Our laboratory is interested in studying the mechanisms by which lactogenic hormones regulate Beta-casein gene expression and how alterations in the levels of these hormones may function in the growth promotion of breast tumors. To understand the role of C/EBPBeta, STAT5, GR and comodulatory factors in hormonally-regulated chromatin remodeling at the Beta-casein promoter and enhancer, we have performed RNA analysis and chromatin immunoprecipitation assays in HC11 mammary epithelial cells and ...
One of the principal objectives of our laboratory is to understand the mechanisms by which hormones and growth factors regulate normal mammary gland development and how these same regulatory pathways become altered in breast cancer. Specific emphasis has been placed upon studying the mechanisms by which the lactogenic hormones, prolactin, hydrocortisone and insulin, regulate milk protein gene expression. The CCAAT/enhancer binding protein B (c/EBPB), Yin Yang-i (YY- 1), signal transducers ...
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