| Compact Gamma Camera System for Breast Cancer Imaging |
JUL 2000 |
10 pages |
| Authors:
Stephen Derenzo; CALIFORNIA UNIV BERKELEY
|
 | The goal of this project is the development of a compact solid-state gamma camera specifically designed to image metabolically active tumors in the breast and axillary nodes with the highest possible detection efficiency and spatial resolution. We have developed or purchased final versions of all major components of the proposed compact solid-state gamma camera: collimators, CsI(T1) scintillator arrays, special low-noise silicon photodiode arrays, and custom integrated circuit readout chips. A ... |
|
| A Novel Techniques to Follow Consequences of Exogenous Factors, Including Therapeutic Drugs, on Living Human Breast Epithelial Cells |
JUL 2000 |
11 pages |
| Authors:
CALIFORNIA UNIV BERKELEY
|
| Monitoring fluorescently tagged proteins in live cells enables the observation of spatial and temporal events in a way that would otherwise not be possible. We are using this approach to examine normal and tumor human mammary epithelial cells (growing in 2D and 3D cultures) before and after addition of exogenous agents. We used confocal microscopy to examine living cells containing proteins tagged with green fluorescent protein (GFP). We examined GFP-tagged ... |
|
| The Future of North Korea: Scenarios and Implications for the United States Army |
08 MAY 2000 |
79 pages |
| Authors:
Darrell H. Zemitis; CALIFORNIA UNIV BERKELEY
|
| In recent years, North Korea has been in plagued by economic decline, famine, and international isolation. Due to the current situation in North Korea, there has been recent speculation about the future of North Korea. Some feel that it will collapse, others hypothesize that North Korea will gradually reform and open itself to the outside world. The hard landing' and soft landing' scenarios for North Koreas future ... |
|
| Nonlinear Dynamics for Communication Systems |
25 APR 2000 |
7 pages |
| Authors:
Leon O. Chua; CALIFORNIA UNIV BERKELEY
|
| We have successfully accomplished all the proposed tasks, and discovered and developed new results of fundamental significance and potential applications in the following areas: 1) robustness of chaotic synchronization schemes, 2) efficiency of chaotic synchronization systems, 3) design of practical chaotic spread-spectrum communication systems, 4) channel capacity of chaotic spread-spectrum communication systems, and 5) potential commercial applications of chaotic spread-spectrum communication systems. ... |
|
| Infrared Cavity Ringdown Laser Absorption Spectroscopy: Metal-ContainingClusters and HEDM Molecules |
04 FEB 2000 |
14 pages |
| Authors:
Richard J. Saykally; CALIFORNIA UNIV BERKELEY
|
| Efforts focused on four activities related to the central objective of studying metal-containing clusters, HEDM molecules, and clusters of ceramic materials. Nineteen AFOSR supported papers were published on the following topics (including five journal cover articles) : 1) Development of high resolution (100 MHz), high sensitivity pulsed infrared cavity ringdown spectroscopy as a general tool for trace species characterization. 2) Infrared cavity ringdown system ... |
|
| Analysis of Ultra-High Speed, High Temperature Superconductor (HTS) digital Circuits |
18 JAN 2000 |
4 pages |
| Authors:
Theodore VAN Duzer; CALIFORNIA UNIV BERKELEY
|
| The purpose of this research was to determine the expected yields and bit error rates of HTS digital circuits operated at tens of gigahertz at various temperatures. This was done by using device parameters from TRW, Conductus, and Northrup Grumman for state-of-the-art devices. The circuits studied included two rapid-single-flux-quantum (RSFQ) T flip-flop circuits. One (with 14 Josephson junctions) included estimated undesirable parasitic inductances and other was assumed ... |
|
| Novel WDM Device and System Research for Ultra High Capacity Optical Interconnects |
18 JAN 2000 |
20 pages |
| Authors:
Connie J. Chang-Hasnain; Alan E. Willner; CALIFORNIA UNIV BERKELEY
|
| Massively parallel interconnection planes can provide an extremely high bandwidth 2-D switching system. By adding wavelength selectivity into the interconnect system, we can significantly increase both the interconnect capacity as well as the dynamically reconfigurable functionality. This program includes a cohesive and comprehensive multi-disciplinary effort at both device and system levels, with novel devices and new systems using these devices. We achieved device-to-systems technology ... |
|
| Very High Frequency Mode-Stabilized VCSELs for Linear/RF Photonic Applications |
18 JAN 2000 |
32 pages |
| Authors:
Connie Chang-Hasnain; Kam Lau; CALIFORNIA UNIV BERKELEY
|
| Vertical cavity surface emitting lasers (VCSELs) have emerged as a key optical source in digital and RF photonics systems. Investigation to date has involved VCSELs of "standard" DBR construction. However, incorporation of a controllable saturable absorber inside the lasing cavity results in a wealth of new dynamic characteristics. The focus of this program is on designs and experiments of a novel three contact vertical cavity ... |
|
| The Compressive Behavior of Glass Fiber Reinforced Composites Subjected to Local Thermal Loading |
2000 |
95 pages |
| Authors:
Catherine M. Westover; CALIFORNIA UNIV BERKELEY
|
| An experimental study has been conducted to determine the effects of local thermal loading on the compressive behavior of glass fiber composites. The primary factors considered were the intensity of thermal loading and the applied compressive load. The material specimens tested were laminate plates composed of Micarta 010 FR4, a fire retardant glass/epoxy laminate. Two types of testing were conducted for heat fluxes of 85 kW/m2, 140 kW/m2, and 195 ... |
|
| Does Vigorous Exercise Prevent Breast Cancer in Women? |
OCT 1999 |
12 pages |
| Authors:
Paul T. Williams; CALIFORNIA UNIV BERKELEY
|
| The original purpose of the IDEA award was to recruit 36,000 additional runners to add to an existing cohort of 14,000 runners in order to create a total cohort of 50,000 who vigorously exercise. (Funding for surveillance was deferred to a future funding application.) We completed the design of the initial survey questionnaire and recruited the sample through direct mail solicitation of female running ... |
|
| Dynamic Threshold-Voltage MOSFET |
23 SEP 1999 |
2 pages |
| Authors:
Chenming Hu; CALIFORNIA UNIV BERKELEY
|
| A Dynamic Threshold MOS (DTMOS) transistor has the unique ability to operate at 0.5V with high speed and current wile delivering a low off state leakage. This project investigated the possibility of using DTMOS at Vdd > 0.5V to achieve higher circuit performance. |
|
| High-Cycle Fatigue and Time-Dependent Failure in Metallic Alloys for Propulsion Systems |
01 SEP 1999 |
48 pages |
| Authors:
Robert O. Ritchie; Subra Suresh; John W. Hutchinson; Walter W. Milligan; Anthony W. Thompson; CALIFORNIA UNIV BERKELEY
|
| This program is focused on the definition, microstructural characterization and mechanism-based modeling of the limiting states of damage associated with the onset of high-cycle fatigue failure in titanium and nickel- base alloys for propulsion systems. Both experimental and theoretical studies are aimed at three areas, namely HCF/LCF interactions, the role of notches and foreign object damage, and fretting fatigue. The approach is to combine new experimental techniques for characterizing microstructural ... |
|
| MAPK-A Critical Intermediate in Anti-Estrogen Resistance |
SEP 1999 |
15 pages |
| Authors:
Ruth F. Lupu; CALIFORNIA UNIV BERKELEY
|
| Heregulin (HRG) is a growth factor that activates erbB-2-3-4 receptors. We have generated a novel model of tumor progression from hormone- dependent to a hormone-independent phenotype by introducing HRG into breast cancer cells. We now would like to investigate the mechanism by which HRG induces tumor progression. Our working hypothesis is that expression of HRG induces an uncontrolled mitogen-activated protein kinase (MAPK) cascade producing unbalanced growth promoting genes. The propose ... |
|
| Response of Breast Cancer Cells to Hormonal Therapy; Quantitative in Vivo NMR Studies |
SEP 1999 |
22 pages |
| Authors:
Douglas S. Clark; CALIFORNIA UNIV BERKELEY
|
| Our research is directed at determining the specific metabolic pathways and the individual reactions affected by estrogen and tamoxifen in both estrogen receptor-positive (ER+) and estrogen receptor-negative (ER-) breast cancer cells through the use of novel NMR methodology and quantitative analysis. In this report period, we have quantified the effect of estrogen on metabolic fluxes in ER+ cells. This was accomplished using a comprehensive metabolic model and NMR data from ... |
|
| Development of Novel Epidermal Growth Receptor-Based Radiopharmaceutical: Imaging Agents for Breast Cancer |
SEP 1999 |
25 pages |
| Authors:
Henry VanBrocklin; CALIFORNIA UNIV BERKELEY
|
| The goal of this research is to develop nuclear medicine imaging agents, to aid in the early detection, diagnosis and treatment of breast cancer, based on the epidermal growth factor receptor (EGFr) biomarker. EUF receptors are upregulated in 45% of breast tumors and tumors possessing these receptors fail to respond to conventional treatment correlating with decreased patient survivability. Our approach is to design and synthesize small ... |
|
| Fluid Transport Mechanisms in Breast Gross Cystic Disease |
SEP 1999 |
32 pages |
| Authors:
Sheldon S. Miller; CALIFORNIA UNIV BERKELEY
|
| The goal of the present work was to develop a model system to study the mechanisms of fluid transport across mammary epithelia. In addition we also examined whether the epithelial ion Cl and Na channels (cystic fibrosis transmembrane conductance regulator, CFTR, and ENaC, respectively) contribute to the ion and fluid transport properties of the mammary epithelial cell line 31EG4. We reasoned that since the mammary gland ... |
|
| Tat-SF: A Cellular Factor for Regulation of Transcriptional Elongation by HIV Tat |
SEP 1999 |
14 pages |
| Authors:
Qiang Zhou; Kunxin Luo; CALIFORNIA UNIV BERKELEY
|
| Deregulation of transcriptional elongation can cause the development of certain malignancies. HIV-1 Tat has been used as a model system to study the control of elongation by RNA polymerase ii. Tat stimulates HIV- 1 transcription by recognizing the TAR RNA structure near the 5' end of the nascent viral transcript and by recruiting the human transcription elongation factor P-TEFb to the HIV-1 promoter. Tat functions in ... |
|
| Control of Breast Tumor Cell Growth by Dietary Indoles |
SEP 1999 |
27 pages |
| Authors:
Leonard Bjeldanes; CALIFORNIA UNIV BERKELEY
|
| Indole-3-carbinol (I3C) is a naturally occurring component of dietary vegetables and a promising cancer preventive agent, most notably against breast cancer. 13C markedly reduces the incidence of spontaneous and carcinogen-induced mammary tumors in rodents and exhibits potent growth inhibitory activity in human breast cancer cells. Although 13C has reached the stage of phase I clinical trials, little is known about the mechanism of its growth inhibitory effects in cancer cells. ... |
|
| Functional Analysis of a Novel Transcription Factor That is Amplified and Overexpressed in Breast Cancer |
SEP 1999 |
21 pages |
| Authors:
Paul Yaswen; CALIFORNIA UNIV BERKELEY
|
| DNA amplification at chromosome position 20q13.2 is common in breast cancer, correlates with poor prognosis, and may reflect the presence of an important oncogene that has not been previously characterized. A candidate oncogene in this region, ZNF2l7, whose level of expression matches degree of amplification, has been identified through gene mapping and expression studies. To begin to understand how ZNF2l7 overexpression contributes to breast cancer progression, in vitro studies are ... |
|
| Interindividual Difference in Metabolism of Carcinogens as a Risk Factor for Breast Cancer |
SEP 1999 |
13 pages |
| Authors:
Regine Goth-Goldstein; CALIFORNIA UNIV BERKELEY
|
| The proposed study seeks to address the interaction of environmental and genetic factors in the etiology of breast cancer. Cytochrome P45O isozyme (CYP1B1) metabolizes environmental and endogenously formed carcinogens in the breast. We are testing the hypothesis that individuals with higher levels of CYP1B1 are at a higher risk for breast cancer because they produce higher amounts of ultimate carcinogen. The expression level of CYP1B1 is being determined in a ... |
|
| Visual Servoing for Optimization of Anticancer Drug Uptake in Human Breast Cancer Cells |
SEP 1999 |
23 pages |
| Authors:
Daniel E. Callahan; CALIFORNIA UNIV BERKELEY
|
| The purpose of this two-year IDEA proposal is to gather preliminary data that demonstrate the feasibility of a new class of in vitro drug response and chemosensitivity assays. Our objectives are to develop an instrument (a visual servoing optical microscope, or VSOM) in a stepwise fashion and gather preliminary data to aid future development of cell culture techniques and fluorescence assays. Our goal is to demonstrate the feasibility of using ... |
|
| BCL-2, Ca, and Apoptosis in Breast Cancer |
AUG 1999 |
8 pages |
| Authors:
Terry E. Machen; CALIFORNIA UNIV BERKELEY
|
| 31EG4 mammary epithelial cells were grown to confluence on filters, and apoptosis was initiated by staurosporine and mitomycin (kinase inhibitors) and also by thapsigargin (releases Ca stores by blocking Ca pump) and collagenase IV (degrades extracellular matrix). As shown by specific staining with fluorescent dyes, apoptosis began to occur in a small percentage of cells (after 16 hrs) as shown by condensation and fragmentation ... |
|
| Proceedings of the 20th International Conference on Defects in Semiconductors Held in Berkeley, CA, USA, 26-30 July 1999 |
30 JUL 1999 |
|
| Authors:
C. Van de Walle; W. Walukiewicz; F. R. De Boer; Z. Fisk; R. Jochemsen; CALIFORNIA UNIV BERKELEY
|
 | These are the proceedings of the 20th International Conference on Defects in Semiconductors, ICDS-20, which was held in Berkeley, California, between July 26-30, 1999. It has been 40 years since the first conference in this series was organized in Gatlinburg, Tennessee, and we take this opportunity to identify and congratulate two of our friends and colleagues, Professors Anant K. Ramdas and George D. Watkins, for their seminal ... |
|
| Nonlinear Circuits and Neural Networks: Chip Implementation and Applications of the TeraOPS CNN Dynamic Array Supercomputer |
15 JUL 1999 |
5 pages |
| Authors:
Leon O. Chua; CALIFORNIA UNIV BERKELEY
|
| Advances in research have been made in the following areas: (1) The detailed test and characterization of the first ever ARAM in the CNN Chip Set Architecture; (2) The constructive use of the local activity principle in designing Cellular Nonlinear Networks with complex behavior; (3) Analogic CNN subroutine design for various practical applications, including coding, and optical flow estimation; and (4) Advances in testing qualitative properties of CNN, including stability ... |
|
| Compact Gamma Camera System for Breast Cancer Imaging |
JUL 1999 |
17 pages |
| Authors:
Stephen E. Derenzo; CALIFORNIA UNIV BERKELEY
|
| The goal of this project is the development of a compact solid-state gamma camera specifically designed to image metabolically active tumors in the breast and axillary nodes with the highest possible detection efficiency and spatial resolution. The compact design also allows for a larger number of oblique views and reduces cost, which will make the instrument more widely available to the medical community. ... |
|
| Modulation of T-Cell Activation in an Experimental Model of Mammary Carcinoma |
JUL 1999 |
52 pages |
| Authors:
Arthur A. Hurwitz; CALIFORNIA UNIV BERKELEY
|
| The goal of this research project was to study the requirements for T cell activation in generating a potent anti-tumor immune response. In the first year, using a transplantable mammary carcinoma model, we demonstrated that the combination of CTLA-4 blockade and a GM-CSF-expressing vaccine was effective for treatment of recently established tumors. This funded year, these findings were to be expanded to 2 additional models: a transplantable ... |
|
| Three Dimensional Structure Determination of Botulinum Neurotoxin |
JUL 1999 |
103 pages |
| Authors:
Raymond C. Stevens; CALIFORNIA UNIV BERKELEY
|
| The immediate goals of the contract on the structure and function relationship of botulinum neurotoxin are: (1) Determine the three-dimensional structure of botulinum neurotoxin at atomic resolution by x-ray crystallography. (2) Based on the structure of the neurotoxin, understand the toxins mechanism of action. We have accomplished the first goal of determining the three-dimensional structure of the 150 kD botulinum neurotoxin serotype A. The toxin is Y-shaped, with a very ... |
|
| A Novel Technique to Follow Consequences of Exogenous Factors, Including Therapeutic Drugs, on Living Human Breast Epithelial Cells |
JUL 1999 |
13 pages |
| Authors:
Carolyn A. Larabell; CALIFORNIA UNIV BERKELEY
|
| My lab is developing techniques for imaging living human breast epithelial cells in 3-D cultures to evaluate their responses to the application of exogenous factors. Unlike most model systems, which utilize cells growing in monolayers on plastic substrates, our system more closely mimics the growth of cells in the body. Recent data from other laboratories demonstrate that cells growing in monolayers do not necessarily respond to exogenous substances in the ... |
|
| Optimal Controller Switching for Stochastic Systems |
01 MAR 1999 |
17 pages |
| Authors:
E. Skafidas; R. J. Evans; I. M. Mareels; A. Nerode; CALIFORNIA UNIV BERKELEY
|
| This paper presents a solution to certain problems in switched controller design for stochastic dynamical systems with a quadratic cost. The main result is a separation theorem for partial information systems. This result is then used to convert the partial information stochastic control problem to a complete information stochastic control problem. We also show that certainty equivalence does not hold. The optimal sequence of controllers can be determined via an ... |
|
| QoS Based Evaluation of the Berkeley Continuous Media Toolkit |
01 MAR 1999 |
30 pages |
| Authors:
D. Wijesekera; S. Varadarajan; S. Parikh; J. Srivastava; A. Nerode; CALIFORNIA UNIV BERKELEY
|
| This paper presents a performance analysis of the Continuous Media service provided by the Berkeley, Continous Media Tool kit (CMT). We show a development of metrics, validation by means of a user study, and a performance evaluation of a prototyping environment. The CMT is a popular environment that satisfies our need of being easily extendible and offers a quick prototyping environment. From a human user's perspective, in order for multimedia ... |
|
| Hydrodynamic Interaction Between Olfactory Antennae and Odor Plumes |
28 FEB 1999 |
309 pages |
| Authors:
M. A. Koehl; CALIFORNIA UNIV BERKELEY
|
| We studied the small-scale hydrodynamics of diverse olfactory antennae of marine animals to elucidate ways in which their physical structure and motion affect how they encounter the concentration distributions in odor plumes, and to gain insights for the design of man-made chemical sensors. The designs and motions of the lobster, crab, and mantis shrimp antennules we studied enhance their ability to take temporally and spatially discrete odor samples. We also ... |
|
| Annual Technical Report on ONR Grant N00014-96-1-0737 for the Support of Infrared Spatial Interferometry |
26 JAN 1999 |
16 pages |
| Authors:
Charles H. Townes; CALIFORNIA UNIV BERKELEY
|
| Further upgrades of the 10 micron interferometer have been made during 1998, tested, and used. The present system now provides improved tracking, stronger signals, and more precise infrared measurements. A number of stars have been measured. Some are newly measured, others are remeasured and show changes. Narrow band filters have been installed and used for interferometry on spectral lines. |
|
| Risk Analysis and Management of Diving Operations: Assessing Human Factors |
20 NOV 1998 |
105 pages |
| Authors:
Timothy C. Liberatore; CALIFORNIA UNIV BERKELEY
|
| Current technological advancements in diving systems have been paramount to increasing the depth and duration of commercial and military diving operations. Even with such advances and the use of proven engineered diving systems, as humans continue to strive for deeper and longer dives, significant risk to all personnel is inherent. Minimization and mitigation of such risk is vital to meet the need for continued use of manned-diving systems to perform ... |
|
| Does Vigorous Exercise Prevent Breast Cancer in Women |
OCT 1998 |
10 pages |
| Authors:
Paul T. Williams; CALIFORNIA UNIV BERKELEY
|
| The purpose of the IDEA award is to establish a cohort of 50,000 vigorous exercisers, provide data on questionnaire validity and provide pilot data on surveillance. (Funding for surveillance will be deferred to a future funding application.) During this first year of funding, we finalized the design of the survey questionnaire and obtained approval from human subjects for its use, determined the best recruitment strategy for recruiting 50,000 women runners, ... |
|
| Postpartum Maternal Weight Changes: Implications for Military Women |
OCT 1998 |
125 pages |
| Authors:
Barbara Abrams; CALIFORNIA UNIV BERKELEY
|
| Maintaining physical readiness to meet demands of combat conditions is of utmost importance for active duty military personnel. As growing numbers of women of childbearing age enter active duty military service, the numbers of pregnancies among female military personnel will also increase. Thus, understanding the impact of pregnancy on subsequent fitness of postpartum active duty women becomes imperative. This project will describe the pattern of maternal weight loss alter delivery ... |
|
| Fluid Transport Mechanisms in Breast Gross Cystic Disease |
SEP 1998 |
27 pages |
| Authors:
Sheldon Miller; CALIFORNIA UNIV BERKELEY
|
| The goal of this research is to develop a pharmacological strategy for reducing or eliminating the pathological accumulation of fluid that occurs in breast gross cystic disease (GCD). Over the last year, we have analyzed several of the transport proteins and intracellular signaling mechanisms that mediate the movement of fluid (and ions) across confluent monolayers of 31EG4 cultured mammary epithelial cells. We hope eventually to be able to analyze cells ... |
|
| Genetic Alterations in Familial Breast Cancer: Mapping and Cloning Genes Other Than BRCAl |
SEP 1998 |
26 pages |
| Authors:
Mary C. King; Warren Winkelstein Jr; CALIFORNIA UNIV BERKELEY
|
| The purpose of this project was to identify genes responsible for inherited predisposition to Breast cancer in families. The gene PTEN was successfully cloned by this project, and simultaneously by others (for a different reason) and proved to be such a gene. This project indicated that inherited mutations in PTEN predispose to breast cancer in women with the rare Cowden's syndrome. However, symptoms of that syndrome may be very subtle, ... |
|
| Response of Breast Cancer Cells to Hormonal Therapy: Quantitative in vivo NMR Studies |
SEP 1998 |
22 pages |
| Authors:
Douglas S. Clark; CALIFORNIA UNIV BERKELEY
|
| Our research is directed at determining the specific metabolic pathways and the individual reactions affected by estrogen and TAM in both ER+ and ER- cells through the use of novel NMR methodology and quantitative analysis. In this report period, we have identified the primary metabolic pathways that are operative in ER+ cells. This was accomplished using a comprehensive metabolic model and NMR data from cell extracts. We have also performed ... |
|
| Directional Irregular Wave Kinematics |
SEP 1998 |
184 pages |
| Authors:
Christopher H. Barker; Rodney J. Sobey; CALIFORNIA UNIV BERKELEY
|
| Coastal and ocean processes are heavily influenced by the kinematics of waves. In order to understand these processes, researchers place a variety of instruments in the sea in an attempt to measure the waves. These instruments all measure a small set of physical quantities at a small number of locations. The balance of the kinematics must be predicted through analysis of the measured records. Most of the ... |
|
| Control of Breast Tumor Cell Growth by Dietary Indoles |
SEP 1998 |
46 pages |
| Authors:
Leonard Bjeldanes; CALIFORNIA UNIV BERKELEY
|
| Introduction: Indole-3-carbinol (13C) is a naturally occurring component of dietary vegetables and a promising cancer preventive agent, most notably against breast cancer. I3C markedly reduces the incidence of spontaneous and carcinogen-induced mammary tumors in rodents and exhibits potent growth inhibitory activity in human breast cancer cells. Although I3C has reached the stage of phase I clinical trials, little is known about the mechanism of its growth inhibitory effects in cancer ... |
|
| Control of Cell Migration during Development |
AUG 1998 |
17 pages |
| Authors:
Wayne C. Forrester; Gian Garriga; CALIFORNIA UNIV BERKELEY
|
| Cell migrations are critical for normal development. For example, much of the human nervous system is generated by cell migration. Also, the spread of cancerous cells is a similar process. Few proteins that guide migrating cells have been identified. To identify additional proteins required for cell migration, we performed two genetic screens for Caenorhabditis Elegans mutants with displaced migratory cells. In these screens we identified 14 genes required for normal ... |
|
| BCL-2, Ca, and Apoptosis in Breast Cancer |
AUG 1998 |
9 pages |
| Authors:
Terry E. Machen; CALIFORNIA UNIV BERKELEY
|
| The central hypothesis of this project is that bcl-2 controls PCD and oncogenesis by altering Ca permeability by the ER/nuclear membranes, mitochondria and/or plasma membrane of mammary epithelial cells. We used fluorescence imaging and electrophysiology to measure Ca permeation and transport across the plasma membranes (and next year across ER and mitochondrial membranes) in control (and next year in bcl-2-transfected) mouse mammary epithelial cells (31EG4) before and during PCD. We ... |
|
| Modulation of T-Cell Activation in an Experimental Model of Mammary Carcinoma |
JUL 1998 |
28 pages |
| Authors:
Arthur A. Hurwitz; CALIFORNIA UNIV BERKELEY
|
| One of the major goals of tumor immunotherapy is the induction of tumor-specific T cell responses that will be effective at eradicating disseminated tumors. The studies described in this update take advantage of our current knowledge of T cell activation and inhibitory signals. Using a transplantable mammary carcinoma, we demonstrated that blockade of inhibitory signals mediated by CTLA-4 using a monoclonal antibody synergizes with ... |
|
| Nonlinear Circuits and Neural Networks: Chip Implementation and Applications of the TeraOPS CNN Dynamic Array Supercomputer |
30 JUN 1998 |
6 pages |
| Authors:
L. Chua; CALIFORNIA UNIV BERKELEY
|
| During the period July 1997 - June 1998 work has continued according to the proposed plan. Advances in research have been made in the following areas: (1) The design and implementation of the first-ever ARAM in the CNN Chip Set Architecture was successfully competed, and the samples were successfully tested; (2) A major theoretical breakthrough has been achieved: it was shown that the genesis of complexity lies in the local ... |
|
| Nonlinear Dynamics for Communication Systems |
30 JUN 1998 |
5 pages |
| Authors:
L. Chua; CALIFORNIA UNIV BERKELEY
|
| We have made impressive research progress on several related aspects of our research grant during the period July 1997 through June 1998; namely, (1) robustness of chaotic synchronization schemes, (2) efficiency of chaotic synchronization systems, (3) design of practical chaotic spread spectrum communication systems, (4) channel capacity of chaotic spread spectrum communication systems, and (5) potential commercial applications of chaotic spread spectrum communication systems. |
|
| Performance Evaluation of Media Synchronization Losses in the Continuous Media Toolkit |
FEB 1998 |
21 pages |
| Authors:
D. Wijesekera; S. Parikh; S. Varadarajan; J. Srivastava; A. Nerode; CALIFORNIA UNIV BERKELEY
|
| This paper presents a performance analysis of synchronization services provided by the Berkeley Continuous Media Toolkit (CMT). The quality of audio video synchronization is measured against processor and network loads for both remote and local clients. The metrics of analysis are the perceptible and tolerable human perceptual limits reported by Steinmetz, and another metric designed to measure synchronization of lossy media streams. It is shown that according to Steinmetz, metric ... |
|
| Annual Technical Report on ONR Grant N00014-96-1-0737 for the Support of Infrared Spatial Interferometry |
31 DEC 97 |
17 pages |
| Authors:
Charles H. Townes; CALIFORNIA UNIV BERKELEY
|
| Recent upgrades of the 10 micron interferometer have during 1997 been fully programmed, tested, and used. They provide improved tracking and stronger signals, and have been extensively used for new stellar measurements. Multiple shells around several stars have been found and analyzed, and movements or other changes with time are seen in the dust shells around some stars. Methods for compensating atmospheric fluctuations have been examined, and measurements of the ... |
|
| Modal Logics for Continuous Dynamics |
NOV 1997 |
143 pages |
| Authors:
Jennifer M. Davoren; CALIFORNIA UNIV BERKELEY
|
| This work is a formal investigation of a number of bimodal and polymodal logics built on a base of propositional S4, and is a contribution to the theory of hybrid control systems. It is the first stage of a larger project of developing logics for the design and verification of such systems. |
|
| Nonlinear Circuits and Neural Networks (AASERT FY94) |
31 OCT 97 |
6 pages |
| Authors:
Leon O. Chua; CALIFORNIA UNIV BERKELEY
|
| Cellular Nonlinear Networks (CNNs) are large arrays of nonlinear circuits coupled to their immediate neighbors. During this funding period we have made many advances in understanding the pattern-forming dynamics of such circuits and their relationship to problems in physics and biology, we have explicated the image processing capabilities of such CNNs, including spatial filtering and multiscale analysis, and finally we have obtained rigorous mathematical results concerning the dynamic behavior of ... |
|
| High-Frequency Integrated Circuits for Communication Systems |
16 OCT 97 |
7 pages |
| Authors:
Robert G. Meyer; Bernhard Boser; CALIFORNIA UNIV BERKELEY
|
| This research was directed towards realization of Si monolithic microwave communication transceivers. New theoretical methods were developed for the analysis of noise and distortion phenomena in nonlinear communication circuits such as low-noise amplifiers (LNAs) in the over-driven condition, mixers, oscillators and detectors. Using these techniques new circuit topologies were synthesized for the realization of various essential transceiver functions, and prototype circuits were built in state-of-the-art Si monolithic processes and experimentally ... |
|
Reports by Corporate Author
