ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD DEPT OF ARBOVIARAL ENTOMOLOGY
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During August and September 1988, we collected adult mosquitoes from 14 locations in the Senegal River basin to search for evidence of Rift Valley fever (RVF) viral activity one year after the 1987 outbreak, which occurred along the Senegal-Mauritania border. More than 62,000 specimens representing 18 species in seven genera were collected with carbon dioxide-baited, solid-state Army miniature light traps and sheep-baited traps. Twenty virus isolations from Culex, Aedes, and ...
The wild-type ZH501 strain of Rift Valley fever (RVF) virus and two small-plaque strains (T1 and T46) derived from it were characterized by plaque size, pathogenicity for hamsters and ability to replicate in Vero cells. Additionally, a mutagenized, attenuated, large-plaque, vaccine-candidate strain of RVF virus (ZH548-M12) was also studied. Infections with either the ZH501 or T46 strain were uniformly fatal to hamsters. In contrast, nearly all hamsters infected with either ...
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