| Functions and Mechanisms of Sleep in Flies and Mammals |
Oct 2009 |
32 pages |
| Authors:
Michael Rosbash; BRANDEIS UNIV WALTHAM MA
|
 | Work on sleep at Brandeis focuses on Drosophila melanogaster as well as the more traditional rodent models. The Drosophila works aims to exploit the genetic advantages of this organism yet still learn about aspects of sleep relevant to humans. The major finding has been that the human therapeutic Carbamazapine is a potent sleep-deprivation agent in flies. Current data indicate that its effects are mediated through the Rdl GABAA receptor, which ... |
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| Effects of Inactivating Ras-Converting Enzyme or Isoprenylcysteine Carboxyl Methyltransferase in the Pathogenesis of Chronic Myelogenous Leukemia |
01-Feb-2008 |
6 pages |
| Authors:
Ruibao Ren; BRANDEIS UNIV WALTHAM MA
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| The BCR-ABL fusion gene, the hallmark of CML, plays a causal role in the development of CML. The BCR-ABL tyrosine kinase inhibitors have been successfully used to treat patients with CML, but residual disease persists and drug resistance emerges. Although BCR-ABL remains to be an attractive target for developing CML therapies, identifying and targeting additional essential components in the development of CML are important for overcoming resistance to BCR-ABL tyrosine ... |
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| Effects of Inactivating Ras-Converting Enzyme or Isoprenylcysteine Carboxyl Methyltransferases in the Pathogenesis of Chronic Myelogenous Leukemia |
FEB 2007 |
6 pages |
| Authors:
Ruibao Ren; BRANDEIS UNIV WALTHAM MA
|
| The BCR-ABL fusion gene, the hallmark of CML, plays a causal role in the development of CML. The BCRABL tyrosine kinase inhibitors have been successfully used to treat patients with CML, but residual disease persists and drug resistance emerges. This clinical time bomb will have to be diffused in the not so distant future. Although BCR-ABL remains to be an attractive target for developing CML therapies, identifying and targeting additional ... |
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| Networks in Neuroscience: The Problem of Stability in the Face of Constant Change |
NOV 2006 |
15 pages |
| Authors:
Eve Marder; BRANDEIS UNIV WALTHAM MA
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| NETWORKS IN NEUROSCIENCE: (1) Every individual neuron contains complex networks of interacting biochemical and molecular processes. (2) The nervous system consists of networks of networks. NEUROSCIENTISTS ATTEMPT TO: (1) Determine how functions are localized in neuronal circuits; (2) Determine the properties of the synaptic wiring and excitability of individual neurons that constitute a network; (3) Explain how network performance arises from the interactions of the components. |
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| Coordinating Representations |
07 APR 2006 |
26 pages |
| Authors:
Richard Alterman; BRANDEIS UNIV WALTHAM MA
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| This project proposed a cognitive framework that explains how participants in a cooperative activity coordinate and jointly make sense of an unfolding situation. The principles that are derived from this framework guide the construction of methods, tools, and interface technology that enable the cognitive engineering of online environments that structure the activities of distributed planners and actors in a manner that reduces the work involved in sharing meanings, understandings, and ... |
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| Functions and Mechanisms of Sleep in Flies and Mammals |
JAN 2006 |
25 pages |
| Authors:
Michael Rosbash; BRANDEIS UNIV WALTHAM MA
|
| Work on sleep at Brandeis focuses on Drosophila melanogaster as well as the more traditional rodent models. The Drosophila works aims to exploit the genetic advantages of this organism yet still learn about aspcts os sleep relevant to humans. The major finding has been that the human therapeutic carbamazepine is a potent sleep-deprivation agent inflies. Current data indicate that its effects are mediated through the rdl GABA receptor, which has ... |
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| Functions and Mechanism of Sleep in Flies and Mammals |
FEB 2005 |
19 pages |
| Authors:
Michael Rosbash; BRANDEIS UNIV WALTHAM MA
|
| The Sleep Consortium at Brandeis consists of 6 PIs, who naturally group into three subsets. Rosbash and Griffith are collaborating on sleep studies in flies (Drosophila melanogaster). The two projects are investigating how drugs affect sleep and have identified the GABA(a) Receptor gene Rdl as a likely drug target for carbamazepine, a drug which enhances locomotor activity in a dose dependent manner. Preliminary results indicate the inhibitory system potentiates sleep ... |
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| Mutual Ground |
Jan 2005 |
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| Authors:
Rick Alterman; BRANDEIS UNIV WALTHAM MA
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 | Model: The Equivalence of Internal Representations; Interaction and Common Ground; Mutual Ground; Accumulation- Conversational Structure, Coordinating Representations, Cycle; Cognition. |
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| Model-Driven Study of Visual Memory |
DEC 2004 |
65 pages |
| Authors:
Robert Sekuler; BRANDEIS UNIV WALTHAM MA
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| Short-term episodic visual recognition memory is crucial to success in many everyday activities. We synthesized concepts, insights, and methods from memory research, and from vision research, working within a coherent, quantitative framework for understanding episodic visual recognition memory. Seven experiments were carried out in two related sub-projects. One sub-project confirmed that high-dimensional stimuli (synthetic human faces) afford important insights into episodic recognition memory. The results were well accommodated by a ... |
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| AASERT: Dynamic Training of Humans and Tutoring Agents |
31 MAR 2001 |
10 pages |
| Authors:
Jordan Pollack; BRANDEIS UNIV WALTHAM MA
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| Our ONR funded research over the past several years has focused on how machine learning systems can continuously improve through the dynamic modification of architecture and the dynamic construction of training environments. Although for different applications we use many different formalisms (neural networks, genetic programs, adaptive dynamical systems), we have focused on a framework for learning in which the environment automatically and incrementally becomes more challenging as the learner progresses. ... |
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| Proceedings of the Fourth International Conference on Simulation of Adaptive Behavior: From Amimals to Animals 4 |
DEC 96 |
645 pages |
| Authors:
Pattie Maes; Maja J. Mataric; Jean-Arcady Merer; Jordan Pollack; Stewart W. Wilson; BRANDEIS UNIV WALTHAM MA
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| Collection of papers refereed and presented at the 'SAB96' Conference. |
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| Acetylcholinesterase and Acetylcholine Receptor |
OCT 95 |
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| Authors:
Saul G. Cohen; BRANDEIS UNIV WALTHAM MA
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| 1 Bromo-214Cpinacolone (34CbrPin) inactivates AcChEs, from T. nobiliana labeling Cys 231, and E. electricus labeling His-440, and possibly Trp-435 and Asn-533. 14Cphenacyl bromide, (14CphABr) inactivates, labeling Cys- 231 and His-550 in T. nobiliana, and His-550 in E. electricus. Five sequenced peptides in T. nobiliana, are identical with those from T. califomica. Four peptides from E. electricus show 77 - 96% homology. Inactivations by BrPin or PhABr exclude 3Hdfp; inactivation by ... |
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| Army Research Office Workshop on Smart Materials Held at Waltham, Massachusetts on 15-17 August 1994 |
AUG 94 |
120 pages |
| Authors:
Robert B. Meyer; Edward Chen; BRANDEIS UNIV WALTHAM MA
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| This document presents proceedings of a workshop on Smart Materials, reviewing the research sponsored by the ARO program in Smart Materials and Systems. Extended abstracts from 18 investigators and 2 invited speakers are included. (MM) |
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| Conformation of Membrane Proteins: Bacteriorhodopsin |
13 MAY 94 |
6 pages |
| Authors:
Gerald D. Fasman; BRANDEIS UNIV WALTHAM MA
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| Bacteriorhodopsin, from the purple membrane (PM) of Halobacterium halobium, was chemically modified with methoxypolyethylene glycol (MW = 5000) succinimidyl carbonate. The polyethylene glycolbacteriorhodopsin (m-PEG-SC-BR33) conjugate, containing one PEG chain, was water soluble. The secondary structure of the conjugate in water appeared partially denatured but was shown to contain a-helical segments by circular dichroism (CD) spectroscopy. The isolated bacteriorhodopsin conjugate, with added retinal, was refolded in a mixed detergent-lipid micelle and ... |
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| Brandeis University's National Center for Complex Systems Construction Project |
18 FEB 94 |
3 pages |
| Authors:
BRANDEIS UNIV WALTHAM MA
|
| This is the Performance and Final Technical Report for Brandeis University's National Center for Complex Systems construction project. This report is brief and in summary format, and it specifically pertains to the construction project itself in accordance with the approved Department of Defense grant budget. |
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| Studies on Conformational Mixtures of Some Linear and Cyclic Beta-Turn Models Using X-Ray Diffraction, NMR, Circular Dichroism Spectroscopic Methods and Molecular Dynamics, |
1992 |
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| Authors:
Andras Perczel; Miklos Hollosi; Bruce M. Foxman; Gerald D. Fasman; BRANDEIS UNIV WALTHAM MA
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| The solid state conformation and/or the dominant solution state conformation was successfully determined for several beta-turns. A few previous attempts have been made to determine the complete conformational set of any beta-turn model in solution. |
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| Conformation of Membrane Proteins: Bacteriorhodopsin |
09 DEC 91 |
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| Authors:
Gerald D. Fasman; BRANDEIS UNIV WALTHAM MA
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| One of the main goals of this research project was accomplished. A water soluble derivative of bacteriorhodopsin (BR) was synthesized. An activated species of methoxypolyethylene glycol (MeOPEG) was synthesized, yielding 2-0- methoxypolyethylene glycol-N-hydroxy succinimyl carbonate. (MeO-PEG-SC). MeOPEG- SC was coupled with the purple membrane (PM) of Halobacterium hilobium to yield MeO-PEG-PM. This product was centrifuged and purified by washing with H20 (76 % conversion), dissolved in buffer with 5 % ... |
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| Sliding Charge Density Waves and Related Problems |
31 MAR 87 |
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| Authors:
L. Sneddon; BRANDEIS UNIV WALTHAM MA
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| From the publications (in many cases from the Figures) it is seen that incommensurate chaines give a surprisingly good account of the following dozen measurements: both components of complex ac conductivities as functions of field and frequency, in both metallic and semiconducting CDW materials; dc characteristics; scaling of ac and dc conductivities; elastic properties - Young's Modules and Q-factor as functions of voltage; bulk oscillations; and both amplitude and phase ... |
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| Interaction of Liquid Crystals with Inhomogeneous Surfaces |
JAN 85 |
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| Authors:
R. B. Meyer; BRANDEIS UNIV WALTHAM MA
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| We undertook the study of the interaction of nematic liquid crystals with inhomogeneous solid surfaces, in the attempt to better understand surface interactions and to fabricate new kinds of devices with novel surface alignment techniques. Along with the surface studies, we considered the optic properties of the new liquid crystal configurations we were attempting to fabricate, and new electro-optical effects that might be achieved. The new surface treatments that we ... |
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| Components of Mental Imagery Representation |
24 JAN 1983 |
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| Authors:
Stephen M. Kosslyn; Jennifer L. Brunn; Kyle R. Cave; Roger W. Wallach; BRANDEIS UNIV WALTHAM MA
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| The key question asked here was, Is mental imagery ability an undifferentiated general skill, or is it composed of a number of distinct subabilities? Further, if imagery is not an undifferentiated general ability, can its structure be understood in terms of the processing components posited by the Kosslyn & Shwartz theory of imagery representation? A set of tasks was administered to a group of 50 people, and a model was ... |
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| Imagery Ability and Task Performance |
24 JAN 1983 |
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| Authors:
Stephen M. Kosslyn; Kyle R. Cave; Zoe E. Forbes; Jennifer L. Brunn; BRANDEIS UNIV WALTHAM MA
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| Fifty subjects on a battery of imagery task, and showed that the subjects differed in their ability to perform specific imagery operations (such as image scanning, rotation, and generation). The generality and reliability of the imagery analyses were examined by testing fourteen of the original subjects in a new imagery experiment. This experiment was conducted over one year after the initial task battery was administered, and relied on a task ... |
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| FINAL REPORT JUNE 1958 - JUNE 1966. |
JUN 1966 |
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| Authors:
BRANDEIS UNIV WALTHAM MA
|
| Mathematicians participating in the contract, their present (1966) addresses, and papers generated under the contract between 1958 and 1966 are listed. |
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| CONTINUOUS REPRESENTATIONS IN THE STATISTICAL THEORY OF ELECTRONIC ENERGIES. THE H2(+) ION. |
15 JUL 1965 |
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| Authors:
George S. Handler; Sidney Golden; BRANDEIS UNIV WALTHAM MA
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| A version of the statistical theory of electronic energies, arising from a consideration of alternative partitionings of the Hamiltonian, has been applied to the H2(+) ion, yielding electronic energies approximately 6% greater in magnitude than the exact theoretical values at several values of the internuclear separation. The binding energy at the theoretical equilibrium separation was calculated to be 0.1024 a.u. compared to the experimental value of 0.1026 a.u. (Author) |
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| THE SPECIES AND COMPOSITION OF DILUTE ALKALI METAL-AMMONIA SOLUTIONS. I. |
01 JUN 1965 |
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| Authors:
Sidney Golden; Charles Guttman; Thomas R. Tuttle Jr.; BRANDEIS UNIV WALTHAM MA
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| Dilute solutions of the alkali metals in liquid ammonia are assumed to consist of the following constituents: M(+), the solvated metal cation; S, the solvent; M(-), the solvated metal anion; S(-), the solvent anion (solvated electron); the solvated ion-pairs M(+). M(-) and M(+). S(-). The presence of the solvated metal anion M(-) is justified on the basis of the observed existence of stable alkali metal anions in the gas phase. ... |
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| CONTINUOUS RETATIONS IN THE STATISTICAL THEORY OF ELECTRONIC ENERGIES |
Apr-1963 |
30 pages |
| Authors:
Sidney Golden; George Handler; BRANDEIS UNIV WALTHAM MA
|
| The use of continuous bases of representation other than a plane-wave basis is considered in the theory developed originally by Thomas and Fermi. The bases considered here are the sets of eigen-functions of Hamiltonians corresponding to a particle subjected to a field of force which varies inversely as the cube of the distance to some fixed point. Variation of the strength of the interaction varies the basis continuously. Calculations of ... |
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| RELAXATION OF QUANTUM MECHANICAL SYSTEMS |
JUL 1962 |
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| Authors:
Peter Mengert; BRANDEIS UNIV WALTHAM MA
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| A general theory of relaxation was developed. The equation for the time-development of expectation values was shown to be equivalent to the density matrix equation of Bloch (except for a correction in sign of one term). Requirements for the validity of the equation are developed. The relaxation of a quantum oscillator is investigated in both the free and driven cases. An expression for the power absorbed when the oscillator is ... |
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| ELECTRON SCREENING IN DENSE DEGENERATE GASES |
30 MAY 1960 |
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| Authors:
JACK S. GOLDSTEIN; BRANDEIS UNIV WALTHAM MA
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| QUANTUM CORRECTED STATISTICAL METHOD |
SEP 1959 |
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| Authors:
L.C.R. ALFRED; BRANDEIS UNIV WALTHAM MA
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| ON A QUANTUM MECHANICAL THEORY OF ABSOLUTE REACTION RATES |
01 APR 1959 |
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| Authors:
Sidney Golden; BRANDEIS UNIV WALTHAM MA
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| ON THE STATISTICAL THEORY OF MANY ELECTRON SYSTEMS. II. DISCRETE BASES OF REPRESENTATION: A QUASI-CLASSICAL APPROXIMATION |
01 MAY 1957 |
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| Authors:
Sidney Golden; BRANDEIS UNIV WALTHAM MA
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| ON THE STATISTICAL THEORY OF MANY - ELECTRON SYSTEMS. I. GENERAL CONSIDERATIONS PERTAINING TO THE THOMAS-FERMI THEORY |
01 JUL 1956 |
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| Authors:
Sidney Golden; BRANDEIS UNIV WALTHAM MA
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