
11 pages |
| Authors:
Paul Davis; CALIFORNIA UNIV DAVIS
|
| A mouse model of prostate cancer i.e. male C57/BL6 mice hemizygous for TRAMP and hetero or homozygous for tocopherol(TOC) transport protein (TTP) knockout was produced. C57/bl6 mice carrying the SV40 T antigen driven by the rat probasin promoter construct (TRAMP+) were bred with TTP knockout C57/bl6 mice, offspring with the desired sex and genotypes were raised on normal mouse chow. Animals were killed at multiple ages and GI tract, prostate ... |
|
| Theoretical Modeling of Molecular Mechanisms, Strains, and Time Scales in Prion Diseases |
JUL 2005 |
42 pages |
| Authors:
Daniel L. Cox; Rajiv R. Singh; CALIFORNIA UNIV DAVIS
|
| We have obtained significant results modeling: (1) the structure of the minimal infectious prion oligomer as a domain swapped beta helical trimer; (2) metal binding to the prion protein showing results consistent with measured affinities and suggesting a detailed molecular role for the protection of the normal prion form against conversion to the infectious scrapies form when copper is bound to a particular site; (3) kinetics of yeast prion aggregation ... |
|
| Synthesis of Bulk Nanostructured Al Alloys with Ultra-High Strength and Wear Resistance for Army Applications |
26 APR 2005 |
24 pages |
| Authors:
E. J. Lavernia; CALIFORNIA UNIV DAVIS
|
| Synthesis/processing of nanostructured (amorphous or ultra fine grained) materials was studied via various processing routes such as gas atomization, melt spinning, cryomilling, equal-channel angular pressing (ECAP) and conventional consolidation. Microstructures and mechanical properties of both the amorphous powders and consolidated bulk materials were characterized. The amorphous alloy of A185Ni10La5 (at.%) was fabricated in terms of melt-spun ribbons and particularly, gas-atomized powders (283 degs, the devitrification tends to complete in a ... |
|
| Mechanoelectrically Activated Synthesis of Dense, Bulk Nanostructured, Complex Crystalline and Glassy Hard Materials |
APR 2005 |
14 pages |
| Authors:
Z. A. Munir; CALIFORNIA UNIV DAVIS
|
| The broad objective of the completed work was to investigate the effect of mechanical and electric field activation on the synthesis and properties of materials, with special emphasis on nanostructured hard materials. We have investigated several aspects of this, including: (a) Synthesis and Microstructural Evolution under Field Application, (b) Synthesis of Bulk Nanostructured Materials by Mechanical and Field Activation, (c) Investigations on FGM Formation and Properties, (d) Investigations on the ... |
|
| Prevention of Post-Radiotherapy Failure in Prostate Cancer by Vitamin D |
MAR 2005 |
112 pages |
| Authors:
Srinivasan Vijayakumar; CALIFORNIA UNIV DAVIS
|
| Prostate cancer patients receive either surgery or radiation therapy as treatment for cancer. Among patients receiving radiation therapy, nearly 50% have an elevation of PSA within five years of treatment. These patients then receive hormone treatment. In this study, we wish to test the theory that chemopreventive agents, which show the ability to prevent or delay the growth of prostate cancer cells in the laboratory, may also prevent or delay ... |
|
| Modulation of Apoptosis-Associated and DNA Repair Genes to Enhance Radiation Therapy |
FEB 2005 |
8 pages |
| Authors:
Paul H. Gumerlock; CALIFORNIA UNIV DAVIS
|
| Of the approximately 220,900 men in the United States diagnosed with carcinoma of the prostate (CaP) in 2003, approximately eighty-five percent presented with presumed localized disease for which external beam radiation therapy (EBRT) was one of the few treatment options. While it is relatively effective, the failure rate still remains unacceptably high with a 5-year biochemical failure rate of 10-40%. The curative potential of radiation therapy still remains to be ... |
|
| Bone Morphogenetic Proteins, Antagonists and Receptors in Prostate Cancer |
JAN 2005 |
22 pages |
| Authors:
A. H. Reddi; CALIFORNIA UNIV DAVIS
|
| Prostate Cancer is a significant cancer in elderly men. In year 2000 nearly 200,000 cases were diagnosed. Unfortunately over 40,000 patients succumbed to this horrendous cancer. Death is preceded by a characteristic triad of diffuse osteoblastic-osteosclerotic skeletal metastases, bone pain and pathologic fractures. A great majority of prostate cancer metastasize to bone, especially spine and pelvis, and cause pathologic fractures due to osteosclerosis. Bone Morphogenetic Proteins (BMPs) are critical signaling ... |
|
| Aberrant Chromatin Modification as a Mechanism of Prostate Cancer Progression |
DEC 2004 |
42 pages |
| Authors:
Hongwu Chen; CALIFORNIA UNIV DAVIS
|
| Prostate cancer almost inevitably progresses from hormone-dependent to hormone-independent state. However, the underlying mechanism is still unclear. The purpose of this study is to test the hypothesis that aberrant chromatin modification plays a critical role in prostate cancer progression. We proposed to analyze histone modifications on AR target genes such as PSA and identify the responsible enzymatic activities in prostate cancer cells. During the entire project time, we have made ... |
|
| Improving Blood Monitoring of Enzymes as Biomarkers of Risk From Anticholinergic Pesticides and Chemical Warfare Agents |
OCT 2004 |
14 pages |
| Authors:
Barry W. Wilson; CALIFORNIA UNIV DAVIS
|
| Blood biomarkers are an important way to monitor exposure to anticholinergic pesticides and chemical warfare agents and to establish whether some are at greater risk than others from exposure to them. Many clinical and research laboratories use the colorimetric Ellman assay based on the hydrolysis of acetylthiocholine. CHPPM (US Army Center for Health Promotion and Preventive Medicine) uses a slower delta pH method based on that of Michel to monitor ... |
|
| GPUs: Engines for Future High-Performance Computing |
30 SEP 2004 |
32 pages |
| Authors:
John Owens; CALIFORNIA UNIV DAVIS
|
| GPUs as Compute Engines: 10 years ago: Graphics done in software; 5 years ago: Full graphics pipeline; Today: 40x geometry, 13x fill vs. 5 yrs ago = Programmable! Programmable, data parallel processing on every desktop; Enormous opportunity to change the way commodity computing is done! |
|
| Theoretical Modeling of Molecular Mechanism, Time Scales, and Strains in Prion Diseases |
JUL 2004 |
131 pages |
| Authors:
Daniel L. Cox; Rajiv R. Singh; CALIFORNIA UNIV DAVIS
|
| We have obtained significant research results on: 1)modeling the role of oligomeric intermediates in prion disease incubation dynamics and aggregation; 2) using an amino acid specific metal ions in the octarepeat regions of the prion protein, and 4) developing stochastic algorithm models for aggregation processes in prion disease. In the coming year we will: 1) attempt to extend our monte carlo code to allow for beta-sheet interactions between peptides; 2) ... |
|
| Innovative Microwave Vacuum Electronics Initiative Consortium (MURI'99) |
30 APR 2004 |
195 pages |
| Authors:
McDermott; J. Booske; G. Caryotakis; R. Gilgenbach; Victor L. Granatstein; CALIFORNIA UNIV DAVIS
|
| This report covers the period May 1, 1999- April 30, 2004 and contains a detailed description of the work conducted by the FY'99 MURI consortium on Innovative Microwave Vacuum Electronics (MVE). The participating institutions were the University of California, Davis (Lead Institution); MIT; Stanford University; University of Maryland, College Park; University of Michigan, Ann Arbor; and the University of Wisconsin. The program was tightly focused on the critical need for ... |
|
| Optimization and Characterization of Prostate Cancer Targeting Peptides |
FEB 2004 |
8 pages |
| Authors:
Jan Marik; Kit Lam; CALIFORNIA UNIV DAVIS
|
| The annual report for postdoctoral traineeship awards "Optimization and Characterization of Prostate Cancer Targeting Peptides" covers the period 02/01/2003-01/31/2004. During the first year, the combinatorial libraries proposed in specific aim 1 were synthesized and screened for DU-145, LNCap, PC3 cell binding (specific aim 2). The libraries were tested for binding of other cancer cell lines such as ovarian, lung and pancreatic cancer cell lines. Several high affinity ligands were identified ... |
|
| Effect of Pyridostigmine on the Physiologic and Morphologic Changes Induced by Soman at the Human Neuromuscular Junction |
JAN 2004 |
10 pages |
| Authors:
Ricardo A. Maselli; CALIFORNIA UNIV DAVIS
|
| Pre-treatment of American troops with pyridostigmine bromide (PB) has been advocated as an effective way to counteract the potential lethal effect of nerve-agent exposure during military operations. This policy is based on experimental evidence indicating that PB provides partial protection to animals exposed to soman. The protecting mechanism of PB involves a temporary inhibition of the end-plate acetylcholinesterase (AChE) which prevents an ensuing irreversible inhibition induced by a nerve agent. ... |
|
| Neural Network Control of a Parallel Hybrid-Electric Propulsion System for a Small Unmanned Aerial Vehicle |
2004 |
29 pages |
| Authors:
Frederick G. Harmon; Andrew A. Frank; Jean-Jacques Chattot; Sanjay S. Joshi; CALIFORNIA UNIV DAVIS
|
| Parallel hybrid-electric propulsion systems would be beneficial for small unmanned aerial vehicles (UAVs) used for military, homeland security, and disaster monitoring missions involving intelligence, surveillance, or reconnaissance (ISR). The benefits include increased time-on-station and range than electric-powered UAVs and stealth modes not available with gasoline-powered UAVs. A conceptual design of a small UAV with a parallel hybrid-electric propulsion system, an optimization routine for the energy use, the application of a ... |
|
| Modeling Communication Losses and Interference in Fiber Optic Systems |
DEC 2003 |
16 pages |
| Authors:
David M. Rocke; Garry Rodrigue; David L. Woodruff; Brian H. Kolner; CALIFORNIA UNIV DAVIS
|
| Philosophy: The transmission characteristics of optical fibers are of utmost importance for future communication systems. Higher bandwidth and better signal quality are but a few of the reasons that fiber optics are replacing conventional means of communication. However, an optical signal experiences all kinds of losses as it propagates and demands the use of regenerators repeaters along the length of the fiber. External factors that can cause such losses include ... |
|
| Improving Blood Monitoring of Enzymes as Biomarkers of Risk Form Anticholinergic Pesticides and Chemical Warfare Agents |
OCT 2003 |
12 pages |
| Authors:
Barry W. Wilson; CALIFORNIA UNIV DAVIS
|
| Blood cholinesterase (ChE) biomarkers are an important way to monitor exposure to anticholinergic pesticides and chemical warfare (CW) agents and to establish whether some are at greater risk tan others form exposure to them. Many clinical and research laboratories use the colorimetric El lam assay based on the hydrolysis of acetylthiocholine. CHPPM (US Army Center For Health Promotion and Preventive Medicine) uses the Michel delta pH method to monitor more ... |
|
| Analysis of Keratin Filament Assembly/Disassembly and Structure Following Modification by Sulfur Mustard Analogs |
JUL 2003 |
24 pages |
| Authors:
John F. Hess; CALIFORNIA UNIV DAVIS
|
| Characterization of vimentin intermediate filament (IF) structure by site directed spin labeling (SDSL) and electron paramagnetic resonance (EPR) has produced new data concerning the All arrangement of molecules in intact filaments. In the All alignement, rod 1B of a dimer is aligned with rod 1B of a second dimer. Our EPR data identify vimentin position 190 as the midpoint of overlap between dimers in the A11 arrangement. In conjunction with ... |
|
| Development of Theoretical Methods for Predicting Solvent Effects on Reaction Rates in Supercritical Water Oxidation Processes |
12 JUN 2003 |
4 pages |
| Authors:
Susan C. Tucker; CALIFORNIA UNIV DAVIS
|
| The design of efficient supercritical water oxidation reactors for the destruction of chemical warfare agents will be facilitated by computational fluid dynamics modeling of these systems. To assist such modeling efforts, the aim of this project is to develop computational methods for predicting how reaction rate constants will vary with thermodynamic condition in supercritical water (SCW). Towards this end, two reactions were examined in SCW: the anisole hydrolysis reaction and ... |
|
| Aberrant Chromatin Modification as a Mechanism of Prostate Cancer |
JUN 2003 |
13 pages |
| Authors:
Hongwu Chen; CALIFORNIA UNIV DAVIS
|
| The purpose of this study was to test me hypothesis that aberrant chromatin modification plays a critical role in prostate cancer (CaP) progression. Scope of this study: We proposed to analyze histone acetylation and phosphorylation patterns on androgen receptor (AR) target genes such as PSA in malignant prostate cancer cells. Comparison of me patterns of histone modifications between different CaP cells will allow us to identify me chromatin modifications mat ... |
|
| Prevention of Post-Radiotherapy Failure in Prostate Cancer by Vitamin D |
MAR 2003 |
192 pages |
| Authors:
Srinivasan Vijayakumar; CALIFORNIA UNIV DAVIS
|
| Prostate cancer patients receive surgery or radiation therapy (RT) as treatment for cancer. Among patients receiving RT, 50% have an elevation of PSA within five years of treatment. These patients then receive hormones. We will test the theory that chemopreventive agents, which can prevent or delay the growth of prostate cancer cells in the laboratory, may prevent or delay the reappearance of prostate cancer in patients who have undergone RT ... |
|
| Low-Level Sarin Neurotoxicity and its Modulation by Pyridostigmine |
FEB 2003 |
57 pages |
| Authors:
Barry W. Wilson; CALIFORNIA UNIV DAVIS
|
| The possibility that a combination of exposures to organophosphate esters (OPs) and the carbamate pyridostigmine bromide (PB) would lead to nerve damage in Gulf War veterans was studied by treating hens and mice with known neuropathic OPs diisopropyl fluorophosphate (DFP), triorthocresyl phosphate (TOCP), sarin and with PB. Subthreshold and threshold levels inducing nerve damage were established in hens repeatedly treated with TOCP and DFP. Multiple doses of sarin did not ... |
|
| Synthesis and Behavior of Nanostructured Coatings Using Thermal Spraying |
22 JAN 2003 |
9 pages |
| Authors:
E. J. Lavernia; CALIFORNIA UNIV DAVIS
|
| Potential applications of thermal spraying coatings span the entire spectrum of technology, from thermal barrier coatings for turbine blades to wear resistant rotating parts. The goal of this research program was to synthesize and characterize nanostructured thermal spraying coatings. The specific objectives were as follows: (1) to synthesize nanostructured powders for fabrication of nanostructured thermal spraying coatings; (2) to improve the spray technology for spraying nanostructured powders; and (3) to ... |
|
| Bone Morphogenetic Proteins, Antagonists and Receptors in Prostate Cancer |
JAN 2003 |
32 pages |
| Authors:
A. H. Reddi; CALIFORNIA UNIV DAVIS
|
| The long-term objective of this proposal is to gain insight into mechanism of prostate cancer metastases to bone and attendant pathology of osteosclerosis. What is the cellular and molecular basis of osteotropism of metastatic prostate cancer in humans? The predominant site of prostate cancer is bone. However, unlike the osteolytic lesions of breast cancer, prostate cancer causes osteoblastic osteosclerosis which leads ultimately to morbidity and mortality. During the osteoscleorotic phase ... |
|
Reports by Corporate Author
