ST-246, a potent, orally available orthopox egress inhibitor, is safe and effective at preventing disease and death in small animal models (mice, rabbits, ground squirrels) challenged by different pathogenic poxv viruses including vaccinia virus, cowpox virus, ectromelia virus, and monkeypox virus. In this report, the antiviral efficacy of ST-246 was assessed in non-human primates infected with variola virus or monkeypox virus. The data indicate that once per day oral dosing ...
Host responses to Venezuelan equine encephalitis viruses (VEEV) were studied in cynomolgus macaques after aerosol exposure to the epizootic virus. Changes in global gene expression were assessed for the brain, lungs, and spleen. In the brain, major histocompatibility complex (MHC) class I transcripts were induced, while the expression of S100b, a factor associated with brain injury, was inhibited, as was expression of the encephalitogenic gene MOG. Cytokine-mediated signals were affected ...
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