Our laboratory research is focused on the potential roles of a TNF-related cytokine named TWEAK and its specific cell surface receptor named Fn14 in tumor biology. We reported previously that the Fn14 gene is highly expressed in many human breast cancers. In this Breast Cancer Concept Award application we proposed to investigate whether we could make Fn14-targeted toxins that would kill Fn14-positive breast cancer cells in vitro and in vivo. ...
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