| Neural Responses to Injury: Prevention, Protection and Repair; Volume 7: Role Growth Factors and Cell Signaling in the Response of Brain and Retina to Injury |
OCT 1996 |
126 pages |
| Authors:
Nicolas G. Bazan; LOUISIANA STATE UNIV NEW ORLEANS
|
 | The experimental animals used during this period for the project, Neural Responses to Injury: Prevention, Protection, and Repair, Subproject: Role of Growth Factors and Cell Signaling in the Response of Brain and Retina to Injury, are as follows: Species Rat(Albino Wistar), Number Allowed: 78, Number Used, 78, LSU IACUC# 1032. The objective of this study is to assay for changes in expression of genes involved in neural growth and differentiation ... |
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| Neural Responses to Injury: Prevention, Protection and Repair; Volume 8: Vision, Laser Eye Injury, and Infectious Diseases |
OCT 1996 |
81 pages |
| Authors:
Nicolas G. Bazan; LOUISIANA STATE UNIV NEW ORLEANS
|
| The experimental animals used during this period for the project, Neural Responses to Injury: Prevention, Protection, and Repair, Subproject: Vision, Laser Eye Injury and Infectious Diseases, are as follows: Species Used Cynomolgus monkey, squirrel monkey, Squirrel monkey SPECIFIC AIMS Study a new confocal microscope that can be used in living eyes to understand the earliest stages of trauma, laser injuries and diseases. Evaluate drugs to prevent retinal damage after laser ... |
|
| Clinical Investigation Annual Research Progress Report FY95 |
15 MAR 96 |
217 pages |
| Authors:
Idelle M. Weisman; Anthony E. Pusater; Elizabeth Young; WILLIAM BEAUMONT ARMY MEDICAL CENTER EL PASO TX DEPT OF CLINICAL INVESTIGATIO N
|
| Subject report identifies the research activities conducted at William Beaumont Army Medical Center by investigators who had protocols approved by the Institutional Review Board and the Institutional Animal Care and Use Committee. This report includes all protocols registered within the Department of Clinical Investigation during FY 1995. All known presentations and publications are also included. The research protocols described were conducted under the provisions of AR 40-38 (Clinical Investigation Program); ... |
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| Clinical Investigation FY 95 Annual Report |
MAR 96 |
216 pages |
| Authors:
Idelle M. Weisman; Anthony E. Pusateri; Elizabeth Young; WILLIAM BEAUMONT ARMY MEDICAL CENTER EL PASO TX DEPT OF CLINICAL INVESTIGATIO N
|
| Subject report identifies the research activities conducted at William Beaumont Army Medical Center by investigators who had protocols approved by the Institutional Review Board and the Institutional Animal Care and Use Committee. This report includes all protocols registered within the Department of Clinical Investigation during FY 1995. All known presentations and publications are also included. The research protocols described were conducted under the provisions of AR 40-38 (Clinical Investigation Program); ... |
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| Institute of Laboratory Animal Resources |
JAN 96 |
|
| Authors:
Thomas L. Wolfle; NATIONAL ACADEMY OF SCIENCES WASHINGTON DC
|
 | This grant provides partial core support for the Institute of Laboratory Animal Resources (ILAR), which is a component of the Commission on Life Sciences, one of the principal operating units of the National Academy of Sciences (Academy). The Academy operates as a private, non-profit institution charged with providing advice to agencies of the federal government on matters of science and technology. ILAR provides information on the selection, care, and use ... |
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| Use of Laboratory Animals in DoD Programs |
17 APR 95 |
|
| Authors:
DEPUTY DIRECTOR OF DEFENSE RESEARCH AND ENGINEERING WASHINGTON DC
|
|
| Institute of Laboratory Animal Resources |
31 JAN 95 |
246 pages |
| Authors:
Thomas L. Wolfle; NATIONAL RESEARCH COUNCIL WASHINGTON DC COMMISSION ON LIFE SCIENCES
|
| This grant provides partial core support for the Institute of Laboratory Animal Resources (ILAR), which is a component of the Commission on Life Sciences (CLS), one of the principal operating units of the National Academy of Sciences (Academy). The Academy operates as a private, non-profit institution charged with providing advice to agencies of the federal government on matters of science and technology. ILAR provides information on the selection, care, and ... |
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| Field Test of First Commercial Formulation of Mycoleptodiscus Terrestris (Gerd.) Ostazeski as a Blocontrol for Eurasian Watermilfoil |
DEC 94 |
|
| Authors:
Judy F. Shearer; ARMY ENGINEER WATERWAYS EXPERIMENT STATION VICKSBURG MS ENVIRONMENTAL LAB
|
| The plant pathogenic fungus Mycoleptodiscus Terrestris (Gerd.) Ostazeski has been identified as a potential biocontrol agent for the submersed aquatic macrophyte Myriophyllum spicatum L. Successful tests in laboratory, pool, and pond experiments led to the development of the organism into the mycoherbicide Aqua-Fyte. Efficacy of the commercial formulation was tested on field populations of Eurasian watermilfoil in Guntersville, AL, July 1992. The mycoherbicide was ineffective in reducing aboveground biomass of ... |
|
| Institute of Laboratory Animal Resources (ILAR) |
12 MAY 94 |
435 pages |
| Authors:
Thomas L. Wolfle; NATIONAL RESEARCH COUNCIL WASHINGTON DC COMMISSION ON LIFE SCIENCES
|
| This grant provides partial core support for the Institute of Laboratory Animal Resources (ILAR), which is a component of the commission on Life Sciences (CLS), one of the principal operating units of the National Academy of Sciences (Academy). The Academy operates as a private, non-profit institution charged with providing advice to agencies of the federal government on matters of science and technology. ILAR provides information on the selection, care, and ... |
|
| Ada Compiler Validation Summary Report: Certificate Number: 940325S1. 11347 DDC-I, DACS Sun SPARC/SunOS to 680x0 Bare Ada Cross Compiler System (SECURE MODE), Version 4.6.9 Sun SPARCstation IPX => Lynwood j435TU (68030) (Bare Machine) |
25 MAR 94 |
|
| Authors:
NATIONAL INST OF STANDARDS AND TECHNOLOGY GAITHERSBURG MD
|
| This Validation Summary Report describes the extent to which a specific Ada compiler conforms to the Ada Standard, ANSI/MIL-STD-1815A. This report explains all technical terms used within it and thoroughly reports the results of testing this compiler using the Ada Compiler Validation Capability. An Ada compiler must be implemented according to the Ada Standard, and any implementation-dependent features must conform to the requirements of the Ada Standard. The Ada Standard ... |
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| Atomic Force Microscopy of the Nacreous Layer in Mollusc Shells |
25 FEB 94 |
34 pages |
| Authors:
S. Manne; C. M. Zaremba; R. Giles; L. Huggins; D. E. Morse; CALIFORNIA UNIV SANTA BARBARA DEPT OF CHEMISTRY
|
| We present atomic force microscopy observations of mature nacre, specifically the polygonal aragonite tablets which comprise the mineral portion of nacre, in two types of molluscs, a bivalve (Atrina serrate) and a gastropod (Haliotis rufescens). By imaging in liquids it was possible to dissolve away the nacre layer by layer to reveal both the structure of a single, tablet and its relationship to vertically adjacent tablets. Atrina tablets (inner face) ... |
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| The Metabolic and Thermoregulatory Responses of Rhesus Monkeys to Combined Exercise and Environmental Heat Load |
AUG 93 |
27 pages |
| Authors:
Cristine L. Heaps; Stefan H. Constable; KRUG LIFE SCIENCES SAN ANTONIO TX SAN ANTONIO DIV
|
| The purpose of the present research was to characterize the effects of selected physiological stressors such as work and various environmental heat loads in rhesus monkeys. Nonhuman primates (N=6) were behaviorally conditioned to exercise in a wheel ergometer at about 3 METs. Core temperature (Tco), body weight (BW) and blood samples were taken immediately before and after exercise. Excessively high heat storage rates dictated that the 35 C trial be ... |
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| Dynamic Simulation of Shipboard Electric Power Systems |
MAY 93 |
|
| Authors:
Timothy J. McCoy; MASSACHUSETTS INST OF TECH CAMBRIDGE DEPT OF OCEAN ENGINEERING
|
| It is the aim of the proposed research to develop digital computer simulation models for a typical shipboard electric propulsion system, conduct dynamic analyses and determine viable control schemes for such a system. Electric propulsion for shipboard use is being considered as an attractive alternative to the geared diesel and gas turbine mechanical drives currently being used in most naval ships. Prior to building an electric propulsion drive system, the ... |
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| Conditioning Bottlenose Dolphins (Tursiops Truncatus Gilli) for Voluntary Diving Studies |
MAR 93 |
13 pages |
| Authors:
Steven F. Shippee; Norman K. Chun; Terrie M. Williams; NAVAL COMMAND CONTROL AND OCEAN SURVEILLANCE CENTER RDT AND E DIV SAN DIEGO CA
|
| The behavior and physiology of diving has been extensively studied in several species of pinnipeds and marine birds. Less is known about the diving adaptations of the most completely aquatic mammals, the cetaceans. Early investigations of the diving abilities of dolphins were conducted using forced dive conditions in the laboratory, resulting in extreme physiological responses. The investigative technique improved during the late 1960's and 70'2 when dolphins were trained for ... |
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| Evaluation of Dried Storage of Platelets for Transfusion: Physiologic Integrity and Hemostatic Functionality |
04 JUN 92 |
|
| Authors:
Arthur P. Bode; Marjorie S. Read; EAST CAROLINA UNIV SCHOOL OF MEDICINE GREENVILLE NC
|
| Studies were begun on a pig made thrombocytopenic by whole body irradiation. The purpose of this study is to evaluate the performance of rehydrated platelets in the absence of normal fresh platelets. The evaluation of tissues and blood samples taken from this animal are still underway. An 81pound female pig was transported to North Carolina State College of Veterinary Medicine where it received a whole body irradiation dose of 8 ... |
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| Army Veterinary Service Role in Low-Intensity Conflict |
06 APR 92 |
67 pages |
| Authors:
Gary L. Stamp; ARMY WAR COLL CARLISLE BARRACKS PA
|
| National security of the United States depends on stability in the Western Hemisphere, and this stability in turn depends in large part on the respective governments being able to control disease, malnutrition, and poverty in their exploding populations. In spite of the remarkable trend of democratization in Latin America, there continues to be widespread political unrest and terrorism as fledgling democracies strive for moral legitimacy to govern. Terrorism and insurgency ... |
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| Beef, Real Food for Real People: An Industrial Analysis of the Beef Industry |
APR 1992 |
83 pages |
| Authors:
Danny C. Struebing; INDUSTRIAL COLL OF THE ARMED FORCES WASHINGTON DC
|
| The beef cattle industry is a key segment of agribusiness, which includes modern farming, food processing, and the industries that support them. As the largest segment of the food business, the red-meat industry accounted for 18.5% or $66.9 billion of food shipments in 1991. This paper will look at the structure, conduct and performance of the beef cattle industry. The paper also will: evaluate the industry in relation to national ... |
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| Electron-Microscopic Examination of the Distribution of Sodium in Corti's Organ of Animals, That Are Located in the State of Relative Rest and in the Conditions of Sonic Action |
18 MAR 92 |
|
| Authors:
K. A. Koychev; FOREIGN AEROSPACE SCIENCE AND TECHNOLOGY CENTER WRIGHT- PATTERSON AFB OH
|
|
| The Effect of Climatic Change on Farming and Soil Erosion in Southern Greenland During the Last Thousand Years, |
MAR 1992 |
|
| Authors:
Bjarne H. Jakobsen; COPENHAGEN UNIV (DENMARK)
|
| Soil studies in low-arctic South Greenland often reveal polysequence soil profiles. The study of these soils, dating of fossil surface horizons, study of land use, and use of paleoclimatic information from studies of ice cores show a complex interplay between climatic change, soil erosion and agricultural land use. Two periods of agricultural land use are known in Greenland. From A.D. 985 to about 1450 Norsemen settled in Greenland, and about ... |
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| Potential Effects of Global Warming on Calving Caribou, |
MAR 1992 |
|
| Authors:
Warren G. Eastland; Robert G. White; ALASKA UNIV FAIRBANKS INST OF ARCTIC BIOLOGY AND MUSEUM
|
| Calving grounds of barren-ground caribou (Rangifer tarandus) are often in the portion of their range that remains covered by snow late into spring. We propose that global warming would alter the duration of snow cover on the calving grounds and the rate of snowmelt, and thus affect caribou population dynamics. The rationale for this hypothesis is based upon the following arguments. For females of the Porcupine Herd, one of the ... |
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| Synthetic and Immunological Studies of Protein P12 from African Swine Fever Virus, |
1992 |
|
| Authors:
C. Carreno; B. Ponsati; C. Lopez-Otin; A. alcami; A. Angulo; BARCELONA UNIV (SPAIN)
|
|
| Marine Mammal Medicine |
DEC 91 |
|
| Authors:
M. C. Magee; NAVAL OCEAN SYSTEMS CENTER SAN DIEGO CA
|
|
| JPRS Report, China |
24 JUN 1991 |
|
| Authors:
JOINT PUBLICATIONS RESEARCH SERVICE ARLINGTON VA
|
| This document contains translated articles from foreign periodicals concerning China. Topics include: economics, national affairs, political science, finance, banking, mineral resources, industry, labor, transportation, agriculture and social affairs. |
|
| Serum Antibody Responses to Oral Microorganisms in Nonhuman Primates |
MAY 91 |
|
| Authors:
Anthony G. Giardino; AIR FORCE INST OF TECH WRIGHT-PATTERSON AFB OH
|
| Porphyromonas gingivalis and Prevotella intermedia have been associated with periodontitis in humans and nonhuman primates (NhP). this investigation characterized serum antibody levels, isotypes and subclass distribution and specificity to P. gingivalis, P. intermedia and Bacteroides fragilis prior to, and after immunization with these bacteria and during ligature-induced periodontitis. Serum from 20 adult, female cynomolgus monkeys was obtained at baseline, after 3 intramuscular injections with 10 to the 9th power bacteria ... |
|
| Northeast Artificial Intelligence Consortium (NAIC). Volume 5. Distributed Planning for Dynamic Environments in the Presence of Time Constraints |
DEC 90 |
|
| Authors:
Susan E. Conry; Robert A. Meyer; Paul R. Cohen; Victor R. Lesser; NORTHEAST ARTIFICIAL INTELLIGENCE CONSORTIUM SYRACUSE NY
|
| The Northeast Artificial Intelligence Consortium (NAIC) was created to conduct pertinent research in artificial intelligence and to perform activities ancillary to this research. This report describes progress during the existence of the NAIC on the technical research tasks undertaken at the member universities. The topics covered in general are: versatile expert systems for equipment maintenance, distributed AI for communications systems control, automatic photointerpretation, time-oriented problem solving, speech understanding systems, knowledge ... |
|
| Rangeland Management: BLM Efforts to Prevent Unauthorized Livestock Grazing Need Strengthening |
DEC 90 |
15 pages |
| Authors:
GENERAL ACCOUNTING OFFICE WASHINGTON DC RESOURCES COMMUNITY AND ECONOMIC DEVE LOPMENT DIV
|
| Before 1934, livestock grazing on public rangelands was uncontrolled, and the lands were damaged by decades of overgrazing. With the passage of the Taylor Grazing Act in 1934, grazing became a regulated activity. However, because it was assumed that the lands would ultimately be transferred to private ownership, BLM's approach to public lands management was relatively passive or custodial |
|
| Evaluation of Hyperbaric Oxygen Therapy in the Treatment of Spinal Cord Injury Using the Rabbit Spinal Stroke Model |
30 NOV 90 |
59 pages |
| Authors:
C. M. Harrison; M. V. Slayter; L. H. Anderson; D. W. Criswell; J. B. Long; ARMED FORCES INST OF PATHOLOGY WASHINGTON DC
|
| This study examined the role of oxygen in the development of neuromotor dysfunction generated by temporary aortic occlusion in awake and anesthetized rabbit models of experimental spinal cord ischemia. Animals underwent 30 minutes of infrarenal aortic occlusion, via a pre-implanted aortic snare, followed by 15 minutes of reperfusion prior to treatment with one of three inhaled gas compositions: air (control), 100% oxygen (sea level oxygen), and 100% oxygen at 2.8 ... |
|
| Effect of Vibration Frequency and Acceleration Magnitude of Chicken Embryos on Viability and Development. Phase 1 |
NOV 90 |
|
| Authors:
Linda C. Taggart; Nabih M. Alem; Helen M. Frear; ARMY AEROMEDICAL RESEARCH LAB FORT RUCKER AL
|
| There is little known about the effect of vibration on developing embryos. The feasibility of developing an avian model to study this effect was established in this study. One hundred chicken eggs were divided into four trays of 25 each and exposed to vibration of 1 Hz .25 G, 5 Hz 3 G, 10 Hz 3 G, and a control of no vibration. Hatch rate was 0 percent for 5 ... |
|
| Effects of Low-Altitude Aircraft Overflights on Domestic Turkey Poults |
30 JUN 90 |
|
| Authors:
Francine Bradley; Cynthia Book; Ann E. Bowles; BBN SYSTEMS AND TECHNOLOGIES CORP CANOGA PARK CA
|
| This study involved a series of experiments on the effects of aircraft overflights and simulated overflight noise on commercial meat turkeys. Experiments sought to quantify the relation between sound characteristics of overflights and turkey responses, to determine how rapidly naive turkeys habituate, to determine whether simulated aircraft noise is an adequate model for real aircraft, and to measure effects of chronic worst-case exposure on weight-gain, mortality and carcass quality in ... |
|
| A Study of Neuronal Properties, Synaptic Plasticity and Network Interactions Using a Computer Reconstituted Neuronal Network Derived from Fundamental Biophysical Principles |
14 JUN 90 |
|
| Authors:
David C. Tam; BAYLOR COLL OF MEDICINE HOUSTON TX DIV OF NEUROSCIENCE
|
| The computer models simulating the biophysical properties of neurons are being implemented on the Macintosh IIci computer. The coding of the neural simulator programs MacNeuron and MacNerveNet have initiated. The software has gone through the design phase, and is now in the development phase. Based on careful analysis, the design decision was made to implement the neural simulators using object-oriented programming language over the traditional procedural programming language. The choice ... |
|
| The Billingsley Dairy: A Family Enterprise in the Prado Basin. CA-RIV- 3508-H |
01 JUN 90 |
|
| Authors:
R. P. Hampson; Roberta S. Greenwood; Mark T. Swanson; James Schoenwetter; GREENWOOD AND ASSOCIATES PACIFIC PALISADES CA
|
| Selection of CA-RIV-3508-H for archaeological testing was based on several considerations. The site was thought to be representative of single family dairy operations in the Prado Basin during the final years of prominence which the dairy industry enjoyed throughout the Prado Basin. Structures and features not previously noted were exposed and closely examined. The entire complex was cleared and carefully examined to provide architectural details and provide answers to such ... |
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| Combined Primate Transport and Restraint Device |
MAR 90 |
|
| Authors:
Scottie B. Reynolds; Harry Zwick; Dave O. Robbins; LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA
|
| This paper describes a practical, inexpensive alternative to the standard poling and chairing method of transferring awake primates. Employing this device, a technician working alone can retrieve, restrain and position an awake primate without endangering either the animal or the technician. The device, basically a Plexiglas box, is placed against an animal's home cage. The animal is trained to avoid the squeeze mechanism of its home cage by entering the ... |
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| Animal Capture Agents |
JAN 90 |
14 pages |
| Authors:
Terry A. Childress; Penny L. French; AIR FORCE OCCUPATIONAL AND ENVIRONMENTAL HEALTH LAB BROOKS AFB TX
|
| This research is written in response to concerns about the safety of using animal capture agents by security police. The report discusses the chemical immobilizing agents, current delivery equipment, first aid and emergency protocols for cases of accidental human exposures. Keywords: Chemical agent delivery systems; Exposure physiology; Toxicity; Therapy; Animal capture agents. (KT) |
|
| Ehrlichiosis: A Vector-Borne Disease of Animals and Humans. Current Topics in Veterinary Medicine and Animal Science, Volume 54 |
90 |
|
| Authors:
Jim C. Williams; Ibulaimu Kakoma; NATIONAL INST OF ALLERGY AND INFECTIOUS DISEASES BETHESDA MD
|
| Partial contents: Historical background and global importance of ehrlichiosis; Current status of the in-vitro cultivation of ehrlichiae; Ultrastructure of rickettsiae with special emphasis on ehrlichiae; Antigenic properties of the ehrlichiae and other rickettsiaceae; Biological properties of the genus Ehrlichia -- Substrate utilization and energy metabolism; Biologic and pathogenic properties of Ehrlichia risticii the etiologic agent of equine monocytic ehrlichiosis; Pathophysiology of canine ehrlichiosis; Experimental ehrlichiosis in nonhuman primates; Human ehrlichiosis ... |
|
| Birds in Human Modified Environments and Bird Damage Control: Social, Economic, and Health Implications |
DEC 89 |
192 pages |
| Authors:
Anthony J. Krzysik; CONSTRUCTION ENGINEERING RESEARCH LAB (ARMY) CHAMPAIGN IL
|
| This report provides a perspective of birds in society and science, provides a descriptive survey of conflicts, problems and economic losses that birds have caused humans, examines potential health and disease risks from birds, identifies tha state-of-the-art technologies and methodologies in bird management and control, and provides an extensive and diverse bibliography. Bird control is a very sensitive public and political issue. The social, scientific, and economic importance of birds ... |
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| Study of Hydrazine Metabolism and Toxicity |
13 NOV 89 |
|
| Authors:
J. A. Timbrell; LONDON UNIV (UNITED KINGDOM) TOXICOLOGY UNIT
|
| The research project studying hydrazine in rats has revealed the following: 1) The uptake of hydrazine into the liver may be a saturable process; 2) After a hepatotoxic dose of hydrazine the concentration in the liver is about 0.2mM; 3) Some hydrazine remains in the liver 24 hours after a single dose at a level higher than the plasma level; 4) At the highest dose level (81mg/kg) rats lost weight ... |
|
| AFRRI (Armed Forces Radiobiology Research Institute) Reports, July, August, September 1989 |
NOV 89 |
|
| Authors:
ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD
|
| This volume contains AFRRI Scientific Reports SR 89-26 through SR89- 39 and Technical Report TR89-1 for Jul-Sep 1989. Partial Contents: Induction of marrow hypoxia by radioprotective agents; Cell-cycle radiation response: Role of intracellular factors; Characteristics of radiation-induced performance changes in bar-press avoidance with and without a preshock warning cue; Norepinephrine- induced phosphorylation of a 25 kd phosphoprotein in rat aorta is altered in intraperitoneal sepsis; Quantitative measurement of radiation-induced base ... |
|
| The Use of Hypertonic Saline/Dextran vs Lactated Ringer's Solution as a Resuscitation Fluid Following Uncontrolled Aortic Hemorrhage in Anesthetized Swine |
NOV 89 |
|
| Authors:
W. H. Bickell; S. P. Bruttig; G. A. Millnamow; J. O'Benar; C. E. Wade; LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA
|
| We tested the hypothesis that following aortotomy, the administration of hypertonic saline/dextran (HSD) will increase hemorrhage and mortality. In this study we also compared the effects of HSD to the standard therapy of attempting to replace three times the amount of lost blood with lactated Ringer's solution (LR). Twenty-four anesthetized Yorkshire swine underwent splenectomy and stainless steel wire placement in the infrarenal aorta and were instrumented with Swan-Ganz and carotid ... |
|
| Renal Response to Graded Hemorrage in Conscious Pigs |
NOV 89 |
|
| Authors:
J. L. Sondeen; G. A. Gonzaludo; J. A. Loveday; G. E. Deshon; C. B. Clifford; LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA
|
| We developed a conscious pig model with a chronically instrumented kidney to measure renal blood flow, glomerular filtration rate, and excretory functions during hemorrhage. Seven to ten days prior to experimentation, pigs were splenectomized, arterial and venous catheters implanted, an ultrasonic flow probe placed on the renal artery, and a pyelostomy performed for non-occlusively placing a ureteral catheter. Measurements were taken prior to hemorrhage, and at hemorrhage volumes of 7, ... |
|
| Immunization against Anthrax with Aromatic-Dependent (Aro-) Mutants of Bacillus anthracis and with Recombinant Strains of Bacillus subtilis Producing Anthrax Protective Antigen |
13 OCT 89 |
34 pages |
| Authors:
Bruce E. Ivins; Susan L. Welkos; Gregory B. Knudson; Stephen F. Little; ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD
|
| The safety and efficacy of five prototype, live anthrax vaccines were studied in Hartly guinea pigs and CBA/J and A/J mice. Two of the strains, Bacillus anthracis FD111 and FD112, are Aro-mutants derived by transposon mutagenesis UM23-1. B. subtilis strains PA1 and PA2 contain a recombinant plasmid, pPA101 or pPA102 respectively, that carriers the gene from B. anthracis encoding protective antigen (PA). B. subtilis DB-104 transformed with pPA101. All five ... |
|
| Workshop on Alternatives to Animals in Research Held in Suffield, Ralston, Alberta on 16-17 September 1987 |
OCT 89 |
|
| Authors:
C. E. Connolley-Mendoza; DEFENCE RESEARCH ESTABLISHMENT SUFFIELD RALSTON (ALBERTA)
|
| This special publication presents the texts of papers presented to the Workshop on Alternatives to Animals held at Defence Research Establishment Suffield, Ralston, Alberta, on September 16-17, 1987. The papers presented by eminent Canadian scientists are concerned with the merits of alternatives to animals used in research. It also includes discussions after each presentation and recommendations emanating from the workshop. Contents: The Value of Short- Term Tests in Reducing the ... |
|
| Isoflurane Anesthesia in the Octodon degus |
SEP 89 |
|
| Authors:
Jeffrey W. Record; C. E. Hargett Jr; ARMY AEROMEDICAL RESEARCH LAB FORT RUCKER AL
|
| Inhalation anesthesia for Octodon degus using isoflurane in a nonrebreathing system is described. Ten laboratory raised degus were used to determine the optimum percentage of isoflurane to maintain surgical anesthesia. Time to loss of righting reflex, time to lsos of toepinch reflex, duration of surgical anesthesia and time to standing unaided were recorded. Findings indicate that 2% isoflurane with 1.5 liters per minute of both nitrous oxide and oxygen provide ... |
|
| Technique for Cardiovascular Monitoring in Awake Tethered Rats |
SEP 89 |
|
| Authors:
Gerald W. Parker; Dale G. Martin; ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD
|
| In the rat, reference values for cardiac output vary from 20.7 to 51. 8 ml.min(-1).100g(-1) and mean arterial pressure from approximately 90 to 175 mm Hg depending on the strain, state of the animal, and method of measurement. Anesthetic agents have been shown to alter the stability of various hemodynamic parameters, as well as, the reactivity of the cardiovascular system to various physiologic and pharmacologic manipulations. Additionally, it has been ... |
|
| Environment Enrichment: Behavioral Response of Rhesus to Puzzle Feeders |
AUG 89 |
|
| Authors:
Kenneth R. Bloom; Marty Cook; LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA
|
| Amendments to Department of Agriculture standards regulating the physical environment of laboratory primates have served as an impetus for research involving environmental enrichment. Tools and techniques are being developed to address the most controversial aspect of the amended standards, i. e., the requirement that the physical environment be adequate to promote the psychological well-being of laboratory primates. The purpose of this study was to assess the utility of one technique ... |
|
| Dose Effect of HSD (Hypertonic Saline/Dextran) Survival Following Hemorrhage |
JUN 89 |
|
| Authors:
LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA
|
| The comparative effectiveness of various dosages of hypertonic saline/dextran (HSD) for the treatment of severe hemorrhage was investigated in conscious swine bled 46 ml/kg over 15 min. Five minutes after the completion of hemorrhage, the animals were treated with 1, 2, 4 or 11.5 ml/kg HSD and were observed over the next 96 hours. The 11.5 ml dose was superior to all other doses, effecting 100% survival. Survival incidence with ... |
|
| Small Volume Resuscitation of Hypovolemic Shock |
01 MAR 89 |
|
| Authors:
Robert A. Gunther; George C. Kramer; CALIFORNIA UNIV DAVIS
|
| Studies of unanesthetized sheep and anesthetized rats were performed to evaluate the effectiveness of hypertonic saline dextran formulations. Based on presented data we conclude: 1) Hypertonic 7.5% saline 6% dextran (HSD) can safely and effectively be delivered via peripheral vessels; 2) Hypertonic saline hetastarch works almost as well as hypertonic saline dextran; 3) Higher concentrations of dextran added to hypertonic saline increase the volume expansion and cardiovascular improvement; 4) NMR ... |
|
| Inhalation Anesthesia in the Chinchilla |
JAN 89 |
|
| Authors:
C. E. Hargett Jr.; Jeffrey W. Record; ARMY AEROMEDICAL RESEARCH UNIT FORT RUCKER AL
|
| Inhalation anesthesia techniques which successfully induce surgical anesthesia in chinchilla villidera are described and compared. Isoflurane- nitrous oxide and halothane-nitrous oxide delivered by a nonrebreathing system are compared to halothane-nitrous oxide delivered by a semiclosed system. Thirty six laboratory raised adult chinchillas in three groups were used in this study. All achieved surgical anesthesia with no deaths. Time to loss of righting reflex, time to surgical anesthesia, duration of surgical ... |
|
| Blood Lactate as a Prognosticator of Survival Following Hemorrhage in Conscious Swine |
JAN 89 |
|
| Authors:
Charles E. Wade; Diane S. Trail; Virginia L. Gildengorin; John P. Hannon; LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA
|
| Arterial blood lactate concentration at the end of fixed volume hemorrhage was evaluated as a predictor of survival in unmedicated chronically instrumented immature swine. Compared to basal values, 8.4 + or - 4.5 milligrams/deciliters hemorrhaged animals with a lactate of 43.9 + or - 37.1 milligrams/deciliters lived while animals with a lactate of 106.5 + or- 40.4 milligrams/deciliters died. Lactate concentration at the end of hemorrhage successfully predicted survival (81.0%). ... |
|
| Opportunities in Biology |
89 |
|
| Authors:
NATIONAL RESEARCH COUNCIL WASHINGTON DC
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| Partial Contents: The New Biology; New Technologies and Instrumentation; Recombinant DNA Techniques; Monoclonal Antibodies; Microchemical Techniques; Flow Cytometry; Computers and Data Analysis; Molecular Structure and Function; Genes and Cells; Development; The Nervous System and Behavior; Nerve Cell Communications; The Cytaskeleton and the Transport of Materials with Nerve Cells; Neurobiology of Perception: Vision; Neurobiology of Motor Control; Neurobiology of Cognition; Abnormalities of Behavior; The Immune System and Infectious Diseases; Evolution and ... |
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| Use of Electrical Impedance to Assess Frostbite Injury Severity in a Swine |
15 SEP 88 |
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| Authors:
Patrica M. Dubill; Neil W. Ahle; Mark W. Sharp; Rodrigo A. Mariano; Florence H. Broski; ARMY BIOMEDICAL RESEARCH AND DEVELOPMENT LAB FORT DETRICK MD
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| Management of frostbite poses a significant problem for the military, because the accepted method of treatment, waiting for demarcation of necrotic tissue, is unsuitable for the combat casualty care environment. A preferable method of frostbite management would be development of an objective indicator of tissue viability that could be used to guide debridement soon after injury, minimizing the hospital stay. Based on previous work on necrotic tissue detection, electrical impedance ... |
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Animal Husbandry and Veterinary Medicine
