| Engineering Protease-Specific Human Antibodies and Discovering Novel Proteases Expressed in Prostate Cancer Using Phage Display |
JAN 2003 |
19 pages |
| Authors:
Jeonghoon Sun; Charles S. Craik; CALIFORNIA UNIV SAN FRANCISCO
|
 | Early studies revealed the importance of MT-SP1 in prostate cancer progression and indicated the existence of other serine proteases involved in the cascade. Developing selective and potent protease inhibitors is challenging due to frequent coexpression of other similar proteases. The antibody scaffold is an attractive choice for the development of highly potent and selective inhibitors. A phage-displayed antibody library was screened against a cancer- associated protease membrane-type serine protease 1 ... |
|
| Lysophosphatidic Acid Regulation and Roles in Human Prostate Cancer |
JAN 2003 |
58 pages |
| Authors:
Sarah Spiegel; VIRGINIA COMMONWEALTH UNIV RICHMOND
|
| Lysophosphatidic acid (LPA) is a major mitogen in serum that regulates an array of cellular processes related to pathogenesis of cancer, especially ovarian, prostate and breast carcinomas. LPA stimulates proliferation by increasing cell cycle progression and suppression of apoptosis, as well as enhancing tumor cell invasion and angiogenesis (1, 2). Several reports have shown that LPA can transactivate the EGF tyrosine kinase receptor (3-5) by stimulating metalloproteinase processing of proHB-EGF ... |
|
| Hyaluronan Biosynthesis in Prostate Carcinoma |
JAN 2003 |
20 pages |
| Authors:
James B. McCarthy; MINNESOTA UNIV MINNEAPOLIS
|
| Despite advances in the diagnosis and treatment of prostate cancer in the last several years, metastasis represents the major cause of frustration and failure in the successful treatment of prostate cancer patients. Hyaluronan (HA) is polymeric anionic carbohydrate that is elevated within primary prostate tumors, most notably within the tumor-associated stroma. Our studies have demonstrated that increased HA synthesis by human prostate carcinoma cells correlates with metastatic potential. This increased ... |
|
| Conditional Estrogen Receptor Knockout Mouse Model for Studying Mammary Tumorigenesis |
JAN 2003 |
11 pages |
| Authors:
Sohaib A. Khan; CINCINNATI UNIV OH
|
| Toward addressing the functions of ER(alpha) in breast cancer, we have proposed to conditionally ablate ER-alpha gene in the mammary gland. A gene-targeting vector was generated from a 9.2 KB BamHI fragment containing the ER-alpha exon 3. The construct was confirmed by restriction enzyme digestion and full length DNA sequencing. The linearized targeting vector was electroporated into mouse 129/J1 embryonic stem cells (ES) and G418 neomycin-resistant clones were expanded. Approximately ... |
|
| PCBs Alter Dopamine Mediated Function in Aging Workers |
JAN 2003 |
77 pages |
| Authors:
Richard F. Seegal; Edward F. Fitzgerald; Eric S. Molho; Kenneth L. Marek; John P. Seibyl; HEALTH RESEARCH INC RENSSELAER NY
|
| The major hypothesis is that occupational exposure to polychiorinated biphenyls (PCBs) results in decrements in neuropsychological and neurological performance and the number of dopamine (DA) terminals in the basal ganglia of former capacitor workers. 248 subjects will undergo neuropsychological and neurological examinations, complete a comprehensive questionnaire, have blood drawn to measure serum PCB concentrations and undergo a non-invasive test to determine bone lead concentrations in Albany, New York. Approximately 40% ... |
|
| The Calcium Channel CaT1 in Prostate Cancer Progression |
JAN 2003 |
18 pages |
| Authors:
Micahel R. Freeman; CHILDREN'S HOSPITAL MEDICAL CENTER BOSTON MA
|
| This project focuses on the potential role of the calcium-selective ion channel, CaT1, in prostate cancer progression. Although the physiological role of CaT1 is still poorly understood, it may be a "store-operated" calcium pore, a type of channel that is known to play a role in cell growth and survival regulation. The Aims of this project are to (1) Develop specific antibodies against CaT1 and characterize its expression pattern(s) in ... |
|
| Gene Methylation in Prostate Cancer |
JAN 2003 |
11 pages |
| Authors:
Huang Wen-Xin; Edward P. Gelmann; AMERICAN UNIV WASHINGTON DC
|
| Background: NKX3. 1 is a homeoprotein with prostate-specific expression in adults. Loss of NKX3.1 correlates with prostate cancer progression. Loss of heterozygosity affects NKK3.1 in about 80% of prostate cancers. This project focuses on DNA methylation of the NKK3.1 gene promoter in prostate cancer cell lines and tissues. Materials and methods: DNA was analyzed by methylation-specific PCR and sequencing of bisulfite-treated DNA. We also treated cultured cells with the methylation ... |
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| Angiogenesis and Invasiveness in Prostate Cancer Detected With Spectral and Spatial Resolution MRI |
JAN 2003 |
7 pages |
| Authors:
Gregory S. Karczmar; CHICAGO UNIV IL
|
| The goal of this research is to use high spectral and spatial resolution (HiSS) MR imaging to improve images of human and murine prostate. Our work on the application of HiSS to improve anatomic and functional imaging was first described in a paper in Academic Radiology 1. Related work from this laboratory is presented in a number of other publications 2-9. Work from other laboratories shows that closely related methods ... |
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| Relationships Between IGF-1, IGF-Binding Proteins and Diet in African American and Caucasian Men |
JAN 2003 |
33 pages |
| Authors:
Tanya Agurs-Collins; HOWARD UNIV WASHINGTON DC
|
| The study aims to determine racial differences between insulin-like growth factor-1 (lGF-1), insulin-like binding protein-1 (IGFBP-2), insulin-like binding protein-3 (IGFBP-3), prostate specific antigen (PSA), testosterone, body mass index (BMI), and diets high in calories, protein and fat. Specifically, the primary objectives are to: (1) define racial differences in serum levels of free and total IGF-1, IGFBP-2, IGFBP-3, and testosterone. (2) Define how diet and BMI impact serum levels of IGF-1, ... |
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| Androgen Ablation Combined With CTLA-4 Blockade-Based Immunotherapy as a Treatment for Prostate Cancer |
JAN 2003 |
9 pages |
| Authors:
Eugene D. Kwon; LOYOLA UNIV MAYWOOD IL
|
| Manipulations capable of repealing host tolerance to induce T cell- mediated prostate tissue-specific responses are of central importance to immunotherapeutic approaches to prostate cancer treatment. Hence in the current proposal, we test whether androgen ablation (by castration) can induce T cell responses targeting murine prostate epithelial and tumor cells. We previously showed that castration of TRAMP mice results in prostate and tumor infiltration by antigen presenting cells (APC's) as well ... |
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| Bone Morphogenetic Proteins, Antagonists and Receptors in Prostate Cancer |
JAN 2003 |
32 pages |
| Authors:
A. H. Reddi; CALIFORNIA UNIV DAVIS
|
| The long-term objective of this proposal is to gain insight into mechanism of prostate cancer metastases to bone and attendant pathology of osteosclerosis. What is the cellular and molecular basis of osteotropism of metastatic prostate cancer in humans? The predominant site of prostate cancer is bone. However, unlike the osteolytic lesions of breast cancer, prostate cancer causes osteoblastic osteosclerosis which leads ultimately to morbidity and mortality. During the osteoscleorotic phase ... |
|
| Insecticide Exposure in Parkinsonism |
JAN 2003 |
61 pages |
| Authors:
Jeffrey R. Bloomquist; Bradley G. Klein; VIRGINIA POLYTECHNIC INST AND STATE UNIV BLACKSBURG
|
| Behavioral, neurochemical, and immunocytochemical studies are characterizing the possible role of insecticide exposure in the etiology of Parkinson's disease as it may relate to Gulf War Syndrome. Chlorpyrifos (CP) and/or permethrin (PM) were given 3 times over a two week period by injection (CP subcutaneous and PM intraperitoneal), with or without a single dose of the Parkinsonian neurotoxin, MPTP (20-30 mg/kg, intraperitoneal). PM upregulates dopamine transporter (DAT) expression with a ... |
|
| Characterizations of Factors Affecting Androgen Receptor Transcriptional Regulation in Prostate Cancer |
JAN 2003 |
45 pages |
| Authors:
Michael J. Garabedian; NEW YORK UNIV NY SCHOOL OF MEDICINE
|
| Androgen Receptor Trapped clone-27 (ART-27) is a transcriptional coactivator of the androgen receptor (AR) that was identified in yeast two- hybrid screen using the AR as bait (see Markus et al). Recent studies suggest that the ART-27 protein is expressed in normal differentiated epithelial cells of the prostate and breast, in contrast to the stroma, where ART-27 is not expressed. Expression of ART-27 in LNCaP cells, an androgen-dependent prostate cancer ... |
|
| New Approaches Towards the Elucidation of Epidermal-Dermal Separation in Sulfur Mustard-Exposed Human Skin and Directions For Therapy |
JAN 2003 |
|
| Authors:
Marijke A. E. Mol; PRINS MAURITS LABORATORIUM TNO RIJSWIJK(NETHERLANDS)
|
 | The first year of the research performed under Award Number DAMD17- 02-02O6 has yielded promising results. with respect to the application of MMP inhibitor BB94 on HD-exposed human skin pieces in order to prevent microvesication. BB94 is effective at a concentration of at least 1 mug/ml and can be added to the culture medium as late as 8 h after exposure to HD, without loosing its inhibiting effect on epidermal-dermal ... |
|
| Role of Androgen Receptor in Growth of Androgen Independent Prostate Cancer |
JAN 2003 |
8 pages |
| Authors:
Charlie D. Chen; CALIFORNIA UNIV LOS ANGELES
|
| Androgen-ablation therapy is the primary treatment for prostate cancer that has escaped local control through surgical excision or radiation (hormone sensitive, HS). While generally effective, the treatment is short-lived and hormone refractory (HR) cancer eventually develops. To identify the responsible mechanisms, we set out a microarray experiment using seven pairs of HS and HR xenografts and identified androgen receptor (AR) overexpression is the only consistent change in the progression of ... |
|
| A Novel Pathway to Down-Regulate ErbB Signaling in Mammary Epithelial Cells |
JAN 2003 |
98 pages |
| Authors:
Lei Duan; Hamid Band; BRIGHAM AND WOMEN'S HOSPITAL BOSTON MA
|
| Activation of tyrosine kinases plays a key role in cell proliferation, and ErbB receptor tyrosine kinases are specifically implicated in breast cancer. Biochemical studies have recently identified the proto-oncogene product Cbl as a negative regulator of EGF receptor and ErbB2. The Cbl-dependent negative regulation of ErbB receptors was associated with their ubiquitin modification and down-regulation from the cell surface. Based on these observations, this proposal is investigating the role of ... |
|
| Regulation of FAK Signaling in Mammary Epithelial Cells by Cbl Proto- Oncogene Product |
JAN 2003 |
98 pages |
| Authors:
Stephen Donoghue; Hamid Band; Amiya Ghosh; BRIGHAM AND WOMEN'S HOSPITAL BOSTON MA
|
| Proliferation and differentiation of normal breast epithelial cells are regulated by activation of the cellular tyrosine kinase machinery upon coordinated cellular stimulation through growth factor receptor tyrosine kinases and extra-cellular matrix receptor-induced activation of focal adhesion kinase FAK. This proposal is designed to investigate a novel hypothesis that Cbl provides, which has become established as a negative regulator of growth factor receptors, attenuates FAK-dependent growth signals in mammary epithelial cells. ... |
|
| Defence Science Journal. Volume 53, Number 1 |
JAN 2003 |
|
| Authors:
MINISTRY OF DEFENCE NEW DELHI (INDIA) DEFENCE RESEARCH AND DEVELOPMENT ORGANISATION
|
|
| UH - USA Agreement - A Telemedicine Research Proposal |
JAN 2003 |
311 pages |
| Authors:
Lawrence P. Burgess; HAWAII UNIV HONOLULU
|
| The purpose of the University of Hawaii Telemedicine Curriculum Research Project is to develop an effective web-based curriculum for training military health care personnel in the use of contemporary communication, automation, and informatics technology in the delivery of health care. The overall curriculum is generic in nature, while specific modules can be tailored to the needs of the military health care provider (HPC). The goal of the telemedicine curriculum is ... |
|
| International Conference on Parkinson's Disease |
JAN 2003 |
372 pages |
| Authors:
Rashid Shaikh; NEW YORK ACADEMY OF SCIENCES NY
|
| Partial Contents: Description of Parkinson's Disease as a Clinical Syndrome. Physiology and Pathophysiology of Parkinson's Disease. PET Studies on the Function of Dopamine in Health and Parkinson's Disease. Midbrain Dopaminergic Neurons: Determination of Their Developmental Fate by Transcription Factors. Transcriptional Control of Dopamine Neuron Development. Transcription Factors in the Development of Midbrain Dopamine Neurons. Postnatal Developmental Programmed Cell Death in Dopamine Neurons The Cast of Molecular Characters Parkinson's Disease: Felons,Conspirators, ... |
|
| Formulated Delivery of Enzyme/Pro-Drug and Cytokine Gene Therapy to Promote Immune Reduction of Treated and Remote Tumors in Mouse Models of Prostate Cancer |
JAN 2003 |
14 pages |
| Authors:
Pamela J. Russell; Gerald W. Both; P. L. Molloy; T. Lockett; NEW SOUTH WALES UNIV SYDNEY (AUSTRALIA)
|
| Prostate cancer is the second highest cause of cancer death in Western society men. Early stages are treatable, but late stage disease is incurable with palliative care the only option. Purpose: We will use a combination of gene therapy approaches to target prostate cancer locally and in other organs (metastases). Gene directed enzyme/pro-drug therapy (GDEPT) is delivered in the prostate. This kills cancer cells and generates an immune reaction, To ... |
|
| Post-Mastectomy and Phantom Breast Pain: Risk Factors, Natural History, and Impact on Quality of Life |
JAN 2003 |
48 pages |
| Authors:
Robert M. Dworkin; ROCHESTER UNIV NY
|
| Post-mastectomy pain syndrome, post-lumpectomy pain, and phantom breast pain are poorly understood chronic pain syndromes that occur following surgical procedures for breast cancer. The primary aims of this research were to identify risk factors for these chronic pain syndromes following surgical procedures for breast cancer, characterize their natural history, and examine their irnpact on quality of life using a prospective research design. Women scheduled for mastectomy, lumpectomy, or excisional biopsy ... |
|
| Oxidative Damage in Parkinson's Disease |
JAN 2003 |
21 pages |
| Authors:
M. F. Beal; CORNELL UNIV MEDICAL COLL (WEILL) NEW YORK
|
| The overall goal of the proposal was to provide a detailed assessment of the role of oxidative damage in Parkinson's Disease (PD) postmortem brain tissue, body fluids of PD patients and in the MPTP model. There were trends towards increased oxidative damage markers in post mortem brain tissue of PD patients and a number of specific genes linked to oxidative stress were reduced in expression. There was increased lipid peroxidation ... |
|
| Peptide-Mediated Transduction of Proteins and Nucleic Acids to Prevent and Treat Experimental Prostate Cancer |
JAN 2003 |
10 pages |
| Authors:
Janey D. Whalen; PITTSBURGH UNIV PA
|
| Our goal in this project is to prevent the occurrence of bone metastasis in early experimental prostate cancer using protein transduction: the ability of small peptides to facilitate the entry of large biologically active fusion protein cargos into cells. The hypothesis to be tested is that protein transduction can deliver therapeutic proteins to skeletal tissues and bone marrow in such a manner that they may facilitate the apoptotic, or programmed ... |
|
| Inhibition of PKR Activity is Required for Survival of Breast Cancer |
JAN 2003 |
14 pages |
| Authors:
George K. Haines; NORTHWESTERN UNIV EVANSTON IL
|
| PKR is an interferon-inducible protein kinase, which has recently been discovered to have pleiotropic effects on the growth and differentiation of normal and neoplastic cells. We reported a direct correlation between PKR expression and differentiation in a variety of human tumors and in normal squamous epithelial, and an inverse association between%PKR expression and proliferation in head and neck cancer. The mechanisms by which PKR produced such effects are being intensively ... |
|
| Ultrasound Imaging Initiative |
JAN 2003 |
|
| Authors:
Raj Shekhar; CLEVELAND CLINIC FOUNDATION OH
|
| This objective of this project was to build a real-time 3D ultrasound imaging system for combat casualty care. The high frame rate necessary for real-time 3D imaging was obtained using a synthetic aperture beamforming technique. The technique uses a fraction of the transmit pulses required by a conventional imaging system and permits very rapid image acquisition with no degradation of image quality. A beamformer capable of generating 650 2D image ... |
|
| Occupational Analysis Products: Histopathology- AFSC 4T0Xjan 20032 (CD-ROM) |
JAN 2003 |
|
| Authors:
Luis A. Berrios; AIR FORCE OCCUPATIONAL MEASUREMENT SQUADRON RANDOLPH AFB TX
|
| ELECTRONIC FILE CHARACTERISTICS: 20 files; HyperText Markup Language (.HTML), MS Word (.DOC), and MS PowerPoint (.PPT). PHYSICAL DESCRIPTION: 1 computer laser optical disc (CD-ROM); 4 3/4 in.; 11.5 MB. SYSTEMS DETAIL NOTE: IBM-clone PC-compatible. ABSTRACT: This CD contains the products of the Occupational Analysis for AFSC 4T0X2 completed in January 2003. The OSR is a summary of the analyses which includes job descriptions of work performed within the AFSC, Duty ... |
|
| Medical Surveillance Monthly Report (MSMR). Volume 9, Number 1, January 2003 |
Jan-2003 |
17 pages |
| Authors:
ARMED FORCES HEALTH SURVEILLANCE CENTER SILVER SPRING MD
|
| Malaria is a mosquito-transmitted febrile infectious disease that is endemic throughout the tropics. It is estimated that malaria accounts for nearly 500 million clinically significant cases and more than one million deaths each year worldwide. In recent years, the intensity and extent of malaria endemicity have increased. In the U.S. Army, many soldiers are permanently assigned in malaria endemic areas; in addition, many soldiers are exposed to malaria risk during ... |
|
| Journal of Special Operations Medicine, Volume 3, Edition 1 |
Jan-2003 |
89 pages |
| Authors:
JOINT SPECIAL OPERATIONS UNIV HURLBURT FIELD FL
|
| The Journal of Special Operations Medicine is an authorized official quarterly publication of the United States Special Operations Command, MacDill Air Force Base, Florida. It is in no way associated with the civilian Special Operations Medical Association (SOMA). Our mission is to promote the professional development of Special Operations medical personnel by providing a forum for the examination of the latest advancements in medicine. Disclosure: The views contained herein are ... |
|
| Journal of Special Operations Medicine, Volume 3, Edition 2 |
Jan-2003 |
89 pages |
| Authors:
JOINT SPECIAL OPERATIONS UNIV HURLBURT FIELD FL
|
| The Journal of Special Operations Medicine is an authorized official quarterly publication of the United States Special Operations Command, MacDill Air Force Base, Florida. It is in no way associated with the civilian Special Operations Medical Association (SOMA). Our mission is to promote the professional development of Special Operations medical personnel by providing a forum for the examination of the latest advancements in medicine. Articles in this issue include topics ... |
|
| Journal of Special Operations Medicine, Volume 3, Edition 3 |
Jan-2003 |
79 pages |
| Authors:
David L Hammer; Michelle D DuGuay; JOINT SPECIAL OPERATIONS UNIV HURLBURT FIELD FL
|
| Greetings again from your HQ/USSOCOM. As we move into the summer months we still find ourselves in awe and in full support of our special ops forces in the fields and towns of Afghanistan, Iraq, and elsewhere in the world (150 countries so far this year). I just read the recent data from Landstuhl Medical Center on the patients moving through that terrific facility and was reminded again of the ... |
|
| Journal of Special Operations Medicine, Volume 3, Edition 4 |
Jan-2003 |
93 pages |
| Authors:
David L Hammer; Michelle D DuGuay; Warner J Anderson; JOINT SPECIAL OPERATIONS UNIV HURLBURT FIELD FL
|
| Advanced Technical Applications for Combat Casualty Care (ATACCC) came and went by for the second year since 9/11--recall that it was during ATACCC that the attack on America happened. There were great presentations--we got feedback by medics with first-hand experience in OEF and OIF and we are more committed than ever to meet the needs of our medics/corpsmen/PJs out there leading the way. |
|
| Staphylococcal Enterotoxins, Toxic Shock Syndrome Toxin-I, and Streptococcal Pyrogenic Exotoxins: Some Basic Biology of Bacterial Superantigens |
2003 |
28 pages |
| Authors:
Teresa Krakauer; Bradley G. Stiles; ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD
|
| Staphylococcus aureus and Streptococcus pyogenes are facultative gram-positive cocci that play an important role in a myriad of human illnesses, including food poisoning, skin infections, pharyngitis, life threatening shock, and autoimmune disorders like arthritis, psoriasis, and atopic dermatitis. These ubiquitous bacteria produce various virulence factors that include superantigens like staphylococcal enterotoxins (SE), toxic shock syndrome toxin-i (TSST-1), and streptococcal pyrogenic exotoxins (SPE). To date, the continually expanding literature describes 15 ... |
|
| Weaving a National Surveillance System - The Role of Federal Healthcare |
2003 |
63 pages |
| Authors:
Nancy E. Tomich; UNITED STATES MEDICINE INST FOR HEALTH STUDIES WASHINGTON DC
|
| The nonprofit U.S. Medicine Institute for Health Studies on March 6, 2003, gathered decisionmakers from government and the private sector to examine the need for a national surveillance system and how such a system might best be developed, given current, often disparate, attempts at various levels of disease detection. Opinions presented at this forum ranged from assertions that "we have a long way to go" in developing a national system ... |
|
| An Analysis of Potential Adjustments to the Veterans Equitable Resource Allocation (VERA) System |
2003 |
|
| Authors:
Jeffrey Wasserman; Jeanne Ringel; Karen Ricci; Jesse Malkin; Michael Shoenbaum; RAND NATIONAL DEFENSE RESEARCH INST SANTA MONICA CA
|
| The Veterans Equitable Resource Allocation (VERA) system was instituted by the VHA in 1997 in a continuing effort to improve the allocation of congressionally appropriated health care funds to the 21 Veterans Integrated Service Networks (VISNs). VERA was designed to fulfill this mission in an equitable, understandable, and efficient manner as well as to address the complexities of providing health care to veterans with service-connected disabilities, low incomes, and special ... |
|
| Impact of a Uniform Formulary on Military Health System Prescribers |
2003 |
|
| Authors:
Terri Tanielian; Katherine Harris; Ana Suarez; Renee Labor; Melissa Bradley; RAND NATIONAL DEFENSE RESEARCH INST SANTA MONICA CA
|
| The Military Health System (MRS) has approximately 8.7 million eligible beneficiaries. These beneficiaries include active duty military personnel and their family members, retired military personnel and their family members, and surviving family members of deceased military personnel. In 2001, the Department of Defense (DoD) spent just over $2 billion on pharmacy benefits. Much like the private health care sector, the MRS has experienced a rapid growth in pharmaceutical expenditures, which ... |
|
| Sedation Assessment: Time for a Change |
2003 |
11 pages |
| Authors:
Marla J. DeJong; AIR FORCE INST OF TECH WRIGHT-PATTERSONAFB OH
|
| Sedative medications are commonly prescribed to critically ill patients to manage a variety of physiologic and psychological conditions. Dosing of sedative agents are typically titrated to achieve an acceptable level of sedation based on frequent patient assessment. Despite a number of published sedation assessment scales, most lack adequate validity and reliability testing and their clinical usefulness in critically ill patients is limited. This panel discussion will compare and contrast the ... |
|
| Improving Dispute Resolution for California's Injured Workers. Executive Summary |
2003 |
|
| Authors:
Nicholas M. Pace; Robert T. Reville; Lionel Galway; Amanda B. Geller; Orla Hayden; RAND CORP SANTA MONICA CA
|
| California's 90-year-old workers' compensation system is designed to provide injured workers immediate and speedy relief without re- sorting to a formal trial. Instead of involving judges and the civil courts, injured workers may simply file a claim through a no-fault, administrative process. In theory, the process for delivering workers' compensation benefits, such as medical care, replacement of lost wages, and vocational ,rehabilitation services, is precisely defined in the California Labor ... |
|
| Military Patient Satisfaction and Self-Care Advice Outcomes with a Telephone Nursing Service |
2003 |
97 pages |
| Authors:
April L. Eckerman; AIR FORCE INST OF TECH WRIGHT-PATTERSONAFB OH
|
| Telephone nursing services facilitate access to appropriate levels of care and provide valuable health care information to callers. Widely viewed as a cost-effective demand management strategy by health maintenance organizations, telephone nursing has seen tremendous growth in recent years. However, little is known about satisfaction with services and influence on self-care activities experienced by patients who use a telephone nursing service. Therefore, further research is needed to explore the usefulness ... |
|
| The Army Medical Department and Full Spectrum Operations |
2003 |
53 pages |
| Authors:
Paula C. Lodi; ARMY COMMAND AND GENERAL STAFF COLL FORT LEAVENWORTH KS SCHOOL OF ADVANCED MILITARY STUDIES
|
| The purpose of this monograph is to examine the Army Medical Department's ability to support full spectrum operations in accordance with current doctrine, given the assessment of current and future operational environment. It is the author's assertion that the AMEDD's force structure does not fully support full spectrum operations with Level III hospital capability. The Medical Reengineering Initiative (MRI) Combat Support Hospital (CSH) does not have adequate mobility or flexibility ... |
|
| Living Well at the End of Life. Adapting Health Care to Serious Chronic Illness in Old Age |
2003 |
|
| Authors:
Joanne Lynn; David M. Adamson; RAND CORP SANTA MONICA CA
|
| Most older Americans now face chronic illness and disability in the final years of life. These final years can prove painful and difficult for sick and disabled elderly people, who may have difficulty finding care to meet their needs. This period is often stressful and expensive for families. As currently configured, health care and community services simply are not organized to meet the needs of the large and growing number ... |
|
| Evaluating the Feasibility of Developing National Outcomes Data Bases to Assist Patients with Marking Treatment Decisions |
2003 |
|
| Authors:
Cheryl L. Damberg; Liisa Hiatt; Kitty S. Chan; Rebecca Nolind; Michael Greenberg; RAND HEALTH SANTA MONICA CA
|
| This report examines the potential for, and range of issues associated with, establishing national health outcomes data bases to help patients and their physicians evaluate tradeoffs among various treatment options. Patients are frequently faced with more than one treatment option and often those treatments have multiple outcomes that need to be understood and evaluated in terms of their risks and benefits to the patient. This work builds on previous Agency ... |
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| Drug and Alcohol Treatment Services Among Privately Insured Individuals in Managed Behavioral Health Care |
2003 |
|
| Authors:
Bradley D. Stein; RAND CORP SANTA MONICA CA
|
| Drug and alcohol problems are a significant public health issue, affecting millions of Americans. Many of these individuals are privately insured. Private insurance coverage for substance abuse (SA) disorders has improved recently, but coverage for SA disorders remains more restricted than for other behavioral health disorders. Behavioral health benefit management has also been changing dramatically; today most privately insured individuals have their behavioral health care benefits managed separately (e.g. carved-out) ... |
|
| Fault Lines in China's Economic Terrain |
2003 |
|
| Authors:
Charles Wolf Jr.; K. C. Yeh; Benjamin Zycher; Nicholas Eberstadt; Sung-Ho Lee; RAND CORP SANTA MONICA CA
|
| The focus of this research is the potential adversities or fault lines (the terms are used synonymously) facing China's economy and affecting its prospects for sustaining high growth through the coming decade. Thus, we deliberately concentrate on what might go seriously awry in the economy and, in the process, slow or even reverse China's double-digit growth rates in the 1980s and high single-digit growth in the 1990s and the early ... |
|
| The Rise of HMOs |
2003 |
|
| Authors:
Martin Markovich; RAND CORP SANTA MONICA CA
|
| The purpose of this research is to determine factors associated with differential HMO enrollment growth across metropolitan statistical areas (MSAs). The study examines 2 periods, 1973-1978 and 1988-1993, during which national HMO enrollment grew substantially. Results for the 2 periods are compared to determine the stability of statistical relationships. Data was collected for the 75 largest U.S. MSAs as of 1990. The study uses multiple regression to test several hypotheses ... |
|
| Smallpox: Is the Department of Defense Prepared? |
2003 |
79 pages |
| Authors:
Stephen M. Ford; ARMY COMMAND AND GENERAL STAFF COLL FORT LEAVENWORTH KS
|
| Biological weapons pose a clear and present danger to U.S. national security, U.S. forces, and key allies and friends. Their low cost, low visibility, high potency, accessibility, and easy delivery make BW attractive to adversaries seeking new methods of violence when current ones no longer achieve their intended effect. With a case fatality rate of 30 percent and no effective treatment smallpox is one of the most feared of all ... |
|
| Calculation of Initial Tidal Volume Settings for Acute Respiratory Distress Syndrome Patients in One Southern Ohio Hospital's Critical Care Units |
2003 |
43 pages |
| Authors:
Heidi M. Stewart; AIR FORCE INST OF TECH WRIGHT-PATTERSONAFB OH
|
| Acute Respiratory Distress Syndrome (ARDS) is characterized by bilateral pulmonary infiltrates, stiff lungs, and hypoxemia, without evidence of cardiac disease. ARDS has a high mortality of around 40-50% (Slutsky, 2002). With the creation of the National Institutes of Health ARDS network in 1994, knowledge about ARDS pathophysiology and treatment has advanced tremendously (Martin, 2002). Several independent studies have shown improved prognosis of patients with Acute (Adult) Respiratory Distress Syndrome (ARDS) ... |
|
| Validation of a Clinical Prediction Rule to Identify Patients Likely to Benefit from Spinal Manipulation: A Randomized Clinical Trial |
2003 |
252 pages |
| Authors:
John D. Childs; PITTSBURGH UNIV PA SCHOOL OF HEALTH AND REHABILITATION SCIENCES
|
| The primary aim of this multicenter, randomized clinical trial was to validate a clinical prediction rule (CPR) to identify patients with low back pain (LBP) likely to benefit from spinal manipulation. Subjects were 131 consecutive patients referred for physical therapy. Patients with positive neurologic signs or other red flags for spinal manipulation were excluded. After completing a standardized history and physical examination, patients were randomly assigned to receive spinal manipulation ... |
|
| Confocal Microscopy for Real Time Detection of Oral Cavity Neoplasia |
2003 |
38 pages |
| Authors:
Anne L. Clark; A. Gillenwater; T. Collier; R. Alizadeh-Naderi; A. K. El-Naggar; TEXAS UNIV AT AUSTIN DEPT OF BIOMEDICALENGINEERING
|
| The goal of this study was to characterize features of normal and neoplastic oral mucosa using reflectance confocal microscopy. Oral cavity biopsies were acquired from 17 patients at the Head and Neck Clinic of the University of Texas M. D. Anderson Cancer Center who were undergoing surgery for squamous cell carcinoma (SCC) within the oral cavity. Reflectance confocal images were obtained at multiple image plane depths from biopsies within 6 ... |
|
| A Five-Country Comparison of Anxiety Early After Acute Myocardial Infarction |
2003 |
21 pages |
| Authors:
Marla J. De Jong; Misook L. Chung; Lynn P. Roser; Lynne A. Jensen; Lynn A. Kelso; KENTUCKY UNIV LEXINGTON COLL OF NURSING
|
| Anxiety is common after acute myocardial infarction (AMI) and has the potential to negatively affect physical and psychosocial recovery. There have been no cross-cultural comparisons of anxiety among AMI patients. The objectives of this study were to evaluate whether anxiety after AMI differs across five diverse countries and to determine whether an interaction between country, sociodemographic variables, and clinical variables contributes to variations in reporting anxiety. A total of 912 ... |
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Medicine and Medical Research
