In the C3(1)/SV40 T-antigen (Tag) FVB/N mouse model of human estrogen and progesterone receptor-negative breast cancer, the stress response elicited by social isolation is associated with increased expression of metabolic genes in the mammary gland. To further understand accelerated tumor growth associated with social isolation, we separated mammary gland adipocytes from ductal epithelium and stroma and then analyzed individual fractions for changes in metabolic gene expression and function. The increased ...
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