The United States Army Research Institute of Environmental Medicine (USARIEM) celebrated its 50th anniversary on July 1, 2011. This article reviews its history, evolution, and transition of its research programs as well as its scientific and military accomplishments, emphasizing the past 25 yr. During the 1990s, USARIEM published a series of pocket guides providing guidance for sustaining Warfighter health and performance in Southwest Asia, Somalia, the former Republic of Yugoslavia, ...
Today's Warfighter is subject to traumatic injuries to skeletal muscle. Tourniquet use for hemorrhage control is common, as well as in surgical situations requiring the restriction of blood flow to an extremity. The reperfusion period following prolonged tourniquet use results in skeletal muscle damage, making ischemia/reperfusion (I/R) injury a concern for military personnel. In regards to acute injury, 63% of injuries sustained in combat are the result of explosive munitions ...
This study was designed to characterize critical molecules involved in skeletal muscle response to ischemia-reperfusion (I/R) and blunt trauma injury in order to identify strategies for pharmacological intervention. For I/R injury, a tourniquet was applied to rat hind limbs for 3 h. Extensor digitorum longus (EDL) muscles from the healthy and I/R leg were harvested 2 h post-reperfusion for analysis. For the blunt trauma model, mice were anesthetized, the tibialis ...
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