We hypothesize that low systemic redox potential (GSH/GSSG; cysteine/cystine) reflects a vulnerability phenotype that is associated with regressive autism and is predictive of the risk of developing autism. The redox vulnerability phenotype is associated with epigenetic alterations in primary immune cells that may be reversible with restoration of intracellular redox potential. The hypothesis predicts that children with regressive autism and high risk (developmentally-delayed) children who are subsequently diagnosed with autism ...
Breast cancer is the most common malignancy of women in the Western world. Many risk factors are associated with the development and progression of breast cancer; however, diet/nutrition constitutes a highly modifiable risk. Breast cancer is considered to be initiated by mutations in a limited population of undifferentiated cells termed mammary stem cells (MaSCs) sitting at the top of the mammary epithelial hierarchy. Over-expansion of the stem cell population leads ...
Epidemiological and case control studies have shown a two- to eight-fold lower occurrence of breast cancer in Asian women whose early intake of soy products is 10 to 20 times higher than their American counterparts (1). Our laboratory has shown that dietary exposure to soy protein isolate (SPI) protects against breast cancer in rats partly due to upregulation of tumor suppressor phosphatase and tensin homologue deleted on chromosome ten (PTEN) ...
We hypothesize that low systemic redox potential (GSH/GSSG; cysteine/cystine) reflects a vulnerability phenotype that is associated with regressive autism and is predictive of the risk of developing autism. The redox vulnerability phenotype is associated with epigenetic alterations in primary immune cells that may be reversible with restoration of intracellular redox potential. The hypothesis predicts that children with regressive autism and high risk (developmentally- delayed) children who are subsequently diagnosed with ...
We hypothesize that low systemic redox potential (GSH/GSSG; cysteine/cystine) reflects a vulnerability phenotype that is associated with regressive autism and is predictive of the risk of developing autism. The redox vulnerability phenotype is associated with epigenetic alterations in primary immune cells that may be reversible with restoration of intracellular redox potential. The hypothesis predicts that children with regressive autism and high risk (developmentally-delayed) children who are subsequently diagnosed with autism ...
Breast cancer is considered to be initiated by mutations in a limited population of undifferentiated cells termed stem cells that ?sit? at the top of the mammary epithelial hierarchy. Over-expansion of the stem cell population leads to increased numbers of mutated stem cells that initiate and maintain tumors that eventually metastasize. Novel strategies to decrease the proliferation and promote the elimination of tumor-initiating stem cells are warranted. Our current studies ...
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