Tumor-associated macrophages may comprise up to 50% of the tumor mass in breast cancer and are capable of producing estrogen and angiogenic cytokines that regulate the growth and angiogenesis of breast cancer. The purpose of this study is to determine whether intratumoral injecUon of liposome-encapsulated dichlornmethyene diphosphonate (clodronate). a potent macrophage-depleting agent. can deplete tumor-associated macrophages in a murine breast cancer model. and whether depletion of tumor-associated macrophages has any ...
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