A study was conducted to evaluate effects of the drug, recombinant activated Factor VII (rFVIIa) on survival, survival time, blood loss, and disseminated intravascular coagulation (DIC) in hypothermic, coagulopathic swine subsequent to severe liver injury and associated hemorrhage. Swine were anesthetized, and catheters were placed in the carotid artery, in the jugular, and in the femoral artery. After midline laparotomy, splenectomy and stabilization of blood pressure, pH, and body temperature, ...
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