| Exploiting the Immunological Effects of Standard Treatments in Prostate Cancer |
Mar-2009 |
40 pages |
| Authors:
Brad H Nelson; BRITISH COLUMBIA CANCER AGENCY VANCOUVER
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 | We previously demonstrated that hormone therapy (HT) and radiation therapy (RT) induce tumor-specific autoantibody responses in human prostate cancer, and this grant investigates the clinical significance of these findings. In Aim 1, the findings that HT induces autoantibody and T cell responses against PABPN1 in the Shionogi tumor model and that these immune responses are associated with inferior outcomes have recently been submitted for publication. We have also shown that ... |
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| Identification of Novel Genes and Candidate Targets in CML Stem Cells |
Jan-2009 |
32 pages |
| Authors:
Connie Eaves; Yun Zhao; BRITISH COLUMBIA CANCER AGENCY VANCOUVER
|
| Chronic myeloid leukemia (CML) is believed to originate from a normal hematopoietc stem cell acquiring the BCR-ABL fusion gene whose protein product has hyperactive tyrosine kinase activity. Though imatinib mesylate(IM) that targets BCR-ABL kinase activity is now widely used, its curative potential as a single agent is not sure, moreover it is unlikely to eliminate the CML stem cells either, which highlights the necessity to elucidate the molecular mechanism operative ... |
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| Characterization of Human Mammary Epithelial Stem Cells |
Oct-2008 |
17 pages |
| Authors:
Peter D Eirew; BRITISH COLUMBIA CANCER AGENCY VANCOUVER
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| The mammary epithelium of normal adult female mice contains stem cells with extensive in vivo regenerative and self-renewal potential. Analogous cells presumably exist in the mammary glands of adult women, and are candidate targets for the first transforming mutations that lead to the evolution of breast cancer stem cells. The objective of this grant is to develop a robust, quantitative and specific assay for these hypothesized normal human mammary stem ... |
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| Eliciting Autoimmunity to Ovarian Tumors in Mice by Genetic Disruption of T Cell Tolerance Mechanisms |
AUG 2006 |
15 pages |
| Authors:
Brad H. Nelson; BRITISH COLUMBIA CANCER AGENCY VANCOUVER
|
| We have developed a mouse model for ovarian cancer that allows monitoring of tumor-specific T cell clones as they encounter ovarian tumors in vivo. We "tagged" the neu oncogene with two defined T cell epitopes so as to confer recognition by available T cell receptor (TCR) transgenic T cells. When expressed in the murine ovarian rumor cell line ID8, epitope-tagged neu (designated neuOT1/OT2) induces the formation of aggressive ovarian adenocarcinomas ... |
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| A Genomic Approach to Identifying Novel Targets for Early Detection and Intervention of Prostate Cancer |
SEP 2003 |
19 pages |
| Authors:
Wan L. Lam; BRITISH COLUMBIA CANCER AGENCY VANCOUVER
|
| Early detection and intervention is key to a favorable prognosis in prostate cancer. Despite advances in the detection and treatment of prostate cancer, the mortality rate remains high. To improve survival, early detection and treatment strategies tailored to pre-invasive prostate cancer are required. We propose to catalog genetic alterations associated with the developmental stages of disease for use as diagnostic tools and to identify the critical genes that drive the ... |
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| Characterization of a New In Vivo Prostate Tumor Model that Progresses to Androgen-Independence and its Application in Determining Changes in Gene Expression |
NOV 2002 |
29 pages |
| Authors:
Marianne D. Sadar; BRITISH COLUMBIA CANCER AGENCY VANCOUVER
|
| Investigation of the molecular events underlying progression of prostate cancer to androgen-independence has been impeded by the lack of an in vivo model that yields pure populations of prostate cancer cells that are not contaminated with host cells. Here we characterize a new in vivo model that employs hollow fibers and allows for the retrieval of uncontaminated prostate cancer cells during various stages of endocrine progression to androgen- independence. Prostate-specific ... |
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| A Genomic Approach to Identifying Novel Targets for Early Detection and Intervention of Prostate Cancer |
SEP 2002 |
11 pages |
| Authors:
Wan L. Lam; Juergan R. Vielkind; BRITISH COLUMBIA CANCER AGENCY VANCOUVER
|
| Early detection and intervention is key to a favorable prognosis in prostate cancer. Despite advances in the detection and treatment, the mortality rate remains high. To improve survival, early detection and treatment strategies tailored to pre-invasive prostate cancer are required. We propose to catalogue genetic alterations associated with the developmental stages of disease for use as diagnostic tools and to identify the critical genes that drive the transformation of premalignant ... |
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Reports by Corporate Author
