| Diversity, Replication, Pathogenicity and Cell Biology of Crimean Congo Hemorrhagic Fever Virus |
OCT 2006 |
15 pages |
| Authors:
Adolfo Garcia-Sastre; MOUNT SINAI SCHOOL OF MEDICINE NEW YORK
|
 | This research project is a result of a collaboration between three research groups aimed at elucidating basic replication processes of CCHFV with the expected outcome of providing basic research reagents and establishing the foundation of knowledge necessary for discovery of vaccines and antiviral therapeutics for Crimean Congo hemorrhagic fever. Our major findings during the second year of support are the following: We have mapped domains in the N and L ... |
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| Large Concentration-Dependent Nonlinear Optical Responses of Starburst Diphenylamino-fluorenocarbonyl Methano[60]Fullerence Pentaads |
OCT 2006 |
35 pages |
| Authors:
Hendry I. Elim; Wei Ji; Robinson Anandakathir; Long Y. Chiang; Rachel Jakubiak; Loon-Seng Tan; NATIONAL UNIV OF SINGAPORE DEPT OF PHYSICS
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| We demonstrated an approach toward the design of starburst C60-keto-DPAF assembly by applying a combination of a starburst macromolecular configuration with C60 as the core center, which is encapsulated by multiple bulky groups leading to the increase of intermolecular separation and aggregation barrier. Molecular compositions of the resulting triad and pentads were clearly confirmed by MALDI-MS (positive ion) detection of protonated molecular mass ions. Both structural isomers, 3a and 3b ... |
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| New Advanced Mass Casualty Breathing System for Oxygen Therapy: Phase 1 |
OCT 2006 |
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| Authors:
F. Bouak; D. J. Eaton; DEFENCE RESEARCH AND DEVELOPMENT TORONTO (CANADA)
|
 | This report describes the first phase of a project to develop an efficient mass casualty oxygen (O2) breathing system for O2 therapy in remote areas. In this first phase, DRDC Toronto was tasked to investigate the performance of the Pulmanex Hi-Ox mask (Hi-Ox) at O2 flow rates from 4 litres per minute (L min-1) down to 0.5 L min-1. Performance was evaluated with eighteen male and female volunteers between the ... |
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| Effects of Solvation On One- and Two-Photon Spectra of Coumarin Derivatives: A TDDFT Study (Preprint) |
OCT 2006 |
36 pages |
| Authors:
Kiet A. Nguyen; Paul N. Day; Ruth Pachter; AIR FORCE RESEARCH LAB WRIGHT-PATTERSON AFB OH SURVIVABILITY AND SENSOR MATERIALS DIV/HARDENED MATERIALS
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| We report one- (OPA) and two-photon absorption (TPA) excitation energies and cross sections for a series of 7-aminocoumarins using time-dependent density functional theory with various basis sets and functionals, including exchange-correlation functionals using the Coulomb-attenuating method (CAMB3LYP and mCAMB3LYP), to evaluate their performance in gas-phase and in solvents. Except for the CAMB3LYP results , the computed OPA excitation energies and transition dipole moments are in good agreement with experiment. The ... |
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| On the Structure of Holographic Polymer-Dispersed Polyethylene Glycol (Postprint) |
OCT 2006 |
11 pages |
| Authors:
Michael J. Birnkrant; Hilary K. McWilliams; Christopher Y. Li; Lalgudi V. Natarajan; Vincent P. Toodiglia; Richard L. Sutherland; Pamela F. Lloyd; Timothy J. Bunning; DREXEL UNIV PHILADELPHIA PA
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| Holographic polymerization (H-P) has been used to fabricate polymer-dispersed liquid crystals and pattern inert nanoparticles. In this article, one-dimensional grating structures of Norland resin and polyethylene glycol (PEG) were achieved using the H-P technique. Both reflection and transmission grating structures were fabricated. The optical properties of the reflection grating structures (also known as Bragg reflectors, BRs) are thermosensitive, which is attributed to the formation and crystallization of PEG crystals. The ... |
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| Feasibility Study of Nanoscale Semiconductor Manufacture Using Thermal Dip Pen Nanolithography |
30 SEP 2006 |
7 pages |
| Authors:
William P. King; GEORGIA TECH RESEARCH CORP ATLANTA
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| This one-year feasibility study explored the use of thermal dip-pen nanolithography (DPN) for the purpose of nanoscale electronics manufacturing. In this project, we have demonstrated that using the thermal DPN technique that both indium metal, and semiconducting organic materials (PDDT, PVDF) can be written in arbitrary locations on semiconductor surfaces with sub-100 nm feature sizes. We have measured the electrical properties of these nanostructure deposits and found them to be ... |
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| International Conference on Electronic Processes in Organic Materials (6th) Held in Gurzuf, Crimea, Ukraine, on September 25-29, 2006 |
29 SEP 2006 |
215 pages |
| Authors:
Ya. Vertsimakha; UKRAINIAN ACADEMY OF SCIENCES KIEV INST OF PHYSICS
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| The Final Proceedings for 6th International Conference `Electronic Processes in Organic Materials', 25-29 September 2006. This conference will cover the following topics: 1. Energy structure of organic materials and electronic processes in organic compounds 2. Electronic processes at interfaces of organic materials to metals, as well as biological, organic, inorganic media and nanostructures 3. Electro-optic processes in confined liquid crystals 4. Nonlinear properties of organic structures and composites 5. Electronic ... |
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| A Study of Impact Response of Electrified Organic Matrix Composites (Preprint) |
SEP 2006 |
21 pages |
| Authors:
Robert L. Sierakowski; Igor Y. Telichev; Olesya I. Zhupanska; AIR FORCE RESEARCH LAB EGLIN AFB FL MUNITIONS DIRECTORATE
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| The existing experimental evidence suggests that organic matrix composites sustain less impact damage when an electric field is applied. The intricate interaction of an electrical field and mechanical load is governed by coupling of the mechanical and electromagnetic fields via the Lorentz force as well as by the processes undergoing at the microscopic level: Joule heat, fiber-matrix interface changes, etc. The current work includes both experimental and theoretical investigations of ... |
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| Optical Spectroscopy and Multiphoton Imaging for the Diagnosis and Characterization of Hyperplasias in the Mouse Mammary |
SEP 2006 |
53 pages |
| Authors:
Melissa C. Skala; DUKE UNIV DURHAM NC
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| The purpose of the first part of this project is to develop a method to diagnose mammary gland hyperplasias in an animal model in vivo using optical spectroscopy, so that the progression of benign lesions could be studied over time. The absorption and scattering parameters extracted from diffuse reflectance spectra measured in vivo were used to differentiate normal tissue (n=23) and benign lesions (n=16) in the mammary glands of ENU-treated ... |
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| Estrogen Receptor Driven Inhibitor Synthesis |
SEP 2006 |
48 pages |
| Authors:
Phani K. Pullela; MARQUETTE UNIV MILWAUKEE WI
|
| Purpose: Establish an estrogen receptor (ER) driven inhibitor synthesis procedure and develop a set of building blocks specific for ER-agonist/ER-antagonist interactions. Scope: The ER-binding pocket size is twice the molecular volume of 17-beta-estradiol (E2) giving rise to the tolerance of a diverse class of compounds resulting in poor interpretability of current SAR models. This project is to establish an ER driven ligand synthesis procedure and define a set of building ... |
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| Neuregulins, Neuroprotection and Parkinson's Disease |
SEP 2006 |
37 pages |
| Authors:
David M. Yurek; Kim B. Seroogy; KENTUCKY UNIV RESEARCH FOUNDATION LEXINGTON
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| The main hypothesis being tested in this research project is that neuregulins, primarily focusing on glial growth factor-2 (GGF2), is neuroprotective and/or neurorestorative for the damaged dopaminergic nigrostriatal system. Other hypotheses to be tested are that GGF2 augments functional indices of the dopaminergic nigrostriatal system and that one of the intracellular signaling mechanisms mediating the protective effects of neuregulins for dopamine neurons involves the PI3-kinase pathway. These studies are being ... |
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| Rapid Molecular Fingerprinting of Pathogens |
31 AUG 2006 |
8 pages |
| Authors:
Patrick Daugherty; CALIFORNIA UNIV SANTA BARBARA
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| The first aim of this project was to identify a set of ligands that bind specifically to each member of a panel of related alpha viruses, namely, equine encephalitis viruses (EEV). The second aim was to develop a bacterial cell-based array platform that can be used to detect viruses present in serum or other complex mixtures. During the course of this project we generated a set of peptides that bind ... |
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| Mass Transfer from Entrapped DNAPL Sources Undergoing Remediation: Characterization Methods and Prediction Tools |
31 AUG 2006 |
437 pages |
| Authors:
Tissa H. Illangasekare; Junko M. Marr; Robert L. Siegrist; Kenichi Soga; Kent L. Glover; Elena Moreno-Barbero; Jeffery L. Heiderscheidt; Satawat Saenton; Mini Matthew; Ann R. Kaplan; COLORADO SCHOOL OF MINES GOLDEN DIVISION OF ENVIRONMENTAL SCIENCE AND ENGINEERING
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| The primary goal of this research was to understand and characterize mass transfer and tracer partitioning in physically heterogeneous DNAPL sources undergoing remediation. Four source zone treatment technologies were evaluated: (1) bio-treatment, (2) in situ chemical oxidation (ISCO), (3) surfactant enhanced dissolution and (4) thermal treatment. Fundamental knowledge was generated to improve and develop tools for evaluating the impact of remediation technologies on DNAPL distribution in heterogeneous systems. Experiments and ... |
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| Interaction of Gases on Single-Wall Carbon Nanotubes |
18 AUG 2006 |
17 pages |
| Authors:
Vijay Kumar; VIJAY KUMAR FOUNDATION CHENNAI (INDIA)
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| This project is a continuation of the earlier study on Interaction of water and methanol with single wall carbon nanotubes. The objective of the project was to supplement previous work by considering (1) more than one molecule in the interaction, (2) extending the previous work by examining interactions with bundles of carbon nanotubes rather than a single nanotube, (3) comparing interactions within and between nanotubes, and "4" examining effects of ... |
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| Ab Initio Design of Metallocene-Based Molecular Electronic Devices AOARD-054095 |
17 AUG 2006 |
8 pages |
| Authors:
Hiroshi Mizuseki; Rodion V. Belosludov; Amir A. Farajian; Tomoki Uehara; Yoshiyuki Kawazoe; NIHON GENE RESEARCH LABS INC SENDAI (JAPAN)
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| The transport properties of two ferrocenedithiolate systems with different five-member ring connections have been estimated using the nonequilibrium Green's function formalism of quantum transport and the density functional theory. The results of the calculations reveal that the conductance through the ferrocene molecule depends on the position of sulfur atoms. The molecule has a higher electrical conductivity at low bias when the same cyclopentadienyl ring is connected to an Au electrode ... |
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| High-Pressure Liquid Chromatograph with Mass Spectrometric Detection for Analysis of Supercritical Fuels Pyrolysis Products |
01 AUG 2006 |
52 pages |
| Authors:
Mary J. Wornat; Michelle L. Somers; Jennifer W. McClaine; Jorge O. Ona; LOUISIANA STATE UNIV BATON ROUGE DEPT OF CHEMICAL ENGINEERING
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| A high-pressure liquid chromatograph with ultraviolet-visible diode-array detection and mass spectrometer (HPLC/UV/MS), purchased with DURIP funds, was used to analyze polycyclic aromatic hydrocarbons (PAH) produced in supercritical pyrolysis experiments with the model fuels 1-methylnaphthalene and toluene. The HPLC/UV/MS instrument facilitated the identification of fifteen 5- to 9-ring PAH from supercritical 1-methylnaphthalene pyrolysis and five 7- to 9-ring PAH from supercritical toluene pyrolysis none of which had ever before been identified ... |
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| Olefin Metathesis in Peptidomimetics, Dynamic Combinatorial Chemistry, and Molecular Imprinting |
AUG 2006 |
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| Authors:
Tammy K. Low; FLORIDA UNIV GAINESVILLE DEPT OF CHEMISTRY
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| Catalyzed based olefin metathesis is a very valuable and useful tool in synthetic organic chemistry. Our research goals consisted of employing olefin metathesis in the synthesis of peptidomimetics, and studying the feasibility of this method in dynamic combinatorial chemistry and molecular imprinting of nerve agents. One of the approaches to the development of peptidomimetics is to attach biologically significant functional groups, such as amino acid side chains, to a scaffold. ... |
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| Demonstration and Analysis of Reusable Launch Vehicle Operations |
AUG 2006 |
39 pages |
| Authors:
John Garvey; GARVEY SPACECRAFT CORP LONG BEACH CA
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| Report developed under SBIR contract for topic AF05-201. The increased use of reusable systems continues to be one of the most promising options for creating advancements in the daily maintenance of rocket systems, lowering hours for preparation and diminishing expenses for preparation. However, since the end of the DC-X/XA Delta Clipper program, flight testing of candidate reusable launch vehicle (RLV) designs, technologies and operations has come to a halt. This ... |
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| Antimicrobial Cellulose: Preparation and Application of 5-Methyl-5-Aminomethylhydantoin |
AUG 2006 |
24 pages |
| Authors:
L. Kou; J. Liang; S. D. Worley; J. Lee; R. M. Broughton; T. S. Huang; AUBURN UNIV AL DEPT OF CHEMISTRY
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| A new N-halamine precursor, 5-methyl-5-aminomethylhydantoin (AH), was synthesized. This N-halamine precursor can be coated onto cotton surfaces with addition of the cross-linking agent butanetetracarboxylic acid (BTCA) and rendered biocidal by exposure to halogen solutions either before or after curing the coating or material. Standard washing tests show that covalently bound AH/BTCA on the cotton swatches can survive repeated washing cycles. After 50 washing cycles, chlorinated cotton swatches had lost 98.7% ... |
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| Role of MicroRNA Genes in Breast Cancer Progression |
AUG 2006 |
10 pages |
| Authors:
Richard W. Padgett; RUTGERS - THE STATE UNIV PISCATAWAY NJ
|
| In this proposal, we asked if miRNA expression is altered as cells progress through the different stages of cancer. Through our microarray experiments, we have shown that many miRNAs are differentially regulated as cells progress through cancer stages. A general trend in miRNA expression emerges from this work. As cells progress toward a metastatic state, more miRNAs are down regulated, rather than up regulated. This suggests that many cellular proteins ... |
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| Development of Novel Two-Photon Absorbing Chromophores |
AUG 2006 |
15 pages |
| Authors:
Thomas M. Cooper; James Heinrichs; Loon-Seng Tan; Augustine M. Urbas; Paul A. Fleitz; Joy E. Rogers; Jonathan E. Slagle; Daniel G. McLean; Richard L. Sutherland; Mark Brant; AIR FORCE RESEARCH LAB WRIGHT-PATTERSON AFB OH MATERIALS AND MANUFACTURING DIRECTORATE
|
| There has been much interest in the development of two-photon absorbing materials and many efforts to understand the nonlinear absorption properties of these dyes, but this area is still not well understood. A computational model has been developed in our lab to understand the nanosecond nonlinear absorption properties that incorporate all of the measured one-photon photophysical parameters of a class of materials called AFX. We have investigated the nonlinear and ... |
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| Asymmetry in Platinum Acetylide Complexes: Confinement of the Triplet Exciton to the Lowest Energy Ligand (Preprint) |
AUG 2006 |
49 pages |
| Authors:
Thomas M. Cooper; Douglas M. Krein; Aaron R. Burke; Daniel G. McLean; Joy E. Rogers; Jonathan E. Slagle; AIR FORCE RESEARCH LAB WRIGHT-PATTERSON AFB OH SURVIVABILITY AND SENSOR MATERIALS DIV/HARDENED MATERIALS
|
| As part of an ongoing investigation of structure-optical property relationships in platinum acetylide complexes, we synthesized the compounds trans-Pt(PBU3)2(C=CC6HS)(C=C-C6H4-C=CC6HS)(PE 1-2), trans- Pt(PBU3h( C=CC6HS)(C=CC6H4-C=C-C6~-C=CC6Hs)(PEl-3) and trans-Pt(PBU3h(C=C-C6~-C=CC6Hs)(C=CC6H4-C=C-C6H4-C=CC6Hs)(PE2-3)that have different ligands on either side of the central platinum and compared their spectroscopic properties to the symmetrical compounds PE1, PE2 and PE3. We measured trends in ground state absorption, fluorescence, phosphorescence and triplet state absorption spectra. We also performed density functional theory calculations of ... |
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| Study on PCB Properties of Epoxy Based Nanocomposites with Different Types of Layered Hybrid Materials |
26 JUL 2006 |
13 pages |
| Authors:
Yun D. Park; SEOUL NATIONAL UNIV (REPUBLIC OF KOREA) SCHOOL OF PHYSICS
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| The contractor shall investigate: (1) An epoxy/clay nanocomposite matrix material for printed circuit boards, (2) A prepreg for printed circuit boards which contains the epoxy/clay nanocomposite matrix material, and (3) A printed circuit board made with at least one of proposed prepregs. |
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| Polyazido Pyrimidines: High Energy Compounds and Precursors to Carbon Nanotubes (PREPRINT) |
13 JUL 2006 |
18 pages |
| Authors:
Chengfeng Ye; Haoxiang Gao; Brendan Twamley; Jean'ne M. Shreeve; Gregory W. Drake; Jerry A. Boatz; IDAHO UNIV MOSCOW DEPT OF CHEMISTRY
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| Organic polyazido substituted compounds are at the forefront of high energy research. Polyazido organic compounds have high relative heats of formation as one azido group adds about 87 kcal/mol of endothermicity to a hydrocarbon compound. In this family of compounds, 3,6-di(azido)-tetrazine (1), has the highest reported heat of formation ~ 1101 kJ mol-1(6709 kJ kg-1). The compound 4,4',6,6'-tetra(azido)azo-1,3,5-triazine (2), has a heat of formation of 2171 (6164 kJ kg -1). ... |
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| Coimmobilization of a Redox Enzyme and a Cofactor Regeneration System |
JUL 2006 |
4 pages |
| Authors:
Lorena Betancor; Cecile Berne; Heather R. Luckarift; Jim C. Spain; GEORGIA INST OF TECH ATLANTA SCHOOL OF CIVIL AND ENVIRONMENTAL ENGINEERING
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| The co-immobilization of nitrobenzene nitroreductase and glucose-6-phosphate dehydrogenase in silica particles enables the continuous conversion of nitrobenzene to hydroxylaminobenzene with NADPH recycling. |
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| Effects of Conjugation in Length and Dimension on Spectroscopic Properties of Fluorene-Based Chromophores from Experiment and Theory (Preprint) |
JUL 2006 |
38 pages |
| Authors:
Loon-Seng Tao; Paul A. Fleitz; Ruth Pachter; Kiet A. Nguyen; Joy E. Rogers; Jonathan E. Slagle; Paul N. Day; Ramamurthi Kannan; AIR FORCE RESEARCH LAB WRIGHT-PATTERSON AFB OH SURVIVABILITY AND SENSOR MATERIALS DIV/HARDENED MATERIALS
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| A series of one-photon (OPA) absorption spectra for fluorine-based donor pi acceptor molecules is presented and spectroscopically assigned, based upon the results obtained from time-dependent density functional theory (TDDFT). The computed excitation energies were generally shown to be in good agreement with experiment, particularly when compared to results from measurements carried out in a nonpolar solvent, which were available for some molecules. The computed oscillator strengths may resolve discordant experimental ... |
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| Development of Bicarbonate-Activated Peroxide as a Chemical and Biological Warfare Agent Decontaminant |
30 JUN 2006 |
48 pages |
| Authors:
David E. Richardson; FLORIDA UNIV GAINESVILLE DEPT OF CHEMISTRY
|
| Several projects were completed in the development of bicarbonate-activated peroxide (BAP) and other chemistry for the decontamination of chemical and biological warfare agents. The mechanism of formation of the active oxidant, peroxymonocarbonate, has been investigated in detail. New surfoxidants (oxidative surfactant formulations) have been explored. The Mn-catalyzed oxidations by BAP solutions have been investigated to define the active oxidant species in kinetic studies. Initial investigations into new methods for oxidation ... |
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| Develop Systems for Manufacturing 100,000,000 Doses of an Emergency Pharmaceutical (e.g. Vaccine or Monoclonal Antibody) Within 2 Months of Product Identification |
08 JUN 2006 |
22 pages |
| Authors:
Toby Baldwin; Dave Estell; Janice Fung; Cherry Lin; Jeff Pucci; Jennifer Razo; Beverly Rider; William Throndset; Don Trimbur; Frans Van Gastel; Huaming Wang; Mick Ward; GENENCOR INTERNATIONAL PALO ALTO CA
|
| Based on the data we have generated in the first six months of the project, we believe we have exceeded the milestones for this project. Initial genetic constructs for the Herceptin IgG human antibody were made and transformed into Trichoderma reesei. These strains were screened for antibody production in shake flasks. A few of the strains were tested at the 14-liter fermentation scale. We have been able to produce over ... |
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| A Comparative Analysis of Single-Stage-To-Orbit Rocket and Air-Breathing Vehicles |
JUN 2006 |
100 pages |
| Authors:
Benjamin S. Orloff; AIR FORCE INST OF TECH WRIGHT-PATTERSON AFB OH DEPT OF AERONAUTICS AND ASTRONAUTICS
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| This study compares and contrasts the performance of a variety of rocket and air breathing, single-stage-to-orbit, reusable launch vehicles. Fuels considered include bi-propellant and tri-propellant combinations of hydrogen and hydrocarbon fuels. Astrox Corporation's HySIDE code was used to model the vehicles and predict their characteristics and performance. Vehicle empty mass, wetted area and growth rates were used as figures of merit to predict the procurement, operational and maintenance cost trends ... |
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| EGFR Activation by Spatially Restricted Ligands |
JUN 2006 |
52 pages |
| Authors:
Katherine N. Clouse; Jennifer S. Goodrich; PRINCETON UNIV NJ
|
| Misregulation of Transforming Growth Factor alpha (TGFalpha) and increased Epidermal Growth Factor Receptor (Egfr) activity has been associated with an increased prognosis of breast cancer. During cogenesis in Drosophila melanogaster local Egfr activation by the spatially-restricted TGFalpha-like ligand Gurken (Grk) is required for axis formation in the egg and future embryo. Squid (Sqd) a heterogeneous nuclear ribonucleoprotein (hnRNF) functions in the localization and translational regulation of grk mRNA. The purpose ... |
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| Structural Analysis and Bioengineering of Thermostable Pyrococcus Furiosus Prolidase for Optimization of Organophosphorus Nerve Agent Detoxification |
JUN 2006 |
34 pages |
| Authors:
Julie Du; Amy M. Grunden; Sherry R. Tove; NORTH CAROLINA STATE UNIV AT RALEIGH OFFICE OF CONTRACTS AND GRANTS
|
| prolidase, aminopeptidase, dinuclear metal center, organophosphorus nerve agent, cobalt enzyme, Pyrococcus furiosus, biodecontamination The aims of this project were to structurally study and bioengineer thermostable prolidase from Pyrococcus furiosus to enable its use for oganophosphorus nerve agent detoxification. Prolidase contains one dinuclear Co metal-center/monomer and has optimal activity at 100 C, exhibiting no activity in the absence of Co2+ or at temperatures |
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| Army Research Office and Air Force Office of Scientific Research Contractors' Meeting in Chemical Propulsion Held in Arlington, Virginia on June 12-14, 2006 |
JUN 2006 |
165 pages |
| Authors:
Kevin McNesby; Julian M. Tishkoff; ARMY RESEARCH OFFICE RESEARCH TRIANGLE PARK NC
|
| Abstracts are given for 6.1 basic research in chemical propulsion sponsored by the Army Research Office and the Air Force Office of Scientific Research. |
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| Novel Optical Interaction in Band-Gap Photonic Crystal Fibers |
31 MAY 2006 |
7 pages |
| Authors:
Gaeta; CORNELL UNIV ITHACA NY OFFICE OF SPONSORED PROGRAMS
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| We have performed several experiments involving electromagnetically-induced transparency in acetylene including our studies of slow light in this system. In addition, near the end of the funding period, we have had recent success producing an appreciable density of Rb atoms into the fiber core. |
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| Shallow Seabed Methane Gas Could Pose Coastal Hazard |
30 MAY 2006 |
3 pages |
| Authors:
Angus I. Best; Michael D. Richardson; Bernard P. Boudreau; Alan G. Judd; Ira Leifer; Anthony P. Lyons; Christopher S. Martens; Danial L. Orange; Simon J. Wheeler; NAVAL RESEARCH LAB STENNIS SPACE CENTER MS SEAFLOOR SCIENCES DIRECTORATE
|
| Abnormally high levels of methane gas in seafloor sediments could pose a major hazard to coastal populations within the next 100 years through their impact on climate change and sea level rise. Marine scientists have known for many years that biogenic methane (CH4) is generated in shallow seabed sediments on continental margins, especially in rapidly deposited muddy sediments with high organic matter content. Grassy sediments are found in river deltas, ... |
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| Realization of New and Enhanced Materials Properties Through Nanostructural Control |
15 MAY 2006 |
22 pages |
| Authors:
Larry Dalton; WASHINGTON UNIV SEATTLE DEPT OF CHEMISTRY
|
| This research focuses on: (1) Organic electro-optic materials with the objective of realizing materials characterized by electro-optic coefficients greater than 300 pm/V at telecommunication wavelengths and which pass telecordial standards. New processing techniques were developed for fabrication 3-D devices and circuits and for achieving low insertion loss electro-optic devices including active wavelength division multiplexing WDM transmitter/receiver systems. During this period of time, the Dalton research group served as the national ... |
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| Platinum Acetylide Materials for Optical Limiting |
10 MAY 2006 |
13 pages |
| Authors:
Kirk S. Schanze; FLORIDA UNIV GAINESVILLE
|
| This project explored linear and non-linear optical structure-property relationships for Pt-acetylide oligomers and polymers. These materials show promise for application in laser protection via the reverse saturable absorption (RSA) mechanism. This basic science program had the following primary objectives: 1) Chemical synthesis and purification of new pi-conjugated Pt-acetylide oligomers and polymers. 2) Characterization of the ground and excited state properties of the new materials, with emphasis placed on measurement of ... |
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| Design, Synthesis and Testing of Novel Antimalarial |
05 MAY 2006 |
50 pages |
| Authors:
Marshall M. Hoffman; NAVAL ACADEMY ANNAPOLIS MD
|
| The purpose of this project was to enhance the effectiveness of the class of chemicals known as isoquinolines against malaria, a disease causing over one million deaths each year. Many drugs are available to combat the parasite responsible for these deaths, but resistance has been recorded to nearly all of them. There is therefore a need for new antimalarial drugs against which the parasite is not resistant. As a contribution ... |
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| Synthesis of Diketopiperizine Peptide Derivatives by Cross-Metathesis |
MAY 2006 |
35 pages |
| Authors:
Tammy K. Low; Daniel Cooper; Ion Ghiviriga; Eric Enholm; FLORIDA UNIV GAINESVILLE DEPT OF CHEMISTRY
|
| The olefin CM reactivity and selectivity of amino acid derivatives with a cyclic scaffold to generate diketopiperizine peptide derivatives were investigated. Product yields were dependent on the amino acid R groups, and whether the amino acid possessed an allyl or homoallyl moiety at the caroxylate side. The stereoselectivity of the dipeptide derivatives was found to be predominantly trans. |
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| Energetic Residues Deposition From 60-mm and 81-mm Mortars |
MAY 2006 |
54 pages |
| Authors:
Michael R. Walsh; Marianne E. Walsh; Charles A. Ramsey; Richard J. Rachow; Jon E. Zufelt; Charles M. Collins; Arthur B. Gelvin; Nancy M. Perron; Stephanie P. Saari; ENGINEERING RESEARCH AND DEVELOPMENT CENTER HANOVER NH COLD REGIONS RESEARCH AND ENGINEERING LAB
|
| Military live-fire training missions utilize a variety of energetic materials that are never completely consumed during firing. Many munitions are issued with various types, quantities, and configurations of propellants. In January 2006, CRREL teamed with the 1st Battalion, 501st Parachute Infantry Regiment (PIR) in Alaska to sample areas used during a mortar training mission. Samples were collected from the snow surface at the firing points for both 81-mm and 60-mm ... |
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| Ultra-Linear Polymer Modulator |
MAY 2006 |
69 pages |
| Authors:
Lou Bintz; Alan Mickelson; LUMERA CORP BOTHELL WA
|
| Polymer electro-optic modulators with applications to photonic link systems requiring high spur free dynamic range are discussed. Multilayer high microbeta electro-optic polymer modulators were designed, fabricated and tested. The linearized designs include three electrode electro-optic modulators, 3dB coupled directional couplers, Mach Zehnder modulators, dual drive modulators. The problem of bias drift is thoroughly discussed. A 3dB coupled directional coupler with increasing separation between arms (splayed) was modeled, fabricated and tested ... |
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| The Structure of the Chromophore within a Red Fluorescent Protein from Zoanthus sp. |
MAY 2006 |
19 pages |
| Authors:
Vladimir I. Martynov; RUSSIAN ACADEMY OF SCIENCES MOSCOW (RUSSIA) SHEMYAKIN-OVCHINNIKOV INST OF BIOORGANIC CHEMISTRY
|
| This report results from a contract tasking Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, RAS as follows: During the past decade, Green Fluorescent Protein (GFP) has become one of the most widely used fluorescent probes that enable direct visualization of the intracellular processes in the living cell. The discovery of the red-emitting GFP-like proteins from Anthozoa species promises considerable broadening of the scope of biochemical applications of these probes. Further rational designing ... |
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| Pharmacological and Behavioral Enhancement of Neuroplasticity in the MPTP-Lesioned Mouse and Nonhuman Primate |
MAY 2006 |
60 pages |
| Authors:
Giselle M. Petzinger; UNIVERSITY OF SOUTHERN CALIFORNIA LOS ANGELES
|
| The purpose of this proposal is to investigate the mechanisms involving pharmacological and behavioral enhanced neuroplasticity of the injured basal ganglia. Our central hypothesis is that exercise and pharmacological intervention, specifically the administration of a D2 dopamine-receptor agonist, enhances neuroplasticity by modulating glutamatedopamine interactions. This proposal has two components. Using the MPTP C57BL/6 mouse Component One will test the hypothesis that exercise enhances plasticity of the MPTP-injured basal ganglia through ... |
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| Hypermethylation of AP-2alpha as a Prognostic Marker for DCIS |
MAY 2006 |
7 pages |
| Authors:
Stephen Baylin; JOHNS HOPKINS UNIV BALTIMORE MD SCHOOL OF MEDICINE
|
| Fifteen to 20% of women with initial DCIS subsequently manifest invasive breast carcinoma. At present, there is no real means to predict which patients will undergo this disease progression and recurrence. The purpose of this IDEA, DOD award is to determine whether hypermethylation of the AP-2alpha, and other genes, may identify those DCIS lesions at high risk for recurrence as invasive breast carcinoma. The idea was based on a small ... |
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| The Regulation of Nuclear Receptor Coactivator SRC-3 Activity Through Membrane Receptor Mediated Signaling Pathways |
MAY 2006 |
18 pages |
| Authors:
Ping Yi; BAYLOR COLL OF MEDICINE HOUSTON TX
|
| SRC-3/AIB1 is a steroid receptor coactivator with potent growth promoting activity. It is overexpressed in a number of cancers and has been shown to have oncogenic potential. An important mechanism for the regulation of SRC-3 coactivator activity is its site-specific phosphorylation status which is controlled by extracellular signals that stimulate specific protein kinase signaling pathways. It is well known that protein kinases such as aPKC are frequently overexpressed in cancers ... |
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| Cas Signaling in Breast Cancer |
MAY 2006 |
9 pages |
| Authors:
Kristiina Vuori; BURNHAM INST LA JOLLA CA
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| Resistance to antiestrogens is a serious clinical problem in breast cancer treatment, and a better understanding of the mechanisms of antiestrogen resistance is urgently needed. Our hypothesis, which is supported by our preliminary data, is that the signaling molecule Cas has an important causal role in the development of antiestrogen resistance. As a corollary, understanding of the pathways that Cas activates may identify key regulators of antiestrogen resistance and novel ... |
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| Modification of Operating Procedure for EZ-Retriever (Trademark) Microwave to Produce Consistent and Reproducible Immunohistochemical Results |
MAY 2006 |
13 pages |
| Authors:
Christina P. Tompkins; Denise M. Fath; Tracey A. Hamilton; Robert K. Kan; ARMY MEDICAL RESEARCH INST OF CHEMICAL DEFENSE ABERDEEN PROVING GROUND MD
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| The present study was conducted to optimize the operating procedure for the EZ- Retriever" microwave oven to produce consistent and reproducible staining results with microtubule-associated protein 2 (MAP-2). After performing microwave antigen retrieval (MAR) at 98 degrees C, as recommended by the manufacturer, inconsistent patterns of MAP-2 immunoreactivity were produced. Uniform patterns of MAP- 2 staining are critical when performing qualitative and quantitative image analysis on sections; therefore, optimizing the ... |
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| Supercritical Hydrocarbon Impinging Injector Simulation Facility |
APR 2006 |
7 pages |
| Authors:
Michael M. Micci; PENNSYLVANIA STATE UNIV UNIVERSITY PARK DEPT OF AEROSPACE ENGINEERING
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| A supercritical hydrocarbon impinging injector simulation facility was procured and installed to increase the available computational capability to conduct molecular dynamics simulations of supercritical impinging injectors using hydrocarbon propellants. Supercritical impinging injectors using hydrocarbon propellants are of interest to the next generation of liquid propellant rocket engines. The procured high performance computing cluster allows simulations to be conducted in a sufficiently short time period to allow investigation of the effects ... |
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| Silanols, a New Class of Antimicrobial Agent |
APR 2006 |
17 pages |
| Authors:
Yun-mi Kim; Samuel Farrah; Ronald H. Baney; FLORIDA UNIV GAINESVILLE DEPT OF MATERIALS SCIENCE AND ENGINEERING
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| Alkyldimethylsilanols, R(CH3)2SiOH, were recently reported to exhibit unexpectedly strong antimicrobial effects. The antimicrobial activities of alkyldimethylsilanols were significantly higher than their analogous alcohols. A study of structural dependence of their antimicrobial activity was conducted with four bacteria, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Enterococcus faecalis. Silanols, alcohols with structures analogous to the silanols, R(CH3)2COH, and substituted phenols were evaluated as a single class of materials. The minimum lethal concentrations ... |
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| Future Fuels |
APR 2006 |
80 pages |
| Authors:
A. M. Andrews; W. Bryzik; R. Carlin; J. M. Feigley; III Harrison W. E.; D. J. Katz; J. Y. Rodriguez; R. L. Snead; J. C. Sommerer; J. T. Tozzi; NAVAL RESEARCH ADVISORY COMMITTEE ARLINGTON VA
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| The challenge "Unleash us from the tether of fuel," came from Lt. Gen. James Mattis, USMC, Commanding General of Marine Corps Combat Development Command (MCCDC), and his Operation Iraqi Freedom (OIF) experience as CG of First Marine Division. As a near-term response, the Panel determined that the fuel tether remains, but found a way to lengthen it (Hybrid Electric Vehicle technology) and untangle it (dynamic fuel management). The Marine Corps ... |
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| Therapy Selection by Gene Profiling |
APR 2006 |
12 pages |
| Authors:
Simon W. Hayward; VANDERBILT UNIV NASHVILLE TN
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| The long term goal of this work is to develop a new prognostic tool with which to determine the response of a patient to a given therapy, with the view of providing the most appropriate treatments tailored to individual patients. The central hypothesis of this proposal is that a subset of the genes expressed in a prostate tumor can be used to predict response to specific therapeutic regimens. The purpose ... |
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Organic Chemistry
