Jeffrey C. Watkins - Storming Media

The Study of Pharmacology & Physiology of N-Methyl-D-Aspartate Receptor Subtypes in the Mammalian Central Nervous System

06 JUL 95

Authors: Daniel T. Monaghan; Jeffrey C. Watkins; NEBRASKA UNIV MEDICAL CENTER OMAHA

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The goal of this project is to identify pharmacological agents that are specific for NMDA receptor subtypes for use as anti-nerve gas agents with acceptable side effects. As proposed in the Statement of Work, we have completed the following studies: Task 1. We have determined the potency of 79 drugs at NMDA receptor subtypes using quantitative image analysis of NMDA receptor- radioligand binding autoradiography. ...