| Nonapoptotic Function of Caspase-6 in Promoting Mammary Carcinogenesis |
Jan 2012 |
13 pages |
| Authors:
Xiangxi Xu; MIAMI UNIV FL
|
 | Malignancy is defined as the elevated mobility and invasiveness of tumor cells, and a deformed nuclear morphology is a common feature of malignant cells. We hypothesized that the decrease or absence of nesprin-1 in breast cancer cells may account for the malignant features of the neoplastic cells, the deformed nuclear morphology and invasiveness/high motility. We propose a pilot study to test this hypothesis. Indeed, we found that nesprin-1 expression is ... |
|
| A Molecular Basis Accounted for the Malignant Features of Breast Cancer Cells |
Oct 2011 |
8 pages |
| Authors:
Xiangxi Xu; MIAMI UNIV FL
|
| Malignancy is defined as the elevated mobility and invasiveness of tumor cells, and a deformed nuclear morphology is a common feature of malignant cells. We hypothesized that the decrease or absence of nesprin-1 in breast cancer cells may account for the malignant features of the neoplastic cells, the deformed nuclear morphology and invasiveness/high motility. We propose a pilot study to test this hypothesis. Indeed, we found that nesprin-1 expression is ... |
|
| A Mouse Model to Investigate Postmenopausal Biology as an Etiology of Ovarian Cancer Risk |
Nov 2009 |
20 pages |
| Authors:
Xiangxi Xu; MIAMI UNIV FL
|
| We are completing this project to use a germ cell deficient Wv mouse model to test the hypothesis of a synergy between oncogenic mutations and postmenopausal biology in ovarian cancer development. We found that crossing of Wv mice into mutant p53 or pten (+/-) background did not lead to a malignant tumor phenotype (Aim 1). Instead, the mutants rescue ovarian germ cells, a very interesting finding. The ovarian surface epithelia ... |
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| A Mouse Model to Investigate Postmenopausal Biology as an Etiology of Ovarian Cancer |
Nov-2008 |
12 pages |
| Authors:
Xiangxi Xu; MIAMI UNIV FL
|
| We are completing this project to use a germ cell deficient Wv mouse model to test the hypothesis of a synergy between oncogenic mutations and postmenopausal biology in ovarian cancer development. We found that crossing of Wv mice into mutant p53 or pten (+/-) background did not lead to a malignant tumor phenotype (Aim 1). Instead, the mutants rescue ovarian germ cells, a very interesting finding. The ovarian surface epithelia ... |
|
| A Mouse Model to Investigate Postmenopausal Biology as an Etiology of Ovarian Cancer Risk |
Nov 2007 |
34 pages |
| Authors:
Xiangxi Xu; FOX CHASE CANCER CENTER PHILADELPHIA PA
|
| This project is to use a unique mouse model to study the interaction of reproductive factors and genetic mutations in the development of ovarian cancer. Ovarian cancer often develops in women of peri-menopausal age. We found that the germ cell deficient Wv mice mimics postmenopausal biology and develop benign ovarian tumors. We plan to test the hypothesis that a synergy exists between oncogenic mutations such as p53, pten, or p27kip1 ... |
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| A Mouse Model to Investigate Postmenopausal Biology as an Etiology of Ovarian Cancer Risk |
NOV 2006 |
31 pages |
| Authors:
Xiangxi Xu; INSTITUTE FOR CANCER RESEARCH PHILADELPHIA PA
|
| This project is to use a unique mouse model to study the interaction of reproductive factors and genetic mutations in the development of ovarian cancer. Ovarian cancer often develops in women of peri-menopausal age. We found that the germ cell deficient Wv mice mimics postmenopausal biology and develop benign ovarian tumors. We plan to test the hypothesis that a synergy exists between oncogenic mutations such as p53, pten, or p27kip1 ... |
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