Although conventional radiation therapy and surgery are potentially curative treatments for organ-confined prostate cancer, there are few effective treatments for metastatic disease. We recently created a potent antitumor agent - the fusogenic oncolytic herpes simplex virus (HSV). The first task originally planned for the first year of this project was to demonstrate the potency of the fusogenic oncolytic HSV against advanced prostate cancer. The subtasks include: a) Production of high ...
The tasks that were originally planned for the first year of this 3 year project are to demonstrate that the fusogenic oncolytic herpes simplex viruses are potent anti-tumor agents for advanced ovarian cancer. Specifically we planned to: 1) produce a large quantity of high grade and high titer viral stocks for the in vivo animal experiments: 2) establish advanced ovarian cancer in the animal model: 3) to therapeutically administer virus, ...
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