This study examined the role of oxygen in amphotericin B-induced killing of Leishmania braziliensis panamensis promastigotes and Candida albicans. In the first phase of the study, we explored the effects of high oxygen tensions on the lethal effects of three reduction-oxidation cycling drugs: amphotericin B, menadione, and phenazine methosulfate. Promastigotes were exposed to the above drugs under normoxic, hyperoxic (100% 02 at 101.3 kPa), ot hyperbaric hyperoxic (100% 02 at ...
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