Rats with a cutaneous burn exhibited a burn-size-related depression of serum thyroid hormones 2 weeks after injury. Thyroidectomized rats had a marked rise in brain in vitro T4 deiodination to T3 and in serum TSH concentration compared to controls. These normal responses to depressed thyroid hormones were not seen in burned rats. The depression of serum thyronines and thyrotrophin suggests that the burned rat may be a model for human ...
The Syrian (golden) hamster has provided the most extensively studied model of pineal physiology, and in the species the pineal gland has a potent suppressive effect on the reproductive system and on serum free thyroxim (T4) concentration. The pineal's suppressive effect on the gonads and T4 is classically evoked by subjecting the hamsters to a short photoperiod (less than 12-h light/day) or to blinding by bilateral orbital enucleation. Additional pinealectomy ...
A single subcutaneous injection of melatonin to rat or mouse pups on the day of birth inhibited the compensatory ovarian hypertrophy response to unilateral ovariectomy at six weeks of age. The body weights of melatonin-treated female mice were significantly depressed as compared to the body weights of control animals and failed to increase after castration. Compensatory adrenal hypertrophy failed to occur in mice treated with melatonin on the day of ...
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