| Role of Cyclin E as an Early Event in Ovarian Carcinogenesis |
Apr 2012 |
59 pages |
| Authors:
Christine Walsh; CEDARS-SINAI MEDICAL CENTER LOS ANGELES CA
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 | At the genetic level, ovarian cancer is characterized by a large degree of genetic instability. High copy-number amplification at the CCNE1 (cyclin E) gene locus is the single most notable recurrent change, occurring in about 20% of tumors. We have hypothesized that CCNE1 gene amplification is an initiating event in the carcinogenic process of a subset of epithelial ovarian cancers. We have made progress towards testing our hypothesis of cyclin ... |
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| Role of Cyclin E as an Early Event in Ovarian Carcinogenesis |
APR 2011 |
40 pages |
| Authors:
Christine Walsh; CEDARS-SINAI MEDICAL CENTER LOS ANGELES CA
|
| At the genetic level, ovarian cancer is characterized by a large degree of genetic instability. High copy-number amplification at the CCNE1 (cyclin E) gene locus is the single most notable recurrent change, occurring in about 20% of tumors. We have hypothesized that CCNE1 gene amplification is an initiating event in the carcinogenic process of a subset of epithelial ovarian cancers. In the first two years of this award, we have ... |
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| Role of Cyclin E as an Early Event in Ovarian Carcinogenesis |
Apr 2010 |
30 pages |
| Authors:
Christine Walsh; CEDARS-SINAI MEDICAL CENTER LOS ANGELES CA
|
| Cyclin E amplification and overexpression characterizes a subset of epithelial ovarian cancers. We hypothesized that this subset of tumors may demonstrate an enhanced response to targeted therapy with the proteasome inhibitor, bortezomib. Cyclin E also exists in multiple low molecular weight (LMW) isoforms in cancer cells which demonstrate greater neoplastic activity. A natural dietary phytochemical called Indole-3-Carbinol (I3C) disrupts cyclin E processing through the inhibition of the enzyme that cleaves ... |
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