In the early nineties, Joyner and coworkers introduced the "coupling clamp" technique in which an isolated cardiac cell can be electrically coupled to either another isolated cardiac cell or to an analog model cell (RC circuit). In brief, an amplifier system does a continuous analog computation of the current that would be flowing between the two cells if there had been an intercellular coupling conductance G sub c, and then ...
In the early nineties, Joyner and coworkers introduced the "coupling clamp" technique in which an isolated cardiac cell can be electrically coupled to either another isolated cardiac cell or to an analog model cell (RC circuit). In brief, an amplifier system does a continuous analog computation of the current that would be flowing between the two cells if there had been an intercellular coupling conductance G(c), and then pro- vides ...
At the Purkinje (P) - ventricular (V) junction a zone of 'transitional (T)' cells is found. In the present study we investigated the role of these T cells in P-to-V conduction. Using the 'model clamp' technique, an experimentally recorded rabbit P cell was coupled to a phase-2 Luo and Rudy (LR) model cell, which in turn was coupled to a strand of phase-2 LR model cells. In our experiments, the ...
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